Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

William T. Pu, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL156503 (PU, WILLIAM TSWENCHING) Mar 1, 2021 - Feb 28, 2025
    NIH
    Genetic regulation of atrial gene expression in development and disease
    Role: Principal Investigator
  2. R01HL151450 (PU, WILLIAM TSWENCHING) Feb 15, 2021 - Jan 31, 2025
    NIH
    Regulation of endothelial cell specification
    Role: Principal Investigator
  3. UG3TR003279 (PU, WILLIAM TSWENCHING) Aug 1, 2020 - Jun 30, 2022
    NIH
    Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardia
    Role: Principal Investigator
  4. R01HL146634 (PU, WILLIAM TSWENCHING) Mar 15, 2019 - Jan 31, 2023
    NIH
    Regulation of Cardiomyocyte Maturation
    Role: Principal Investigator
  5. R21HD094909 (PU, WILLIAM TSWENCHING) Aug 3, 2018 - Jul 31, 2020
    NIH
    Enabling mammalian in vivo forward genetic screens based on cell morphology
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang S, Pu WT. Calcific aortic valve disease: turning therapeutic discovery up a notch. Nat Rev Cardiol. 2021 May; 18(5):309-310. PMID: 33608670.
    Citations:    Fields:    
  2. Liu X, Wang S, Guo X, Li Y, Ogurlu R, Lu F, Prondzynski M, de la Serna Buzon S, Ma Q, Zhang D, Wang G, Cotton J, Guo Y, Xiao L, Milan DJ, Xu Y, Schlame M, Bezzerides VJ, Pu WT. Increased ROS-Mediated CaMKII Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. Circulation. 2021 Apr 01. PMID: 33793303.
    Citations:    Fields:    
  3. Bezzerides VJ, Pu WT. Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. Cardiovasc Res. 2021 Mar 21; 117(4):983-984. PMID: 33155033.
    Citations:    Fields:    
  4. Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 Mar 05. PMID: 33663221.
    Citations:    Fields:    
  5. Liu J, Wen T, Dong K, He X, Zhou H, Shen J, Fu Z, Hu G, Ma W, Li J, Wang W, Wang L, Akerberg BN, Xu J, Osman I, Zheng Z, Wang W, Du Q, Pu WT, Xiang M, Chen W, Su H, Zhang W, Zhou J. TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. Cell Death Differ. 2021 Jan 19. PMID: 33469230.
    Citations:    Fields:    
  6. Guo Y, Cao Y, Jardin BD, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, Pu WT. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). PMID: 33361330.
    Citations:    Fields:    
  7. Wang S, Guo Y, Pu WT. AAV Gene Transfer to the Heart. Methods Mol Biol. 2021; 2158:269-280. PMID: 32857380.
    Citations: 2     Fields:    Translation:HumansCells
  8. Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, Haeussler M, Pu WT, Stuart JM, Seidman CE, Seidman JG, Heyn H, Bruneau BG. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 Feb 08; 56(3):292-309.e9. PMID: 33321106.
    Citations: 2     Fields:    
  9. Guo H, Lu YW, Lin Z, Huang ZP, Liu J, Wang Y, Seok HY, Hu X, Ma Q, Li K, Kyselovic J, Wang Q, Lin JL, Lin JJ, Cowan DB, Naya F, Chen Y, Pu WT, Wang DZ. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666. PMID: 32938943.
    Citations:    Fields:    Translation:AnimalsCells
  10. Konstantinidis K, Bezzerides VJ, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL, Gladyshev VN, Hund TJ, Pu WT, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678. PMID: 32749237.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Cai W, Huang J, Zhu Q, Li BE, Seruggia D, Zhou P, Nguyen M, Fujiwara Y, Xie H, Yang Z, Hong D, Ren P, Xu J, Pu WT, Yuan GC, Orkin SH. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21450-21458. PMID: 32817427.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z, Pu WT, Chen S, Chen Y, Sun K, Ge B, Zhang B. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18; 32(7):108058. PMID: 32814055.
