Harvard Catalyst Profiles

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Jacob M Hooker, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS111168 (HOOKER, JACOB M.) Dec 1, 2019 - Nov 30, 2024
    COX-2-selective PET imaging as an onset marker of Huntington's disease
    Role: Principal Investigator
  2. S10OD023517 (HOOKER, JACOB M.) Apr 15, 2018 - Apr 14, 2019
    Carbon-11 Automation Equipment for Human PET Radiotracer Production
    Role: Principal Investigator
  3. R01NS099250 (HOOKER, JACOB M.) Jul 1, 2017 - Apr 30, 2022
    Epigenetic Radiotracers for PET Imaging: Isoform-SelectiveHDAC Probes
    Role: Principal Investigator
  4. R21MH111971 (HOOKER, JACOB M.) Jul 1, 2017 - Dec 31, 2019
    Epigenetic mechanisms in schizophrenia quantified by non-invasive PET imaging
    Role: Principal Investigator
  5. R21MH110933 (DICHTER, GABRIEL S) Sep 6, 2016 - Oct 31, 2018
    A Simultaneous PET/MR Study of Striatal Dopamine Binding in Autism
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guo M, Bakhoda A, Gao ZG, Ramsey JM, Li Y, O'Conor KA, Kelleher AC, Eisenberg SM, Kang Y, Yan X, Javdan C, Fowler JS, Rice KC, Hooker JM, Jacobson KA, Kim SW, Volkow ND. Discovery of Highly Potent Adenosine A1 Receptor Agonists: Targeting Positron Emission Tomography Probes. ACS Chem Neurosci. 2021 Sep 01. PMID: 34469110.
    Citations:    Fields:    
  2. Hooker JM. FDA Approval of Aducanumab Divided the Community but Also Connected and United It. ACS Chem Neurosci. 2021 08 04; 12(15):2716-2717. PMID: 34228436.
    Citations:    Fields:    
  3. Sander CY, Bovo S, Torrado-Carvajal A, Albrecht D, Deng H, Napadow V, Price JC, Hooker JM, Loggia ML. [11C]PBR28 radiotracer kinetics are not driven by alterations in cerebral blood flow. J Cereb Blood Flow Metab. 2021 Jun 23; 271678X211023387. PMID: 34159823.
    Citations:    Fields:    
  4. de Laat B, Kling YE, Schroyen G, Ooms M, Hooker JM, Bormans G, Van Laere K, Ceccarini J. Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [18F]JNJ42259152 PET study in rats. Eur J Nucl Med Mol Imaging. 2021 Jun 17. PMID: 34142214.
    Citations:    Fields:    
  5. Hooker JM. A Reflection on Juneteenth and the Diversity of Our Chemical Neuroscience Community. ACS Chem Neurosci. 2021 07 07; 12(13):2254-2255. PMID: 34115487.
    Citations:    Fields:    
  6. Lindsley CW, Hooker JM, Liotta DC. Giving Credit Where Credit Is Due: Properly Citing Relevant Prior Art. ACS Med Chem Lett. 2021 May 13; 12(5):669. PMID: 34055203.
  7. Lindsley CW, Hooker JM, Liotta DC. Giving Credit Where Credit Is Due: Properly Citing Relevant Prior Art. ACS Chem Neurosci. 2021 05 05; 12(9):1465. PMID: 33899459.
    Citations:    Fields:    
  8. Lindsley CW, Hooker JM, Liotta DC. Giving Credit Where Credit Is Due: Properly Citing Relevant Prior Art. J Med Chem. 2021 05 13; 64(9):5225. PMID: 33899467.
    Citations:    Fields:    
  9. Babu S, Hightower BG, Chan J, Zürcher NR, Kivisäkk P, Tseng CJ, Sanders DL, Robichaud A, Banno H, Evora A, Ashokkumar A, Pothier L, Paganoni S, Chew S, Dojillo J, Matsuda K, Gudesblatt M, Berry JD, Cudkowicz ME, Hooker JM, Atassi N. Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial. Neuroimage Clin. 2021; 30:102672. PMID: 34016561.
    Citations:    Fields:    Translation:Humans
  10. Zürcher NR, Roberts VHJ, Schabel MC, Edlow AG, Hooker JM, Lo JO. Imaging Epigenetics of Prenatal THC. ACS Chem Neurosci. 2021 05 05; 12(9):1466-1468. PMID: 33852273.
    Citations:    Fields:    Translation:Animals
  11. Torrado-Carvajal A, Toschi N, Albrecht DS, Chang K, Akeju O, Kim M, Edwards RR, Zhang Y, Hooker JM, Duggento A, Kalpathy-Cramer J, Napadow V, Loggia ML. Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain. Pain. 2021 04 01; 162(4):1241-1249. PMID: 33065737.
    Citations: 3     Fields:    Translation:Humans
  12. Makary MM, Weerasekara A, Rodham H, Hightower BG, Tseng CJ, Chan J, Chew S, Paganoni S, Ratai EM, Zürcher NR, Hooker JM, Atassi N, Babu S. Comparison of Two Clinical Upper Motor Neuron Burden Rating Scales in ALS Using Quantitative Brain Imaging. ACS Chem Neurosci. 2021 03 03; 12(5):906-916. PMID: 33576234.
    Citations: 1     Fields:    Translation:HumansCells
  13. Zürcher NR, Walsh EC, Phillips RD, Cernasov PM, Tseng CJ, Dharanikota A, Smith E, Li Z, Kinard JL, Bizzell JC, Greene RK, Dillon D, Pizzagalli DA, Izquierdo-Garcia D, Truong K, Lalush D, Hooker JM, Dichter GS. A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism. Transl Psychiatry. 2021 01 11; 11(1):33. PMID: 33431841.
    Citations: 1     Fields:    Translation:Humans
  14. Hooker JM. Chemical Neuroscience and the Paths to Impact. ACS Chem Neurosci. 2021 01 06; 12(1):1. PMID: 33401914.
    Citations:    Fields:    
  15. Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT. Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa157. PMID: 33392506.
    Citations: 1     
  16. Dalton RM, Krishnan HS, Parker VS, Catanese MC, Hooker JM. Coevolution of Atomic Resolution and Whole-Brain Imaging for Tau Neurofibrillary Tangles. ACS Chem Neurosci. 2020 09 02; 11(17):2513-2522. PMID: 32786315.
    Citations: 1     Fields:    Translation:HumansCells
  17. Downer OM, Marcus REG, Zürcher NR, Hooker JM. Tracing the History of the Human Translocator Protein to Recent Neurodegenerative and Psychiatric Imaging. ACS Chem Neurosci. 2020 08 05; 11(15):2192-2200. PMID: 32662626.
