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Pu, William
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William T. Pu, M.D.
Title
Aldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular Research
Institution
Boston Children's Hospital
Department
Pediatrics
Address
Childrens Hospital
Cardiology, Enders 13
300 Longwood Ave
Boston MA 02115
Phone
617/919-2091
Fax
617/730-0140
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01HL156503
(PU, WILLIAM TSWENCHING)
Mar 1, 2021 - Feb 28, 2025
NIH
Genetic regulation of atrial gene expression in development and disease
Role: Principal Investigator
R01HL151450
(PU, WILLIAM TSWENCHING)
Feb 15, 2021 - Jan 31, 2025
NIH
Regulation of endothelial cell specification
Role: Principal Investigator
UG3TR003279
(PU, WILLIAM TSWENCHING)
Aug 1, 2020 - Jul 31, 2022
NIH
Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardia
Role: Principal Investigator
R01HL146634
(PU, WILLIAM TSWENCHING)
Mar 15, 2019 - Jan 31, 2023
NIH
Regulation of Cardiomyocyte Maturation
Role: Principal Investigator
R21HD094909
(PU, WILLIAM TSWENCHING)
Aug 3, 2018 - Jul 31, 2020
NIH
Enabling mammalian in vivo forward genetic screens based on cell morphology
Role: Principal Investigator
UH3HL141798
(PARKER, KEVIN KIT)
Sep 1, 2017 - Jul 31, 2022
NIH
Multi-scale modeling of inherited pediatric cardiomyopathies
Role: Co-Principal Investigator
UG3HL141798
(PARKER, KEVIN KIT)
Sep 1, 2017 - Jul 31, 2019
NIH
Multi-scale modeling of inherited pediatric cardiomyopathies
Role: Co-Principal Investigator
R01HL138571
(PU, WILLIAM TSWENCHING)
Aug 1, 2017 - Jul 31, 2021
NIH
Transcriptional regulation of arteriovenous differentiation
Role: Principal Investigator
R01HL128694
(PU, WILLIAM TSWENCHING)
Jul 1, 2015 - Apr 30, 2020
NIH
Understanding mitochondrial regulation of cardiac development and function through studies of Barth Syndrome
Role: Principal Investigator
R13HL128009
(PU, WILLIAM TSWENCHING)
Apr 30, 2015 - Apr 29, 2016
NIH
2015 Weinstein Cardiovaascular Development Conference
Role: Principal Investigator
R01HL116461
(PU, WILLIAM TSWENCHING)
Feb 1, 2013 - Jan 31, 2018
NIH
YAP1 Regulation of cardiomyocyte proliferation, function, and regeneration
Role: Principal Investigator
R01HL095712
(PU, WILLIAM TSWENCHING)
Jan 15, 2010 - Dec 31, 2014
NIH
Regulation of Heart Function by a Gata4-Fog2 transcriptional complex
Role: Principal Investigator
UM1HL098166
(SEIDMAN, JONATHAN G)
Sep 30, 2009 - Oct 31, 2020
NIH
Regulation of Cardiac Development in Health and Disease
Role: Co-Principal Investigator
RC1HL099618
(PU, WILLIAM TSWENCHING)
Sep 30, 2009 - Aug 31, 2012
NIH
Characterization of Cardiac Progenitors Derived from 22q11-deleted Patients
Role: Co-Principal Investigator
R01HL094683
(PU, WILLIAM TSWENCHING)
Jan 1, 2009 - Jun 30, 2018
NIH
Epicardial progenitors in the developing and postnatal heart
Role: Principal Investigator
R21HL089417
(PU, WILLIAM TSWENCHING)
Jul 17, 2007 - Jun 30, 2010
NIH
Genome-wide discovery of alternative splicing in human heart failure
Role: Principal Investigator
K08HL004387
(PU, WILLIAM TSWENCHING)
Jul 1, 2000 - Jun 30, 2005
NIH
HAND GENES IN CARDIAC DEVELOPMENT
Role: Principal Investigator
T32HL007572
(PU, WILLIAM TSWENCHING)
Jan 1, 1983 - Jun 30, 2026
NIH
Research Methods in Pediatric Cardiovascular Disease
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L,
Pu WT
, Parker KK. Addendum: A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2022 Mar 08.
PMID:
35260798
.
Citations:
Fields:
Bio
Biomedical Engineering
Zheng Y,
VanDusen NJ
, Butler CE, Ma Q, King JS,
Pu WT
. Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes. Circulation. 2022 Mar 08; 145(10):787-789.
PMID:
35254919
.
Citations:
Fields:
Car
Cardiology
Vas
Vascular Diseases
Sohn J,
Milosevic J
, Brouse T, Aziz N, Elkhoury J, Wang S, Hauschild A, van Gastel N,
Cetinbas M
, Tufa SF, Keene DR,
Sadreyev R
,
Pu WT
,
Sykes DB
. A new murine model of Barth Syndrome neutropenia links TAFAZZIN deficiency to increased ER stress induced apoptosis. Blood Adv. 2022 Jan 03.
