Harvard Catalyst Profiles

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Yi-Fen Yen, Ph.D.

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Available: 01/10/22, Expires: 12/01/22

Hyperpolarized metabolic imaging will revolutionize how we study and manage diseases. My lab explores new hyperpolarized imaging contrast agents, investigates potential applications in cancer, aging and cardiac research, and develops multinuclear MR techniques to advance hyperpolarized imaging for translational research. The Hyperpolarized Imaging Lab is a new facility in the Martinos Center in Charlestown, with two brand-new next generation hyperpolarizers funded by an NIH High-end Instrumentation grant. We are looking forward to working with future physician-scientists with expertise in chemistry, biology, metabolism, NMR/MRI, RF coils, imaging analysis, animal handling, or pharmacology. MRI, spectroscopic imaging, dynamic nuclear polarization, chemical formulation. Chemistry lab work, assisting contrast agent development, operation of hyperpolarizers, animal handling, RF coil construction, assisting MRI scans, data entry, MRI data processing, literature search, presentations, and reporting. We welcome students with talent and skills in various areas, such as chemistry lab skills, animal handling, NMR/MRI, RF coils, image processing, Matlab coding, or python programming.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism. Radiology. 2018 03; 286(3):865-872. PMID: 29117483; PMCID: PMC5831267.
    Citations: 20     Fields:    Translation:Animals
  2. Newitt DC, Malyarenko D, Chenevert TL, Quarles CC, Bell L, Fedorov A, Fennessy F, Jacobs MA, Solaiyappan M, Hectors S, Taouli B, Muzi M, Kinahan PE, Schmainda KM, Prah MA, Taber EN, Kroenke C, Huang W, Arlinghaus LR, Yankeelov TE, Cao Y, Aryal M, Yen YF, Kalpathy-Cramer J, Shukla-Dave A, Fung M, Liang J, Boss M, Hylton N. Multisite concordance of apparent diffusion coefficient measurements across the NCI Quantitative Imaging Network. J Med Imaging (Bellingham). 2018 Jan; 5(1):011003. PMID: 29021993; PMCID: PMC5633866.
    Citations: 15     
  3. Josan S, Park JM, Hurd R, Yen YF, Pfefferbaum A, Spielman D, Mayer D. In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate. NMR Biomed. 2013 Dec; 26(12):1680-7. PMID: 23904148.
    Citations: 14     Fields:    Translation:Animals
  4. Josan S, Hurd R, Park JM, Yen YF, Watkins R, Pfefferbaum A, Spielman D, Mayer D. Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation. Magn Reson Med. 2014 Jun; 71(6):2051-8. PMID: 23878057.
    Citations: 23     Fields:    Translation:Animals
  5. Park JM, Josan S, Grafendorfer T, Yen YF, Hurd RE, Spielman DM, Mayer D. Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-¹³C]pyruvate. NMR Biomed. 2013 Oct; 26(10):1197-203. PMID: 23553852.
    Citations: 34     Fields:    Translation:AnimalsCells
  6. Park JM, Recht LD, Josan S, Merchant M, Jang T, Yen YF, Hurd RE, Spielman DM, Mayer D. Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging. Neuro Oncol. 2013 Apr; 15(4):433-41. PMID: 23328814; PMCID: PMC3607261.
    Citations: 37     Fields:    Translation:AnimalsCells
  7. Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate. NMR Biomed. 2013 Jun; 26(6):607-12. PMID: 23225495.
    Citations: 8     Fields:    Translation:Animals
  8. Hurd RE, Yen YF, Chen A, Ardenkjaer-Larsen JH. Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization. J Magn Reson Imaging. 2012 Dec; 36(6):1314-28. PMID: 23165733.
    Citations: 43     Fields:    Translation:Humans
  9. Hurd RE, Spielman D, Josan S, Yen YF, Pfefferbaum A, Mayer D. Exchange-linked dissolution agents in dissolution-DNP (13)C metabolic imaging. Magn Reson Med. 2013 Oct; 70(4):936-42. PMID: 23165935.
    Citations: 18     Fields:    Translation:Animals
  10. Josan S, Hurd R, Billingsley K, Senadheera L, Park JM, Yen YF, Pfefferbaum A, Spielman D, Mayer D. Effects of isoflurane anesthesia on hyperpolarized (13)C metabolic measurements in rat brain. Magn Reson Med. 2013 Oct; 70(4):1117-24. PMID: 23086864.
    Citations: 23     Fields:    Translation:Animals
  11. Park JM, Josan S, Jang T, Merchant M, Yen YF, Hurd RE, Recht L, Spielman DM, Mayer D. Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate. Magn Reson Med. 2012 Dec; 68(6):1886-93. PMID: 22334279.