    Citations: 3     Fields:    Translation:Humans
  18. Antonelli R, Jiménez C, Riley M, Servidei T, Riccardi R, Soriano A, Roma J, Martínez-Saez E, Martini M, Ruggiero A, Moreno L, Sánchez de Toledo J, Gallego S, Bové J, Hooker JM, Segura MF. CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models. Cancers (Basel). 2020 Jul 16; 12(7). PMID: 32708733.
    Citations: 2     
  19. Katsumi Y, Racine AM, Torrado-Carvajal A, Loggia ML, Hooker JM, Greve DN, Hightower BG, Catana C, Cavallari M, Arnold SE, Fong TG, Vasunilashorn SM, Marcantonio ER, Schmitt EM, Xu G, Libermann TA, Barrett LF, Inouye SK, Dickerson BC, Touroutoglou A, Collins JA. The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium. Neuroimage Clin. 2020; 27:102346. PMID: 32712451.
    Citations: 3     Fields:    Translation:Humans
  20. Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM. In vivo human brain expression of histone deacetylases in bipolar disorder. Transl Psychiatry. 2020 07 08; 10(1):224. PMID: 32641695.
    Citations: 2     Fields:    Translation:Humans
  21. Koole M, Van Weehaeghe D, Serdons K, Herbots M, Cawthorne C, Celen S, Schroeder FA, Hooker JM, Bormans G, de Hoon J, Kranz JE, Van Laere K, Gilbert TM. Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain. Eur J Nucl Med Mol Imaging. 2021 02; 48(2):596-611. PMID: 32638097.
    Citations: 2     Fields:    Translation:Humans
  22. Donovan LL, Magnussen JH, Dyssegaard A, Lehel S, Hooker JM, Knudsen GM, Hansen HD. Imaging HDACs In Vivo: Cross-Validation of the [11C]Martinostat Radioligand in the Pig Brain. Mol Imaging Biol. 2020 06; 22(3):569-577. PMID: 31290052.
    Citations: 1     Fields:    Translation:HumansAnimals
  23. Parmar A, Zürcher NR, Hooker JM. Time Will Tell the Utility of Biomarkers. ACS Chem Neurosci. 2020 06 17; 11(12):1692-1695. PMID: 32463674.
    Citations:    Fields:    Translation:Humans
  24. Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA. Extra-Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura. Ann Neurol. 2020 06; 87(6):939-949. PMID: 32239542.
    Citations: 3     Fields:    Translation:Humans
  25. Celen S, Rokka J, Gilbert TM, Koole M, Vermeulen I, Serdons K, Schroeder FA, Wagner FF, Bleeser T, Hightower BG, Hu J, Rahal D, Beyzavi MH, Vanduffel W, Van Laere K, Kranz JE, Hooker JM, Bormans G, Cawthorne CJ. Translation of HDAC6 PET Imaging Using [18F]EKZ-001-cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates. ACS Chem Neurosci. 2020 04 01; 11(7):1093-1101. PMID: 32159328.
    Citations: 3     Fields:    Translation:Animals
  26. Van Weehaeghe D, Babu S, De Vocht J, Zürcher NR, Chew S, Tseng CJ, Loggia ML, Koole M, Rezaei A, Schramm G, Van Damme P, Hooker JM, Van Laere K, Atassi N. Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands. J Nucl Med. 2020 11; 61(11):1621-1627. PMID: 32169920.
    Citations: 3     Fields:    Translation:Humans
  27. Zürcher NR, Loggia ML, Mullett JE, Tseng C, Bhanot A, Richey L, Hightower BG, Wu C, Parmar AJ, Butterfield RI, Dubois JM, Chonde DB, Izquierdo-Garcia D, Wey HY, Catana C, Hadjikhani N, McDougle CJ, Hooker JM. [11C]PBR28 MR-PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder. Mol Psychiatry. 2021 05; 26(5):1659-1669. PMID: 32076115.
    Citations: 4     Fields:    Translation:Humans
  28. L 'Estrade ET, Shalgunov V, Edgar FG, Strebl-Bantillo MG, Xiong M, Crestey F, Neelamegam R, Dyssegaard A, Lehel S, Erlandsson M, Ohlsson T, Hooker JM, Knudsen GM, Herth MM, Hansen HD. Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors. J Labelled Comp Radiopharm. 2020 02; 63(2):46-55. PMID: 31674045.
    Citations: 1     Fields:    
  29. Osko JD, Porter NJ, Narayana Reddy PA, Xiao YC, Rokka J, Jung M, Hooker JM, Salvino JM, Christianson DW. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. J Med Chem. 2020 01 09; 63(1):295-308. PMID: 31793776.
    Citations: 4     Fields:    Translation:AnimalsCells
  30. Gerstner ER, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T. Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma. Clin Cancer Res. 2020 01 01; 26(1):206-212. PMID: 31558474.
    Citations: 11     Fields:    Translation:Humans
  31. Dios AM, Babu S, Granucci EJ, Mueller KA, Mills AN, Alshikho MJ, Zürcher NR, Cernasov P, Gilbert TM, Glass JD, Berry JD, Atassi N, Hooker JM, Sadri-Vakili G. Class I and II histone deacetylase expression is not altered in human amyotrophic lateral sclerosis: Neuropathological and positron emission tomography molecular neuroimaging evidence. Muscle Nerve. 2019 10; 60(4):443-452. PMID: 31241177.
    Citations: 2     Fields:    Translation:Humans
  32. Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, Wang C, Roffman JL, Holt DJ, Greve DN, Pasternak O, Kubicki M, Wey HY, Hooker JM. Neuroepigenetic signatures of age and sex in the living human brain. Nat Commun. 2019 07 03; 10(1):2945. PMID: 31270332.
    Citations: 8     Fields:    Translation:Humans
  33. Smith CJ, Bhanot A, Norman E, Mullett JE, Bilbo SD, McDougle CJ, Zürcher NR, Hooker JM. A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder. J Autism Dev Disord. 2019 Jul; 49(7):3036-3044. PMID: 31004246.
    Citations: 6     Fields:    Translation:Humans
  34. Hooker JM, Carson RE. Human Positron Emission Tomography Neuroimaging. Annu Rev Biomed Eng. 2019 06 04; 21:551-581. PMID: 31167104.
    Citations: 5     Fields:    Translation:HumansCells
  35. Albrecht DS, Kim M, Akeju O, Torrado-Carvajal A, Edwards RR, Zhang Y, Bergan C, Protsenko E, Kucyi A, Wasan AD, Hooker JM, Napadow V, Loggia ML. The neuroinflammatory component of negative affect in patients with chronic pain. Mol Psychiatry. 2021 03; 26(3):864-874. PMID: 31138890.
