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Silke Nuber, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS109510 (NUBER, SILKE) May 15, 2019 - Mar 31, 2024
    Biologically novel mouse models of PD with progressive synucleinopathy and early-onset tremor and motor deficits responsive to L-DOPA
    Role: Principal Investigator
  2. R21NS103123 (NUBER, SILKE) Aug 15, 2017 - Jul 31, 2019
    Shifting Multimers: New mouse and culture models of ?-synuclein truncation by calpain in PD
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nuber S, Selkoe DJ. The Parkinson-Associated Toxin Paraquat Shifts Physiological a-Synuclein Tetramers toward Monomers That Can Be Calpain Truncated and Form Oligomers. Am J Pathol. 2023 Feb 09. PMID: 36773784.
    Citations:    Fields:    
  2. Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U. Dynamic physiological a-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinsons Dis. 2023 Jan 16; 9(1):4. PMID: 36646701; PMCID: PMC9842642.
  3. Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses a-Synuclein Toxicity. Neurotherapeutics. 2022 Jul; 19(4):1434. PMID: 35792968; PMCID: PMC9587197.
    Citations:    Fields:    
  4. Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses a-Synuclein Toxicity. Neurotherapeutics. 2022 04; 19(3):1018-1036. PMID: 35445353; PMCID: PMC9294123.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched a-Synuclein Converge on Fatty Acid Homeostasis. J Neurosci. 2022 03 09; 42(10):2116-2130. PMID: 35086904; PMCID: PMC8916762.
    Citations:    Fields:    Translation:AnimalsCells
  6. Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Wild-type GBA1 increases the a-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). PMID: 34326260; PMCID: PMC8346893.
    Citations: 2     Fields:    Translation:Animals
  7. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of a-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Rep. 2021 07 06; 36(1):109333. PMID: 34233191; PMCID: PMC8552450.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in a-Synuclein Mice. Ann Neurol. 2021 01; 89(1):74-90. PMID: 32996158.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  9. Rajsombath MM, Nam AY, Ericsson M, Nuber S. Female Sex and Brain-Selective Estrogen Benefit a-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice. J Neurosci. 2019 09 18; 39(38):7628-7640. PMID: 31405930; PMCID: PMC6750939.
    Citations: 11     Fields:    Translation:Animals
  10. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8. PMID: 30527540; PMCID: PMC6408259.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  11. Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native a-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 10 10; 100(1):75-90.e5. PMID: 30308173; PMCID: PMC6211795.
    Citations: 48     Fields:    Translation:AnimalsCells
  12. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 09 15; 26(18):3466-3481. PMID: 28911198; PMCID: PMC5884392.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  13. Casadei N, Sood P, Ulrich T, Fallier-Becker P, Kieper N, Helling S, May C, Glaab E, Chen J, Nuber S, Wolburg H, Marcus K, Rapaport D, Ott T, Riess O, Krüger R, Fitzgerald JC. Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016 12 15; 25(24):5513. PMID: 28031291.
    Citations: 2     Fields:    
  14. Nuber S, Selkoe DJ. Caspase-1 clipping causes complications for a-synuclein. Proc Natl Acad Sci U S A. 2016 Sep 06; 113(36):9958-60. PMID: 27551083; PMCID: PMC5018740.
    Citations: 5     Fields:    Translation:HumansCells
  15. Casadei N, Sood P, Ulrich T, Fallier-Becker P, Kieper N, Helling S, May C, Glaab E, Chen J, Nuber S, Wolburg H, Marcus K, Rapaport D, Ott T, Riess O, Krüger R, Fitzgerald JC. Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016 02 01; 25(3):459-71. PMID: 26604148.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Kohl Z, Ben Abdallah N, Vogelgsang J, Tischer L, Deusser J, Amato D, Anderson S, Müller CP, Riess O, Masliah E, Nuber S, Winkler J. Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC a-synuclein transgenic rat model of Parkinson's disease. Neurobiol Dis. 2016 Jan; 85:206-217. PMID: 26523794; PMCID: PMC4974940.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  17. Schlachetzki JC, Grimm T, Schlachetzki Z, Ben Abdallah NM, Ettle B, Vöhringer P, Ferger B, Winner B, Nuber S, Winkler J. Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of a-synuclein. J Neurosci Res. 2016 Jan; 94(1):62-73. PMID: 26451750.
    Citations: 9     Fields:    Translation:Animals
  18. Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V. Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors. Neurobiol Aging. 2015 Mar; 36(3):1543-58. PMID: 25599874.
    Citations: 34     Fields:    Translation:AnimalsCells
  19. Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E. Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models. J Neurosci. 2014 Jul 09; 34(28):9441-54. PMID: 25009275.