PMID:
34979560
.
Citations:
Fields:
Hem
Hematology
Thompson R, Jefferies J, Wang S,
Pu WT
, Takemoto C, Hornby B, Heyman A, Chin MT, Vernon HJ. Current and future treatment approaches for Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):17-28.
PMID:
34713454
.
Citations:
Fields:
Met
Metabolism
Translation:
Humans
Animals
VanDusen NJ
, Lee JY, Gu W, Butler CE, Sethi I, Zheng Y, King JS, Zhou P,
Suo S
, Guo Y, Ma Q, Yuan GC,
Pu WT
. Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 Aug 19; 12(1):5105.
PMID:
34413306
.
Citations:
1
Fields:
Bio
Biology
Sci
Science
Pu WT
. Experimental models of Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):72-81.
PMID:
34370877
.
Citations:
Fields:
Met
Metabolism
Translation:
Humans
Animals
Cells
He X, Liu J, Gu F, Chen J,
Lu YW
, Ding J, Guo H, Nie M, Kataoka M, Lin Z, Hu X, Chen H, Liao X, Dong Y, Min W, Deng ZL,
Pu WT
, Huang ZP,
Wang DZ
. Cardiac CIP protein regulates dystrophic cardiomyopathy. Mol Ther. 2022 02 02; 30(2):898-914.
PMID:
34400329
.
Citations:
Fields:
Mol
Molecular Biology
The
Therapeutics
VanDusen NJ
, Lee JY, Gu W, Butler CE, Sethi I, Zheng Y, King JS, Zhou P,
Suo S
, Guo Y, Ma Q, Yuan GC,
Pu WT
. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 07 21; 12(1):4442.
PMID:
34290256
.
Citations:
2
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Dalal JS,
Winden KD
,
Salussolia CL
,
Sundberg M
, Singh A, Pham TT, Zhou P,
Pu WT
, Miller MT,
Sahin M
. Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts. Elife. 2021 07 14; 10.
PMID:
34259631
.
Citations:
Fields:
Bio
Biology
Translation:
Animals
Cells
Gao Y, Sun Y, Ercan-Sencicek AG, King JS, Akerberg BN, Ma Q,
Kontaridis MI
,
Pu WT
, Lin Z. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021 Jun 22; 22(13).
PMID:
34206257
.
Citations:
3
Fields:
Bio
Biochemistry
Che
Chemistry
Mol
Molecular Biology
Translation:
Animals
Cells
Wang S,
Pu WT
. Calcific aortic valve disease: turning therapeutic discovery up a notch. Nat Rev Cardiol. 2021 05; 18(5):309-310.
PMID:
33608670
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Cells
Liu X, Wang S, Guo X, Li Y, Ogurlu R, Lu F,
Prondzynski M
,
de la Serna Buzon S
, Ma Q, Zhang D, Wang G, Cotton J, Guo Y,
Xiao L
, Milan DJ, Xu Y, Schlame M,
Bezzerides VJ
,
Pu WT
. Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. Circulation. 2021 05 11; 143(19):1894-1911.
PMID:
33793303
.
Citations:
8
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Bezzerides VJ
,
Pu WT
. Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. Cardiovasc Res. 2021 03 21; 117(4):983-984.
PMID:
33155033
.
Citations:
1
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C,
Pu WT
, Sun K, Zhang B. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 05 18; 143(20):2007-2022.
PMID:
33663221
.
Citations:
1
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Liu J, Wen T, Dong K, He X, Zhou H, Shen J, Fu Z, Hu G, Ma W, Li J, Wang W, Wang L, Akerberg BN, Xu J, Osman I, Zheng Z, Wang W, Du Q,
Pu WT
, Xiang M, Chen W, Su H, Zhang W, Zhou J. TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. Cell Death Differ. 2021 07; 28(7):2045-2059.
PMID:
33469230
.
Citations:
5
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Guo Y, Cao Y, Jardin BD, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N,
Trembley MA
, Small EM, Yuan GC,
Beggs AH
,
Pu WT
. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 01 12; 118(2).
PMID:
33361330
.
Citations:
8
Fields:
Sci
Science
Translation:
Animals
Cells
Wang S, Guo Y,
Pu WT
. AAV Gene Transfer to the Heart. Methods Mol Biol. 2021; 2158:269-280.
PMID:
32857380
.
Citations:
2
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, Haeussler M,
Pu WT
, Stuart JM,
Seidman CE
,
Seidman JG
, Heyn H, Bruneau BG. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 02 08; 56(3):292-309.e9.
PMID:
33321106
.