    Citations: 8     Fields:    Translation:HumansCells
  36. Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Loggia ML, Hadjikhani N. Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study. Neurology. 2019 04 23; 92(17):e2038-e2050. PMID: 30918090.
    Citations: 8     Fields:    Translation:Humans
  37. Lindsley CW, Abbott C, Andrews AM, Hooker JM, Zhou J. Editors' Favorites: Best of 2018. ACS Chem Neurosci. 2019 01 16; 10(1):1-4. PMID: 30990663.
    Citations:    Fields:    Translation:Humans
  38. Paganoni S, Alshikho MJ, Luppino S, Chan J, Pothier L, Schoenfeld D, Andres PL, Babu S, Zürcher NR, Loggia ML, Barry RL, Luotti S, Nardo G, Trolese MC, Pantalone S, Bendotti C, Bonetto V, De Marchi F, Rosen B, Hooker J, Cudkowicz M, Atassi N. A pilot trial of RNS60 in amyotrophic lateral sclerosis. Muscle Nerve. 2019 03; 59(3):303-308. PMID: 30458059.
    Citations: 7     Fields:    Translation:Humans
  39. Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019 01 02; 129(1):364-372. PMID: 30530989.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  40. Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM. Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging. ACS Chem Neurosci. 2019 01 16; 10(1):384-395. PMID: 30212182.
    Citations: 7     Fields:    Translation:AnimalsCells
  41. Sander CY, Schoenberger M, Hooker JM. Response to Comment on "In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates". ACS Chem Neurosci. 2019 01 16; 10(1):773-775. PMID: 30346705.
    Citations: 2     Fields:    Translation:Animals
  42. Albrecht DS, Forsberg A, Sandström A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, Taylor N, Kim M, Hooker JM, Edwards RR, Napadow V, Kosek E, Loggia ML. Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation. Brain Behav Immun. 2019 01; 75:72-83. PMID: 30223011.
    Citations: 46     Fields:    Translation:HumansCells
  43. Porter NJ, Osko JD, Diedrich D, Kurz T, Hooker JM, Hansen FK, Christianson DW. Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. J Med Chem. 2018 09 13; 61(17):8054-8060. PMID: 30118224.
    Citations: 21     Fields:    Translation:AnimalsCells
  44. Ratai EM, Alshikho MJ, Zürcher NR, Loggia ML, Cebulla CL, Cernasov P, Reynolds B, Fish J, Seth R, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated imaging of [11C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy 1H-MRS in amyotrophic lateral sclerosis. Neuroimage Clin. 2018; 20:357-364. PMID: 30112276.
    Citations: 11     Fields:    Translation:Humans
  45. Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Reynolds B, Pijanowski O, Chonde DB, Izquierdo Garcia D, Mainero C, Catana C, Chan J, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated magnetic resonance imaging and [11 C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis. Ann Neurol. 2018 06; 83(6):1186-1197. PMID: 29740862.
    Citations: 25     Fields:    Translation:Humans
  46. Larimer BM, Dubois F, Bloch E, Nesti S, Placzek M, Zadra G, Hooker JM, Loda M, Mahmood U. Specific 18F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone-Binding Globulin. J Nucl Med. 2018 10; 59(10):1538-1543. PMID: 29853654.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  47. Lois C, González I, Izquierdo-García D, Zürcher NR, Wilkens P, Loggia ML, Hooker JM, Rosas HD. Neuroinflammation in Huntington's Disease: New Insights with 11C-PBR28 PET/MRI. ACS Chem Neurosci. 2018 11 21; 9(11):2563-2571. PMID: 29719953.
    Citations: 13     Fields:    Translation:HumansCells
  48. Albrecht DS, Ahmed SU, Kettner NW, Borra RJH, Cohen-Adad J, Deng H, Houle TT, Opalacz A, Roth SA, Melo MFV, Chen L, Mao J, Hooker JM, Loggia ML, Zhang Y. Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients. Pain. 2018 May; 159(5):968-977. PMID: 29419657.
    Citations: 25     Fields:    Translation:Humans
  49. Albrecht DS, Granziera C, Hooker JM, Loggia ML. Correction to In Vivo Imaging of Human Neuroinflammation. ACS Chem Neurosci. 2018 06 20; 9(6):1515. PMID: 29708334.
    Citations:    Fields:    
  50. Weïwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, D Ordevic L, Sacher JR, Skepner A, Fei D, Dennehy K, Nguyen S, Faloon PW, Perez J, Cottrell JR, Liu F, Palmer M, Pan JQ, Hooker JM, Zhang YL, Scolnick E, Wagner FF, Holson EB. Functionally Biased D2R Antagonists: Targeting the ß-Arrestin Pathway to Improve Antipsychotic Treatment. ACS Chem Biol. 2018 04 20; 13(4):1038-1047. PMID: 29485852.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  51. Krishnan HS, Bernard-Gauthier V, Placzek MS, Dahl K, Narayanaswami V, Livni E, Chen Z, Yang J, Collier TL, Ran C, Hooker JM, Liang SH, Vasdev N. Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [11C]PBT2. Mol Pharm. 2018 02 05; 15(2):695-702. PMID: 29298483.
    Citations: 2     Fields:    Translation:HumansAnimals
  52. Lindsley CW, Cunningham KA, Hooker JM, Andrews AM. Editors' Favorites of 2017. ACS Chem Neurosci. 2018 01 17; 9(1):1-4. PMID: 29338186.
    Citations:    Fields:    Translation:HumansAnimals
  53. Strebl MG, Yang J, Isaacs L, Hooker JM. Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET. Mol Imaging. 2018 Jan-Dec; 17:1536012118799838. PMID: 30354934.
    Citations: 3     Fields:    Translation:Animals
  54. Liu W, Huang X, Placzek MS, Krska SW, McQuade P, Hooker JM, Groves JT. Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin. Chem Sci. 2018 Feb 07; 9(5):1168-1172. PMID: 29675161.
    Citations: 7     
  55. Linnman C, Catana C, Petkov MP, Chonde DB, Becerra L, Hooker J, Borsook D. Molecular and functional PET-fMRI measures of placebo analgesia in episodic migraine: Preliminary findings. Neuroimage Clin. 2018; 17:680-690. PMID: 29255671.
    Citations: 4     Fields:    Translation:Humans
  56. Schoenberger M, Schroeder FA, Placzek MS, Carter RL, Rosen BR, Hooker JM, Sander CY. In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates. ACS Chem Neurosci. 2018 02 21; 9(2):298-305. PMID: 29050469.