    Citations: 24     Fields:    Translation:AnimalsCells
  12. Josan S, Spielman D, Yen YF, Hurd R, Pfefferbaum A, Mayer D. Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvate. NMR Biomed. 2012 Aug; 25(8):993-9. PMID: 22331837.
    Citations: 14     Fields:    Translation:Animals
  13. Mayer D, Yen YF, Josan S, Park JM, Pfefferbaum A, Hurd RE, Spielman DM. Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism. NMR Biomed. 2012 Oct; 25(10):1119-24. PMID: 22278751.
    Citations: 17     Fields:    Translation:Animals
  14. Xu T, Mayer D, Gu M, Yen YF, Josan S, Tropp J, Pfefferbaum A, Hurd R, Spielman D. Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI. NMR Biomed. 2011 Oct; 24(8):997-1005. PMID: 21538639.
    Citations: 24     Fields:    Translation:Animals
  15. MacKenzie JD, Yen YF, Mayer D, Tropp JS, Hurd RE, Spielman DM. Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy. Radiology. 2011 May; 259(2):414-20. PMID: 21406626; PMCID: PMC3079121.
    Citations: 34     Fields:    Translation:Animals
  16. Josan S, Yen YF, Hurd R, Pfefferbaum A, Spielman D, Mayer D. Application of double spin echo spiral chemical shift imaging to rapid metabolic mapping of hyperpolarized [1-¹³C]-pyruvate. J Magn Reson. 2011 Apr; 209(2):332-6. PMID: 21316280.
    Citations: 14     Fields:    Translation:Animals
  17. Yen YF, Nagasawa K, Nakada T. Promising application of dynamic nuclear polarization for in vivo (13)C MR imaging. Magn Reson Med Sci. 2011; 10(4):211-7. PMID: 22214905.
    Citations: 6     Fields:    Translation:HumansAnimals
  18. Darpolor MM, Yen YF, Chua MS, Xing L, Clarke-Katzenberg RH, Shi W, Mayer D, Josan S, Hurd RE, Pfefferbaum A, Senadheera L, So S, Hofmann LV, Glazer GM, Spielman DM. In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma. NMR Biomed. 2011 Jun; 24(5):506-13. PMID: 21674652.
    Citations: 31     Fields:    Translation:HumansAnimals
  19. Mayer D, Yen YF, Takahashi A, Josan S, Tropp J, Rutt BK, Hurd RE, Spielman DM, Pfefferbaum A. Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert. Magn Reson Med. 2011 May; 65(5):1228-33. PMID: 21500253.
    Citations: 29     Fields:    Translation:Animals
  20. Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7. PMID: 21130012.
    Citations: 31     Fields:    Translation:Animals
  21. Hurd RE, Yen YF, Tropp J, Pfefferbaum A, Spielman DM, Mayer D. Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging. J Cereb Blood Flow Metab. 2010 Oct; 30(10):1734-41. PMID: 20588318.
    Citations: 29     Fields:    Translation:Animals
  22. Hurd RE, Yen YF, Mayer D, Chen A, Wilson D, Kohler S, Bok R, Vigneron D, Kurhanewicz J, Tropp J, Spielman D, Pfefferbaum A. Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med. 2010 May; 63(5):1137-43. PMID: 20432284.
    Citations: 61     Fields:    Translation:Animals
  23. Mayer D, Yen YF, Levin YS, Tropp J, Pfefferbaum A, Hurd RE, Spielman DM. In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: comparison with phase-encoded CSI. J Magn Reson. 2010 Jun; 204(2):340-5. PMID: 20346717.
    Citations: 19     Fields:    Translation:Animals
  24. Yen YF, Le Roux P, Mayer D, King R, Spielman D, Tropp J, Butts Pauly K, Pfefferbaum A, Vasanawala S, Hurd R. T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate. NMR Biomed. 2010 May; 23(4):414-23. PMID: 20175135.
    Citations: 30     Fields:    Translation:Animals
  25. Zierhut ML, Yen YF, Chen AP, Bok R, Albers MJ, Zhang V, Tropp J, Park I, Vigneron DB, Kurhanewicz J, Hurd RE, Nelson SJ. Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson. 2010 Jan; 202(1):85-92. PMID: 19884027.
    Citations: 82     Fields:    Translation:Animals
  26. Costa AF, Yen YF, Drangova M. Registering spherical navigators with spherical harmonic expansions to measure three-dimensional rotations in magnetic resonance imaging. Magn Reson Imaging. 2010 Feb; 28(2):185-94. PMID: 19755205.
    Citations:    Fields:    
  27. Mayer D, Yen YF, Tropp J, Pfefferbaum A, Hurd RE, Spielman DM. Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1-pyruvate. Magn Reson Med. 2009 Sep; 62(3):557-64. PMID: 19585607.
