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Jorge E. Chavarro, Sc.D., M.D.

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Biography
National University of ColombiaMDMedicine
Harvard School of Public HealthScMEpidemiology
Harvard School of Public HealthScDNutrition and Epidemiology

Overview
My research focuses on understanding how nutritional and lifestyle factors affect human reproduction and reproductive milestones throughout the life course, and how these events, in turn, impact other aspects of health. Over the last decade, this broad interest has focused primarily on understanding how nutrition impacts human fertility. More recently, my work has expanded to understand how reproductive events impact health throughout life.

The overarching goal of my infertility research is to identify modifiable lifestyle factors that may improve fertility in humans. Towards achieving this goal, I have developed and adapted a series conducted population-based and hospital-based epidemiologic studies which, together, allow a comprehensive examination of the relationship between nutrition and fertility. My work in population-based cohorts has included the identification of nutritional risk factors for infertility and conditions associated with infertility or decreased fecundity such as endometriosis, spontaneous abortion and ectopic pregnancy, as well studies of how nutrition relates to semen quality and other markers of testicular function in healthy young men. My parallel work among couples undergoing infertility treatment, which has primarily taken place at the Massachusetts General Hospital Fertility Center, has focused on understanding how pre-treatment diet of both the female and the male partner influence their chances of a successful treatment.

My research agenda has expanded to include the study of long-term health consequences exposures and events before and during pregnancy on the health of mother and child alike. This work is currently focused on two fronts. First, I am currently investigating how cesarean delivery influences growth and health trajectories throughout the life-course relative to being born by vaginal delivery. My group’s work is aimed at understanding whether differences in growth and health trajectories can be explained by incomplete accounting for confounders while also investigating potential biologic mediators of these relations including changes to the gut microbiome and changes to the epigenome. Second, we are also investigating how reproductive traits, fertility and pregnancy complications influence women’s health after pregnancy, as they go through the menopausal transition and beyond.

In order to support my substantive research, I have developed research infrastructure platforms that can be used as a multi-purpose platform supporting life course epidemiologic research. One of these platforms is the Nurses’ Health Study 3 (www.nhs3.org), an ongoing, open, web-based prospective cohort study of more than 50,000 young health professional women aimed at evaluating the role of diet, lifestyle, and biological factors on various aspects of women’s health, including fertility and health during pregnancy. In parallel, I have been involved in modifying related cohort studies, in particular the Growing Up Today Study (www.gutsweb.org) and to a lesser extent the Nurses’ Health Study II, to facilitate life course epidemiologic research integrating data across these three cohorts as a single cohesive resource for understanding the life course determinants of chronic diseases manifesting in adult life.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD096032 (OKEN, EMILY) Jul 10, 2019 - Apr 30, 2024
    NIH
    A lifecourse approach to women's cardiometabolic and bone health: from fertility to perimenopause
    Role: Co-Principal Investigator
  2. U01HL145386 (CHAVARRO, JORGE EDUARDO) Feb 8, 2019 - Jan 31, 2026
    NIH
    Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research
    Role: Principal Investigator
  3. R24ES028521 (LADEN, FRANCINE) Sep 30, 2018 - Jun 30, 2023
    NIH
    Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults
    Role: Co-Principal Investigator
  4. R01HD093761 (CHAVARRO, JORGE EDUARDO) Sep 1, 2018 - Jun 30, 2023
    NIH
    Long-term health consequences of birth by cesarean section
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Solazzo AL, Arvizu M, VanKim NA, Chavarro J, Tabaac AR, Charlton BM. Variation in diet quality across sexual orientation in a cohort of U.S. women. Cancer Causes Control. 2021 Jun; 32(6):645-651. PMID: 33846853.
    Citations:    Fields:    
  2. Mínguez-Alarcón L, Rifas-Shiman SL, Mitchell C, Sordillo J, Aris IM, Hivert MF, Oken E, Chavarro JE. Cesarean delivery and metabolic health and inflammation biomarkers during mid-childhood and early adolescence. Pediatr Res. 2021 Apr 06. PMID: 33824455.
    Citations:    Fields:    
  3. Wang YX, Mínguez-Alarcón L, Gaskins AJ, Missmer SA, Rich-Edwards JW, Manson JE, Pan A, Chavarro JE. Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study. BMJ. 2021 03 24; 372:n530. PMID: 33762255.