    Citations: 6     Fields:    Translation:AnimalsCells
  57. Van de Bittner GC, Van de Bittner KC, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM. Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A. ACS Chem Neurosci. 2018 02 21; 9(2):358-368. PMID: 29035509.
    Citations: 4     Fields:    Translation:AnimalsCells
  58. Paganoni S, Alshikho MJ, Zürcher NR, Cernasov P, Babu S, Loggia ML, Chan J, Chonde DB, Garcia DI, Catana C, Mainero C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Imaging of glia activation in people with primary lateral sclerosis. Neuroimage Clin. 2018; 17:347-353. PMID: 29159046.
    Citations: 11     Fields:    Translation:HumansCells
  59. Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional Characterization of 5-HT1B Receptor Drugs in Nonhuman Primates Using Simultaneous PET-MR. J Neurosci. 2017 11 01; 37(44):10671-10678. PMID: 28972127.
    Citations: 3     Fields:    Translation:Animals
  60. Strebl MG, Campbell AJ, Zhao WN, Schroeder FA, Riley MM, Chindavong PS, Morin TM, Haggarty SJ, Wagner FF, Ritter T, Hooker JM. HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. ACS Cent Sci. 2017 Sep 27; 3(9):1006-1014. PMID: 28979942.
    Citations: 12     
  61. Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zürcher NR, Barth VN, Guehl NJ, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts. J Nucl Med. 2018 01; 59(1):107-114. PMID: 28818984.
    Citations: 7     Fields:    Translation:HumansCells
  62. Sander CY, Mandeville JB, Wey HY, Catana C, Hooker JM, Rosen BR. Effects of flow changes on radiotracer binding: Simultaneous measurement of neuroreceptor binding and cerebral blood flow modulation. J Cereb Blood Flow Metab. 2019 01; 39(1):131-146. PMID: 28816571.
    Citations: 14     Fields:    Translation:AnimalsCells
  63. Beyzavi MH, Mandal D, Strebl MG, Neumann CN, D'Amato EM, Chen J, Hooker JM, Ritter T. 18F-Deoxyfluorination of Phenols via Ru p-Complexes. ACS Cent Sci. 2017 Sep 27; 3(9):944-948. PMID: 28979935.
    Citations: 16     
  64. Kanthan M, Cumming P, Hooker JM, Vasdev N. Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET. ACS Chem Neurosci. 2017 09 20; 8(9):1817-1819. PMID: 28719177.
    Citations: 1     Fields:    Translation:Humans
  65. Ma L, Placzek MS, Hooker JM, Vasdev N, Liang SH. [11C]Cyanation of arylboronic acids in aqueous solutions. Chem Commun (Camb). 2017 Jun 21; 53(49):6597-6600. PMID: 28580477.
    Citations: 7     Fields:    
  66. Zhao W, Lee HG, Buchwald SL, Hooker JM. Direct 11CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions. J Am Chem Soc. 2017 05 31; 139(21):7152-7155. PMID: 28502164.
    Citations: 13     Fields:    Translation:Cells
  67. Zhu H, Xue X, Wang E, Wallack M, Na H, Hooker JM, Kowall N, Tao Q, Stein TD, Wolozin B, Qiu WQ. Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease. Neuropharmacology. 2017 06; 119:170-181. PMID: 28363773.
    Citations: 12     Fields:    Translation:HumansAnimals
  68. Hooker JM, Strebl MG, Schroeder FA, Wey HY, Ambardekar AV, McKinsey TA, Schoenberger M. Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. Sci Rep. 2017 02 16; 7:42136. PMID: 28205593.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  69. Atzil S, Touroutoglou A, Rudy T, Salcedo S, Feldman R, Hooker JM, Dickerson BC, Catana C, Barrett LF. Dopamine in the medial amygdala network mediates human bonding. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2361-2366. PMID: 28193868.
    Citations: 28     Fields:    Translation:Humans
  70. Schuetze KB, Stratton MS, Blakeslee WW, Wempe MF, Wagner FF, Holson EB, Kuo YM, Andrews AJ, Gilbert TM, Hooker JM, McKinsey TA. Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther. 2017 04; 361(1):140-150. PMID: 28174211.
    Citations: 9     Fields:    Translation:AnimalsCells
  71. Hu K, Patnaik D, Collier TL, Lee KN, Gao H, Swoyer MR, Rotstein BH, Krishnan HS, Liang SH, Wang J, Yan Z, Hooker JM, Vasdev N, Haggarty SJ, Ngai MY. Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3ß Ligands for Positron Emission Tomography Imaging. ACS Med Chem Lett. 2017 Mar 09; 8(3):287-292. PMID: 28337318.
    Citations: 5     
  72. Fuin N, Pedemonte S, Catalano OA, Izquierdo-Garcia D, Soricelli A, Salvatore M, Heberlein K, Hooker JM, Van Leemput K, Catana C. PET/MRI in the Presence of Metal Implants: Completion of the Attenuation Map from PET Emission Data. J Nucl Med. 2017 05; 58(5):840-845. PMID: 28126884.
    Citations: 6     Fields:    Translation:Humans
  73. Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O'Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM. Nasal neuron PET imaging quantifies neuron generation and degeneration. J Clin Invest. 2017 Feb 01; 127(2):681-694. PMID: 28112682.
    Citations: 7     Fields:    Translation:Animals
  74. Herranz E, Hooker JM, Izquierdo-Garcia D, Loggia ML, Mainero C. Reply. Ann Neurol. 2017 02; 81(2):324-325. PMID: 28032651.
    Citations: 2     Fields:    Translation:Humans
  75. Lindsley CW, Hooker JM, Cunningham KA, Andrews AM. Editors' Favorites of 2016. ACS Chem Neurosci. 2017 01 18; 8(1):1-3. PMID: 28095678.
    Citations:    Fields:    
  76. Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017 01 16; 8:14064. PMID: 28091604.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  77. Campbell MG, Mercier J, Genicot C, Gouverneur V, Hooker JM, Ritter T. Bridging the gaps in 18F PET tracer development. Nat Chem. 2016 12 20; 9(1):1-3. PMID: 27995923.
    Citations: 11     Fields:    
  78. Schroeder FA, Gilbert TM, Feng N, Taillon BD, Volkow ND, Innis RB, Hooker JM, Lipska BK. Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. ACS Chem Neurosci. 2017 03 15; 8(3):662-668. PMID: 27959513.
    Citations: 10     Fields:    Translation:HumansCells
  79. Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Chonde DB, Izquierdo Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis. Neurology. 2016 Dec 13; 87(24):2554-2561. PMID: 27837005.
