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Richard John Hargreaves, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Borsook D, Upadhyay J, Hargreaves R, Wager T. Enhancing Choice and Outcomes for Therapeutic Trials in Chronic Pain: N-of-1 + Imaging (+ i). Trends Pharmacol Sci. 2020 Feb; 41(2):85-98. PMID: 31928747.
    Citations:    
  2. Hargreaves R, Olesen J. Calcitonin Gene-Related Peptide Modulators - The History and Renaissance of a New Migraine Drug Class. Headache. 2019 06; 59(6):951-970. PMID: 31020659.
    Citations:    
  3. Bigal ME, Rapoport AM, Silberstein SD, Walter S, Hargreaves RJ, Aycardi E. From LBR-101 to Fremanezumab for Migraine. CNS Drugs. 2018 11; 32(11):1025-1037. PMID: 30311143.
    Citations:    Fields:    
  4. Avants BB, Hutchison RM, Mikulskis A, Salinas-Valenzuela C, Hargreaves R, Beaver J, Chiao P. Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity. Neurobiol Aging. 2019 02; 74:191-201. PMID: 30471630.
    Citations:    
  5. Nyman M, Eskola O, Kajander J, Jokinen R, Penttinen J, Karjalainen T, Nummenmaa L, Hirvonen J, Burns D, Hargreaves R, Solin O, Hietala J. Brain neurokinin-1 receptor availability in never-medicated patients with major depression - A pilot study. J Affect Disord. 2019 01 01; 242:188-194. PMID: 30193189.
    Citations:    Fields:    
  6. Upadhyay J, Geber C, Hargreaves R, Birklein F, Borsook D. A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process. Neurosci Biobehav Rev. 2018 Jan; 84:407-423. PMID: 28807753.
    Citations: 3     Fields:    Translation:HumansAnimals
  7. Hastings NB, Wang X, Song L, Butts BD, Grotz D, Hargreaves R, Fred Hess J, Hong KK, Huang CR, Hyde L, Laverty M, Lee J, Levitan D, Lu SX, Maguire M, Mahadomrongkul V, McEachern EJ, Ouyang X, Rosahl TW, Selnick H, Stanton M, Terracina G, Vocadlo DJ, Wang G, Duffy JL, Parker EM, Zhang L. Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice. Mol Neurodegener. 2017 05 18; 12(1):39. PMID: 28521765.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Tannenbaum PL, Tye SJ, Stevens J, Gotter AL, Fox SV, Savitz AT, Coleman PJ, Uslaner JM, Kuduk SD, Hargreaves R, Winrow CJ, Renger JJ. Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys. Sleep. 2016 Mar 01; 39(3):603-12. PMID: 26943466.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Schytz HW, Hargreaves R, Ashina M. Challenges in developing drugs for primary headaches. Prog Neurobiol. 2017 05; 152:70-88. PMID: 26751129.
    Citations: 5     Fields:    Translation:Humans
  10. Upadhyay J, Lemme J, Anderson J, Bleakman D, Large T, Evelhoch JL, Hargreaves R, Borsook D, Becerra L. Test-retest reliability of evoked heat stimulation BOLD fMRI. J Neurosci Methods. 2015 Sep 30; 253:38-46. PMID: 26072245.
    Citations: 5     Fields:    Translation:Humans
  11. Zhao F, Holahan MA, Houghton AK, Hargreaves R, Evelhoch JL, Winkelmann CT, Williams DS. Functional imaging of olfaction by CBV fMRI in monkeys: insight into the role of olfactory bulb in habituation. Neuroimage. 2015 Feb 01; 106:364-72. PMID: 25498426.
    Citations: 3     Fields:    Translation:Animals
  12. Hoffmann J, Supronsinchai W, Akerman S, Andreou AP, Winrow CJ, Renger J, Hargreaves R, Goadsby PJ. Evidence for orexinergic mechanisms in migraine. Neurobiol Dis. 2015 Feb; 74:137-43. PMID: 25447225.
    Citations: 11     Fields:    Translation:Animals
  13. Ball WA, Snavely DB, Hargreaves RJ, Szegedi A, Lines C, Reines SA. Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder. Hum Psychopharmacol. 2014 Nov; 29(6):568-77. PMID: 25330122.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  14. Patel M, Gleason A, O'Malley S, Connolly B, Suresch D, Virostko J, Phillips N, Lin SA, Chen TB, Klimas M, Hargreaves RJ, Sur C, Williams DL, Powers AC, Bednar B. Non-invasive bioluminescence imaging of ß-cell function in obese-hyperglycemic [ob/ob] mice. PLoS One. 2014; 9(9):e106693. PMID: 25198535.
    Citations: 2     Fields:    Translation:Animals
  15. Liu H, Zhou D, Garcia ML, Kohler MG, Shen X, Williams DS, Klimas MT, Hargreaves RJ, Kaczorowski GJ. Characteristic time courses of cortical and medullary sodium signals measured by noninvasive (23) Na-MRI in rat kidney induced by furosemide. J Magn Reson Imaging. 2015 Jun; 41(6):1622-8. PMID: 25168165.
