Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

William T. Pu, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL156503 (PU, WILLIAM TSWENCHING) Mar 1, 2021 - Feb 28, 2025
    NIH
    Genetic regulation of atrial gene expression in development and disease
    Role: Principal Investigator
  2. R01HL151450 (PU, WILLIAM TSWENCHING) Feb 15, 2021 - Jan 31, 2025
    NIH
    Regulation of endothelial cell specification
    Role: Principal Investigator
  3. UG3TR003279 (PU, WILLIAM TSWENCHING) Aug 1, 2020 - Jul 31, 2022
    NIH
    Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardia
    Role: Principal Investigator
  4. R01HL146634 (PU, WILLIAM TSWENCHING) Mar 15, 2019 - Jan 31, 2023
    NIH
    Regulation of Cardiomyocyte Maturation
    Role: Principal Investigator
  5. R21HD094909 (PU, WILLIAM TSWENCHING) Aug 3, 2018 - Jul 31, 2020
    NIH
    Enabling mammalian in vivo forward genetic screens based on cell morphology
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guo Y, Cao Y, Jardin BD, Zhang X, Zhou P, Guatimosim S, Lin J, Chen Z, Zhang Y, Mazumdar N, Lu F, Ma Q, Lu YW, Zhao M, Wang DZ, Dong E, Pu WT. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 Mar 17; 119(1):221-235. PMID: 35576474.
    Citations:    Fields:    
  2. Wang S, Yazawa E, Keating E, Mazumdar N, Hauschild A, Ma Q, Wu H, Xu Y, Shi X, Strathdee D, Gerszten RE, Schlame M, Pu WT. Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome. Hum Mol Genet. 2023 Mar 14. PMID: 36917259.
    Citations:    Fields:    
  3. McDonald CL, Qasba P, Anderson DG, Bao G, Colvin RA, Kohn DB, Malik P, Mitchell MJ, Pu WT, Rawlings DJ, Williams DA, Flotte TR. Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop. Hum Gene Ther. 2023 02; 34(3-4):83-89. PMID: 36794978.
    Citations:    Fields:    
  4. Cao Y, Zhang X, Akerberg BN, Yuan H, Sakamoto T, Xiao F, VanDusen NJ, Zhou P, Sweat ME, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu WT. In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation. 2023 Mar 14; 147(11):881-896. PMID: 36705030; PMCID: PMC10010668.
    Citations:    Fields:    
  5. Akerberg AA, Trembley M, Butty V, Schwertner A, Zhao L, Beerens M, Liu X, Mahamdeh M, Yuan S, Boyer L, MacRae C, Nguyen C, Pu WT, Burns CE, Burns CG. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022 12 02; 131(12):980-1000. PMID: 36367103; PMCID: PMC9770155.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK. Addendum: A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2022 11; 6(11):1318. PMID: 35260798.
    Citations:    Fields:    
  7. Zhou P, Zhang Y, Sethi I, Ye L, Trembley MA, Cao Y, Akerberg BN, Xiao F, Zhang X, Li K, Jardin BD, Mazumdar N, Ma Q, He A, Zhou B, Pu WT. GATA4 Regulates Developing Endocardium Through Interaction With ETS1. Circ Res. 2022 11 11; 131(11):e152-e168. PMID: 36263775; PMCID: PMC9669226.
    Citations:    Fields:    Translation:AnimalsCells
  8. Huang M, Akerberg AA, Zhang X, Yoon H, Joshi S, Hallinan C, Nguyen C, Pu WT, Haigis MC, Burns CG, Burns CE. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nat Commun. 2022 10 05; 13(1):5877. PMID: 36198703; PMCID: PMC9534849.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Yue P, Zhang Y, Liu L, Zhou K, Xia S, Peng M, Yan H, Tang X, Chen Z, Zhang D, Guo J, Pu WT, Guo Y, Hua Y, Li Y. Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload. Theranostics. 2022; 12(16):7009-7031. PMID: 36276651; PMCID: PMC9576622.