    Citations: 33     Fields:    Translation:HumansCells
  80. Wang C, Schroeder FA, Hooker JM. Development of New Positron Emission Tomography Radiotracer for BET Imaging. ACS Chem Neurosci. 2017 01 18; 8(1):17-21. PMID: 27806195.
    Citations: 4     Fields:    Translation:AnimalsCells
  81. Herranz E, Giannì C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, Hooker JM, Taylor N, Ionete C, Kinkel RP, Mainero C. Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol. 2016 Nov; 80(5):776-790. PMID: 27686563.
    Citations: 51     Fields:    Translation:Humans
  82. Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR. Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma. Transl Oncol. 2016 Oct; 9(5):431-437. PMID: 27751347.
    Citations: 8     
  83. Ricq EL, Hooker JM, Haggarty SJ. Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch. J Biol Chem. 2016 Nov 18; 291(47):24756-24767. PMID: 27634040.
    Citations: 1     Fields:    Translation:HumansCells
  84. Ricq EL, Hooker JM, Haggarty SJ. Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation. Psychiatry Clin Neurosci. 2016 Dec; 70(12):536-550. PMID: 27485392.
    Citations: 1     Fields:    Translation:HumansAnimals
  85. Rotstein BH, Placzek MS, Krishnan HS, Pekošak A, Collier TL, Wang C, Liang SH, Burstein ES, Hooker JM, Vasdev N. Preclinical PET Neuroimaging of [11C]Bexarotene. Mol Imaging. 2016; 15. PMID: 27553293.
    Citations: 1     Fields:    Translation:Animals
  86. Rotstein BH, Liang SH, Placzek MS, Hooker JM, Gee AD, Dollé F, Wilson AA, Vasdev N. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals. Chem Soc Rev. 2016 Aug 22; 45(17):4708-26. PMID: 27276357.
    Citations: 26     Fields:    Translation:HumansCells
  87. Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Sci Transl Med. 2016 08 10; 8(351):351ra106. PMID: 27510902.
    Citations: 34     Fields:    Translation:HumansCTClinical Trials
  88. Neumann CN, Hooker JM, Ritter T. Corrigendum: Concerted nucleophilic aromatic substitution with 19F- and 18F. Nature. 2016 Oct 13; 538(7624):274. PMID: 27487221.
    Citations: 2     Fields:    
  89. Heidari P, Szretter A, Rushford LE, Stevens M, Collier L, Sore J, Hooker J, Mahmood U. Design, construction and testing of a low-cost automated (68)Gallium-labeling synthesis unit for clinical use. Am J Nucl Med Mol Imaging. 2016; 6(3):176-84. PMID: 27508104.
    Citations: 4     
  90. Mandeville JB, Sander CYM, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. A regularized full reference tissue model for PET neuroreceptor mapping. Neuroimage. 2016 Oct 01; 139:405-414. PMID: 27364474.
    Citations: 2     Fields:    Translation:HumansAnimals
  91. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J, Minocha J, Valasek MA, Aryafar H, Brenner DA, Sirlin CB, Loomba R. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Aliment Pharmacol Ther. 2016 08; 44(3):287-99. PMID: 27279429.
    Citations: 9     Fields:    Translation:Humans
  92. Roffman JL, Tanner AS, Eryilmaz H, Rodriguez-Thompson A, Silverstein NJ, Ho NF, Nitenson AZ, Chonde DB, Greve DN, Abi-Dargham A, Buckner RL, Manoach DS, Rosen BR, Hooker JM, Catana C. Dopamine D1 signaling organizes network dynamics underlying working memory. Sci Adv. 2016 06; 2(6):e1501672. PMID: 27386561.
    Citations: 20     Fields:    Translation:HumansCells
  93. Neumann CN, Hooker JM, Ritter T. Concerted nucleophilic aromatic substitution with (19)F(-) and (18)F(-). Nature. 2016 06 16; 534(7607):369-73. PMID: 27281221.
    Citations: 37     Fields:    Translation:Cells
  94. Hooker JM. Neuroinflammation: Brain on Fire? ACS Chem Neurosci. 2016 Apr 20; 7(4):415. PMID: 27094163.
    Citations:    Fields:    Translation:Humans
  95. Albrecht DS, Granziera C, Hooker JM, Loggia ML. In Vivo Imaging of Human Neuroinflammation. ACS Chem Neurosci. 2016 Apr 20; 7(4):470-83. PMID: 26985861.
    Citations: 53     Fields:    Translation:Humans
  96. Hoover AJ, Lazari M, Ren H, Narayanam MK, Murphy JM, van Dam RM, Hooker JM, Ritter T. A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging. Organometallics. 2016 Apr 11; 35(7):1008-1014. PMID: 27087736.
    Citations: 16     
  97. Wang C, Placzek MS, Van de Bittner GC, Schroeder FA, Hooker JM. A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. ACS Chem Neurosci. 2016 Apr 20; 7(4):484-9. PMID: 26694017.
    Citations: 12     Fields:    Translation:Animals
  98. Placzek MS, Zhao W, Wey HY, Morin TM, Hooker JM. PET Neurochemical Imaging Modes. Semin Nucl Med. 2016 Jan; 46(1):20-7. PMID: 26687854.
    Citations: 4     Fields:    Translation:HumansAnimals
  99. Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM. Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. ACS Chem Neurosci. 2016 05 18; 7(5):528-33. PMID: 26675505.
    Citations: 8     Fields:    Translation:Animals
  100. Lee SJ, Fowler JS, Alexoff D, Schueller M, Kim D, Nauth A, Weber C, Kim SW, Hooker JM, Ma L, Qu W. An efficient and practical synthesis of [2-(11)C]indole via superfast nucleophilic [(11)C]cyanation and RANEY® Nickel catalyzed reductive cyclization. Org Biomol Chem. 2015 Dec 14; 13(46):11235-43. PMID: 26411301.
    Citations: 2     Fields:    
  101. Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M, Walpita D, Mandrup-Poulsen T, Wagner BK, Holson EB. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection. ACS Chem Biol. 2016 Feb 19; 11(2):363-74. PMID: 26640968.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  102. Huang X, Liu W, Hooker JM, Groves JT. Corrigendum: Targeted Fluorination with the Fluoride Ion by Manganese-Catalyzed Decarboxylation. Angew Chem Int Ed Engl. 2015 Nov 23; 54(48):14215. PMID: 26768105.
    Citations:    Fields:    
  103. Sander CY, Hooker JM, Catana C, Rosen BR, Mandeville JB. Imaging Agonist-Induced D2/D3 Receptor Desensitization and Internalization In Vivo with PET/fMRI. Neuropsychopharmacology. 2016 Apr; 41(5):1427-36. PMID: 26388148.