    Citations:    Fields:    Translation:Animals
  16. Thomae D, Morley TJ, Hamill T, Carroll VM, Papin C, Twardy NM, Lee HS, Hargreaves R, Baldwin RM, Tamagnan G, Alagille D. Automated one-step radiosynthesis of the CB1 receptor imaging agent [(18) F]MK-9470. J Labelled Comp Radiopharm. 2014 Aug; 57(10):611-4. PMID: 25156811.
    Citations:    Fields:    
  17. Borsook D, Hargreaves R, Bountra C, Porreca F. Lost but making progress--Where will new analgesic drugs come from? Sci Transl Med. 2014 Aug 13; 6(249):249sr3. PMID: 25122640.
    Citations: 14     Fields:    Translation:Humans
  18. Van Laere KJ, Sanabria-Bohórquez SM, Mozley DP, Burns DH, Hamill TG, Van Hecken A, De Lepeleire I, Koole M, Bormans G, de Hoon J, Depré M, Cerchio K, Plalcza J, Han L, Renger J, Hargreaves RJ, Iannone R. (11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists. J Nucl Med. 2014 Jan; 55(1):65-72. PMID: 24263088.
    Citations: 4     Fields:    Translation:HumansAnimals
  19. Bigal ME, Hargreaves RJ. Why does sleep stop migraine? Curr Pain Headache Rep. 2013 Oct; 17(10):369. PMID: 24037443.
    Citations: 3     Fields:    Translation:Humans
  20. Zhao F, Williams M, Bowlby M, Houghton A, Hargreaves R, Evelhoch J, Williams DS. Qualification of fMRI as a biomarker for pain in anesthetized rats by comparison with behavioral response in conscious rats. Neuroimage. 2014 Jan 01; 84:724-32. PMID: 24064074.
    Citations: 6     Fields:    Translation:Animals
  21. Hargreaves RJ, Rabiner EA. Translational PET imaging research. Neurobiol Dis. 2014 Jan; 61:32-8. PMID: 24055214.
    Citations: 6     Fields:    Translation:Humans
  22. Hostetler ED, Joshi AD, Sanabria-Bohórquez S, Fan H, Zeng Z, Purcell M, Gantert L, Riffel K, Williams M, O'Malley S, Miller P, Selnick HG, Gallicchio SN, Bell IM, Salvatore CA, Kane SA, Li CC, Hargreaves RJ, de Groot T, Bormans G, Van Hecken A, Derdelinckx I, de Hoon J, Reynders T, Declercq R, De Lepeleire I, Kennedy WP, Blanchard R, Marcantonio EE, Sur C, Cook JJ, Van Laere K, Evelhoch JL. In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232. J Pharmacol Exp Ther. 2013 Nov; 347(2):478-86. PMID: 23975906.
    Citations: 19     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  23. Bell IM, Gallicchio SN, Stump CA, Bruno JG, Fan H, Gantert LT, Hostetler ED, Kemmerer AL, McWherter M, Moore EL, Mosser SD, Purcell ML, Riffel K, Salvatore CA, Sanabria-Bohórquez S, Staas DD, White RB, Williams M, Zartman CB, Cook JJ, Hargreaves RJ, Kane SA, Graham SL, Selnick HG. [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. ACS Med Chem Lett. 2013 Sep 12; 4(9):863-8. PMID: 24900761.
    Citations: 1     
  24. Kassick AJ, Jiang J, Bunda J, Wilson D, Bao J, Lu H, Lin P, Ball RG, Doss GA, Tong X, Tsao KL, Wang H, Chicchi G, Karanam B, Tschirret-Guth R, Samuel K, Hora DF, Kumar S, Madeira M, Eng W, Hargreaves R, Purcell M, Gantert L, Cook J, DeVita RJ, Mills SG. 2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways. J Med Chem. 2013 Jul 25; 56(14):5940-8. PMID: 23808489.
    Citations: 1     Fields:    Translation:Humans
  25. Williams DS, McCracken PJ, Purcell M, Pickarski M, Mathers PD, Savitz AT, Szumiloski J, Jayakar RY, Somayajula S, Krause S, Brown K, Winkelmann CT, Scott BB, Cook L, Motzel SL, Hargreaves R, Evelhoch JL, Cabal A, Dardzinski BJ, Hangartner TN, Duong LT. Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate. Bone. 2013 Oct; 56(2):489-96. PMID: 23806798.
    Citations: 11     Fields:    Translation:Animals
  26. Cabal A, Jayakar RY, Sardesai S, Phillips EA, Szumiloski J, Posavec DJ, Mathers PD, Savitz AT, Scott BB, Winkelmann CT, Motzel S, Cook L, Hargreaves R, Evelhoch JL, Dardzinski BJ, Hangartner TN, McCracken PJ, Duong LT, Williams DS. High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate. Bone. 2013 Oct; 56(2):497-505. PMID: 23791777.
    Citations: 7     Fields:    Translation:Animals
  27. Fox SV, Gotter AL, Tye SJ, Garson SL, Savitz AT, Uslaner JM, Brunner JI, Tannenbaum PL, McDonald TP, Hodgson R, Yao L, Bowlby MR, Kuduk SD, Coleman PJ, Hargreaves R, Winrow CJ, Renger JJ. Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats. Neuropsychopharmacology. 2013 Nov; 38(12):2401-8. PMID: 23722242.