    Citations:    Fields:    Translation:AnimalsCells
  10. Sheldon C, Farley A, Ma Q, Pu WT, Lin Z. Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development. Cells. 2022 09 10; 11(18). PMID: 36139407; PMCID: PMC9496954.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Zech ATL, Prondzynski M, Singh SR, Pietsch N, Orthey E, Alizoti E, Busch J, Madsen A, Behrens CS, Meyer-Jens M, Mearini G, Lemoine MD, Krämer E, Mosqueira D, Virdi S, Indenbirken D, Depke M, Salazar MG, Völker U, Braren I, Pu WT, Eschenhagen T, Hammer E, Schlossarek S, Carrier L. ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes. Cells. 2022 09 02; 11(17). PMID: 36078153; PMCID: PMC9454684.
    Citations: 1     Fields:    Translation:HumansCells
  12. Hylind RJ, Pereira AC, Quiat D, Chandler SF, Roston TM, Pu WT, Bezzerides VJ, Seidman JG, Seidman CE, Abrams DJ. Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis. Circ Genom Precis Med. 2022 06; 15(3):e003507. PMID: 35536239; PMCID: PMC9400410.
    Citations:    Fields:    Translation:Humans
  13. Sohn J, Milosevic J, Brouse T, Aziz N, Elkhoury J, Wang S, Hauschild A, van Gastel N, Cetinbas M, Tufa SF, Keene DR, Sadreyev RI, Pu WT, Sykes DB. A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis. Blood Adv. 2022 04 26; 6(8):2557-2577. PMID: 34979560; PMCID: PMC9043941.
    Citations: 3     Fields:    Translation:HumansAnimals
  14. Lu F, Ma Q, Xie W, Liou CL, Zhang D, Sweat ME, Jardin BD, Naya FJ, Guo Y, Cheng H, Pu WT. CMYA5 establishes cardiac dyad architecture and positioning. Nat Commun. 2022 04 21; 13(1):2185. PMID: 35449169; PMCID: PMC9023524.
    Citations: 1     Fields:    Translation:Cells
  15. Robbe ZL, Shi W, Wasson LK, Scialdone AP, Wilczewski CM, Sheng X, Hepperla AJ, Akerberg BN, Pu WT, Cristea IM, Davis IJ, Conlon FL. CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart. Genes Dev. 2022 04 01; 36(7-8):468-482. PMID: 35450884; PMCID: PMC9067406.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Yan Y, Long T, Su Q, Wang Y, Chen K, Yang T, Zhao G, Ma Q, Hu X, Liu C, Liao X, Min W, Li S, Zhang D, Yang Y, Pu WT, Dong Y, Wang DZ, Chen Y, Huang ZP. Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure. Front Cardiovasc Med. 2022; 9:857049. PMID: 35369338; PMCID: PMC8970336.
    Citations:    
  17. Zheng Y, VanDusen NJ, Butler CE, Ma Q, King JS, Pu WT. Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes. Circulation. 2022 03 08; 145(10):787-789. PMID: 35254919; PMCID: PMC9157414.
    Citations: 2     Fields:    Translation:HumansCells
  18. Thompson R, Jefferies J, Wang S, Pu WT, Takemoto C, Hornby B, Heyman A, Chin MT, Vernon HJ. Current and future treatment approaches for Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):17-28. PMID: 34713454.
    Citations: 3     Fields:    Translation:HumansAnimals
  19. VanDusen NJ, Lee JY, Gu W, Butler CE, Sethi I, Zheng Y, King JS, Zhou P, Suo S, Guo Y, Ma Q, Yuan GC, Pu WT. Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 Aug 19; 12(1):5105. PMID: 34413306.