    Citations:    Fields:    
  13. Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z, Pu WT, Chen S, Chen Y, Sun K, Ge B, Zhang B. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 07 28; 32(4):107974. PMID: 32726637.
    Citations: 1     Fields:    
  14. Liu J, Huang ZP, Nie M, Wang G, Silva WJ, Yang Q, Freire PP, Hu X, Chen H, Deng Z, Pu WT, Wang DZ. Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19254-19265. PMID: 32719146.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Wang K, Lin RZ, Hong X, Ng AH, Lee CN, Neumeyer J, Wang G, Wang X, Ma M, Pu WT, Church GM, Melero-Martin JM. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 Jul; 6(30):eaba7606. PMID: 32832668.
    Citations: 3     Fields:    
  16. Bezzerides VJ, Prondzynski M, Carrier L, Pu WT. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 Jul 15; 116(9):1635-1650. PMID: 32321160.
    Citations: 2     Fields:    
  17. Lu F, Pu WT. The architecture and function of cardiac dyads. Biophys Rev. 2020 Aug; 12(4):1007-1017. PMID: 32661902.
    Citations: 2     
  18. Akerberg BN, Pu WT. Genetic and Epigenetic Control of Heart Development. Cold Spring Harb Perspect Biol. 2020 07 01; 12(7). PMID: 31818853.
    Citations: 2     Fields:    
  19. Guo Y, Pu WT. Cardiomyocyte Maturation: New Phase in Development. Circ Res. 2020 04 10; 126(8):1086-1106. PMID: 32271675.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  20. Wang S, Li Y, Xu Y, Ma Q, Lin Z, Schlame M, Bezzerides VJ, Strathdee D, Pu WT. AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. Circ Res. 2020 04 10; 126(8):1024-1039. PMID: 32146862.
    Citations: 5     Fields:    Translation:AnimalsCells
  21. Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. PMID: 32091396.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Chen J, Liang X, Zhang S, Wang S, Garcia SP, Yan P, Yu H, Li Z, Liu L, Zhang F, Wei W, Le H, Zhang Y, Yuan GC, Chen S, Chen Y, Sun K, Pu WT, Zhang B. Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020 01 30; 11(1):75. PMID: 32001672.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Chen J, Ma Q, King JS, Sun Y, Xu B, Zhang X, Zohrabian S, Guo H, Cai W, Li G, Bruno I, Cooke JP, Wang C, Kontaridis M, Wang DZ, Luo H, Pu WT, Lin Z. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020 01; 3(1). PMID: 31843959.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  24. Pu W, Wang Y, Yang N, Guo G, Li H, Li Q, Ur Rehman N, Zheng L, Wang P, Han S, Zhou CC, Zheng J, Zeng J, Yuan J. Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. J Appl Microbiol. 2020 Mar; 128(3):784-793. PMID: 31651063.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 10 28; 10(1):4907. PMID: 31659164.
    Citations: 14     Fields:    Translation:AnimalsCells
  26. Liu Q, Lin J, Han J, Zhang Y, Lu J, Tu W, Zhao Y, Guo G, Chu H, Pu W, Liu J, Ma Y, Chen X, Zhang R, Gu J, Zou H, Jin L, Wu W, Ren S, Wang J. Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification. Scand J Rheumatol. 2020 Mar; 49(2):146-153. PMID: 31538512.
    Citations: 1     Fields:    Translation:Humans
  27. Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. PMID: 31028357.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  28. Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 07 30; 140(5):390-404. PMID: 31311300.
    Citations: 17     Fields:    Translation:HumansCells
  29. Bezzerides VJ, Caballero A, Wang S, Ai Y, Hylind RJ, Lu F, Heims-Waldron DA, Chambers KD, Zhang D, Abrams DJ, Pu WT. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. Circulation. 2019 07 30; 140(5):405-419. PMID: 31155924.
    Citations: 11     Fields:    Translation:AnimalsCells
  30. Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu WT, Wang J, Chen J, Wang DZ. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 04 17; 10(1):1802. PMID: 30996254.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  31. Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y, Park PJ, Liu ZJ, Sun K, Yuan GC, Pu WT, Zhang B. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Res. 2019 02; 29(2):193-207. PMID: 30670628.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  32. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169. PMID: 30605412.