    Citations: 10     Fields:    Translation:Animals
  28. Liu P, Hamill TG, Chioda M, Chobanian H, Fung S, Guo Y, Chang L, Bakshi R, Hong Q, Dellureficio J, Lin LS, Abbadie C, Alexander J, Jin H, Mandala S, Shiao LL, Li W, Sanabria S, Williams D, Zeng Z, Hajdu R, Jochnowitz N, Rosenbach M, Karanam B, Madeira M, Salituro G, Powell J, Xu L, Terebetski JL, Leone JF, Miller P, Cook J, Holahan M, Joshi A, O'Malley S, Purcell M, Posavec D, Chen TB, Riffel K, Williams M, Hargreaves R, Sullivan KA, Nargund RP, DeVita RJ. Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase. ACS Med Chem Lett. 2013 Jun 13; 4(6):509-13. PMID: 24900701.
    Citations: 7     
  29. Becerra L, Upadhyay J, Chang PC, Bishop J, Anderson J, Baumgartner R, Schwarz AJ, Coimbra A, Wallin D, Nutile L, George E, Maier G, Sunkaraneni S, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Borsook D. Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects. J Pharmacol Exp Ther. 2013 Apr; 345(1):41-51. PMID: 23370795.
    Citations: 9     Fields:    Translation:HumansAnimals
  30. Parmentier-Batteur S, Hutson PH, Menzel K, Uslaner JM, Mattson BA, O'Brien JA, Magliaro BC, Forest T, Stump CA, Tynebor RM, Anthony NJ, Tucker TJ, Zhang XF, Gomez R, Huszar SL, Lambeng N, Fauré H, Le Poul E, Poli S, Rosahl TW, Rocher JP, Hargreaves R, Williams TM. Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target. Neuropharmacology. 2014 Jul; 82:161-73. PMID: 23291536.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  31. Hostetler ED, Sanabria-Bohórquez S, Eng W, Joshi AD, Patel S, Gibson RE, O'Malley S, Krause SM, Ryan C, Riffel K, Bi S, Okamoto O, Kawamoto H, Ozaki S, Ohta H, de Groot T, Bormans G, Depré M, de Hoon J, De Lepeleire I, Reynders T, Cook JJ, Burns HD, Egan M, Cho W, van Laere K, Hargreaves RJ. Evaluation of [¹8F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human. Neuroimage. 2013 Mar; 68:1-10. PMID: 23238431.
    Citations: 6     Fields:    Translation:HumansAnimals
  32. Hargreaves RJ. "It Ain't Over 'til It's Over" (a) -The Search for Treatments and Cures for Alzheimer's Disease. ACS Med Chem Lett. 2012 Nov 08; 3(11):862-6. PMID: 24900392.
    Citations:    
  33. Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ. Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discov Today. 2012 Sep; 17(17-18):964-73. PMID: 22579743.
    Citations: 7     Fields:    Translation:HumansAnimals
  34. Jayakar RY, Cabal A, Szumiloski J, Sardesai S, Phillips EA, Laib A, Scott BB, Pickarski M, Duong LT, Winkelmann CT, McCracken PJ, Hargreaves R, Hangartner TN, Williams DS. Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: a study with odanacatib treatment in the ovariectomized adult rhesus monkey. Bone. 2012 Jun; 50(6):1379-88. PMID: 22469953.
    Citations: 9     Fields:    Translation:HumansAnimals
  35. Michelson D, Hargreaves R, Alexander R, Ceesay P, Hietala J, Lines C, Reines S. Lack of efficacy of L-759274, a novel neurokinin 1 (substance P) receptor antagonist, for the treatment of generalized anxiety disorder. Int J Neuropsychopharmacol. 2013 Feb; 16(1):1-11. PMID: 22433185.
    Citations: 7     Fields:    Translation:Humans
  36. Connolly BM, Vanko A, McQuade P, Guenther I, Meng X, Rubins D, Waterhouse R, Hargreaves R, Sur C, Hostetler E. Ex vivo imaging of pancreatic beta cells using a radiolabeled GLP-1 receptor agonist. Mol Imaging Biol. 2012 Feb; 14(1):79-87. PMID: 21394533.
    Citations: 16     Fields:    Translation:AnimalsCells
  37. Gotter AL, Roecker AJ, Hargreaves R, Coleman PJ, Winrow CJ, Renger JJ. Orexin receptors as therapeutic drug targets. Prog Brain Res. 2012; 198:163-88. PMID: 22813974.
    Citations: 18     Fields:    Translation:HumansAnimals
  38. Myers KS, Rudd JH, Hailman EP, Bolognese JA, Burke J, Pinto CA, Klimas M, Hargreaves R, Dansky HM, Fayad ZA. Correlation between arterial FDG uptake and biomarkers in peripheral artery disease. JACC Cardiovasc Imaging. 2012 Jan; 5(1):38-45. PMID: 22239891.
    Citations: 19     Fields:    Translation:Humans
  39. Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Schwarz AJ, Pendse G, Wallin D, Nutile L, Bishop J, George E, Elman I, Sunkaraneni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine. Neuroimage. 2012 Feb 15; 59(4):3762-73. PMID: 22119647.