Citations:
11
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Humans
Animals
Cells
Guo H,
Lu YW
, Lin Z, Huang ZP, Liu J, Wang Y, Seok HY, Hu X, Ma Q, Li K, Kyselovic J, Wang Q, Lin JL, Lin JJ,
Cowan DB
, Naya F, Chen Y,
Pu WT
,
Wang DZ
. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666.
PMID:
32938943
.
Citations:
2
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Konstantinidis K,
Bezzerides VJ
, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL,
Gladyshev VN
, Hund TJ,
Pu WT
, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678.
PMID:
32749237
.
Citations:
5
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Cai W, Huang J,
Zhu Q
, Li BE, Seruggia D, Zhou P, Nguyen M,
Fujiwara Y
, Xie H, Yang Z, Hong D, Ren P, Xu J,
Pu WT
, Yuan GC,
Orkin SH
. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21450-21458.
PMID:
32817427
.
Citations:
6
Fields:
Sci
Science
Translation:
Animals
Cells
Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z,
Pu WT
, Chen S, Chen Y, Sun K, Ge B, Zhang B. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18; 32(7):108058.
PMID:
32814055
.
Citations:
1
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z,
Pu WT
, Chen S, Chen Y, Sun K, Ge B, Zhang B. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 07 28; 32(4):107974.
PMID:
32726637
.
Citations:
2
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Liu J, Huang ZP, Nie M, Wang G, Silva WJ, Yang Q, Freire PP, Hu X, Chen H, Deng Z,
Pu WT
,
Wang DZ
. Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19254-19265.
PMID:
32719146
.
Citations:
6
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Wang K,
Lin RZ
,
Hong X
, Ng AH, Lee CN, Neumeyer J, Wang G, Wang X, Ma M,
Pu WT
, Church GM,
Melero-Martin JM
. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 07; 6(30):eaba7606.
PMID:
32832668
.
Citations:
15
Fields:
Sci
Science
Bezzerides VJ
,
Prondzynski M
, Carrier L,
Pu WT
. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 07 15; 116(9):1635-1650.
PMID:
32321160
.
Citations:
5
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Lu F,
Pu WT
. The architecture and function of cardiac dyads. Biophys Rev. 2020 Aug; 12(4):1007-1017.
PMID:
32661902
.
Citations:
5
Akerberg BN,
Pu WT
. Genetic and Epigenetic Control of Heart Development. Cold Spring Harb Perspect Biol. 2020 07 01; 12(7).
PMID:
31818853
.
Citations:
5
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Guo Y,
Pu WT
. Cardiomyocyte Maturation: New Phase in Development. Circ Res. 2020 04 10; 126(8):1086-1106.
PMID:
32271675
.
Citations:
71
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Wang S, Li Y, Xu Y, Ma Q, Lin Z, Schlame M,
Bezzerides VJ
, Strathdee D,
Pu WT
. AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. Circ Res. 2020 04 10; 126(8):1024-1039.
PMID:
32146862
.
Citations:
16
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A,
Singh SA
,
Aikawa M
, Holton K, Proia RL, Kono M,
Pu WT
, Camerer E, Betsholtz C,
Hla T
. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9.
PMID:
32091396
.
Citations:
10
Fields:
Bio
Biology
Translation:
Animals
Cells
Chen J, Liang X, Zhang S, Wang S, Garcia SP, Yan P, Yu H, Li Z, Liu L, Zhang F, Wei W, Le H, Zhang Y, Yuan GC, Chen S, Chen Y, Sun K,
Pu WT
, Zhang B. Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020 01 30; 11(1):75.
PMID:
32001672
.
Citations:
3
Fields:
Cel
Cell Biology
Int
Internal Medicine
Translation:
Humans
Animals
Cells
Chen J, Ma Q, King JS, Sun Y, Xu B, Zhang X, Zohrabian S, Guo H, Cai W, Li G, Bruno I, Cooke JP, Wang C,
Kontaridis M
,
Wang DZ
, Luo H,
Pu WT
, Lin Z. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020 01; 3(1).
PMID:
31843959
.
Citations:
9
Fields:
Bio
Biochemistry
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Pu W
, Wang Y, Yang N, Guo G, Li H, Li Q, Ur Rehman N, Zheng L, Wang P, Han S, Zhou CC, Zheng J, Zeng J, Yuan J. Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. J Appl Microbiol. 2020 Mar; 128(3):784-793.
PMID:
31651063
.
Citations:
2
Fields:
Mic
Microbiology
Translation:
Humans
Animals
Cells
Akerberg BN, Gu F,
VanDusen NJ
, Zhang X,
Dong R
, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P,
Pu WT
. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 10 28; 10(1):4907.
PMID:
31659164
.
Citations:
28
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Liu Q, Lin J, Han J, Zhang Y, Lu J, Tu W, Zhao Y, Guo G, Chu H,
Pu W
, Liu J, Ma Y, Chen X, Zhang R, Gu J, Zou H, Jin L, Wu W, Ren S, Wang J. Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification. Scand J Rheumatol. 2020 Mar; 49(2):146-153.