    Citations: 6     Fields:    Translation:HumansAnimals
  33. Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 11 20; 138(21):e653-e711. PMID: 30571578.
    Citations: 35     Fields:    Translation:Humans
  34. Guo Y, Jardin BD, Zhou P, Sethi I, Akerberg BN, Toepfer CN, Ai Y, Li Y, Ma Q, Guatimosim S, Hu Y, Varuzhanyan G, VanDusen NJ, Zhang D, Chan DC, Yuan GC, Seidman CE, Seidman JG, Pu WT. Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor. Nat Commun. 2018 09 21; 9(1):3837. PMID: 30242271.
    Citations: 15     Fields:    Translation:AnimalsCells
  35. Xiong S, Berkhouse H, Schooler M, Pu W, Sun A, Gong E, Yan LL. Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review. Curr Hypertens Rep. 2018 08 07; 20(10):86. PMID: 30088110.
    Citations: 9     Fields:    Translation:Humans
  36. MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK. A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2018 12; 2(12):930-941. PMID: 31015723.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  37. Zhang D, Pu WT. Exercising engineered heart muscle to maturity. Nat Rev Cardiol. 2018 07; 15(7):383-384. PMID: 29795442.
    Citations: 2     Fields:    Translation:HumansCells
  38. Guo Y, Pu WT. Genetic Mosaics for Greater Precision in Cardiovascular Research. Circ Res. 2018 06 22; 123(1):27-29. PMID: 29929974.
    Citations: 5     Fields:    Translation:AnimalsCells
  39. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12):1488-1498. PMID: 29131159.
    Citations: 50     Fields:    Translation:AnimalsCells
  40. Zhang D, Li Y, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J, Wang DZ, Pu WT. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87. PMID: 29021295.
    Citations: 18     Fields:    Translation:AnimalsCells
  41. VanDusen NJ, Guo Y, Gu W, Pu WT. CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo. Curr Protoc Mol Biol. 2017 10 02; 120:31.11.1-31.11.14. PMID: 28967995.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  42. Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. PMID: 28851877.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  43. Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM, Pu WT, Anderson RH, Zhou B. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun. 2017 07 20; 8(1):87. PMID: 28729659.
    Citations: 16     Fields:    Translation:AnimalsCells
  44. Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, Melero-Martin JM. Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1. PMID: 28868207.
    Citations: 14     Fields:    
  45. Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul; 49(7):1152-1159. PMID: 28530678.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  46. Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C, Pu WT, He A. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circ Res. 2017 Jul 07; 121(2):106-112. PMID: 28512107.
    Citations: 18     Fields:    Translation:AnimalsCells
  47. Sun Y, Lin Z, Liu CH, Gong Y, Liegl R, Fredrick TW, Meng SS, Burnim SB, Wang Z, Akula JD, Pu WT, Chen J, Smith LEH. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. PMID: 28465464.
    Citations: 15     Fields:    Translation:AnimalsCells
  48. Yu W, Zhang F, Wang S, Fu Y, Chen J, Liang X, Le H, Pu WT, Zhang B. Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 04 13; 8(4):e2744. PMID: 28406475.
    Citations: 5     Fields:    Translation:AnimalsCells
  49. Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 04 10; 6. PMID: 28394251.
    Citations: 15     Fields:    Translation:AnimalsCells
  50. Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT. Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 09; 120(12):1874-1888. PMID: 28356340.
    Citations: 35     Fields:    Translation:AnimalsCells
  51. Galdos FX, Guo Y, Paige SL, VanDusen NJ, Wu SM, Pu WT. Cardiac Regeneration: Lessons From Development. Circ Res. 2017 Mar 17; 120(6):941-959. PMID: 28302741.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  52. Zhou P, Gu F, Zhang L, Akerberg BN, Ma Q, Li K, He A, Lin Z, Stevens SM, Zhou B, Pu WT. Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq. Elife. 2017 01 25; 6. PMID: 28121289.