    Citations: 1     Fields:    
  20. Pu WT. Experimental models of Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):72-81. PMID: 34370877; PMCID: PMC8814986.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. He X, Liu J, Gu F, Chen J, Lu YW, Ding J, Guo H, Nie M, Kataoka M, Lin Z, Hu X, Chen H, Liao X, Dong Y, Min W, Deng ZL, Pu WT, Huang ZP, Wang DZ. Cardiac CIP protein regulates dystrophic cardiomyopathy. Mol Ther. 2022 02 02; 30(2):898-914. PMID: 34400329; PMCID: PMC8822131.
    Citations: 2     Fields:    Translation:HumansAnimals
  22. VanDusen NJ, Lee JY, Gu W, Butler CE, Sethi I, Zheng Y, King JS, Zhou P, Suo S, Guo Y, Ma Q, Yuan GC, Pu WT. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 07 21; 12(1):4442. PMID: 34290256; PMCID: PMC8295283.
    Citations: 9     Fields:    Translation:AnimalsCells
  23. Dalal JS, Winden KD, Salussolia CL, Sundberg M, Singh A, Pham TT, Zhou P, Pu WT, Miller MT, Sahin M. Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts. Elife. 2021 07 14; 10. PMID: 34259631.
    Citations: 6     Fields:    Translation:AnimalsCells
  24. Gao Y, Sun Y, Ercan-Sencicek AG, King JS, Akerberg BN, Ma Q, Kontaridis MI, Pu WT, Lin Z. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021 Jun 22; 22(13). PMID: 34206257; PMCID: PMC8268263.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Wang S, Pu WT. Calcific aortic valve disease: turning therapeutic discovery up a notch. Nat Rev Cardiol. 2021 05; 18(5):309-310. PMID: 33608670.
    Citations: 1     Fields:    Translation:HumansCells
  26. Liu X, Wang S, Guo X, Li Y, Ogurlu R, Lu F, Prondzynski M, de la Serna Buzon S, Ma Q, Zhang D, Wang G, Cotton J, Guo Y, Xiao L, Milan DJ, Xu Y, Schlame M, Bezzerides VJ, Pu WT. Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. Circulation. 2021 05 11; 143(19):1894-1911. PMID: 33793303; PMCID: PMC8691127.
    Citations: 18     Fields:    Translation:HumansAnimals
  27. Bezzerides VJ, Pu WT. Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. Cardiovasc Res. 2021 03 21; 117(4):983-984. PMID: 33155033; PMCID: PMC7983003.
    Citations: 2     Fields:    Translation:Humans
  28. Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 05 18; 143(20):2007-2022. PMID: 33663221.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  29. Liu J, Wen T, Dong K, He X, Zhou H, Shen J, Fu Z, Hu G, Ma W, Li J, Wang W, Wang L, Akerberg BN, Xu J, Osman I, Zheng Z, Wang W, Du Q, Pu WT, Xiang M, Chen W, Su H, Zhang W, Zhou J. TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. Cell Death Differ. 2021 07; 28(7):2045-2059. PMID: 33469230; PMCID: PMC8257617.
    Citations: 14     Fields:    Translation:AnimalsCells
  30. Guo Y, Cao Y, Jardin BD, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, Pu WT. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). PMID: 33361330; PMCID: PMC7812832.
    Citations: 16     Fields:    Translation:AnimalsCells
  31. Wang S, Guo Y, Pu WT. AAV Gene Transfer to the Heart. Methods Mol Biol. 2021; 2158:269-280. PMID: 32857380.
    Citations: 3     Fields:    Translation:HumansCells
  32. Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, Haeussler M, Pu WT, Stuart JM, Seidman CE, Seidman JG, Heyn H, Bruneau BG. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 02 08; 56(3):292-309.e9. PMID: 33321106; PMCID: PMC7878434.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  33. Guo H, Lu YW, Lin Z, Huang ZP, Liu J, Wang Y, Seok HY, Hu X, Ma Q, Li K, Kyselovic J, Wang Q, Lin JL, Lin JJ, Cowan DB, Naya F, Chen Y, Pu WT, Wang DZ. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666. PMID: 32938943; PMCID: PMC7494909.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Konstantinidis K, Bezzerides VJ, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL, Gladyshev VN, Hund TJ, Pu WT, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678. PMID: 32749237; PMCID: PMC7456244.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  35. Cai W, Huang J, Zhu Q, Li BE, Seruggia D, Zhou P, Nguyen M, Fujiwara Y, Xie H, Yang Z, Hong D, Ren P, Xu J, Pu WT, Yuan GC, Orkin SH. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21450-21458. PMID: 32817427; PMCID: PMC7474592.