PMID:
31538512
.
Citations:
3
Fields:
Rhe
Rheumatology
Translation:
Humans
Austin KM
,
Trembley MA
, Chandler SF,
Sanders SP
,
Saffitz JE
,
Abrams DJ
,
Pu WT
. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537.
PMID:
31028357
.
Citations:
49
Fields:
Car
Cardiology
Translation:
Humans
Animals
Cells
Park SJ, Zhang D, Qi Y, Li Y, Lee KY,
Bezzerides VJ
, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J,
Roberts AE
,
Kleber AG
,
Abrams DJ
,
Pu WT
, Parker KK. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 07 30; 140(5):390-404.
PMID:
31311300
.
Citations:
30
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Cells
Bezzerides VJ
, Caballero A, Wang S, Ai Y, Hylind RJ, Lu F, Heims-Waldron DA,
Chambers KD
, Zhang D,
Abrams DJ
,
Pu WT
. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. Circulation. 2019 07 30; 140(5):405-419.
PMID:
31155924
.
Citations:
24
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X,
Pu WT
, Wang J, Chen J,
Wang DZ
. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 04 17; 10(1):1802.
PMID:
30996254
.
Citations:
69
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y,
Park PJ
, Liu ZJ, Sun K, Yuan GC,
Pu WT
, Zhang B. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Res. 2019 02; 29(2):193-207.
PMID:
30670628
.
Citations:
3
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R,
Pu WT
, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169.
PMID:
30605412
.
Citations:
10
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Pierpont ME, Brueckner M, Chung WK, Garg V,
Lacro RV
, McGuire AL, Mital S, Priest JR,
Pu WT
, Roberts A, Ware SM, Gelb BD, Russell MW. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 11 20; 138(21):e653-e711.
PMID:
30571578
.
Citations:
87
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Guo Y, Jardin BD, Zhou P, Sethi I, Akerberg BN, Toepfer CN, Ai Y, Li Y, Ma Q, Guatimosim S, Hu Y, Varuzhanyan G,
VanDusen NJ
, Zhang D, Chan DC, Yuan GC,
Seidman CE
,
Seidman JG
,
Pu WT
. Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor. Nat Commun. 2018 09 21; 9(1):3837.
PMID:
30242271
.
Citations:
23
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Xiong S, Berkhouse H, Schooler M,
Pu W
, Sun A, Gong E, Yan LL. Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review. Curr Hypertens Rep. 2018 08 07; 20(10):86.
PMID:
30088110
.
Citations:
22
Fields:
Vas
Vascular Diseases
Translation:
Humans
MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L,
Pu WT
, Parker KK. A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2018 12; 2(12):930-941.
PMID:
31015723
.
Citations:
44
Fields:
Bio
Biomedical Engineering
Translation:
Humans
Animals
Cells
Zhang D,
Pu WT
. Exercising engineered heart muscle to maturity. Nat Rev Cardiol. 2018 07; 15(7):383-384.
PMID:
29795442
.
Citations:
4
Fields:
Car
Cardiology
Translation:
Humans
Cells
Guo Y,
Pu WT
. Genetic Mosaics for Greater Precision in Cardiovascular Research. Circ Res. 2018 06 22; 123(1):27-29.
PMID:
29929974
.
Citations:
7
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H,
Pu WT
, Zhou B. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12):1488-1498.
PMID:
29131159
.
Citations:
76
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Animals
Cells
Zhang D, Li Y, Heims-Waldron D,
Bezzerides V
, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J,
Wang DZ
,
Pu WT
. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87.
PMID:
29021295
.
Citations:
32
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
VanDusen NJ
, Guo Y, Gu W,
Pu WT
. CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo. Curr Protoc Mol Biol. 2017 10 02; 120:31.11.1-31.11.14.
PMID:
28967995
.
Citations:
11
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Chen J, Fu Y, Day DS,
Sun Y
, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y,
Lin RZ
,
Smith LEH
, Zhang J, Sun K,
Melero-Martin JM
, Han Z,
Park PJ
, Zhang B,
Pu WT
. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383.
PMID:
28851877
.
Citations:
32
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM,
Pu WT
, Anderson RH, Zhou B. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun. 2017 07 20; 8(1):87.
PMID:
28729659
.
Citations:
24
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Lin RZ
, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P,
Moses MA
, Sachdev M,
Pu WT
, Emani S,
Melero-Martin JM
. Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1.
PMID:
28868207
.
Citations:
26
Fields:
Bio
Biomedical Engineering
Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M,
Pu W
, Watkins S, Grossfeld P, Murray SA, Porter GA, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul; 49(7):1152-1159.
PMID:
28530678
.
Citations:
66
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C,
Pu WT
, He A. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circ Res. 2017 Jul 07; 121(2):106-112.
PMID:
28512107
.