    Citations: 19     Fields:    Translation:AnimalsCells
  53. Ding J, Lin ZQ, Jiang JM, Seidman CE, Seidman JG, Pu WT, Wang DZ. Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. J Vis Exp. 2016 12 17; (118). PMID: 28060283.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  54. Wang G, Yang L, Grishin D, Rios X, Ye LY, Hu Y, Li K, Zhang D, Church GM, Pu WT. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nat Protoc. 2017 Jan; 12(1):88-103. PMID: 27929521.
    Citations: 23     Fields:    Translation:HumansCells
  55. Bezzerides VJ, Zhang D, Pu WT. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21. PMID: 27916777.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  56. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. PMID: 27840107.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  57. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. PMID: 27803039.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  58. Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Nov 01; 112(2):543-554. PMID: 27557636.
    Citations: 22     Fields:    
  59. Lin Z, Guo H, Cao Y, Zohrabian S, Zhou P, Ma Q, VanDusen N, Guo Y, Zhang J, Stevens SM, Liang F, Quan Q, van Gorp PR, Li A, Dos Remedios C, He A, Bezzerides VJ, Pu WT. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479. PMID: 27720608.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  60. Day DS, Zhang B, Stevens SM, Ferrari F, Larschan EN, Park PJ, Pu WT. Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. Genome Biol. 2016 06 03; 17(1):120. PMID: 27259512.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  61. Stevens SM, von Gise A, VanDusen N, Zhou B, Pu WT. Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016 05 15; 413(2):153-159. PMID: 26988120.
    Citations: 15     Fields:    Translation:AnimalsCells
  62. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B. GATA4 regulates Fgf16 to promote heart repair after injury. Development. 2016 Mar 15; 143(6):936-49. PMID: 26893347.
    Citations: 32     Fields:    Translation:AnimalsCells
  63. Zhou P, Pu WT. Recounting Cardiac Cellular Composition. Circ Res. 2016 Feb 05; 118(3):368-70. PMID: 26846633.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  64. von Gise A, Stevens SM, Honor LB, Oh JH, Gao C, Zhou B, Pu WT. Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):222-30. PMID: 26121126.
    Citations: 6     Fields:    Translation:AnimalsCells
  65. Pu W, Luo Q, Palaniyappan L, Xue Z, Yao S, Feng J, Liu Z. Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia. Psychol Med. 2016 Apr; 46(6):1211-24. PMID: 26743997.
    Citations: 14     Fields:    Translation:Humans
  66. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. PMID: 26436652.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  67. Sun Y, Ju M, Lin Z, Fredrick TW, Evans LP, Tian KT, Saba NJ, Morss PC, Pu WT, Chen J, Stahl A, Joyal JS, Smith LE. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. PMID: 26396267.
    Citations: 18     Fields:    Translation:AnimalsCells
  68. Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR. Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015; 10(9):e0136025. PMID: 26390289.
    Citations: 7     Fields:    Translation:AnimalsCells
  69. Sun Y, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A, Pu WT, Kamenecka TM, Solt LA, Chen J. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. PMID: 26243880.
    Citations: 20     Fields:    Translation:AnimalsCells
  70. Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng ZL, Pu WT, Wang DZ. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83. PMID: 26029872.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  71. Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105. PMID: 26023924.
    Citations: 18     Fields:    Translation:AnimalsCells
  72. Tian X, Pu WT, Zhou B. Cellular origin and developmental program of coronary angiogenesis. Circ Res. 2015 Jan 30; 116(3):515-30. PMID: 25634974.
    Citations: 49     Fields:    Translation:HumansAnimals
  73. Lin Z, Pu WT. Releasing YAP from an a-catenin trap increases cardiomyocyte proliferation. Circ Res. 2015 Jan 02; 116(1):9-11. PMID: 25552687.
    Citations: 6     Fields:    Translation:AnimalsCells
  74. Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J, Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun. 2014 Nov 26; 5:5507. PMID: 25425480.
