Harvard Catalyst Profiles

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Yingzi Yang, Ph.D.

Other Positions

Fudan University, Shanghai, ChinaBS07/1988Biophysics
Cornell University Medical School, New York CityPhD01/1996Molecular Biology
Harvard University, Cambridgepostdoctoral fellow06/2000Developmental Genetics

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13AR074892 (YANG, YINGZI) Feb 1, 2019 - Jan 31, 2020
    2018 Cartilage Biology and Pathology Gordon Research Conferences
    Role: Principal Investigator
  2. R01CA222571 (YANG, YINGZI) Aug 30, 2018 - Jul 31, 2023
    Cellular and molecular mechanism of Hippo signaling in suppressing liver tumor formation
    Role: Principal Investigator
  3. R21AA025725 (YANG, YINGZI) Jul 20, 2017 - Jun 30, 2019
    Mechanisms of Hippo signaling in Alcoholic liver disease
    Role: Principal Investigator
  4. R01AR070877 (YANG, YINGZI) Feb 7, 2017 - Dec 31, 2022
    Molecular Mechanism of Wnt/Planar Cell Polarity Signaling
    Role: Principal Investigator
  5. R01DE025866 (YANG, YINGZI) Jul 5, 2016 - Jun 30, 2021
    Gas-Hedgehog signaling in intramembranous bone formation and expansion
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y. Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/ß-catenin signaling. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34172578.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  2. Cong Q, Liu Y, Zhou T, Zhou Y, Xu R, Cheng C, Chung HS, Yan M, Zhou H, Liao Z, Gao B, Bocobo GA, Covington TA, Song HJ, Su P, Yu PB, Yang Y. A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification. Sci Transl Med. 2021 06 23; 13(599). PMID: 34162750.
    Citations:    Fields:    Translation:Animals
  3. Feng S, Bao L, Qiu G, Liao Z, Deng Z, Chen N, Chu Y, Luo Z, Jin Y, Li X, Yang Y, Zhao L. [Observation of dendrite osteocytes of mice at different developmental stages using Ploton silver staining and phalloidin staining]. Nan Fang Yi Ke Da Xue Xue Bao. 2020 Nov 30; 40(11):1656-1661. PMID: 33243734.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Moore ER, Mathews OA, Yao Y, Yang Y. Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice. Bone. 2021 02; 143:115738. PMID: 33188955.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Liu Y, Wang X, Yang Y. Hepatic Hippo signaling inhibits development of hepatocellular carcinoma. Clin Mol Hepatol. 2020 10; 26(4):742-750. PMID: 32981290.
    Citations: 9     Fields:    Translation:HumansCells
  6. Li C, Wang N, Schäffer AA, Liu X, Zhao Z, Elliott G, Garrett L, Choi NT, Wang Y, Wang Y, Wang C, Wang J, Chan D, Su P, Cui S, Yang Y, Gao B. Author Correction: Mutations in COMP cause familial carpal tunnel syndrome. Nat Commun. 2020 08 03; 11(1):3931. PMID: 32747625.
    Citations:    Fields:    
  7. Li C, Wang N, Schäffer AA, Liu X, Zhao Z, Elliott G, Garrett L, Choi NT, Wang Y, Wang Y, Wang C, Wang J, Chan D, Su P, Cui S, Yang Y, Gao B. Mutations in COMP cause familial carpal tunnel syndrome. Nat Commun. 2020 07 20; 11(1):3642. PMID: 32686688.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y. Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin. Elife. 2020 03 18; 9. PMID: 32186512.
    Citations: 38     Fields:    Translation:AnimalsCells
  9. Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256. PMID: 32015438.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  10. Cho YS, Li S, Wang X, Zhu J, Zhuo S, Han Y, Yue T, Yang Y, Jiang J. CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus. Genes Dev. 2020 01 01; 34(1-2):53-71. PMID: 31857346.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  11. Clara JA, Monge C, Yang Y, Takebe N. Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update. Nat Rev Clin Oncol. 2020 04; 17(4):204-232. PMID: 31792354.