Citations:
25
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Sun Y
, Lin Z, Liu CH, Gong Y, Liegl R, Fredrick TW, Meng SS, Burnim SB, Wang Z,
Akula JD
,
Pu WT
,
Chen J
,
Smith LEH
. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767.
PMID:
28465464
.
Citations:
28
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Animals
Cells
Yu W, Zhang F, Wang S, Fu Y, Chen J, Liang X, Le H,
Pu WT
, Zhang B. Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 04 13; 8(4):e2744.
PMID:
28406475
.
Citations:
15
Fields:
Cel
Cell Biology
Int
Internal Medicine
Translation:
Animals
Cells
Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z,
Zhou P
, Xie H, Prendiville TW, Zheng W, Liu Y,
Orkin SH
, Wang DZ, Yu J,
Pu WT
, He A. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 04 10; 6.
PMID:
28394251
.
Citations:
21
Fields:
Bio
Biology
Translation:
Animals
Cells
Guo Y,
VanDusen NJ
, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS,
Pu WT
. Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 09; 120(12):1874-1888.
PMID:
28356340
.
Citations:
50
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Galdos FX, Guo Y, Paige SL,
VanDusen NJ
, Wu SM,
Pu WT
. Cardiac Regeneration: Lessons From Development. Circ Res. 2017 Mar 17; 120(6):941-959.
PMID:
28302741
.
Citations:
54
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Zhou P
, Gu F, Zhang L, Akerberg BN, Ma Q, Li K, He A, Lin Z, Stevens SM, Zhou B,
Pu WT
. Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq. Elife. 2017 01 25; 6.
PMID:
28121289
.
Citations:
28
Fields:
Bio
Biology
Translation:
Animals
Cells
Ding J, Lin ZQ, Jiang JM,
Seidman CE
,
Seidman JG
,
Pu WT
,
Wang DZ
. Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. J Vis Exp. 2016 12 17; (118).
PMID:
28060283
.
Citations:
3
Fields:
Bio
Biology
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Wang G, Yang L, Grishin D, Rios X, Ye LY, Hu Y, Li K, Zhang D,
Church GM
,
Pu WT
. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nat Protoc. 2017 Jan; 12(1):88-103.
PMID:
27929521
.
Citations:
32
Fields:
Cli
Clinical Laboratory Techniques
Sci
Science
Translation:
Humans
Cells
Bezzerides VJ
, Zhang D,
Pu WT
. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21.
PMID:
27916777
.
Citations:
6
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
DeLaughter DM, Bick AG,
Wakimoto H
, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J,
Pu W
, Bruneau BG,
Seidman JG
,
Seidman CE
. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490.
PMID:
27840107
.
Citations:
159
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Humans
Animals
Cells
Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD,
Pu WT
, Chien KR. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72.
PMID:
27803039
.
Citations:
28
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG,
Pu WT
,
Wang DZ
. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Nov 01; 112(2):543-554.
PMID:
27557636
.
Citations:
31
Fields:
Car
Cardiology
Vas
Vascular Diseases
Lin Z, Guo H, Cao Y, Zohrabian S,
Zhou P
, Ma Q,
VanDusen N
, Guo Y, Zhang J, Stevens SM,
Liang F
, Quan Q, van Gorp PR, Li A, Dos Remedios C, He A,
Bezzerides VJ
,
Pu WT
. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479.
PMID:
27720608
.
Citations:
43
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Humans
Animals
Cells
Day DS, Zhang B, Stevens SM, Ferrari F, Larschan EN,
Park PJ
,
Pu WT
. Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. Genome Biol. 2016 06 03; 17(1):120.
PMID:
27259512
.
Citations:
24
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Stevens SM, von Gise A,
VanDusen N
, Zhou B,
Pu WT
. Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016 05 15; 413(2):153-159.
PMID:
26988120
.
Citations:
21
Fields:
Bio
Biology
Emb
Embryology
Translation:
Animals
Cells
Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B,
Pu W
, Lui KO, Zhou B. GATA4 regulates Fgf16 to promote heart repair after injury. Development. 2016 Mar 15; 143(6):936-49.
PMID:
26893347
.
Citations:
46
Fields:
Bio
Biology
Emb
Embryology
Translation:
Animals
Cells
Zhou P
,
Pu WT
. Recounting Cardiac Cellular Composition. Circ Res. 2016 Feb 05; 118(3):368-70.
PMID:
26846633
.
Citations:
122
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
von Gise A, Stevens SM, Honor LB, Oh JH, Gao C, Zhou B,
Pu WT
. Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):222-30.
PMID:
26121126
.
Citations:
13
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Pu W
, Luo Q, Palaniyappan L, Xue Z, Yao S, Feng J, Liu Z. Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia. Psychol Med. 2016 Apr; 46(6):1211-24.
PMID:
26743997
.
