Harvard Catalyst Profiles

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Steven Shuyu Hou, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Algamal M, Russ AN, Miller MR, Hou SS, Maci M, Munting LP, Zhao Q, Gerashchenko D, Bacskai BJ, Kastanenka KV. Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease. Commun Biol. 2022 Dec 02; 5(1):1323. PMID: 36460716; PMCID: PMC9718858.
  2. Houser MC, Hou SS, Perrin F, Turchyna Y, Bacskai BJ, Berezovska O, Maesako M. A Novel NIR-FRET Biosensor for Reporting PS/?-Secretase Activity in Live Cells. Sensors (Basel). 2020 Oct 22; 20(21). PMID: 33105735.
    Citations: 2     Fields:    Translation:HumansCells
  3. Calvo-Rodriguez M, Hou SS, Snyder AC, Kharitonova EK, Russ AN, Das S, Fan Z, Muzikansky A, Garcia-Alloza M, Serrano-Pozo A, Hudry E, Bacskai BJ. Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nat Commun. 2020 05 01; 11(1):2146. PMID: 32358564.
    Citations: 66     Fields:    Translation:AnimalsCells
  4. van Veluw SJ, Hou SS, Calvo-Rodriguez M, Arbel-Ornath M, Snyder AC, Frosch MP, Greenberg SM, Bacskai BJ. Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain. Neuron. 2020 02 05; 105(3):549-561.e5. PMID: 31810839.
    Citations: 85     Fields:    Translation:AnimalsCells
  5. Calvo-Rodriguez M, Hou SS, Snyder AC, Dujardin S, Shirani H, Nilsson KPR, Bacskai BJ. In vivo detection of tau fibrils and amyloid ß aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy. Acta Neuropathol Commun. 2019 11 08; 7(1):171. PMID: 31703739.
    Citations: 16     Fields:    Translation:AnimalsCells
  6. Kastanenka KV, Calvo-Rodriguez M, Hou SS, Zhou H, Takeda S, Arbel-Ornath M, Lariviere A, Lee YF, Kim A, Hawkes JM, Logan R, Feng D, Chen X, Gomperts SN, Bacskai BJ. Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology. Sci Rep. 2019 06 20; 9(1):8964. PMID: 31221985.
    Citations: 11     Fields:    Translation:AnimalsCells
  7. Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, Kuchibhotla KV, Betensky RA, Spires-Jones T, Hyman BT. Opposing Roles of apolipoprotein E in aging and neurodegeneration. Life Sci Alliance. 2019 02; 2(1). PMID: 30760557.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  8. Kelly P, Hudry E, Hou SS, Bacskai BJ. In Vivo Two Photon Imaging of Astrocytic Structure and Function in Alzheimer's Disease. Front Aging Neurosci. 2018; 10:219. PMID: 30072889; PMCID: PMC6060286.
    Citations: 4     
  9. Kumar ATN, Hou SS, Rice WL. Tomographic fluorescence lifetime multiplexing in the spatial frequency domain. Optica. 2018 May; 5(5):624-627. PMID: 30984803; PMCID: PMC6457659.
    Citations: 2     
  10. Funane T, Hou SS, Zoltowska KM, van Veluw SJ, Berezovska O, Kumar ATN, Bacskai BJ. Selective plane illumination microscopy (SPIM) with time-domain fluorescence lifetime imaging microscopy (FLIM) for volumetric measurement of cleared mouse brain samples. Rev Sci Instrum. 2018 May; 89(5):053705. PMID: 29864842.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-ß induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Mol Neurodegener. 2017 03 21; 12(1):27. PMID: 28327181.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  12. Kastanenka KV, Hou SS, Shakerdge N, Logan R, Feng D, Wegmann S, Chopra V, Hawkes JM, Chen X, Bacskai BJ. Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. PLoS One. 2017; 12(1):e0170275. PMID: 28114405.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  13. Hou SS, Bacskai BJ, Kumar AT. Comparison of tomographic fluorescence spectral and lifetime multiplexing. Opt Lett. 2016 Nov 15; 41(22):5337-5340. PMID: 27842127; PMCID: PMC9158487.
    Citations: 1     Fields:    
  14. Hou SS, Bacskai BJ, Kumar AT. Optimal estimator for tomographic fluorescence lifetime multiplexing. Opt Lett. 2016 Apr 01; 41(7):1352-5. PMID: 27192234.
    Citations: 5     Fields:    
  15. Hou SS, Rice WL, Bacskai BJ, Kumar AT. Tomographic lifetime imaging using combined early- and late-arriving photons. Opt Lett. 2014 Mar 01; 39(5):1165-8. PMID: 24690697.
    Citations: 9     Fields:    
  16. Neal KL, Shakerdge NB, Hou SS, Klunk WE, Mathis CA, Nesterov EE, Swager TM, McLean PJ, Bacskai BJ. Development and screening of contrast agents for in vivo imaging of Parkinson's disease. Mol Imaging Biol. 2013 Oct; 15(5):585-95. PMID: 23624948.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Arbel-Ornath M, Hudry E, Eikermann-Haerter K, Hou S, Gregory JL, Zhao L, Betensky RA, Frosch MP, Greenberg SM, Bacskai BJ. Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models. Acta Neuropathol. 2013 Sep; 126(3):353-64. PMID: 23818064.
    Citations: 107     Fields:    Translation:AnimalsCells
  18. Rice WL, Hou S, Kumar AT. Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing. Opt Lett. 2013 Jun 15; 38(12):2038-40. PMID: 23938969.
    Citations: 3     Fields:    
  19. Xie H, Hou S, Jiang J, Sekutowicz M, Kelly J, Bacskai BJ. Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7904-9. PMID: 23610434.
    Citations: 56     Fields:    Translation:AnimalsCells
  20. Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-ß. Brain. 2012 Jul; 135(Pt 7):2155-68. PMID: 22637583; PMCID: PMC3381721.
    Citations: 125     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.