    Citations: 132     Fields:    Translation:HumansAnimals
  20. Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E. Accumulation of oligomer-prone a-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513. PMID: 24662516; PMCID: PMC3999721.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  21. Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]aSyn transgenic mice. Hum Mol Genet. 2014 Aug 01; 23(15):3975-89. PMID: 24619358.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  22. May VE, Ettle B, Poehler AM, Nuber S, Ubhi K, Rockenstein E, Winner B, Wegner M, Masliah E, Winkler J. a-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Neurobiol Aging. 2014 Oct; 35(10):2357-68. PMID: 24698767.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  23. Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. PMID: 24509835.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Oliveras-Salvá M, Van der Perren A, Casadei N, Stroobants S, Nuber S, D'Hooge R, Van den Haute C, Baekelandt V. rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration. Mol Neurodegener. 2013 Nov 25; 8:44. PMID: 24267638.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  25. Casadei N, Pöhler AM, Tomás-Zapico C, Torres-Peraza J, Schwedhelm I, Witz A, Zamolo I, De Heer R, Spruijt B, Noldus LP, Klucken J, Lucas JJ, Kahle PJ, Krüger R, Riess O, Nuber S. Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice. Hum Mol Genet. 2014 Feb 01; 23(3):767-81. PMID: 24064336.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  26. Marxreiter F, Ettle B, May VE, Esmer H, Patrick C, Kragh CL, Klucken J, Winner B, Riess O, Winkler J, Masliah E, Nuber S. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol Dis. 2013 Nov; 59:38-51. PMID: 23867236; PMCID: PMC4324756.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  27. Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O. A progressive dopaminergic phenotype associated with neurotoxic conversion of a-synuclein in BAC-transgenic rats. Brain. 2013 Feb; 136(Pt 2):412-32. PMID: 23413261; PMCID: PMC3572936.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  28. Games D, Seubert P, Rockenstein E, Patrick C, Trejo M, Ubhi K, Ettle B, Ghassemiam M, Barbour R, Schenk D, Nuber S, Masliah E. Axonopathy in an a-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated a-synuclein. Am J Pathol. 2013 Mar; 182(3):940-53. PMID: 23313024; PMCID: PMC3589076.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  29. May VE, Nuber S, Marxreiter F, Riess O, Winner B, Winkler J. Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein. Neuroscience. 2012 Oct 11; 222:343-55. PMID: 22814000.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  30. Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy. 2012 May 01; 8(5):754-66. PMID: 22647715.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  31. Nuber S, Petrasch-Parwez E, Arias-Carrión O, Koch L, Kohl Z, Schneider J, Calaminus C, Dermietzel R, Samarina A, Boy J, Nguyen HP, Teismann P, Velavan TP, Kahle PJ, von Hörsten S, Fendt M, Krüger R, Riess O. Olfactory neuron-specific expression of A30P a-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages. Neurobiol Dis. 2011 Nov; 44(2):192-204. PMID: 21767644.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  32. Kurz A, Double KL, Lastres-Becker I, Tozzi A, Tantucci M, Bockhart V, Bonin M, García-Arencibia M, Nuber S, Schlaudraff F, Liss B, Fernández-Ruiz J, Gerlach M, Wüllner U, Lüddens H, Calabresi P, Auburger G, Gispert S. A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS One. 2010 Jul 07; 5(7):e11464. PMID: 20628651.
    Citations: 63     Fields:    Translation:HumansAnimals
  33. Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rüb U, Krüger R. First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Ann Neurol. 2010 May; 67(5):684-9. PMID: 20437567.
    Citations: 41     Fields:    Translation:HumansCells
  34. Nuber S, Franck T, Wolburg H, Schumann U, Casadei N, Fischer K, Calaminus C, Pichler BJ, Chanarat S, Teismann P, Schulz JB, Luft AR, Tomiuk J, Wilbertz J, Bornemann A, Krüger R, Riess O. Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice. Neurogenetics. 2010 Feb; 11(1):107-20. PMID: 19760259.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  35. Boy J, Schmidt T, Wolburg H, Mack A, Nuber S, Böttcher M, Schmitt I, Holzmann C, Zimmermann F, Servadio A, Riess O. Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3. Hum Mol Genet. 2009 Nov 15; 18(22):4282-95. PMID: 19666958.
    Citations: 47     Fields:    Translation:HumansAnimals
  36. Marxreiter F, Nuber S, Kandasamy M, Klucken J, Aigner R, Burgmayer R, Couillard-Despres S, Riess O, Winkler J, Winner B. Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. Eur J Neurosci. 2009 Mar; 29(5):879-90. PMID: 19291219.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  37. Nuber S, Petrasch-Parwez E, Winner B, Winkler J, von Hörsten S, Schmidt T, Boy J, Kuhn M, Nguyen HP, Teismann P, Schulz JB, Neumann M, Pichler BJ, Reischl G, Holzmann C, Schmitt I, Bornemann A, Kuhn W, Zimmermann F, Servadio A, Riess O. Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J Neurosci. 2008 Mar 05; 28(10):2471-84. PMID: 18322092.
    Citations: 82     Fields:    Translation:HumansAnimals
  38. Boy J, Leergaard TB, Schmidt T, Odeh F, Bichelmeier U, Nuber S, Holzmann C, Wree A, Prusiner SB, Bujard H, Riess O, Bjaalie JG. Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models. Neuroimage. 2006 Nov 01; 33(2):449-62. PMID: 16931059.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  39. Riess O, Krüger R, Hochstrasser H, Soehn AS, Nuber S, Franck T, Berg D. Genetic causes of Parkinson's disease: extending the pathway. J Neural Transm Suppl. 2006; (70):181-9. PMID: 17017528.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.