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Yi-Fen Yen, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism. Radiology. 2018 03; 286(3):865-872. PMID: 29117483.
    View in: PubMed
  2. Newitt DC, Malyarenko D, Chenevert TL, Quarles CC, Bell L, Fedorov A, Fennessy F, Jacobs MA, Solaiyappan M, Hectors S, Taouli B, Muzi M, Kinahan PE, Schmainda KM, Prah MA, Taber EN, Kroenke C, Huang W, Arlinghaus LR, Yankeelov TE, Cao Y, Aryal M, Yen YF, Kalpathy-Cramer J, Shukla-Dave A, Fung M, Liang J, Boss M, Hylton N. Multisite concordance of apparent diffusion coefficient measurements across the NCI Quantitative Imaging Network. J Med Imaging (Bellingham). 2018 Jan; 5(1):011003. PMID: 29021993.
    View in: PubMed
  3. Lin MT, Wang CC, Cheng YF, Eng HL, Yen YH, Tsai MC, Tseng PL, Chang KC, Wu CK, Hu TH. Comprehensive Comparison of Multiple-Detector Computed Tomography and Dynamic Magnetic Resonance Imaging in the Diagnosis of Hepatocellular Carcinoma with Varying Degrees of Fibrosis. PLoS One. 2016; 11(11):e0166157. PMID: 27829060.
    View in: PubMed
  4. Josan S, Park JM, Hurd R, Yen YF, Pfefferbaum A, Spielman D, Mayer D. In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate. NMR Biomed. 2013 Dec; 26(12):1680-7. PMID: 23904148; PMCID: PMC3838505.
  5. Josan S, Hurd R, Park JM, Yen YF, Watkins R, Pfefferbaum A, Spielman D, Mayer D. Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation. Magn Reson Med. 2014 Jun; 71(6):2051-8. PMID: 23878057; PMCID: PMC3849119.
  6. Park JM, Josan S, Grafendorfer T, Yen YF, Hurd RE, Spielman DM, Mayer D. Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-¹³C]pyruvate. NMR Biomed. 2013 Oct; 26(10):1197-203. PMID: 23553852; PMCID: PMC3726546.
  7. Park JM, Recht LD, Josan S, Merchant M, Jang T, Yen YF, Hurd RE, Spielman DM, Mayer D. Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging. Neuro Oncol. 2013 Apr; 15(4):433-41. PMID: 23328814; PMCID: PMC3607261.
  8. Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate. NMR Biomed. 2013 Jun; 26(6):607-12. PMID: 23225495; PMCID: PMC3634870.
  9. Hurd RE, Yen YF, Chen A, Ardenkjaer-Larsen JH. Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization. J Magn Reson Imaging. 2012 Dec; 36(6):1314-28. PMID: 23165733.
    View in: PubMed
  10. Hurd RE, Spielman D, Josan S, Yen YF, Pfefferbaum A, Mayer D. Exchange-linked dissolution agents in dissolution-DNP (13)C metabolic imaging. Magn Reson Med. 2013 Oct; 70(4):936-42. PMID: 23165935; PMCID: PMC3660543.
  11. Josan S, Hurd R, Billingsley K, Senadheera L, Park JM, Yen YF, Pfefferbaum A, Spielman D, Mayer D. Effects of isoflurane anesthesia on hyperpolarized (13)C metabolic measurements in rat brain. Magn Reson Med. 2013 Oct; 70(4):1117-24. PMID: 23086864; PMCID: PMC3674171.
  12. Park JM, Josan S, Jang T, Merchant M, Yen YF, Hurd RE, Recht L, Spielman DM, Mayer D. Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate. Magn Reson Med. 2012 Dec; 68(6):1886-93. PMID: 22334279; PMCID: PMC3376665.
  13. Josan S, Spielman D, Yen YF, Hurd R, Pfefferbaum A, Mayer D. Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvate. NMR Biomed. 2012 Aug; 25(8):993-9. PMID: 22331837; PMCID: PMC3366020.
  14. Mayer D, Yen YF, Josan S, Park JM, Pfefferbaum A, Hurd RE, Spielman DM. Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism. NMR Biomed. 2012 Oct; 25(10):1119-24. PMID: 22278751; PMCID: PMC3357452.