    Citations: 57     Fields:    Translation:HumansCells
  75. Harvey RP, Graham RM, Pu WT. Introduction to the special issue on heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):521-2. PMID: 25459518.
    Citations: 1     Fields:    Translation:HumansAnimals
  76. Prendiville T, Jay PY, Pu WT. Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med. 2014 Oct 01; 4(10). PMID: 25274754.
    Citations: 12     Fields:    Translation:HumansAnimals
  77. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B. Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9. PMID: 25257468.
    Citations: 18     Fields:    Translation:AnimalsCells
  78. He A, Gu F, Hu Y, Ma Q, Ye LY, Akiyama JA, Visel A, Pennacchio LA, Pu WT. Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun. 2014 Sep 24; 5:4907. PMID: 25249388.
    Citations: 63     Fields:    Translation:AnimalsCells
  79. Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45. PMID: 25249570.
    Citations: 88     Fields:    Translation:AnimalsCells
  80. Li K, Wang G, Andersen T, Zhou P, Pu WT. Optimization of genome engineering approaches with the CRISPR/Cas9 system. PLoS One. 2014; 9(8):e105779. PMID: 25166277.
    Citations: 54     Fields:    Translation:AnimalsCells
  81. Prendiville TW, Ma Q, Lin Z, Zhou P, He A, Pu WT. Ultrasound-guided transthoracic intramyocardial injection in mice. J Vis Exp. 2014 Aug 05; (90):e51566. PMID: 25146757.
    Citations: 5     Fields:    Translation:Animals
  82. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 04; 345(6192):90-4. PMID: 24994653.
    Citations: 60     Fields:    Translation:Animals
  83. Lin Z, Pu WT. Strategies for cardiac regeneration and repair. Sci Transl Med. 2014 Jun 04; 6(239):239rv1. PMID: 24898748.
    Citations: 46     Fields:    Translation:HumansCells
  84. Aronson BE, Rabello Aronson S, Berkhout RP, Chavoushi SF, He A, Pu WT, Verzi MP, Krasinski SD. GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. Biochim Biophys Acta. 2014 Nov; 1839(11):1273-82. PMID: 24878542.
    Citations: 8     Fields:    Translation:AnimalsCells
  85. Zhang B, Pu WT. Notching up vascular regeneration. Cell Res. 2014 Jul; 24(7):777-8. PMID: 24853955.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  86. Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, Pu WT. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014 Jul 18; 115(3):354-63. PMID: 24833660.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
  87. Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014 Jul 04; 289(27):18681-92. PMID: 24831012.
    Citations: 59     Fields:    Translation:AnimalsCells
  88. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. PMID: 24813252.
    Citations: 281     Fields:    Translation:HumansCells
  89. Lin Z, Pu WT. Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):571-81. PMID: 24881775.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  90. Hu Y, Pu WT. Hippo activation in arrhythmogenic cardiomyopathy. Circ Res. 2014 Jan 31; 114(3):402-5. PMID: 24481838.
    Citations: 4     Fields:    Translation:HumansAnimals
  91. Tian X, Hu T, He L, Zhang H, Huang X, Poelmann RE, Liu W, Yang Z, Yan Y, Pu WT, Zhou B. Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PLoS One. 2013; 8(11):e80857. PMID: 24278332.
    Citations: 10     Fields:    Translation:AnimalsCells
  92. Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A. WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14; 27(1):5-18. PMID: 24135228.
    Citations: 34     Fields:    Translation:AnimalsCells
  93. Christoffels VM, Pu WT. Developing insights into cardiac regeneration. Development. 2013 Oct; 140(19):3933-7. PMID: 24046314.
    Citations: 11     Fields:    Translation:HumansCells
  94. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. PMID: 24013197.
    Citations: 172     Fields:    Translation:HumansAnimalsCells
  95. Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15395-400. PMID: 24003143.