    Citations: 7     Fields:    Translation:AnimalsCells
  36. Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z, Pu WT, Chen S, Chen Y, Sun K, Ge B, Zhang B. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18; 32(7):108058. PMID: 32814055.
    Citations: 1     Fields:    
  37. Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z, Pu WT, Chen S, Chen Y, Sun K, Ge B, Zhang B. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 07 28; 32(4):107974. PMID: 32726637.
    Citations: 3     Fields:    Translation:HumansCells
  38. Liu J, Huang ZP, Nie M, Wang G, Silva WJ, Yang Q, Freire PP, Hu X, Chen H, Deng Z, Pu WT, Wang DZ. Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19254-19265. PMID: 32719146; PMCID: PMC7430979.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  39. Wang K, Lin RZ, Hong X, Ng AH, Lee CN, Neumeyer J, Wang G, Wang X, Ma M, Pu WT, Church GM, Melero-Martin JM. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 07; 6(30):eaba7606. PMID: 32832668; PMCID: PMC7439318.
    Citations: 30     Fields:    Translation:HumansCells
  40. Bezzerides VJ, Prondzynski M, Carrier L, Pu WT. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 07 15; 116(9):1635-1650. PMID: 32321160.
    Citations: 8     Fields:    Translation:HumansAnimals
  41. Lu F, Pu WT. The architecture and function of cardiac dyads. Biophys Rev. 2020 Aug; 12(4):1007-1017. PMID: 32661902.
    Citations: 8     
  42. Akerberg BN, Pu WT. Genetic and Epigenetic Control of Heart Development. Cold Spring Harb Perspect Biol. 2020 07 01; 12(7). PMID: 31818853; PMCID: PMC7280077.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  43. Guo Y, Pu WT. Cardiomyocyte Maturation: New Phase in Development. Circ Res. 2020 04 10; 126(8):1086-1106. PMID: 32271675.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  44. Wang S, Li Y, Xu Y, Ma Q, Lin Z, Schlame M, Bezzerides VJ, Strathdee D, Pu WT. AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. Circ Res. 2020 04 10; 126(8):1024-1039. PMID: 32146862.
    Citations: 30     Fields:    Translation:AnimalsCells
  45. Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. PMID: 32091396.
    Citations: 20     Fields:    Translation:AnimalsCells
  46. Chen J, Liang X, Zhang S, Wang S, Garcia SP, Yan P, Yu H, Li Z, Liu L, Zhang F, Wei W, Le H, Zhang Y, Yuan GC, Chen S, Chen Y, Sun K, Pu WT, Zhang B. Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020 01 30; 11(1):75. PMID: 32001672.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  47. Chen J, Ma Q, King JS, Sun Y, Xu B, Zhang X, Zohrabian S, Guo H, Cai W, Li G, Bruno I, Cooke JP, Wang C, Kontaridis M, Wang DZ, Luo H, Pu WT, Lin Z. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020 01; 3(1). PMID: 31843959; PMCID: PMC6918510.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  48. Pu W, Wang Y, Yang N, Guo G, Li H, Li Q, Ur Rehman N, Zheng L, Wang P, Han S, Zhou CC, Zheng J, Zeng J, Yuan J. Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. J Appl Microbiol. 2020 Mar; 128(3):784-793. PMID: 31651063.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  49. Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 10 28; 10(1):4907. PMID: 31659164; PMCID: PMC6817842.