  15. Xu T, Mayer D, Gu M, Yen YF, Josan S, Tropp J, Pfefferbaum A, Hurd R, Spielman D. Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI. NMR Biomed. 2011 Oct; 24(8):997-1005. PMID: 21538639; PMCID: PMC3169748.
  16. MacKenzie JD, Yen YF, Mayer D, Tropp JS, Hurd RE, Spielman DM. Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy. Radiology. 2011 May; 259(2):414-20. PMID: 21406626; PMCID: PMC3079121.
  17. Josan S, Yen YF, Hurd R, Pfefferbaum A, Spielman D, Mayer D. Application of double spin echo spiral chemical shift imaging to rapid metabolic mapping of hyperpolarized [1-¹³C]-pyruvate. J Magn Reson. 2011 Apr; 209(2):332-6. PMID: 21316280; PMCID: PMC3072043.
  18. Yen YF, Nagasawa K, Nakada T. Promising application of dynamic nuclear polarization for in vivo (13)C MR imaging. Magn Reson Med Sci. 2011; 10(4):211-7. PMID: 22214905.
    View in: PubMed
  19. Darpolor MM, Yen YF, Chua MS, Xing L, Clarke-Katzenberg RH, Shi W, Mayer D, Josan S, Hurd RE, Pfefferbaum A, Senadheera L, So S, Hofmann LV, Glazer GM, Spielman DM. In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma. NMR Biomed. 2011 Jun; 24(5):506-13. PMID: 21674652; PMCID: PMC3073155.
  20. Mayer D, Yen YF, Takahashi A, Josan S, Tropp J, Rutt BK, Hurd RE, Spielman DM, Pfefferbaum A. Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert. Magn Reson Med. 2011 May; 65(5):1228-33. PMID: 21500253; PMCID: PMC3126907.
  21. Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7. PMID: 21130012; PMCID: PMC3387549.
  22. Hurd RE, Yen YF, Tropp J, Pfefferbaum A, Spielman DM, Mayer D. Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging. J Cereb Blood Flow Metab. 2010 Oct; 30(10):1734-41. PMID: 20588318; PMCID: PMC2975615.
  23. Hurd RE, Yen YF, Mayer D, Chen A, Wilson D, Kohler S, Bok R, Vigneron D, Kurhanewicz J, Tropp J, Spielman D, Pfefferbaum A. Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med. 2010 May; 63(5):1137-43. PMID: 20432284; PMCID: PMC2890241.
  24. Mayer D, Yen YF, Levin YS, Tropp J, Pfefferbaum A, Hurd RE, Spielman DM. In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: comparison with phase-encoded CSI. J Magn Reson. 2010 Jun; 204(2):340-5. PMID: 20346717; PMCID: PMC2893149.
  25. Yen YF, Le Roux P, Mayer D, King R, Spielman D, Tropp J, Butts Pauly K, Pfefferbaum A, Vasanawala S, Hurd R. T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate. NMR Biomed. 2010 May; 23(4):414-23. PMID: 20175135; PMCID: PMC2891253.
  26. Zierhut ML, Yen YF, Chen AP, Bok R, Albers MJ, Zhang V, Tropp J, Park I, Vigneron DB, Kurhanewicz J, Hurd RE, Nelson SJ. Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson. 2010 Jan; 202(1):85-92. PMID: 19884027; PMCID: PMC2833325.
  27. Costa AF, Yen YF, Drangova M. Registering spherical navigators with spherical harmonic expansions to measure three-dimensional rotations in magnetic resonance imaging. Magn Reson Imaging. 2010 Feb; 28(2):185-94. PMID: 19755205.
    View in: PubMed
  28. Mayer D, Yen YF, Tropp J, Pfefferbaum A, Hurd RE, Spielman DM. Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1-pyruvate. Magn Reson Med. 2009 Sep; 62(3):557-64. PMID: 19585607; PMCID: PMC2782691.