Citations:
16
Fields:
Psy
Psychology
Translation:
Humans
Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B,
Wakimoto H
, Zeng C, Kyselovic J, Deng ZL,
Seidman CE
,
Seidman JG
,
Pu WT
,
Wang DZ
. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34.
PMID:
26436652
.
Citations:
19
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Sun Y
, Ju M, Lin Z, Fredrick TW, Evans LP, Tian KT, Saba NJ, Morss PC,
Pu WT
,
Chen J
, Stahl A, Joyal JS,
Smith LE
. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94.
PMID:
26396267
.
Citations:
19
Fields:
Cel
Cell Biology
Phy
Physiology
Sci
Science
Translation:
Animals
Cells
Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B,
Pu WT
, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR. Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015; 10(9):e0136025.
PMID:
26390289
.
Citations:
11
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Sun Y
, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A,
Pu WT
, Kamenecka TM, Solt LA,
Chen J
. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6.
PMID:
26243880
.
Citations:
24
Fields:
Sci
Science
Translation:
Animals
Cells
Ding J, Chen J, Wang Y, Kataoka M, Ma L,
Zhou P
, Hu X, Lin Z, Nie M, Deng ZL,
Pu WT
,
Wang DZ
. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83.
PMID:
26029872
.
Citations:
32
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Prendiville TW, Guo H, Lin Z,
Zhou P
, Stevens SM, He A,
VanDusen N
, Chen J, Zhong L,
Wang DZ
, Gao G,
Pu WT
. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105.
PMID:
26023924
.
Citations:
20
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Tian X,
Pu WT
, Zhou B. Cellular origin and developmental program of coronary angiogenesis. Circ Res. 2015 Jan 30; 116(3):515-30.
PMID:
25634974
.
Citations:
57
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Lin Z,
Pu WT
. Releasing YAP from an a-catenin trap increases cardiomyocyte proliferation. Circ Res. 2015 Jan 02; 116(1):9-11.
PMID:
25552687
.
Citations:
6
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Yang L, Grishin D, Wang G, Aach J,
Zhang CZ
, Chari R, Homsy J, Cai X, Zhao Y, Fan JB,
Seidman C
,
Seidman J
,
Pu W
,
Church G
. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun. 2014 Nov 26; 5:5507.
PMID:
25425480
.
Citations:
71
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Harvey RP, Graham RM,
Pu WT
. Introduction to the special issue on heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):521-2.
PMID:
25459518
.
Citations:
1
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Prendiville T, Jay PY,
Pu WT
. Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med. 2014 Oct 01; 4(10).
PMID:
25274754
.
Citations:
16
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Liu Q, Huang X, Oh JH,
Lin RZ
, Duan S, Yu Y, Yang R, Qiu J,
Melero-Martin JM
,
Pu WT
, Zhou B. Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9.
PMID:
25257468
.
Citations:
21
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
He A, Gu F, Hu Y, Ma Q, Ye LY, Akiyama JA, Visel A, Pennacchio LA,
Pu WT
. Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun. 2014 Sep 24; 5:4907.
PMID:
25249388
.
Citations:
79
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Lin Z,
Zhou P
, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR,
Wang DZ
,
Pu WT
. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45.
PMID:
25249570
.
Citations:
110
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Li K, Wang G, Andersen T,
Zhou P
,
Pu WT
. Optimization of genome engineering approaches with the CRISPR/Cas9 system. PLoS One. 2014; 9(8):e105779.
PMID:
25166277
.
Citations:
63
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Prendiville TW, Ma Q, Lin Z,
Zhou P
, He A,
Pu WT
. Ultrasound-guided transthoracic intramyocardial injection in mice. J Vis Exp. 2014 Aug 05; (90):e51566.
PMID:
25146757
.
Citations:
7
Fields:
Bio
Biology
Med
Medicine (General)
Translation:
Animals
Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP,
Pu WT
, Zhou B. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 04; 345(6192):90-4.
PMID:
24994653
.
Citations:
75
Fields:
Sci
Science
Translation:
Animals
Lin Z,
Pu WT
. Strategies for cardiac regeneration and repair. Sci Transl Med. 2014 Jun 04; 6(239):239rv1.
PMID:
24898748
.
Citations:
59
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Aronson BE, Rabello Aronson S, Berkhout RP, Chavoushi SF, He A,
Pu WT
, Verzi MP, Krasinski SD. GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. Biochim Biophys Acta. 2014 Nov; 1839(11):1273-82.
PMID:
24878542
.
Citations:
9
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Animals
Cells
Zhang B,
Pu WT
. Notching up vascular regeneration. Cell Res. 2014 Jul; 24(7):777-8.
PMID:
24853955
.
Citations:
1
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Lin Z, von Gise A,
Zhou P
, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J,
Seidman JG
,
Wang DZ
,
Pu WT
. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014 Jul 18; 115(3):354-63.
PMID:
24833660
.
Citations:
154
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL,
Camargo FD
,
Pu WT
, Zhou B. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014 Jul 04; 289(27):18681-92.