    Citations: 9     Fields:    Translation:Humans
  40. Upadhyay J, Anderson J, Schwarz AJ, Coimbra A, Baumgartner R, Pendse G, George E, Nutile L, Wallin D, Bishop J, Neni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Imaging drugs with and without clinical analgesic efficacy. Neuropsychopharmacology. 2011 Dec; 36(13):2659-73. PMID: 21849979.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  41. Zhao F, Welsh D, Williams M, Coimbra A, Urban MO, Hargreaves R, Evelhoch J, Williams DS. fMRI of pain processing in the brain: a within-animal comparative study of BOLD vs. CBV and noxious electrical vs. noxious mechanical stimulation in rat. Neuroimage. 2012 Jan 16; 59(2):1168-79. PMID: 21856430.
    Citations: 11     Fields:    Translation:Animals
  42. Hostetler ED, Sanabria-Bohórquez S, Fan H, Zeng Z, Gammage L, Miller P, O'Malley S, Connolly B, Mulhearn J, Harrison ST, Wolkenberg SE, Barrow JC, Williams DL, Hargreaves RJ, Sur C, Cook JJ. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey. Nucl Med Biol. 2011 Nov; 38(8):1193-203. PMID: 21741254.
    Citations: 2     Fields:    Translation:HumansAnimals
  43. Borsook D, Hargreaves R, Becerra L. Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery? Expert Opin Drug Discov. 2011 Jun 01; 6(6):597-617. PMID: 21765857.
    Citations: 12     Fields:    
  44. Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements. Drug Discov Today. 2011 Jul; 16(13-14):583-93. PMID: 21635967.
    Citations: 4     Fields:    Translation:Humans
  45. Harrison ST, Mulhearn J, Wolkenberg SE, Miller PJ, O'Malley SS, Zeng Z, Williams DL, Hostetler ED, Sanabria-Bohórquez S, Gammage L, Fan H, Sur C, Culberson JC, Hargreaves RJ, Cook JJ, Hartman GD, Barrow JC. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as ß-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Jul 14; 2(7):498-502. PMID: 24900338.
    Citations: 2     
  46. Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices. Drug Discov Today. 2011 Aug; 16(15-16):671-82. PMID: 21477664.
    Citations: 4     Fields:    Translation:Humans
  47. Hamill TG, Eng W, Jennings A, Lewis R, Thomas S, Wood S, Street L, Wisnoski D, Wolkenberg S, Lindsley C, Sanabria-Bohórquez SM, Patel S, Riffel K, Ryan C, Cook J, Sur C, Burns HD, Hargreaves R. The synthesis and preclinical evaluation in rhesus monkey of [¹8F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers. Synapse. 2011 Apr; 65(4):261-70. PMID: 20687108.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  48. Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13; 286(19):17217-26. PMID: 21454574.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  49. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions. Discov Med. 2011 Mar; 11(58):197-207. PMID: 21447279.
    Citations: 34     Fields:    Translation:Humans
  50. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging. Discov Med. 2011 Mar; 11(58):209-19. PMID: 21447280.
    Citations: 21     Fields:    Translation:Humans
  51. Hargreaves R, Ferreira JC, Hughes D, Brands J, Hale J, Mattson B, Mills S. Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Ann N Y Acad Sci. 2011 Mar; 1222:40-8. PMID: 21434941.
    Citations: 16     Fields:    Translation:Humans
  52. James LM, Iannone R, Palcza J, Renger JJ, Calder N, Cerchio K, Gottesdiener K, Hargreaves R, Murphy MG, Boyle J, Dijk DJ. Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers. Psychopharmacology (Berl). 2011 Jun; 215(4):643-53. PMID: 21301819.
    Citations: 4     Fields:    Translation:Humans
  53. Hostetler ED, Eng W, Joshi AD, Sanabria-Bohórquez S, Kawamoto H, Ito S, O'Malley S, Krause S, Ryan C, Patel S, Williams M, Riffel K, Suzuki G, Ozaki S, Ohta H, Cook J, Burns HD, Hargreaves R. Synthesis, characterization, and monkey PET studies of [¹8F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435. Synapse. 2011 Feb; 65(2):125-35. PMID: 20524178.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  54. Hostetler ED, Sanabria-Bohórquez S, Fan H, Zeng Z, Gantert L, Williams M, Miller P, O'Malley S, Kameda M, Ando M, Sato N, Ozaki S, Tokita S, Ohta H, Williams D, Sur C, Cook JJ, Burns HD, Hargreaves R. Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor. Neuroimage. 2011 Feb 14; 54(4):2635-42. PMID: 21078401.
    Citations: 9     Fields:    Translation:HumansAnimals
  55. Borsook D, Hargreaves R. Brain imaging in migraine research. Headache. 2010 Oct; 50(9):1523-7. PMID: 20958298.
    Citations: 5     Fields:    Translation:Humans
  56. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91. PMID: 20582997.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  57. Lynch JJ, Regan CP, Edvinsson L, Hargreaves RJ, Kane SA. Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries. J Cardiovasc Pharmacol. 2010 May; 55(5):518-21. PMID: 20164785.