    Citations: 131     Fields:    Translation:HumansCells
  12. Wickström SA, Yang Y. Editorial overview: Cell differentiation and development - wiring principles of transcriptional states, signaling networks and cell fate trajectories. Curr Opin Cell Biol. 2019 12; 61:iii-vi. PMID: 31735435.
    Citations:    Fields:    
  13. Deng Q, Li P, Che M, Liu J, Biswas S, Ma G, He L, Wei Z, Zhang Z, Yang Y, Liu H, Li B. Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/ß-Catenin. Elife. 2019 09 04; 8. PMID: 31482846.
    Citations: 26     Fields:    Translation:AnimalsCells
  14. Seo W, Gao Y, He Y, Sun J, Xu H, Feng D, Park SH, Cho YE, Guillot A, Ren T, Wu R, Wang J, Kim SJ, Hwang S, Liangpunsakul S, Yang Y, Niu J, Gao B. ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles. J Hepatol. 2019 11; 71(5):1000-1011. PMID: 31279903.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  15. Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho EH, Cha B, Jeung YJ, Zhang L, Gao B, Wei W, Jiang J, Chung KS, Yang Y. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9423-9432. PMID: 31000600.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  16. Cong Q, Xu R, Yang Y. Gas signaling in skeletal development, homeostasis and diseases. Curr Top Dev Biol. 2019; 133:281-307. PMID: 30902256.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  17. Jiang Y, Feng D, Ma X, Fan S, Gao Y, Fu K, Wang Y, Sun J, Yao X, Liu C, Zhang H, Xu L, Liu A, Gonzalez FJ, Yang Y, Gao B, Huang M, Bi H. Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice. Hepatology. 2019 01; 69(1):343-358. PMID: 30048004.
    Citations: 19     Fields:    Translation:AnimalsCells
  18. Xu R, Khan SK, Zhou T, Gao B, Zhou Y, Zhou X, Yang Y. Gas signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/ß-catenin signaling. Bone Res. 2018; 6:33. PMID: 30479847.
    Citations: 17     
  19. Jin Y, Cong Q, Gvozdenovic-Jeremic J, Hu J, Zhang Y, Terkeltaub R, Yang Y. Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling. Development. 2018 09 20; 145(18). PMID: 30111653.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Gao B, Ajima R, Yang W, Li C, Song H, Anderson MJ, Liu RR, Lewandoski MB, Yamaguchi TP, Yang Y. Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity. Development. 2018 04 13; 145(8). PMID: 29615464.
    Citations: 14     Fields:    Translation:AnimalsCells
  21. Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS. Expression of an active Gas mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E428-E437. PMID: 29282319.
    Citations: 14     Fields:    Translation:AnimalsCells
  22. Khan SK, Yadav PS, Elliott G, Hu DZ, Xu R, Yang Y. Induced GnasR201H expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/ß-catenin signaling. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E418-E427. PMID: 29158412.
    Citations: 22     Fields:    Translation:HumansCells
  23. Yang W, Garrett L, Feng D, Elliott G, Liu X, Wang N, Wong YM, Choi NT, Yang Y, Gao B. Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res. 2017 Dec; 27(12):1466-1484. PMID: 29056748.
    Citations: 23     Fields:    Translation:AnimalsCells
  24. Xu R, Hu J, Zhou X, Yang Y. Heterotopic ossification: Mechanistic insights and clinical challenges. Bone. 2018 04; 109:134-142. PMID: 28855144.
    Citations: 24     Fields:    Translation:HumansAnimals
  25. Kim W, Khan SK, Liu Y, Xu R, Park O, He Y, Cha B, Gao B, Yang Y. Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma. Gut. 2018 09; 67(9):1692-1703. PMID: 28866620.