    Citations: 42     Fields:    Translation:AnimalsCells
  50. Liu Q, Lin J, Han J, Zhang Y, Lu J, Tu W, Zhao Y, Guo G, Chu H, Pu W, Liu J, Ma Y, Chen X, Zhang R, Gu J, Zou H, Jin L, Wu W, Ren S, Wang J. Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification. Scand J Rheumatol. 2020 Mar; 49(2):146-153. PMID: 31538512.
    Citations: 3     Fields:    Translation:Humans
  51. Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. PMID: 31028357; PMCID: PMC6871180.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  52. Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 07 30; 140(5):390-404. PMID: 31311300; PMCID: PMC6750809.
    Citations: 44     Fields:    Translation:HumansCells
  53. Bezzerides VJ, Caballero A, Wang S, Ai Y, Hylind RJ, Lu F, Heims-Waldron DA, Chambers KD, Zhang D, Abrams DJ, Pu WT. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. Circulation. 2019 07 30; 140(5):405-419. PMID: 31155924; PMCID: PMC7274838.
    Citations: 34     Fields:    Translation:AnimalsCells
  54. Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu WT, Wang J, Chen J, Wang DZ. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 04 17; 10(1):1802. PMID: 30996254; PMCID: PMC6470165.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  55. Pu W, Guo G, Yang N, Li Q, Yin F, Wang P, Zheng J, Zeng J. Three species of Aeromonas (A. dhakensis, A. hydrophila and A. jandaei) isolated from freshwater crocodiles (Crocodylus siamensis) with pneumonia and septicemia. Lett Appl Microbiol. 2019 Mar; 68(3):212-218. PMID: 30609084.
    Citations: 6     Fields:    Translation:AnimalsCells
  56. Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y, Park PJ, Liu ZJ, Sun K, Yuan GC, Pu WT, Zhang B. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Res. 2019 02; 29(2):193-207. PMID: 30670628; PMCID: PMC6360815.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  57. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169. PMID: 30605412; PMCID: PMC6350935.
    Citations: 11     Fields:    Translation:HumansAnimals
  58. Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 11 20; 138(21):e653-e711. PMID: 30571578; PMCID: PMC6555769.
    Citations: 142     Fields:    Translation:Humans
  59. Guo Y, Jardin BD, Zhou P, Sethi I, Akerberg BN, Toepfer CN, Ai Y, Li Y, Ma Q, Guatimosim S, Hu Y, Varuzhanyan G, VanDusen NJ, Zhang D, Chan DC, Yuan GC, Seidman CE, Seidman JG, Pu WT. Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor. Nat Commun. 2018 09 21; 9(1):3837. PMID: 30242271; PMCID: PMC6155060.
    Citations: 34     Fields:    Translation:AnimalsCells
  60. Xiong S, Berkhouse H, Schooler M, Pu W, Sun A, Gong E, Yan LL. Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review. Curr Hypertens Rep. 2018 08 07; 20(10):86. PMID: 30088110.
    Citations: 29     Fields:    Translation:Humans
  61. MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK. A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2018 12; 2(12):930-941. PMID: 31015723; PMCID: PMC6774355.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  62. Zhang D, Pu WT. Exercising engineered heart muscle to maturity. Nat Rev Cardiol. 2018 07; 15(7):383-384. PMID: 29795442.
    Citations: 4     Fields:    Translation:HumansCells
  63. Guo Y, Pu WT. Genetic Mosaics for Greater Precision in Cardiovascular Research. Circ Res. 2018 06 22; 123(1):27-29. PMID: 29929974; PMCID: PMC6025841.
    Citations: 8     Fields:    Translation:AnimalsCells
  64. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12):1488-1498. PMID: 29131159; PMCID: PMC6913096.
    Citations: 100     Fields:    Translation:AnimalsCells
  65. Zhang D, Li Y, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J, Wang DZ, Pu WT. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87. PMID: 29021295; PMCID: PMC5756124.