    Citations: 53     Fields:    Translation:Animals
  28. Spielman DM, Mayer D, Yen YF, Tropp J, Hurd RE, Pfefferbaum A. In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate. Magn Reson Med. 2009 Aug; 62(2):307-13. PMID: 19526498.
    Citations: 27     Fields:    Translation:Animals
  29. Hu S, Chen AP, Zierhut ML, Bok R, Yen YF, Schroeder MA, Hurd RE, Nelson SJ, Kurhanewicz J, Vigneron DB. In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol. 2009 Nov-Dec; 11(6):399-407. PMID: 19424761.
    Citations: 31     Fields:    Translation:Animals
  30. Gofton TE, Chouinard PA, Young GB, Bihari F, Nicolle MW, Lee DH, Sharpe MD, Yen YF, Takahashi AM, Mirsattari SM. Functional MRI study of the primary somatosensory cortex in comatose survivors of cardiac arrest. Exp Neurol. 2009 Jun; 217(2):320-7. PMID: 19306870.
    Citations: 11     Fields:    Translation:Humans
  31. Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson SJ, Vigneron DB, Kurhanewicz J. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res. 2008 Oct 15; 68(20):8607-15. PMID: 18922937; PMCID: PMC2829248.
    Citations: 271     Fields:    Translation:Animals
  32. Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med. 2007 Dec; 58(6):1099-106. PMID: 17969006.
    Citations: 108     Fields:    Translation:HumansAnimals
  33. Reeder SB, Brittain JH, Grist TM, Yen YF. Least-squares chemical shift separation for (13)C metabolic imaging. J Magn Reson Imaging. 2007 Oct; 26(4):1145-52. PMID: 17896366.
    Citations: 44     Fields:    Translation:Humans
  34. Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen YF, Pauly JM, Nelson SJ, Vigneron DB. Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson. 2007 Aug; 187(2):357-62. PMID: 17562376.
    Citations: 95     Fields:    Translation:Animals
  35. Petrie DW, Costa AF, Takahashi A, Yen YF, Drangova M. Optimizing spherical navigator echoes for three-dimensional rigid-body motion detection. Magn Reson Med. 2005 May; 53(5):1080-7. PMID: 15844145.
    Citations: 2     Fields:    
  36. Costa AF, Petrie DW, Yen YF, Drangova M. Using the axis of rotation of polar navigator echoes to rapidly measure 3D rigid-body motion. Magn Reson Med. 2005 Jan; 53(1):150-8. PMID: 15690514.
    Citations: 3     Fields:    Translation:Humans
  37. Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen YF, Moody DM. Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal. AJNR Am J Neuroradiol. 2003 Sep; 24(8):1607-11. PMID: 13679279.
    Citations: 32     Fields:    Translation:HumansCTClinical Trials
  38. Zhang B, Yen YF, Chronik BA, McKinnon GC, Schaefer DJ, Rutt BK. Peripheral nerve stimulation properties of head and body gradient coils of various sizes. Magn Reson Med. 2003 Jul; 50(1):50-8. PMID: 12815678.
    Citations: 25     Fields:    Translation:HumansCTClinical Trials
  39. Coghill RC, McHaffie JG, Yen YF. Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci U S A. 2003 07 08; 100(14):8538-42. PMID: 12824463; PMCID: PMC166264.
    Citations: 155     Fields:    Translation:Humans
  40. Field AS, Laurienti PJ, Yen YF, Burdette JH, Moody DM. Dietary caffeine consumption and withdrawal: confounding variables in quantitative cerebral perfusion studies? Radiology. 2003 Apr; 227(1):129-35. PMID: 12616005.
    Citations: 45     Fields:    Translation:HumansCTClinical Trials
  41. Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen YF, Moody DM. Dietary caffeine consumption modulates fMRI measures. Neuroimage. 2002 Oct; 17(2):751-7. PMID: 12377150.
    Citations: 45     Fields:    Translation:HumansCTClinical Trials
  42. Chepuri NB, Yen YF, Burdette JH, Li H, Moody DM, Maldjian JA. Diffusion anisotropy in the corpus callosum. AJNR Am J Neuroradiol. 2002 May; 23(5):803-8. PMID: 12006281.
    Citations: 48     Fields:    Translation:HumansCells
  43. Yen YF, Field AS, Martin EM, Ari N, Burdette JH, Moody DM, Takahashi AM. Test-retest reproducibility of quantitative CBF measurements using FAIR perfusion MRI and acetazolamide challenge. Magn Reson Med. 2002 May; 47(5):921-8. PMID: 11979571.
    Citations: 38     Fields:    Translation:Humans
  44. Laurienti PJ, Burdette JH, Wallace MT, Yen YF, Field AS, Stein BE. Deactivation of sensory-specific cortex by cross-modal stimuli. J Cogn Neurosci. 2002 Apr 01; 14(3):420-9. PMID: 11970801.
    Citations: 127     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.