    Citations:    Fields:    Translation:Humans
  4. Wang YX, Arvizu M, Rich-Edwards JW, Wang L, Rosner B, Stuart JJ, Rexrode KM, Chavarro JE. Hypertensive Disorders of Pregnancy and Subsequent Risk of Premature Mortality. J Am Coll Cardiol. 2021 Mar 16; 77(10):1302-1312. PMID: 33706872.
    Citations: 1     Fields:    
  5. Gaskins AJ, Arvizu M, Mínguez-Alarcón L, Dadd R, Souter I, Chavarro JE. Substantial Weight Gain in Adulthood Is Associated with Lower Probability of Live Birth Following Assisted Reproduction. J Nutr. 2021 03 11; 151(3):649-656. PMID: 33438025.
    Citations:    Fields:    
  6. Seshasayee SM, Rifas-Shiman SL, Chavarro JE, Carwile JL, Lin PD, Calafat AM, Sagiv SK, Oken E, Fleisch AF. Dietary patterns and PFAS plasma concentrations in childhood: Project Viva, USA. Environ Int. 2021 06; 151:106415. PMID: 33706127.
    Citations:    Fields:    Translation:HumansAnimals
  7. Sakaki JR, Li J, Gao S, Ha K, Tamimi RM, Chavarro JE, Chen MH, Sun Q, Hart JE, Chun OK. Associations between fruit juice and milk consumption and change in BMI in a large prospective cohort of U.S. adolescents and preadolescents. Pediatr Obes. 2021 Mar 01; e12781. PMID: 33648027.
    Citations:    Fields:    
  8. Dumas O, Gaskins AJ, Boggs KM, Henn SA, Le Moual N, Varraso R, Chavarro JE, Camargo CA. Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study. Occup Environ Med. 2021 Apr; 78(4):244-247. PMID: 33452037.
    Citations:    Fields:    
  9. Chavarro JE. Glycemic status and fertility-implications for preconception care. Fertil Steril. 2021 Jan; 115(1):80. PMID: 33413961.
    Citations:    Fields:    
  10. Bedrick BS, Eskew AM, Chavarro JE, Jungheim ES. Self-Administered Questionnaire to Screen for Polycystic Ovarian Syndrome. Womens Health Rep (New Rochelle). 2020; 1(1):566-573. PMID: 33786523.
    Citations:    
  11. Arvizu M, Stuart JJ, Rich-Edwards JW, Gaskins AJ, Rosner B, Chavarro JE. Prepregnancy adherence to dietary recommendations for the prevention of cardiovascular disease in relation to risk of hypertensive disorders of pregnancy. Am J Clin Nutr. 2020 12 10; 112(6):1429-1437. PMID: 32778894.
    Citations:    Fields:    Translation:Humans
  12. Ardisson Korat AV, Chiu YH, Bertrand KA, Zhang S, Epstein MM, Rosner BA, Chiuve S, Campos H, Giovannucci EL, Chavarro JE, Birmann BM. Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case-control study. Am J Clin Nutr. 2020 12 10; 112(6):1576-1583. PMID: 33022699.
    Citations:    Fields:    Translation:HumansCells
  13. Ding M, Markon A, Wolpert B, Chavarro JE. Associations of body mass index and waist circumference with risk of Guillain-Barré syndrome in women and men: A prospective analysis of three cohort studies. PLoS One. 2020; 15(12):e0239099. PMID: 33259491.
    Citations:    Fields:    Translation:Humans
  14. Wang YX, Shan Z, Arvizu M, Pan A, Manson JE, Missmer SA, Sun Q, Chavarro JE. Associations of Menstrual Cycle Characteristics Across the Reproductive Life Span and Lifestyle Factors With Risk of Type 2 Diabetes. JAMA Netw Open. 2020 12 01; 3(12):e2027928. PMID: 33346844.
    Citations: 3     Fields:    Translation:Humans
  15. Mueller NT, Zhang M, Rifas-Shiman SL, Oken E, Hivert MF, Chavarro J. Mode of delivery, type of labor, and measures of adiposity from childhood to teenage: Project Viva. Int J Obes (Lond). 2021 Jan; 45(1):36-44. PMID: 33199815.
    Citations:    Fields:    
  16. Charlton BM, Reynolds CA, Janiak E, DiVasta AD, Jones RK, Chavarro JE, Sarda V, Austin SB. Sexual orientation-related differences in contraceptive use: A brief report based on a cohort of adolescent and young women. Contraception. 2021 Mar; 103(3):195-198. PMID: 33189707.