PMID:
24831012
.
Citations:
77
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J,
Roberts AE
, Ma Q, Ding J, Chen J,
Wang DZ
, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI,
Church GM
, Parker KK,
Pu WT
. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23.
PMID:
24813252
.
Citations:
365
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Lin Z,
Pu WT
. Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):571-81.
PMID:
24881775
.
Citations:
25
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Hu Y,
Pu WT
. Hippo activation in arrhythmogenic cardiomyopathy. Circ Res. 2014 Jan 31; 114(3):402-5.
PMID:
24481838
.
Citations:
5
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Tian X, Hu T, He L, Zhang H, Huang X, Poelmann RE, Liu W, Yang Z, Yan Y,
Pu WT
, Zhou B. Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PLoS One. 2013; 8(11):e80857.
PMID:
24278332
.
Citations:
11
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A,
Pu WT
, Hohenstein P, Martinez A, Schedl A. WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14; 27(1):5-18.
PMID:
24135228
.
Citations:
39
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Animals
Cells
Christoffels VM,
Pu WT
. Developing insights into cardiac regeneration. Development. 2013 Oct; 140(19):3933-7.
PMID:
24046314
.
Citations:
11
Fields:
Bio
Biology
Emb
Embryology
Translation:
Humans
Cells
Zangi L, Lui KO, von Gise A, Ma Q, Ebina W,
Ptaszek LM
, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B,
Nahrendorf M
,
Briscoe DM
, Li RA,
Wagers AJ
, Rossi DJ,
Pu WT
, Chien KR. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907.
PMID:
24013197
.
Citations:
220
Fields:
Bio
Biotechnology
Translation:
Humans
Animals
Cells
Zhou P
, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D,
Pu WT
. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15395-400.
PMID:
24003143
.
Citations:
60
Fields:
Sci
Science
Translation:
Animals
Cells
Stevens SM,
Pu WT
. HCN4 charges up the first heart field. Circ Res. 2013 Aug 02; 113(4):350-1.
PMID:
23908325
.
Citations:
2
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Zhang B,
Pu WT
. The mysterious origins of coronary vessels. Cell Res. 2013 Sep; 23(9):1063-4.
PMID:
23835479
.
Citations:
2
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D,
Pu WT
, Mangoni ME,
Clapham DE
. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14.
PMID:
23734001
.
Citations:
47
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Zhang B, Day DS, Ho JW, Song L, Cao J, Christodoulou D,
Seidman JG
, Crawford GE,
Park PJ
,
Pu WT
. A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res. 2013 Jun; 23(6):917-27.
PMID:
23547170
.
Citations:
51
Fields:
Gen
Genetics
Translation:
Humans
Cells
Zou L, Luo Y, Chen M, Wang G, Ding M, Petersen CC, Kang R, Dagnaes-Hansen F, Zeng Y, Lv N, Ma Q, Le DQ, Besenbacher F, Bolund L, Jensen TG, Kjems J,
Pu WT
, Bünger C. A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Sci Rep. 2013; 3:2243.
PMID:
23873182
.
Citations:
53
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Sartori DJ, Wilbur CJ, Long SY, Rankin MM, Li C, Bradfield JP, Hakonarson H, Grant SF,
Pu WT
, Kushner JA. GATA factors promote ER integrity and ß-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan; 28(1):28-39.
PMID:
24284823
.
Citations:
10
Fields:
End
Endocrinology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Zhou B,
Pu WT
. Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles. Circ Res. 2012 Nov 09; 111(11):e276-80.
PMID:
23139287
.
Citations:
34
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Riegler J, Price AN, Lythgoe MF, Davidson S, Yellon D,
Pu WT
, Riley PR. Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart. Ann N Y Acad Sci. 2012 Oct; 1269:92-101.
PMID:
23045976
.
Citations:
19
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Lage K, Greenway SC, Rosenfeld JA,
Wakimoto H
, Gorham JM, Segrè AV,
Roberts AE
, Smoot LB,
Pu WT
,
Pereira AC
, Mesquita SM, Tommerup N, Brunak S, Ballif BC, Shaffer LG,
Donahoe PK
,
Daly MJ
,
Seidman JG
,
Seidman CE
, Larsen LA. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14035-40.
PMID:
22904188
.
Citations:
61
Fields:
Sci
Science
Translation:
Humans
Cells
He A,
Pu WT
. Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2. Circ Res. 2012 Jul 06; 111(2):162-4.
PMID:
22773425
.
Citations:
3
Fields:
Car
Cardiology
Vas
Vascular Diseases
Sunshine SB, Dallabrida SM, Durand E, Ismail NS, Bazinet L, Birsner AE, Sohn R, Ikeda S,
Pu WT
, Kulke MH, Javaherian K,
Zurakowski D
, Folkman JM, Rupnick M. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11306-11.
PMID:
22733742
.