    Citations: 49     Fields:    Translation:AnimalsCells
  96. Stevens SM, Pu WT. HCN4 charges up the first heart field. Circ Res. 2013 Aug 02; 113(4):350-1. PMID: 23908325.
    Citations: 2     Fields:    Translation:AnimalsCells
  97. Zhang B, Pu WT. The mysterious origins of coronary vessels. Cell Res. 2013 Sep; 23(9):1063-4. PMID: 23835479.
    Citations: 1     Fields:    Translation:AnimalsCells
  98. Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. PMID: 23734001.
    Citations: 40     Fields:    Translation:AnimalsCells
  99. Zhang B, Day DS, Ho JW, Song L, Cao J, Christodoulou D, Seidman JG, Crawford GE, Park PJ, Pu WT. A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res. 2013 Jun; 23(6):917-27. PMID: 23547170.
    Citations: 40     Fields:    Translation:HumansCells
  100. Zou L, Luo Y, Chen M, Wang G, Ding M, Petersen CC, Kang R, Dagnaes-Hansen F, Zeng Y, Lv N, Ma Q, Le DQ, Besenbacher F, Bolund L, Jensen TG, Kjems J, Pu WT, Bünger C. A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Sci Rep. 2013; 3:2243. PMID: 23873182.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  101. Sartori DJ, Wilbur CJ, Long SY, Rankin MM, Li C, Bradfield JP, Hakonarson H, Grant SF, Pu WT, Kushner JA. GATA factors promote ER integrity and ß-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan; 28(1):28-39. PMID: 24284823.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  102. Zhou B, Pu WT. Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles. Circ Res. 2012 Nov 09; 111(11):e276-80. PMID: 23139287.
    Citations: 28     Fields:    Translation:AnimalsCells
  103. Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Riegler J, Price AN, Lythgoe MF, Davidson S, Yellon D, Pu WT, Riley PR. Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart. Ann N Y Acad Sci. 2012 Oct; 1269:92-101. PMID: 23045976.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  104. Lage K, Greenway SC, Rosenfeld JA, Wakimoto H, Gorham JM, Segrè AV, Roberts AE, Smoot LB, Pu WT, Pereira AC, Mesquita SM, Tommerup N, Brunak S, Ballif BC, Shaffer LG, Donahoe PK, Daly MJ, Seidman JG, Seidman CE, Larsen LA. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14035-40. PMID: 22904188.
    Citations: 51     Fields:    Translation:HumansCells
  105. He A, Pu WT. Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2. Circ Res. 2012 Jul 06; 111(2):162-4. PMID: 22773425.
    Citations: 2     Fields:    
  106. Sunshine SB, Dallabrida SM, Durand E, Ismail NS, Bazinet L, Birsner AE, Sohn R, Ikeda S, Pu WT, Kulke MH, Javaherian K, Zurakowski D, Folkman JM, Rupnick M. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11306-11. PMID: 22733742.
    Citations: 13     Fields:    Translation:HumansAnimals
  107. von Gise A, Pu WT. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ Res. 2012 Jun 08; 110(12):1628-45. PMID: 22679138.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  108. Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012; 8(5):e1002690. PMID: 22589735.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  109. Lin RZ, Moreno-Luna R, Zhou B, Pu WT, Melero-Martin JM. Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis. 2012 Sep; 15(3):443-55. PMID: 22527199.
    Citations: 42     Fields:    Translation:AnimalsCells
  110. Ounzain S, Kobayashi S, Peterson RE, He A, Motterle A, Samani NJ, Menick DR, Pu WT, Liang Q, Chong NW. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012 May; 32(10):1830-43. PMID: 22431517.
    Citations: 7     Fields:    Translation:AnimalsCells
  111. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30. PMID: 22343712.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  112. von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B, Camargo FD, Pu WT. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2394-9. PMID: 22308401.
    Citations: 196     Fields:    Translation:AnimalsCells
  113. Bisping E, Ikeda S, Sedej M, Wakula P, McMullen JR, Tarnavski O, Sedej S, Izumo S, Pu WT, Pieske B. Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem. 2012 Mar 23; 287(13):9827-9834. PMID: 22228770.