    Citations: 5     Fields:    Translation:Humans
  58. Das R, Nachbar RB, Edelstein-Keshet L, Saltzman JS, Wiener MC, Bagchi A, Bailey J, Coombs D, Simon AJ, Hargreaves RJ, Cook JJ. Modeling effect of a ?-secretase inhibitor on amyloid-ß dynamics reveals significant role of an amyloid clearance mechanism. Bull Math Biol. 2011 Jan; 73(1):230-47. PMID: 20411345.
    Citations: 8     Fields:    Translation:HumansAnimals
  59. Waeber C, Hargreaves R. Current and emerging therapies for migraine prevention and treatment. Handb Clin Neurol. 2010; 97:789-809. PMID: 20816471.
    Citations:    Fields:    Translation:Humans
  60. Kossodo S, Pickarski M, Lin SA, Gleason A, Gaspar R, Buono C, Ho G, Blusztajn A, Cuneo G, Zhang J, Jensen J, Hargreaves R, Coleman P, Hartman G, Rajopadhye M, Duong LT, Sur C, Yared W, Peterson J, Bednar B. Dual in vivo quantification of integrin-targeted and protease-activated agents in cancer using fluorescence molecular tomography (FMT). Mol Imaging Biol. 2010 Oct; 12(5):488-99. PMID: 19960268.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  61. Hamill TG, Sato N, Jitsuoka M, Tokita S, Sanabria S, Eng W, Ryan C, Krause S, Takenaga N, Patel S, Zeng Z, Williams D, Sur C, Hargreaves R, Burns HD. Inverse agonist histamine H3 receptor PET tracers labelled with carbon-11 or fluorine-18. Synapse. 2009 Dec; 63(12):1122-32. PMID: 19670309.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  62. Upadhyay J, Pendse G, Anderson J, Schwarz AJ, Baumgartner R, Coimbra A, Bishop J, Knudsen J, George E, Grachev I, Iyengar S, Bleakman D, Hargreaves R, Borsook D, Becerra L. Improved characterization of BOLD responses for evoked sensory stimuli. Neuroimage. 2010 Feb 01; 49(3):2275-86. PMID: 19854280.
    Citations: 9     Fields:    Translation:Humans
  63. Ator NA, Atack JR, Hargreaves RJ, Burns HD, Dawson GR. Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes. J Pharmacol Exp Ther. 2010 Jan; 332(1):4-16. PMID: 19789360.
    Citations: 23     Fields:    Translation:AnimalsCells
  64. Atack JR, Wong DF, Fryer TD, Ryan C, Sanabria S, Zhou Y, Dannals RF, Eng WS, Gibson RE, Burns HD, Vega JM, Vessy L, Scott-Stevens P, Beech JS, Baron JC, Sohal B, Schrag ML, Aigbirhio FI, McKernan RM, Hargreaves RJ. Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans. J Pharmacol Exp Ther. 2010 Jan; 332(1):17-25. PMID: 19779131.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  65. Atack JR, Maubach KA, Wafford KA, O'Connor D, Rodrigues AD, Evans DC, Tattersall FD, Chambers MS, MacLeod AM, Eng WS, Ryan C, Hostetler E, Sanabria SM, Gibson RE, Krause S, Burns HD, Hargreaves RJ, Agrawal NG, McKernan RM, Murphy MG, Gingrich K, Dawson GR, Musson DG, Petty KJ. In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. J Pharmacol Exp Ther. 2009 Nov; 331(2):470-84. PMID: 19704033.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  66. Zhang GJ, Chen TB, Connolly B, Lin SA, Hargreaves R, Vanko A, Bednar B, Macneil DJ, Sur C, Williams DL. In vivo optical imaging of LacZ expression using lacZ transgenic mice. Assay Drug Dev Technol. 2009 Aug; 7(4):391-9. PMID: 19689207.
    Citations: 4     Fields:    Translation:Animals
  67. Prescot A, Becerra L, Pendse G, Tully S, Jensen E, Hargreaves R, Renshaw P, Burstein R, Borsook D. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009 Jun 30; 5:34. PMID: 19566960.
    Citations: 22     Fields:    Translation:Humans
  68. Zhao F, Williams M, Welsh DC, Meng X, Ritter A, Abbadie C, Cook JJ, Reicin AS, Hargreaves R, Williams DS. fMRI investigation of the effect of local and systemic lidocaine on noxious electrical stimulation-induced activation in spinal cord. Pain. 2009 Sep; 145(1-2):110-9. PMID: 19560271.
    Citations: 7     Fields:    Translation:Animals
  69. Jiang J, Bunda JL, Doss GA, Chicchi GG, Kurtz MM, Tsao KL, Tong X, Zheng S, Upthagrove A, Samuel K, Tschirret-Guth R, Kumar S, Wheeldon A, Carlson EJ, Hargreaves R, Burns D, Hamill T, Ryan C, Krause SM, Eng W, DeVita RJ, Mills SG. Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists. J Med Chem. 2009 May 14; 52(9):3039-46. PMID: 19354254.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  70. Bigal ME, Krymchantowski AV, Hargreaves R. The triptans. Expert Rev Neurother. 2009 May; 9(5):649-59. PMID: 19402776.
    Citations: 5     Fields:    Translation:Humans
  71. Atack JR, Eng WS, Gibson RE, Ryan C, Francis B, Sohal B, Dawson GR, Hargreaves RJ, Burns HD. The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates. Br J Pharmacol. 2009 Jul; 157(5):796-803. PMID: 19422390.