Citations:
15
Fields:
Sci
Science
Translation:
Humans
Animals
von Gise A,
Pu WT
. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ Res. 2012 Jun 08; 110(12):1628-45.
PMID:
22679138
.
Citations:
144
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA,
Pu WT
, Srivastava D, Garg V. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012; 8(5):e1002690.
PMID:
22589735
.
Citations:
39
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Lin RZ
, Moreno-Luna R, Zhou B,
Pu WT
,
Melero-Martin JM
. Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis. 2012 Sep; 15(3):443-55.
PMID:
22527199
.
Citations:
51
Fields:
Hem
Hematology
Translation:
Animals
Cells
Ounzain S, Kobayashi S, Peterson RE, He A, Motterle A, Samani NJ, Menick DR,
Pu WT
, Liang Q, Chong NW. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012 May; 32(10):1830-43.
PMID:
22431517
.
Citations:
7
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y,
Pu WT
,
Wang DZ
. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30.
PMID:
22343712
.
Citations:
16
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B,
Camargo FD
,
Pu WT
. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2394-9.
PMID:
22308401
.
Citations:
234
Fields:
Sci
Science
Translation:
Animals
Cells
Bisping E, Ikeda S, Sedej M, Wakula P, McMullen JR, Tarnavski O, Sedej S, Izumo S,
Pu WT
, Pieske B. Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem. 2012 Mar 23; 287(13):9827-9834.
PMID:
22228770
.
Citations:
14
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Zhou P
, He A,
Pu WT
. Regulation of GATA4 transcriptional activity in cardiovascular development and disease. Curr Top Dev Biol. 2012; 100:143-69.
PMID:
22449843
.
Citations:
49
Fields:
Emb
Embryology
Translation:
Humans
Animals
Cells
He A, Shen X, Ma Q, Cao J, von Gise A,
Zhou P
, Wang G, Marquez VE,
Orkin SH
,
Pu WT
. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 01; 26(1):37-42.
PMID:
22215809
.
Citations:
130
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Zhou B,
Pu WT
. Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. Methods Mol Biol. 2012; 843:155-68.
PMID:
22222530
.
Citations:
13
Fields:
Mol
Molecular Biology
Translation:
Animals
He A, Ma Q, Cao J, von Gise A,
Zhou P
, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P,
Daley GQ
,
Kong SW
,
Orkin SH
,
Seidman CE
,
Seidman JG
,
Pu WT
. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 03; 110(3):406-15.
PMID:
22158708
.
Citations:
94
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, Heffernan C, Menon MK, Scarlett CJ, Rashidianfar A, Biben C, Zoellner H, Colvin EK, Pimanda JE, Biankin AV, Zhou B,
Pu WT
, Prall OW, Harvey RP. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell. 2011 Dec 02; 9(6):527-40.
PMID:
22136928
.
Citations:
173
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Zhou B,
Pu WT
. Epicardial epithelial-to-mesenchymal transition in injured heart. J Cell Mol Med. 2011 Dec; 15(12):2781-3.
PMID:
21914126
.
Citations:
30
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Zhou B, Honor LB, Ma Q, Oh JH,
Lin RZ
,
Melero-Martin JM
, von Gise A,
Zhou P
, Hu T, He L, Wu KH, Zhang H, Zhang Y,
Pu WT
. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):43-7.
PMID:
21907210
.
Citations:
52
Fields:
Car
Cardiology
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Seok HY, Tatsuguchi M, Callis TE, He A,
Pu WT
,
Wang DZ
. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011 Oct 14; 286(41):35339-35346.
PMID:
21868385
.
Citations:
50
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
van Berlo JH, Elrod JW, Aronow BJ,
Pu WT
, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12331-6.
PMID:
21746915
.
Citations:
49
Fields:
Sci
Science
Translation:
Animals
Cells
Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF,
Pu WT
, Riley PR. De novo cardiomyocytes from within the activated adult heart after injury. Nature. 2011 Jun 08; 474(7353):640-4.
PMID:
21654746
.
Citations:
278
Fields:
Sci
Science
Translation:
Animals
Cells
von Gise A, Zhou B, Honor LB, Ma Q, Petryk A,
Pu WT
. WT1 regulates epicardial epithelial to mesenchymal transition through ß-catenin and retinoic acid signaling pathways. Dev Biol. 2011 Aug 15; 356(2):421-31.
PMID:
21663736
.
Citations:
109
Fields:
Bio
Biology
Emb
Embryology
Translation:
Animals
Cells
Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C,
Lin RZ
,
Melero-Martin JM
, Dolmatova E, Duffy HS, Gise Av,
Zhou P
, Hu YW, Wang G, Zhang B, Wang L, Hall JL,
Moses MA
, McGowan FX,
Pu WT
. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May; 121(5):1894-904.
PMID:
21505261
.
Citations:
253
Fields:
Med
Medicine (General)
Translation:
Animals
Cells