    Citations: 49     Fields:    Translation:AnimalsCells
  66. VanDusen NJ, Guo Y, Gu W, Pu WT. CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo. Curr Protoc Mol Biol. 2017 10 02; 120:31.11.1-31.11.14. PMID: 28967995.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  67. Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. PMID: 28851877.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  68. Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM, Pu WT, Anderson RH, Zhou B. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun. 2017 07 20; 8(1):87. PMID: 28729659; PMCID: PMC5519540.
    Citations: 32     Fields:    Translation:AnimalsCells
  69. Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, Melero-Martin JM. Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1. PMID: 28868207.
    Citations: 29     Fields:    
  70. Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul; 49(7):1152-1159. PMID: 28530678; PMCID: PMC5737968.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  71. Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C, Pu WT, He A. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circ Res. 2017 Jul 07; 121(2):106-112. PMID: 28512107; PMCID: PMC5527745.
    Citations: 29     Fields:    Translation:AnimalsCells
  72. Sun Y, Lin Z, Liu CH, Gong Y, Liegl R, Fredrick TW, Meng SS, Burnim SB, Wang Z, Akula JD, Pu WT, Chen J, Smith LEH. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. PMID: 28465464; PMCID: PMC5461000.
    Citations: 37     Fields:    Translation:AnimalsCells
  73. Yu W, Zhang F, Wang S, Fu Y, Chen J, Liang X, Le H, Pu WT, Zhang B. Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 04 13; 8(4):e2744. PMID: 28406475.
    Citations: 17     Fields:    Translation:AnimalsCells
  74. Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 04 10; 6. PMID: 28394251.
    Citations: 25     Fields:    Translation:AnimalsCells
  75. Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT. Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 09; 120(12):1874-1888. PMID: 28356340; PMCID: PMC5466492.
    Citations: 62     Fields:    Translation:AnimalsCells
  76. Galdos FX, Guo Y, Paige SL, VanDusen NJ, Wu SM, Pu WT. Cardiac Regeneration: Lessons From Development. Circ Res. 2017 Mar 17; 120(6):941-959. PMID: 28302741; PMCID: PMC5358810.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  77. Zhou P, Gu F, Zhang L, Akerberg BN, Ma Q, Li K, He A, Lin Z, Stevens SM, Zhou B, Pu WT. Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq. Elife. 2017 01 25; 6. PMID: 28121289.
    Citations: 32     Fields:    Translation:AnimalsCells
  78. Ding J, Lin ZQ, Jiang JM, Seidman CE, Seidman JG, Pu WT, Wang DZ. Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. J Vis Exp. 2016 12 17; (118). PMID: 28060283; PMCID: PMC5226409.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  79. Wang G, Yang L, Grishin D, Rios X, Ye LY, Hu Y, Li K, Zhang D, Church GM, Pu WT. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nat Protoc. 2017 Jan; 12(1):88-103. PMID: 27929521.
    Citations: 42     Fields:    Translation:HumansCells
  80. Bezzerides VJ, Zhang D, Pu WT. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21. PMID: 27916777; PMCID: PMC5436929.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  81. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. PMID: 27840107; PMCID: PMC5198784.
    Citations: 184     Fields:    Translation:HumansAnimalsCells
  82. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. PMID: 27803039; PMCID: PMC5195872.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  83. Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Nov 01; 112(2):543-554. PMID: 27557636; PMCID: PMC5079274.
    Citations: 36     Fields:    
  84. Lin Z, Guo H, Cao Y, Zohrabian S, Zhou P, Ma Q, VanDusen N, Guo Y, Zhang J, Stevens SM, Liang F, Quan Q, van Gorp PR, Li A, Dos Remedios C, He A, Bezzerides VJ, Pu WT. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479. PMID: 27720608; PMCID: PMC5121000.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  85. Day DS, Zhang B, Stevens SM, Ferrari F, Larschan EN, Park PJ, Pu WT. Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. Genome Biol. 2016 06 03; 17(1):120. PMID: 27259512; PMCID: PMC4893286.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  86. Stevens SM, von Gise A, VanDusen N, Zhou B, Pu WT. Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016 05 15; 413(2):153-159. PMID: 26988120; PMCID: PMC5064848.