    Citations: 19     Fields:    Translation:Animals
  104. Wang H, Liu L, Lu Y, Pan P, Hooker JM, Fowler JS, Tonge PJ. Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4782-4786. PMID: 26227776.
    Citations: 1     Fields:    Translation:AnimalsCells
  105. Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM. Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET. Neuropsychopharmacology. 2015 Dec; 40(13):2865-72. PMID: 26058662.
    Citations: 7     Fields:    Translation:AnimalsCells
  106. Giancardo L, Sánchez-Ferro A, Butterworth I, Mendoza CS, Hooker JM. Psychomotor impairment detection via finger interactions with a computer keyboard during natural typing. Sci Rep. 2015 Apr 16; 5:9678. PMID: 25882641.
    Citations: 8     Fields:    Translation:Humans
  107. Wey HY, Wang C, Schroeder FA, Logan J, Price JC, Hooker JM. Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain. ACS Chem Neurosci. 2015 May 20; 6(5):708-15. PMID: 25768025.
    Citations: 19     Fields:    Translation:Animals
  108. Liang SH, Holland JP, Stephenson NA, Kassenbrock A, Rotstein BH, Daignault CP, Lewis R, Collier L, Hooker JM, Vasdev N. PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates. ACS Chem Neurosci. 2015 Apr 15; 6(4):535-41. PMID: 25776827.
    Citations: 4     Fields:    Translation:HumansAnimals
  109. Huang X, Liu W, Hooker JM, Groves JT. Targeted fluorination with the fluoride ion by manganese-catalyzed decarboxylation. Angew Chem Int Ed Engl. 2015 Apr 20; 54(17):5241-5. PMID: 25736895.
    Citations: 15     Fields:    Translation:Cells
  110. Borra RJ, Cho HS, Bowen SL, Attenberger U, Arabasz G, Catana C, Josephson L, Rosen BR, Guimaraes AR, Hooker JM. Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model. EJNMMI Phys. 2015 Dec; 2(1):6. PMID: 26501808.
    Citations: 6     
  111. Zürcher NR, Bhanot A, McDougle CJ, Hooker JM. A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: current state and future research opportunities. Neurosci Biobehav Rev. 2015 May; 52:56-73. PMID: 25684726.
    Citations: 27     Fields:    Translation:Humans
  112. Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage Clin. 2015; 7:409-14. PMID: 25685708.
    Citations: 78     Fields:    Translation:HumansCells
  113. Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, Rosen BR, Napadow V, Hooker JM. Evidence for brain glial activation in chronic pain patients. Brain. 2015 Mar; 138(Pt 3):604-15. PMID: 25582579.
    Citations: 127     Fields:    Translation:HumansCells
  114. Lee HG, Milner PJ, Placzek MS, Buchwald SL, Hooker JM. Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes. J Am Chem Soc. 2015 Jan 21; 137(2):648-51. PMID: 25565277.
    Citations: 17     Fields:    
  115. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022.
    Citations: 49     Fields:    Translation:Humans
  116. McDougle CJ, Landino SM, Vahabzadeh A, O'Rourke J, Zurcher NR, Finger BC, Palumbo ML, Helt J, Mullett JE, Hooker JM, Carlezon WA. Toward an immune-mediated subtype of autism spectrum disorder. Brain Res. 2015 Aug 18; 1617:72-92. PMID: 25445995.
    Citations: 31     Fields:    Translation:HumansAnimals
  117. Van de Bittner GC, Ricq EL, Hooker JM. A philosophy for CNS radiotracer design. Acc Chem Res. 2014 Oct 21; 47(10):3127-34. PMID: 25272291.
    Citations: 27     Fields:    Translation:Humans
  118. Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. ACS Chem Neurosci. 2014 Oct 15; 5(10):1055-62. PMID: 25188794.
    Citations: 15     Fields:    Translation:Animals
  119. Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J Med Chem. 2014 Oct 09; 57(19):7999-8009. PMID: 25203558.
    Citations: 26     Fields:    Translation:HumansAnimals
  120. Wang H, Lu Y, Liu L, Kim SW, Hooker JM, Fowler JS, Tonge PJ. Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus. Eur J Med Chem. 2014 Dec 17; 88:66-73. PMID: 25217335.
    Citations: 2     Fields:    Translation:AnimalsCells
  121. Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Chonde DB, Rosen BR, Gollub RL, Kong J. Simultaneous fMRI-PET of the opioidergic pain system in human brain. Neuroimage. 2014 Nov 15; 102 Pt 2:275-82. PMID: 25107855.
    Citations: 22     Fields:    Translation:Humans
  122. Rotstein BH, Wey HY, Shoup TM, Wilson AA, Liang SH, Hooker JM, Vasdev N. PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates. Mol Pharm. 2014 Nov 03; 11(11):3832-8. PMID: 25004399.
    Citations: 5     Fields:    Translation:Animals
  123. Catana C, Chonde DB, Chen KT, Izquierdo-Garcia D, Bowen S, Hooker J, Roffman J. Combined MR-assisted motion and partial volume effects corrections - impact on PET data quantification. EJNMMI Phys. 2014 Jul; 1(Suppl 1):A38. PMID: 26501625.
  124. Villien M, Wey HY, Mandeville JB, Catana C, Polimeni JR, Sander CY, Zürcher NR, Chonde DB, Fowler JS, Rosen BR, Hooker JM. Dynamic functional imaging of brain glucose utilization using fPET-FDG. Neuroimage. 2014 Oct 15; 100:192-9. PMID: 24936683.
    Citations: 36     Fields:    Translation:HumansAnimals
  125. Ren H, Wey HY, Strebl M, Neelamegam R, Ritter T, Hooker JM. Synthesis and imaging validation of [¹8F]MDL100907 enabled by Ni-mediated fluorination. ACS Chem Neurosci. 2014 Jul 16; 5(7):611-5. PMID: 24845956.
    Citations: 15     Fields:    Translation:AnimalsCells
  126. Seo YJ, Kang Y, Muench L, Reid A, Caesar S, Jean L, Wagner F, Holson E, Haggarty SJ, Weiss P, King P, Carter P, Volkow ND, Fowler JS, Hooker JM, Kim SW. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci. 2014 Jul 16; 5(7):588-96. PMID: 24780082.
    Citations: 23     Fields:    Translation:HumansAnimals
  127. Granda ML, Schroeder FA, Borra RH, Schauer N, Aisaborhale E, Guimaraes AR, Hooker JM. First D1-like receptor PET imaging of the rat and primate kidney: implications for human disease monitoring. Am J Physiol Renal Physiol. 2014 Jul 01; 307(1):F116-21. PMID: 24808534.