  29. Spielman DM, Mayer D, Yen YF, Tropp J, Hurd RE, Pfefferbaum A. In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate. Magn Reson Med. 2009 Aug; 62(2):307-13. PMID: 19526498; PMCID: PMC2780439.
  30. Hu S, Chen AP, Zierhut ML, Bok R, Yen YF, Schroeder MA, Hurd RE, Nelson SJ, Kurhanewicz J, Vigneron DB. In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol. 2009 Nov-Dec; 11(6):399-407. PMID: 19424761; PMCID: PMC2763080.
  31. Gofton TE, Chouinard PA, Young GB, Bihari F, Nicolle MW, Lee DH, Sharpe MD, Yen YF, Takahashi AM, Mirsattari SM. Functional MRI study of the primary somatosensory cortex in comatose survivors of cardiac arrest. Exp Neurol. 2009 Jun; 217(2):320-7. PMID: 19306870.
    View in: PubMed
  32. Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson SJ, Vigneron DB, Kurhanewicz J. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res. 2008 Oct 15; 68(20):8607-15. PMID: 18922937; PMCID: PMC2829248.
  33. Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med. 2007 Dec; 58(6):1099-106. PMID: 17969006.
    View in: PubMed
  34. Reeder SB, Brittain JH, Grist TM, Yen YF. Least-squares chemical shift separation for (13)C metabolic imaging. J Magn Reson Imaging. 2007 Oct; 26(4):1145-52. PMID: 17896366.
    View in: PubMed
  35. Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen YF, Pauly JM, Nelson SJ, Vigneron DB. Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson. 2007 Aug; 187(2):357-62. PMID: 17562376.
    View in: PubMed
  36. Petrie DW, Costa AF, Takahashi A, Yen YF, Drangova M. Optimizing spherical navigator echoes for three-dimensional rigid-body motion detection. Magn Reson Med. 2005 May; 53(5):1080-7. PMID: 15844145.
    View in: PubMed
  37. Costa AF, Petrie DW, Yen YF, Drangova M. Using the axis of rotation of polar navigator echoes to rapidly measure 3D rigid-body motion. Magn Reson Med. 2005 Jan; 53(1):150-8. PMID: 15690514.
    View in: PubMed
  38. Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen YF, Moody DM. Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal. AJNR Am J Neuroradiol. 2003 Sep; 24(8):1607-11. PMID: 13679279.
    View in: PubMed
  39. Zhang B, Yen YF, Chronik BA, McKinnon GC, Schaefer DJ, Rutt BK. Peripheral nerve stimulation properties of head and body gradient coils of various sizes. Magn Reson Med. 2003 Jul; 50(1):50-8. PMID: 12815678.
    View in: PubMed
  40. Coghill RC, McHaffie JG, Yen YF. Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci U S A. 2003 07 08; 100(14):8538-42. PMID: 12824463.
    View in: PubMed
  41. Field AS, Laurienti PJ, Yen YF, Burdette JH, Moody DM. Dietary caffeine consumption and withdrawal: confounding variables in quantitative cerebral perfusion studies? Radiology. 2003 Apr; 227(1):129-35. PMID: 12616005.
    View in: PubMed
  42. Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen YF, Moody DM. Dietary caffeine consumption modulates fMRI measures. Neuroimage. 2002 Oct; 17(2):751-7. PMID: 12377150.
    View in: PubMed
  43. Chepuri NB, Yen YF, Burdette JH, Li H, Moody DM, Maldjian JA. Diffusion anisotropy in the corpus callosum. AJNR Am J Neuroradiol. 2002 May; 23(5):803-8. PMID: 12006281.
    View in: PubMed
  44. Yen YF, Field AS, Martin EM, Ari N, Burdette JH, Moody DM, Takahashi AM. Test-retest reproducibility of quantitative CBF measurements using FAIR perfusion MRI and acetazolamide challenge. Magn Reson Med. 2002 May; 47(5):921-8. PMID: 11979571.
    View in: PubMed
  45. Laurienti PJ, Burdette JH, Wallace MT, Yen YF, Field AS, Stein BE. Deactivation of sensory-specific cortex by cross-modal stimuli. J Cogn Neurosci. 2002 Apr 01; 14(3):420-9. PMID: 11970801.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.