    Citations: 14     Fields:    Translation:AnimalsCells
  114. Zhou P, He A, Pu WT. Regulation of GATA4 transcriptional activity in cardiovascular development and disease. Curr Top Dev Biol. 2012; 100:143-69. PMID: 22449843.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  115. He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 01; 26(1):37-42. PMID: 22215809.
    Citations: 111     Fields:    Translation:AnimalsCells
  116. Zhou B, Pu WT. Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. Methods Mol Biol. 2012; 843:155-68. PMID: 22222530.
    Citations: 11     Fields:    Translation:Animals
  117. He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 03; 110(3):406-15. PMID: 22158708.
    Citations: 81     Fields:    Translation:AnimalsCells
  118. Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, Heffernan C, Menon MK, Scarlett CJ, Rashidianfar A, Biben C, Zoellner H, Colvin EK, Pimanda JE, Biankin AV, Zhou B, Pu WT, Prall OW, Harvey RP. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell. 2011 Dec 02; 9(6):527-40. PMID: 22136928.
    Citations: 149     Fields:    Translation:AnimalsCells
  119. Zhou B, Pu WT. Epicardial epithelial-to-mesenchymal transition in injured heart. J Cell Mol Med. 2011 Dec; 15(12):2781-3. PMID: 21914126.
    Citations: 27     Fields:    Translation:AnimalsCells
  120. Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):43-7. PMID: 21907210.
    Citations: 45     Fields:    Translation:AnimalsCells
  121. Seok HY, Tatsuguchi M, Callis TE, He A, Pu WT, Wang DZ. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011 Oct 14; 286(41):35339-35346. PMID: 21868385.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  122. van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12331-6. PMID: 21746915.
    Citations: 40     Fields:    Translation:AnimalsCells
  123. Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR. De novo cardiomyocytes from within the activated adult heart after injury. Nature. 2011 Jun 08; 474(7353):640-4. PMID: 21654746.
    Citations: 250     Fields:    Translation:AnimalsCells
  124. von Gise A, Zhou B, Honor LB, Ma Q, Petryk A, Pu WT. WT1 regulates epicardial epithelial to mesenchymal transition through ß-catenin and retinoic acid signaling pathways. Dev Biol. 2011 Aug 15; 356(2):421-31. PMID: 21663736.
    Citations: 85     Fields:    Translation:AnimalsCells
  125. Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise Av, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May; 121(5):1894-904. PMID: 21505261.
    Citations: 220     Fields:    Translation:AnimalsCells
  126. Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr; 121(4):1585-95. PMID: 21364285.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  127. He A, Kong SW, Ma Q, Pu WT. Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5632-7. PMID: 21415370.
    Citations: 184     Fields:    Translation:AnimalsCells
  128. Manuylov NL, Zhou B, Ma Q, Fox SC, Pu WT, Tevosian SG. Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. Dev Biol. 2011 May 15; 353(2):229-41. PMID: 21385577.
    Citations: 25     Fields:    Translation:AnimalsCells
  129. Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE. Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4006-11. PMID: 21330551.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  130. Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. PMID: 21294146.
    Citations: 109     Fields:    Translation:AnimalsCells
  131. Murry CE, Pu WT. Reprogramming fibroblasts into cardiomyocytes. N Engl J Med. 2011 Jan 13; 364(2):177-8. PMID: 21226585.
    Citations: 3     Fields:    Translation:AnimalsCells
  132. Kuttippurathu L, Hsing M, Liu Y, Schmidt B, Maskell DL, Lee K, He A, Pu WT, Kong SW. CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments. Bioinformatics. 2011 Mar 01; 27(5):715-7. PMID: 21183585.
    Citations: 24     Fields:    Translation:Cells
  133. He A, Pu WT. Genome-wide location analysis by pull down of in vivo biotinylated transcription factors. Curr Protoc Mol Biol. 2010 Oct; Chapter 21:Unit 21.20. PMID: 20890903.