    Citations:    Fields:    
  17. Ding M, Chavarro JE, Fitzmaurice GM. Development of a mixture model allowing for smoothing functions of longitudinal trajectories. Stat Methods Med Res. 2021 Feb; 30(2):549-562. PMID: 33106119.
    Citations:    Fields:    
  18. Goodman D, González-Rivas JP, Jaacks LM, Duran M, Marulanda MI, Ugel E, Mattei J, Chavarro JE, Nieto-Martinez R. Dietary intake and cardiometabolic risk factors among Venezuelan adults: a nationally representative analysis. BMC Nutr. 2020; 6:61. PMID: 33088579.
    Citations: 1     
  19. Mínguez-Alarcón L, Bellavia A, Gaskins AJ, Chavarro JE, Ford JB, Souter I, Calafat AM, Hauser R, Williams PL. Paternal mixtures of urinary concentrations of phthalate metabolites, bisphenol A and parabens in relation to pregnancy outcomes among couples attending a fertility center. Environ Int. 2021 01; 146:106171. PMID: 33069985.
    Citations:    Fields:    Translation:Humans
  20. Sakaki JR, Li J, Melough MM, Ha K, Tamimi RM, Chavarro JE, Chen MH, Chun OK. Orange juice intake and anthropometric changes in children and adolescents. Public Health Nutr. 2020 Oct 07; 1-8. PMID: 33023713.
    Citations:    Fields:    
  21. Sacha CR, Chavarro JE, Williams PL, Ford J, Zhang L, Donahoe PK, Souter IC, Hauser R, Pépin D, Mínguez-Alarcón L. Follicular fluid anti-Müllerian hormone (AMH) concentrations and outcomes of in vitro fertilization cycles with fresh embryo transfer among women at a fertility center. J Assist Reprod Genet. 2020 Nov; 37(11):2757-2766. PMID: 33025399.
    Citations: 1     Fields:    
  22. Ley SH, Chavarro JE, Hinkle SN, Li M, Tsai MY, Hu FB, Zhang C. Lifetime duration of lactation and chronic inflammation among middle-aged women with a history of gestational diabetes. BMJ Open Diabetes Res Care. 2020 10; 8(2). PMID: 33115816.
    Citations:    
  23. Bedrick BS, Eskew AM, Chavarro JE, Jungheim ES. Dietary Patterns, Physical Activity, and Socioeconomic Associations in a Midwestern Cohort of Healthy Reproductive-Age Women. Matern Child Health J. 2020 Oct; 24(10):1299-1307. PMID: 32748288.
    Citations:    Fields:    Translation:Humans
  24. Wang YX, Arvizu M, Rich-Edwards JW, Stuart JJ, Manson JE, Missmer SA, Pan A, Chavarro JE. Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study. BMJ. 2020 09 30; 371:m3464. PMID: 32998909.
    Citations: 4     Fields:    Translation:Humans
  25. Calzo JP, Austin SB, Charlton BM, Missmer SA, Kathrins M, Gaskins AJ, Chavarro JE. Erectile Dysfunction in a Sample of Sexually Active Young Adult Men from a U.S. Cohort: Demographic, Metabolic and Mental Health Correlates. J Urol. 2021 02; 205(2):539-544. PMID: 32935616.
    Citations:    Fields:    Translation:Humans
  26. Gaskins AJ, Mínguez-Alarcón L, Williams PL, Chavarro JE, Schwartz JD, Kloog I, Souter I, Hauser R, Laden F. Ambient air pollution and risk of pregnancy loss among women undergoing assisted reproduction. Environ Res. 2020 12; 191:110201. PMID: 32937174.
    Citations:    Fields:    Translation:HumansPHPublic Health
  27. Nassan FL, Chavarro JE, Johnson CY, Boiano JM, Rocheleau CM, Rich-Edwards JW, Lawson CC. Prepregnancy handling of antineoplastic drugs and risk of miscarriage in female nurses. Ann Epidemiol. 2021 01; 53:95-102.e2. PMID: 32920100.
    Citations:    Fields:    Translation:HumansPHPublic Health
  28. Ding M, Strohmaier S, Schernhammer E, Yuan C, Sun Q, Michels KB, Tamimi R, Chavarro JE. Grand-maternal lifestyle during pregnancy and body mass index in adolescence and young adulthood: an intergenerational cohort study. Sci Rep. 2020 09 02; 10(1):14432. PMID: 32879408.