    Citations:    Fields:    Translation:AnimalsCells
  72. Fujimura Y, Yasuno F, Farris A, Liow JS, Geraci M, Drevets W, Pine DS, Ghose S, Lerner A, Hargreaves R, Burns HD, Morse C, Pike VW, Innis RB. Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ. Biol Psychiatry. 2009 Jul 01; 66(1):94-7. PMID: 19200949.
    Citations: 9     Fields:    Translation:HumansCells
  73. Hargreaves RJ. 10 years of rizatriptan. Headache. 2009 Feb; 49 Suppl 1:S1-2. PMID: 19161561.
    Citations: 1     Fields:    Translation:Humans
  74. Hargreaves RJ, Lines CR, Rapoport AM, Ho TW, Sheftell FD. Ten years of rizatriptan: from development to clinical science and future directions. Headache. 2009 Feb; 49 Suppl 1:S3-20. PMID: 19161563.
    Citations: 4     Fields:    Translation:HumansAnimals
  75. Hamill TG, Lin LS, Hagmann W, Liu P, Jewell J, Sanabria S, Eng W, Ryan C, Fong TM, Connolly B, Vanko A, Hargreaves R, Goulet MT, Burns HD. PET imaging studies in rhesus monkey with the cannabinoid-1 (CB1) receptor ligand [11C]CB-119. Mol Imaging Biol. 2009 Jul-Aug; 11(4):246-52. PMID: 19130142.
    Citations: 4     Fields:    Translation:AnimalsCells
  76. Bigal ME, Rapoport AM, Hargreaves R. Advances in the pharmacologic treatment of tension-type headache. Curr Pain Headache Rep. 2008 Dec; 12(6):442-6. PMID: 18973738.
    Citations: 3     Fields:    Translation:Humans
  77. Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799. PMID: 19030105.
    Citations: 56     Fields:    Translation:HumansCells
  78. Goadsby PJ, Hargreaves R. Refractory migraine and chronic migraine: pathophysiological mechanisms. Headache. 2008 Oct; 48(9):1399-405. PMID: 19006557.
    Citations: 2     Fields:    Translation:Humans
  79. Walker M, Campbell BR, Azer K, Tong C, Fang K, Cook JJ, Forrest MJ, Kempadoo K, Wright SD, Saltzman JS, MacIntyre E, Hargreaves R. A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis. Atherosclerosis. 2009 May; 204(1):55-65. PMID: 19135672.
    Citations: 4     Fields:    Translation:Animals
  80. Zhao F, Williams M, Meng X, Welsh DC, Grachev ID, Hargreaves R, Williams DS. Pain fMRI in rat cervical spinal cord: an echo planar imaging evaluation of sensitivity of BOLD and blood volume-weighted fMRI. Neuroimage. 2009 Jan 15; 44(2):349-62. PMID: 18835453.
    Citations: 6     Fields:    Translation:Animals
  81. Borsook D, Bleakman D, Hargreaves R, Upadhyay J, Schmidt KF, Becerra L. A 'BOLD' experiment in defining the utility of fMRI in drug development. Neuroimage. 2008 Aug 15; 42(2):461-6. PMID: 18598770.
    Citations: 7     Fields:    Translation:Humans
  82. Goadsby PJ, Hargreaves R. Refractory migraine and chronic migraine: pathophysiological mechanisms. Headache. 2008 Jun; 48(6):799-804. PMID: 18549357.
    Citations: 5     Fields:    Translation:Humans
  83. Van Laere K, Bormans G, Sanabria-Bohórquez SM, de Groot T, Dupont P, De Lepeleire I, de Hoon J, Mortelmans L, Hargreaves RJ, Atack JR, Burns HD. In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-a partial agonist. Biol Psychiatry. 2008 Jul 15; 64(2):153-61. PMID: 18339360.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  84. Van Laere K, Koole M, Sanabria Bohorquez SM, Goffin K, Guenther I, Belanger MJ, Cote J, Rothenberg P, De Lepeleire I, Grachev ID, Hargreaves RJ, Bormans G, Burns HD. Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects. J Nucl Med. 2008 Mar; 49(3):439-45. PMID: 18287275.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  85. Addy C, Wright H, Van Laere K, Gantz I, Erondu N, Musser BJ, Lu K, Yuan J, Sanabria-Bohórquez SM, Stoch A, Stevens C, Fong TM, De Lepeleire I, Cilissen C, Cote J, Rosko K, Gendrano IN, Nguyen AM, Gumbiner B, Rothenberg P, de Hoon J, Bormans G, Depré M, Eng WS, Ravussin E, Klein S, Blundell J, Herman GA, Burns HD, Hargreaves RJ, Wagner J, Gottesdiener K, Amatruda JM, Heymsfield SB. The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. Cell Metab. 2008 Jan; 7(1):68-78. PMID: 18177726.
    Citations: 41     Fields:    Translation:Humans
  86. Zhang GJ, Chen TB, Hargreaves R, Sur C, Williams DL. Bioluminescence imaging of hollow fibers in living animals: its application in monitoring molecular pathways. Nat Protoc. 2008; 3(5):891-9. PMID: 18451797.