    Citations: 2     Fields:    Translation:Animals
  128. Huang X, Liu W, Ren H, Neelamegam R, Hooker JM, Groves JT. Late stage benzylic C-H fluorination with [¹8F]fluoride for PET imaging. J Am Chem Soc. 2014 May 14; 136(19):6842-5. PMID: 24766544.
    Citations: 33     Fields:    Translation:Cells
  129. Diyabalanage HV, Van de Bittner GC, Ricq EL, Hooker JM. A chemical strategy for the cell-based detection of HDAC activity. ACS Chem Biol. 2014 Jun 20; 9(6):1257-62. PMID: 25056147.
    Citations: 1     Fields:    Translation:HumansCells
  130. Rotstein BH, Hooker JM, Woo J, Collier TL, Brady TJ, Liang SH, Vasdev N. Synthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging. ACS Med Chem Lett. 2014 Jun 12; 5(6):668-72. PMID: 24944741.
    Citations: 16     
  131. Neelamegam R, Hellenbrand T, Schroeder FA, Wang C, Hooker JM. Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization. J Med Chem. 2014 Feb 27; 57(4):1488-94. PMID: 24491146.
    Citations: 10     Fields:    Translation:Cells
  132. Wang C, Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelamegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. Am J Nucl Med Mol Imaging. 2013; 4(1):29-38. PMID: 24380043.
    Citations: 13     
  133. Seo YJ, Muench L, Reid A, Chen J, Kang Y, Hooker JM, Volkow ND, Fowler JS, Kim SW. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorg Med Chem Lett. 2013 Dec 15; 23(24):6700-5. PMID: 24210501.
    Citations: 14     Fields:    Translation:Animals
  134. Wang C, Schroeder FA, Hooker JM. Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques. Neuroscience. 2014 Apr 04; 264:186-97. PMID: 24051365.
    Citations: 11     Fields:    Translation:Humans
  135. Wang C, Wilson CM, Moseley CK, Carlin SM, Hsu S, Arabasz G, Schroeder FA, Sander CY, Hooker JM. Evaluation of potential PET imaging probes for the orexin 2 receptors. Nucl Med Biol. 2013 Nov; 40(8):1000-5. PMID: 23953751.
    Citations: 6     Fields:    Translation:Animals
  136. Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, Petryshen TL. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One. 2013; 8(8):e71323. PMID: 23967191.
    Citations: 54     Fields:    Translation:AnimalsCells
  137. Kim SW, Hooker JM, Otto N, Win K, Muench L, Shea C, Carter P, King P, Reid AE, Volkow ND, Fowler JS. Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. Nucl Med Biol. 2013 Oct; 40(7):912-8. PMID: 23906667.
    Citations: 24     Fields:    Translation:Animals
  138. Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neurosci Lett. 2013 Aug 29; 550:119-24. PMID: 23810801.
    Citations: 7     Fields:    Translation:Animals
  139. Wang Y, Zhang YL, Hennig K, Gale JP, Hong Y, Cha A, Riley M, Wagner F, Haggarty SJ, Holson E, Hooker J. Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics. 2013 Jul; 8(7):756-64. PMID: 23803584.
    Citations: 12     Fields:    Translation:AnimalsCells
  140. Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM, Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11169-74. PMID: 23723346.
    Citations: 43     Fields:    Translation:Animals
  141. Rotstein BH, Liang SH, Holland JP, Collier TL, Hooker JM, Wilson AA, Vasdev N. 11CO2 fixation: a renaissance in PET radiochemistry. Chem Commun (Camb). 2013 Jun 25; 49(50):5621-9. PMID: 23673726.
    Citations: 38     Fields:    
  142. Wang C, Moseley CK, Carlin SM, Wilson CM, Neelamegam R, Hooker JM. Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors. Bioorg Med Chem Lett. 2013 Jun 01; 23(11):3389-92. PMID: 23601709.
    Citations: 4     Fields:    Translation:HumansAnimals
  143. Kamlet AS, Neumann CN, Lee E, Carlin SM, Moseley CK, Stephenson N, Hooker JM, Ritter T. Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation. PLoS One. 2013; 8(3):e59187. PMID: 23554994.
    Citations: 19     Fields:    Translation:AnimalsCells
  144. Mandeville JB, Sander CYM, Jenkins BG, Hooker JM, Catana C, Vanduffel W, Alpert NM, Rosen BR, Normandin MD. A receptor-based model for dopamine-induced fMRI signal. Neuroimage. 2013 Jul 15; 75:46-57. PMID: 23466936.
    Citations: 20     Fields:    Translation:HumansAnimals
  145. Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Mol Psychiatry. 2013 Apr; 18(4):404-16. PMID: 23439487.
    Citations: 31     Fields:    Translation:HumansAnimals
  146. Granda ML, Carlin SM, Moseley CK, Neelamegam R, Mandeville JB, Hooker JM. Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors. ACS Chem Neurosci. 2013 Feb 20; 4(2):261-5. PMID: 23421677.
    Citations: 5     Fields:    Translation:AnimalsCells
  147. Moseley CK, Carlin SM, Neelamegam R, Hooker JM. An efficient and practical radiosynthesis of [11C]temozolomide. Org Lett. 2012 Dec 07; 14(23):5872-5. PMID: 23151019.
    Citations: 6     Fields:    Translation:Cells
  148. Lee E, Hooker JM, Ritter T. Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride. J Am Chem Soc. 2012 Oct 24; 134(42):17456-8. PMID: 23061667.
    Citations: 68     Fields:    Translation:Cells
  149. Diyabalanage HV, Granda ML, Hooker JM. Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer. Cancer Lett. 2013 Feb 01; 329(1):1-8. PMID: 23032720.
    Citations: 27     Fields:    Translation:Humans
  150. Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice. Antimicrob Agents Chemother. 2012 Dec; 56(12):6284-90. PMID: 23006755.
    Citations: 24     Fields:    Translation:AnimalsCells
  151. Ran C, Zhang Z, Hooker J, Moore A. In vivo photoactivation without "light": use of Cherenkov radiation to overcome the penetration limit of light. Mol Imaging Biol. 2012 Apr; 14(2):156-62. PMID: 21538154.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  152. Lee E, Kamlet AS, Powers DC, Neumann CN, Boursalian GB, Furuya T, Choi DC, Hooker JM, Ritter T. A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging. Science. 2011 Nov 04; 334(6056):639-42. PMID: 22053044.
    Citations: 86     Fields:    Translation:Cells
  153. Riss PJ, Hooker JM, Shea C, Xu Y, Carter P, Warner D, Ferrari V, Kim SW, Aigbirhio FI, Fowler JS, Roesch F. Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):679-82. PMID: 22082561.