    Citations: 22     Fields:    Translation:AnimalsCells
  134. Zhang X, Wang X, Zhu H, Zhu C, Wang Y, Pu WT, Jegga AG, Fan GC. Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol. 2010 Nov; 49(5):841-50. PMID: 20708014.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  135. Ikeda S, Pu WT. Expression and function of microRNAs in heart disease. Curr Drug Targets. 2010 Aug; 11(8):913-25. PMID: 20415651.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  136. Beuling E, Kerkhof IM, Nicksa GA, Giuffrida MJ, Haywood J, aan de Kerk DJ, Piaseckyj CM, Pu WT, Buchmiller TL, Dawson PA, Krasinski SD. Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. Gut. 2010 Jul; 59(7):888-95. PMID: 20581237.
    Citations: 19     Fields:    Translation:Animals
  137. Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM, Roberts AE, Smoot LB, Pu WT, Donahoe PK, Tommerup N, Brunak S, Seidman CE, Seidman JG, Larsen LA. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol. 2010 Jun 22; 6:381. PMID: 20571530.
    Citations: 46     Fields:    Translation:HumansCells
  138. Kong SW, Hu YW, Ho JW, Ikeda S, Polster S, John R, Hall JL, Bisping E, Pieske B, dos Remedios CG, Pu WT. Heart failure-associated changes in RNA splicing of sarcomere genes. Circ Cardiovasc Genet. 2010 Apr; 3(2):138-46. PMID: 20124440.
    Citations: 57     Fields:    Translation:HumansCells
  139. Wu B, Zhou B, Wang Y, Cheng HL, Hang CT, Pu WT, Chang CP, Zhou B. Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis. 2010 Jan; 48(1):63-72. PMID: 20014345.
    Citations: 19     Fields:    Translation:AnimalsCells
  140. Zhou B, von Gise A, Ma Q, Hu YW, Pu WT. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol. 2010 Feb 15; 338(2):251-61. PMID: 20025864.
    Citations: 71     Fields:    Translation:Animals
  141. Pu WT. Identification of a cardiac disease modifier gene using forward genetics in the mouse. PLoS Genet. 2009 Sep; 5(9):e1000643. PMID: 19763163.
    Citations: 1     Fields:    Translation:HumansAnimals
  142. Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun; 119(6):1462-76. PMID: 19411759.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  143. Ikeda S, He A, Kong SW, Lu J, Bejar R, Bodyak N, Lee KH, Ma Q, Kang PM, Golub TR, Pu WT. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009 Apr; 29(8):2193-204. PMID: 19188439.
    Citations: 135     Fields:    Translation:AnimalsCells
  144. Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD. Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res. 2008 Dec 05; 103(12):1393-401. PMID: 18948621.
    Citations: 85     Fields:    Translation:AnimalsCells
  145. Zhou B, Pu WT. More than a cover: epicardium as a novel source of cardiac progenitor cells. Regen Med. 2008 Sep; 3(5):633-5. PMID: 18729786.
    Citations: 15     Fields:    Translation:AnimalsCells
  146. Ma Q, Zhou B, Pu WT. Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol. 2008 Nov 01; 323(1):98-104. PMID: 18775691.
    Citations: 92     Fields:    Translation:AnimalsCells
  147. Zhou B, von Gise A, Ma Q, Rivera-Feliciano J, Pu WT. Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):450-3. PMID: 18722343.
    Citations: 48     Fields:    Translation:AnimalsCells
  148. Rojas A, Kong SW, Agarwal P, Gilliss B, Pu WT, Black BL. GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol. 2008 Sep; 28(17):5420-31. PMID: 18591257.
    Citations: 60     Fields:    Translation:AnimalsCells
  149. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 03; 454(7200):109-13. PMID: 18568026.
    Citations: 407     Fields:    Translation:AnimalsCells
  150. Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT. Altered microRNA expression in human heart disease. Physiol Genomics. 2007 Nov 14; 31(3):367-73. PMID: 17712037.
    Citations: 224     Fields:    Translation:Humans
  151. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007 Aug; 13(8):952-61. PMID: 17660828.
    Citations: 763     Fields:    Translation:HumansAnimalsCells
  152. Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec; 43(6):677-85. PMID: 17643447.
    Citations: 82