    Citations:    Fields:    Translation:Humans
  29. Chavarro JE. The little cell that can … and how nutrition makes it happen. Am J Clin Nutr. 2020 09 01; 112(3):510-511. PMID: 32766877.
    Citations:    Fields:    Translation:Cells
  30. Nguyen LH, Drew DA, Graham MS, Joshi AD, Guo CG, Ma W, Mehta RS, Warner ET, Sikavi DR, Lo CH, Kwon S, Song M, Mucci LA, Stampfer MJ, Willett WC, Eliassen AH, Hart JE, Chavarro JE, Rich-Edwards JW, Davies R, Capdevila J, Lee KA, Lochlainn MN, Varsavsky T, Sudre CH, Cardoso MJ, Wolf J, Spector TD, Ourselin S, Steves CJ, Chan AT. Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study. Lancet Public Health. 2020 09; 5(9):e475-e483. PMID: 32745512.
    Citations: 178     Fields:    Translation:HumansPHPublic Health
  31. Perng W, Rahman ML, Aris IM, Michelotti G, Sordillo JE, Chavarro JE, Oken E, Hivert MF. Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence. Metabolites. 2020 Jul 31; 10(8). PMID: 32751947.
    Citations:    
  32. Maldonado-Cárceles AB, Mínguez-Alarcón L, Souter I, Gaskins AJ, Arvizu M, Williams PL, Ford JB, Chavarro JE. Dietary patterns and ovarian reserve among women attending a fertility clinic. Fertil Steril. 2020 09; 114(3):610-617. PMID: 32712021.
    Citations:    Fields:    Translation:HumansPHPublic Health
  33. Chavarro JE. Carbohydrates and fertility: just the tip of the (fertility) iceberg. Am J Clin Nutr. 2020 07 01; 112(1):1-2. PMID: 32119733.
    Citations:    Fields:    Translation:PHPublic Health
  34. Souter I, Bellavia A, Williams PL, Korevaar TIM, Meeker JD, Braun JM, de Poortere RA, Broeren MA, Ford JB, Calafat AM, Chavarro JE, Hauser R, Mínguez-Alarcón L. Urinary Concentrations of Phthalate Metabolite Mixtures in Relation to Serum Biomarkers of Thyroid Function and Autoimmunity among Women from a Fertility Center. Environ Health Perspect. 2020 06; 128(6):67007. PMID: 32515996.
    Citations: 1     Fields:    Translation:Humans
  35. Nguyen LH, Drew DA, Joshi AD, Guo CG, Ma W, Mehta RS, Sikavi DR, Lo CH, Kwon S, Song M, Mucci LA, Stampfer MJ, Willett WC, Eliassen AH, Hart JE, Chavarro JE, Rich-Edwards JW, Davies R, Capdevila J, Lee KA, Lochlainn MN, Varsavsky T, Graham MS, Sudre CH, Cardoso MJ, Wolf J, Ourselin S, Steves CJ, Spector TD, Chan AT. Risk of COVID-19 among frontline healthcare workers and the general community: a prospective cohort study. medRxiv. 2020 May 25. PMID: 32511531.
    Citations:    
  36. Chan AT, Drew DA, Nguyen LH, Joshi AD, Ma W, Guo CG, Lo CH, Mehta RS, Kwon S, Sikavi DR, Magicheva-Gupta MV, Fatehi ZS, Flynn JJ, Leonardo BM, Albert CM, Andreotti G, Beane-Freeman LE, Balasubramanian BA, Brownstein JS, Bruinsma F, Cowan AN, Deka A, Ernst ME, Figueiredo JC, Franks PW, Gardner CD, Ghobrial IM, Haiman CA, Hall JE, Deming-Halverson SL, Kirpach B, Lacey JV, Marchand LL, Marinac CR, Martinez ME, Milne RL, Murray AM, Nash D, Palmer JR, Patel AV, Rosenberg L, Sandler DP, Sharma SV, Schurman SH, Wilkens LR, Chavarro JE, Eliassen AH, Hart JE, Kang JH, Koenen KC, Kubzansky LD, Mucci LA, Ourselin S, Rich-Edwards JW, Song M, Stampfer MJ, Steves CJ, Willett WC, Wolf J, Spector T. The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action. Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1283-1289. PMID: 32371551.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  37. Ding M, Ahmad S, Qi L, Hu Y, Bhupathiraju SN, Guasch-Ferré M, Jensen MK, Chavarro JE, Ridker PM, Willett WC,