    Citations: 1     Fields:    Translation:AnimalsCells
  154. Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci. 2012 Feb 15; 3(2):120-128. PMID: 22754608.
    Citations: 34     Fields:    
  155. Behrens CR, Hooker JM, Obermeyer AC, Romanini DW, Katz EM, Francis MB. Rapid chemoselective bioconjugation through oxidative coupling of anilines and aminophenols. J Am Chem Soc. 2011 Oct 19; 133(41):16398-401. PMID: 21919497.
    Citations: 14     Fields:    Translation:Cells
  156. Hooker JM, Kim SW, Reibel AT, Alexoff D, Xu Y, Shea C. Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates. Bioorg Med Chem. 2010 Nov 15; 18(22):7739-45. PMID: 20451398.
    Citations: 4     Fields:    Translation:AnimalsCells
  157. Liu L, Xu Y, Shea C, Fowler JS, Hooker JM, Tonge PJ. Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons. J Med Chem. 2010 Apr 08; 53(7):2882-91. PMID: 20205479.
    Citations: 22     Fields:    Translation:HumansAnimals
  158. Schönberger M, Leggett C, Kim SW, Hooker JM. Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography. Bioorg Med Chem Lett. 2010 May 15; 20(10):3103-6. PMID: 20400305.
    Citations: 4     Fields:    Translation:Animals
  159. Biegon A, Kim SW, Logan J, Hooker JM, Muench L, Fowler JS. Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons. Biol Psychiatry. 2010 Apr 15; 67(8):774-7. PMID: 20188349.
    Citations: 13     Fields:    Translation:Animals
  160. Hooker JM, Kim SW, Alexoff D, Xu Y, Shea C, Reid A, Volkow N, Fowler JS. Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography. ACS Chem Neurosci. 2010; 1(1):65-73. PMID: 20657706.
    Citations: 34     Fields:    
  161. Hooker JM. Modular strategies for PET imaging agents. Curr Opin Chem Biol. 2010 Feb; 14(1):105-11. PMID: 19880343.
    Citations: 12     Fields:    
  162. Hooker JM, Munro TA, Béguin C, Alexoff D, Shea C, Xu Y, Cohen BM. Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence. Neuropharmacology. 2009 Sep; 57(4):386-91. PMID: 19591852.
    Citations: 19     Fields:    Translation:Animals
  163. Riss PJ, Hooker JM, Alexoff D, Kim SW, Fowler JS, Rösch F. [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4343-5. PMID: 19525112.
    Citations: 1     Fields:    Translation:AnimalsCells
  164. Schiffer WK, Liebling CN, Reiszel C, Hooker JM, Brodie JD, Dewey SL. Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents. J Neurosci. 2009 May 13; 29(19):6176-85. PMID: 19439595.
    Citations: 14     Fields:    Translation:Animals
  165. Kim SW, Biegon A, Katsamanis ZE, Ehrlich CW, Hooker JM, Shea C, Muench L, Xu Y, King P, Carter P, Alexoff DL, Fowler JS. Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase. Nucl Med Biol. 2009 Apr; 36(3):323-34. PMID: 19324278.
    Citations: 8     Fields:    Translation:AnimalsCells
  166. Reid AE, Hooker J, Shumay E, Logan J, Shea C, Kim SW, Collins S, Xu Y, Volkow N, Fowler JS. Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain. Nucl Med Biol. 2009 Apr; 36(3):247-58. PMID: 19324270.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  167. Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, Xu Y, Muench L, Apelskog-Torres K. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA. 2009 Mar 18; 301(11):1148-54. PMID: 19293415.
    Citations: 173     Fields:    Translation:Humans
  168. Hooker JM, Patel V, Kothari S, Schiffer WK. Metabolic changes in the rodent brain after acute administration of salvinorin A. Mol Imaging Biol. 2009 May-Jun; 11(3):137-43. PMID: 19132449.
    Citations: 15     Fields:    Translation:Animals
  169. Hooker JM, Reibel AT, Hill SM, Schueller MJ, Fowler JS. One-pot, direct incorporation of [11C]CO2 into carbamates. Angew Chem Int Ed Engl. 2009; 48(19):3482-5. PMID: 19350593.
    Citations: 28     Fields:    
  170. Hooker JM, O'Neil JP, Romanini DW, Taylor SE, Francis MB. Genome-free viral capsids as carriers for positron emission tomography radiolabels. Mol Imaging Biol. 2008 Jul-Aug; 10(4):182-91. PMID: 18437498.
    Citations: 23     Fields:    Translation:AnimalsCells
  171. Hooker JM, Xu Y, Schiffer W, Shea C, Carter P, Fowler JS. Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans. Neuroimage. 2008 Jul 01; 41(3):1044-50. PMID: 18434204.
    Citations: 38     Fields:    Translation:HumansAnimals
  172. Datta A, Hooker JM, Botta M, Francis MB, Aime S, Raymond KN. High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents. J Am Chem Soc. 2008 Feb 27; 130(8):2546-52. PMID: 18247608.
    Citations: 61     Fields:    Translation:Cells
  173. Hooker JM, Schönberger M, Schieferstein H, Fowler JS. A simple, rapid method for the preparation of [11C]formaldehyde. Angew Chem Int Ed Engl. 2008; 47(32):5989-92. PMID: 18604787.
    Citations: 15     Fields:    
  174. Hooker JM, Datta A, Botta M, Raymond KN, Francis MB. Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. . 2007 Aug; 7(8):2207-10. PMID: 17630809.
    Citations: 47     Translation:Cells
  175. Kovacs EW, Hooker JM, Romanini DW, Holder PG, Berry KE, Francis MB. Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system. Bioconjug Chem. 2007 Jul-Aug; 18(4):1140-7. PMID: 17602681.
    Citations: 50     Fields:    Translation:Cells
  176. Johnson HR, Hooker JM, Francis MB, Clark DS. Solubilization and stabilization of bacteriophage MS2 in organic solvents. Biotechnol Bioeng. 2007 Jun 01; 97(2):224-34. PMID: 17099911.
    Citations: 8     Fields:    Translation:Cells
  177. Hooker JM, Esser-Kahn AP, Francis MB. Modification of aniline containing proteins using an oxidative coupling strategy. J Am Chem Soc. 2006 Dec 13; 128(49):15558-9. PMID: 17147343.
    Citations: 18     Fields:    Translation:Cells
  178. Hooker JM, Kovacs EW, Francis MB. Interior surface modification of bacteriophage MS2. J Am Chem Soc. 2004 Mar 31; 126(12):3718-9. PMID: 15038717.
    Citations: 58     Fields:    Translation:Cells
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