    Citations: 4     Fields:    Translation:AnimalsCells
  87. Zhao F, Williams M, Meng X, Welsh DC, Coimbra A, Crown ED, Cook JJ, Urban MO, Hargreaves R, Williams DS. BOLD and blood volume-weighted fMRI of rat lumbar spinal cord during non-noxious and noxious electrical hindpaw stimulation. Neuroimage. 2008 Mar 01; 40(1):133-47. PMID: 18164630.
    Citations: 6     Fields:    Translation:Animals
  88. Zhang GJ, Chen TB, Bednar B, Connolly BM, Hargreaves R, Sur C, Williams DL. Optical imaging of tumor cells in hollow fibers: evaluation of the antitumor activities of anticancer drugs and target validation. Neoplasia. 2007 Aug; 9(8):652-61. PMID: 17786184.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  89. Lin P, Chang L, Devita RJ, Young JR, Eid R, Tong X, Zheng S, Ball RG, Tsou NN, Chicchi GG, Kurtz MM, Tsao KL, Wheeldon A, Carlson EJ, Eng W, Burns HD, Hargreaves RJ, Mills SG. The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5191-8. PMID: 17637506.
    Citations:    Fields:    Translation:HumansAnimals
  90. Liu P, Lin LS, Hamill TG, Jewell JP, Lanza TJ, Gibson RE, Krause SM, Ryan C, Eng W, Sanabria S, Tong X, Wang J, Levorse DA, Owens KA, Fong TM, Shen CP, Lao J, Kumar S, Yin W, Payack JF, Springfield SA, Hargreaves R, Burns HD, Goulet MT, Hagmann WK. Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use. J Med Chem. 2007 Jul 26; 50(15):3427-30. PMID: 17608398.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  91. Burns HD, Van Laere K, Sanabria-Bohórquez S, Hamill TG, Bormans G, Eng WS, Gibson R, Ryan C, Connolly B, Patel S, Krause S, Vanko A, Van Hecken A, Dupont P, De Lepeleire I, Rothenberg P, Stoch SA, Cote J, Hagmann WK, Jewell JP, Lin LS, Liu P, Goulet MT, Gottesdiener K, Wagner JA, de Hoon J, Mortelmans L, Fong TM, Hargreaves RJ. [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9800-5. PMID: 17535893.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  92. Yasuno F, Sanabria SM, Burns D, Hargreaves RJ, Ghose S, Ichise M, Chin FT, Morse CL, Pike VW, Innis RB. PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility. Synapse. 2007 Apr; 61(4):242-51. PMID: 17230546.
    Citations: 5     Fields:    Translation:Humans
  93. Hargreaves R. New migraine and pain research. Headache. 2007 Apr; 47 Suppl 1:S26-43. PMID: 17425708.
    Citations: 21     Fields:    Translation:Humans
  94. Sprague DR, Chin FT, Liow JS, Fujita M, Burns HD, Hargreaves R, Stubbs JB, Pike VW, Innis RB, Mozley PD. Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis. J Nucl Med. 2007 Jan; 48(1):100-7. PMID: 17204705.
    Citations: 9     Fields:    Translation:Humans
  95. Bednar B, Zhang GJ, Williams DL, Hargreaves R, Sur C. Optical molecular imaging in drug discovery and clinical development. Expert Opin Drug Discov. 2007 Jan; 2(1):65-85. PMID: 23496038.
    Citations: 3     Fields:    
  96. Atack JR, Scott-Stevens P, Beech JS, Fryer TD, Hughes JL, Cleij MC, Baron JC, Clark JC, Hargreaves RJ, Aigbirhio FI. Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) binding and [11C]flumazenil micro-positron emission tomography. J Pharmacol Exp Ther. 2007 Mar; 320(3):1030-7. PMID: 17164474.
    Citations: 3     Fields:    Translation:AnimalsCells
  97. Erondu N, Gantz I, Musser B, Suryawanshi S, Mallick M, Addy C, Cote J, Bray G, Fujioka K, Bays H, Hollander P, Sanabria-Bohórquez SM, Eng W, Långström B, Hargreaves RJ, Burns HD, Kanatani A, Fukami T, MacNeil DJ, Gottesdiener KM, Amatruda JM, Kaufman KD, Heymsfield SB. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct; 4(4):275-82. PMID: 17011500.
    Citations: 32     Fields:    Translation:HumansCells
  98. Meurer LC, Finke PE, Owens KA, Tsou NN, Ball RG, Mills SG, Maccoss M, Sadowski S, Cascieri MA, Tsao KL, Chicchi GG, Egger LA, Luell S, Metzger JM, Macintyre DE, Rupniak NM, Williams AR, Hargreaves RJ. Cyclopentane-based human NK1 antagonists. Part 2: development of potent, orally active, water-soluble derivatives. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4504-11. PMID: 16831551.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  99. Borsook D, Becerra L, Hargreaves R. A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov. 2006 May; 5(5):411-24. PMID: 16604100.
    Citations: 46     Fields:    Translation:HumansAnimals
  100. Nyman MJ, Eskola O, Kajander J, Vahlberg T, Sanabria S, Burns D, Hargreaves R, Solin O, Hietala J. Gender and age affect NK1 receptors in the human brain - a positron emission tomography study with [18F]SPA-RQ. Int J Neuropsychopharmacol. 2007 Apr; 10(2):219-29. PMID: 16573846.