    Citations: 26     Fields:    Translation:AnimalsCells
  87. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B. GATA4 regulates Fgf16 to promote heart repair after injury. Development. 2016 Mar 15; 143(6):936-49. PMID: 26893347.
    Citations: 52     Fields:    Translation:AnimalsCells
  88. Zhou P, Pu WT. Recounting Cardiac Cellular Composition. Circ Res. 2016 Feb 05; 118(3):368-70. PMID: 26846633; PMCID: PMC4755297.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  89. von Gise A, Stevens SM, Honor LB, Oh JH, Gao C, Zhou B, Pu WT. Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):222-30. PMID: 26121126; PMCID: PMC4821041.
    Citations: 15     Fields:    Translation:AnimalsCells
  90. Pu W, Luo Q, Palaniyappan L, Xue Z, Yao S, Feng J, Liu Z. Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia. Psychol Med. 2016 Apr; 46(6):1211-24. PMID: 26743997.
    Citations: 19     Fields:    Translation:Humans
  91. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. PMID: 26436652; PMCID: PMC4639982.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  92. Sun Y, Ju M, Lin Z, Fredrick TW, Evans LP, Tian KT, Saba NJ, Morss PC, Pu WT, Chen J, Stahl A, Joyal JS, Smith LE. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. PMID: 26396267.
    Citations: 22     Fields:    Translation:AnimalsCells
  93. Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR. Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015; 10(9):e0136025. PMID: 26390289; PMCID: PMC4577115.
    Citations: 12     Fields:    Translation:AnimalsCells
  94. Sun Y, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A, Pu WT, Kamenecka TM, Solt LA, Chen J. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. PMID: 26243880; PMCID: PMC4547221.
    Citations: 30     Fields:    Translation:AnimalsCells
  95. Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng ZL, Pu WT, Wang DZ. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83. PMID: 26029872; PMCID: PMC4485565.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  96. Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105. PMID: 26023924.
    Citations: 23     Fields:    Translation:AnimalsCells
  97. Tian X, Pu WT, Zhou B. Cellular origin and developmental program of coronary angiogenesis. Circ Res. 2015 Jan 30; 116(3):515-30. PMID: 25634974; PMCID: PMC6914229.
    Citations: 68     Fields:    Translation:HumansAnimals
  98. Lin Z, Pu WT. Releasing YAP from an a-catenin trap increases cardiomyocyte proliferation. Circ Res. 2015 Jan 02; 116(1):9-11. PMID: 25552687; PMCID: PMC4283556.
    Citations: 6     Fields:    Translation:AnimalsCells
  99. Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J, Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun. 2014 Nov 26; 5:5507. PMID: 25425480; PMCID: PMC4352754.
    Citations: 75     Fields:    Translation:HumansCells
  100. Harvey RP, Graham RM, Pu WT. Introduction to the special issue on heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):521-2. PMID: 25459518.
    Citations: 1     Fields:    Translation:HumansAnimals
  101. Prendiville T, Jay PY, Pu WT. Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med. 2014 Oct 01; 4(10). PMID: 25274754.
    Citations: 18     Fields:    Translation:HumansAnimals
  102. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B. Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9. PMID: 25257468; PMCID: PMC4220154.
    Citations: 24     Fields:    Translation:AnimalsCells
  103. He A, Gu F, Hu Y, Ma Q, Ye LY, Akiyama JA, Visel A, Pennacchio LA, Pu WT. Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun. 2014 Sep 24; 5:4907. PMID: 25249388.
    Citations: 90     Fields:    Translation:AnimalsCells
  104. Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45. PMID: 25249570; PMCID: PMC4282610.
    Citations: 131     Fields:    Translation:AnimalsCells
  105. Li K, Wang G, Andersen T, Zhou P, Pu WT. Optimization of genome engineering approaches with the CRISPR/Cas9 system. PLoS One. 2014; 9(8):e105779. PMID: 25166277.
    Citations: 70     Fields:    Translation:AnimalsCells