    Citations: 11     Fields:    Translation:Humans
  101. Patel S, O'Malley S, Connolly B, Liu W, Hargreaves R, Sur C, Gibson RE. In vitro characterization of a gamma-secretase radiotracer in mammalian brain. J Neurochem. 2006 Jan; 96(1):171-8. PMID: 16300641.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  102. Keller M, Montgomery S, Ball W, Morrison M, Snavely D, Liu G, Hargreaves R, Hietala J, Lines C, Beebe K, Reines S. Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder. Biol Psychiatry. 2006 Feb 01; 59(3):216-23. PMID: 16248986.
    Citations: 62     Fields:    Translation:HumansCTClinical Trials
  103. Hietala J, Nyman MJ, Eskola O, Laakso A, Grönroos T, Oikonen V, Bergman J, Haaparanta M, Forsback S, Marjamäki P, Lehikoinen P, Goldberg M, Burns D, Hamill T, Eng WS, Coimbra A, Hargreaves R, Solin O. Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain. Mol Imaging Biol. 2005 Jul-Aug; 7(4):262-72. PMID: 16155744.
    Citations: 22     Fields:    Translation:Humans
  104. Hamill TG, Krause S, Ryan C, Bonnefous C, Govek S, Seiders TJ, Cosford ND, Roppe J, Kamenecka T, Patel S, Gibson RE, Sanabria S, Riffel K, Eng W, King C, Yang X, Green MD, O'Malley SS, Hargreaves R, Burns HD. Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers. Synapse. 2005 Jun 15; 56(4):205-16. PMID: 15803497.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  105. Hershey JC, Corcoran HA, Baskin EP, Salvatore CA, Mosser S, Williams TM, Koblan KS, Hargreaves RJ, Kane SA. Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay. Regul Pept. 2005 Apr 15; 127(1-3):71-7. PMID: 15680472.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  106. Solin O, Eskola O, Hamill TG, Bergman J, Lehikoinen P, Grönroos T, Forsback S, Haaparanta M, Viljanen T, Ryan C, Gibson R, Kieczykowski G, Hietala J, Hargreaves R, Burns HD. Synthesis and characterization of a potent, selective, radiolabeled substance-P antagonist for NK1 receptor quantitation: ([18F]SPA-RQ). Mol Imaging Biol. 2004 Nov-Dec; 6(6):373-84. PMID: 15564148.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  107. Pendergrass K, Hargreaves R, Petty KJ, Carides AD, Evans JK, Horgan KJ. Aprepitant: an oral NK1 antagonist for the prevention of nausea and vomiting induced by highly emetogenic chemotherapy. Drugs Today (Barc). 2004 Oct; 40(10):853-63. PMID: 15605119.
    Citations: 4     Fields:    Translation:Humans
  108. Bergström M, Hargreaves RJ, Burns HD, Goldberg MR, Sciberras D, Reines SA, Petty KJ, Ogren M, Antoni G, Långström B, Eskola O, Scheinin M, Solin O, Majumdar AK, Constanzer ML, Battisti WP, Bradstreet TE, Gargano C, Hietala J. Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant. Biol Psychiatry. 2004 May 15; 55(10):1007-12. PMID: 15121485.
    Citations: 35     Fields:    Translation:HumansCellsCTClinical Trials
  109. Shen YT, Mallee JJ, Handt LK, Gilberto DB, Lynch JJ, Hargreaves RJ, Koblan KS, Gould RJ, Kane SA. Effects of inhibition of alpha-CGRP receptors on cardiac and peripheral vascular dynamics in conscious dogs with chronic heart failure. J Cardiovasc Pharmacol. 2003 Nov; 42(5):656-61. PMID: 14576515.
    Citations: 2     Fields:    Translation:Animals
  110. Frank R, Hargreaves R. Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov. 2003 Jul; 2(7):566-80. PMID: 12838269.
    Citations: 121     Fields:    Translation:Humans
  111. Evans DC, O'Connor D, Lake BG, Evers R, Allen C, Hargreaves R. Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. Drug Metab Dispos. 2003 Jul; 31(7):861-9. PMID: 12814962.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  112. Huskey SE, Dean BJ, Bakhtiar R, Sanchez RI, Tattersall FD, Rycroft W, Hargreaves R, Watt AP, Chicchi GG, Keohane C, Hora DF, Chiu SH. Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets. Drug Metab Dispos. 2003 Jun; 31(6):785-91. PMID: 12756213.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  113. Shen YT, Lynch JJ, Hargreaves RJ, Gould RJ. A growth hormone secretagogue prevents ischemic-induced mortality independently of the growth hormone pathway in dogs with chronic dilated cardiomyopathy. J Pharmacol Exp Ther. 2003 Aug; 306(2):815-20. PMID: 12750438.
    Citations: 3     Fields:    Translation:Animals
  114. Hargreaves R. Imaging substance P receptors (NK1) in the living human brain using positron emission tomography. J Clin Psychiatry. 2002; 63 Suppl 11:18-24. PMID: 12562139.
    Citations: 27     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.