    Citations: 54     Fields:    Translation:AnimalsCells
  26. Kim W, Khan SK, Yang Y. Interacting network of Hippo, Wnt/ß-catenin and Notch signaling represses liver tumor formation. BMB Rep. 2017 Jan; 50(1):1-2. PMID: 27881216.
    Citations: 16     Fields:    Translation:HumansCells
  27. Yuan J, Cha J, Deng W, Bartos A, Sun X, Ho HH, Borg JP, Yamaguchi TP, Yang Y, Dey SK. Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8079-E8088. PMID: 27911818.
    Citations: 19     Fields:    Translation:AnimalsCells
  28. Kim W, Khan SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y. Hippo signaling interactions with Wnt/ß-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017 01 03; 127(1):137-152. PMID: 27869648.
    Citations: 91     Fields:    Translation:AnimalsCells
  29. Jin Y, Yang Y. LGR4: A new receptor for a stronger bone. Sci China Life Sci. 2016 Jul; 59(7):735-6. PMID: 27178473.
    Citations: 1     Fields:    Translation:HumansAnimals
  30. Yang J, Andre P, Ye L, Yang YZ. The Hedgehog signalling pathway in bone formation. Int J Oral Sci. 2015 Jun 26; 7(2):73-9. PMID: 26023726.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  31. Andre P, Song H, Kim W, Kispert A, Yang Y. Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15; 142(8):1516-27. PMID: 25813538.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  32. Yang Y, Mlodzik M. Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt). Annu Rev Cell Dev Biol. 2015; 31:623-46. PMID: 26566118.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  33. Zhao H, Zhou W, Yao Z, Wan Y, Cao J, Zhang L, Zhao J, Li H, Zhou R, Li B, Wei G, Zhang Z, French CA, Dekker JD, Yang Y, Fisher SE, Tucker HO, Guo X. Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol. 2015 Feb 15; 398(2):242-54. PMID: 25527076.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  34. Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS. Casein kinase 1d functions at the centrosome and Golgi to promote ciliogenesis. Mol Biol Cell. 2014 May; 25(10):1629-40. PMID: 24648492.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  35. Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y. Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med. 2013 Nov; 19(11):1505-12. PMID: 24076664.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  36. Gao B, Yang Y. Planar cell polarity in vertebrate limb morphogenesis. Curr Opin Genet Dev. 2013 Aug; 23(4):438-44. PMID: 23747034.
    Citations: 22     Fields:    Translation:AnimalsCells
  37. Regard JB, Zhong Z, Williams BO, Yang Y. Wnt signaling in bone development and disease: making stronger bone with Wnts. Cold Spring Harb Perspect Biol. 2012 Dec 01; 4(12). PMID: 23209148.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  38. Andre P, Wang Q, Wang N, Gao B, Schilit A, Halford MM, Stacker SA, Zhang X, Yang Y. The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem. 2012 Dec 28; 287(53):44518-25. PMID: 23144463.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  39. Glasco DM, Sittaramane V, Bryant W, Fritzsch B, Sawant A, Paudyal A, Stewart M, Andre P, Cadete Vilhais-Neto G, Yang Y, Song MR, Murdoch JN, Chandrasekhar A. The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Dev Biol. 2012 Sep 15; 369(2):211-22. PMID: 22771245.
    Citations: 31     Fields:    Translation:AnimalsCells
  40. Yang Y. Wnt signaling in development and disease. Cell Biosci. 2012 Apr 20; 2(1):14. PMID: 22520685.
    Citations: 56     
  41. Zhu X, Zhu H, Zhang L, Huang S, Cao J, Ma G, Feng G, He L, Yang Y, Guo X. Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis. Dev Biol. 2012 May 15; 365(2):328-38. PMID: 22377357.
    Citations: 26     Fields:    Translation:Animals
  42. Yang Y. Planar cell polarity during development. Preface. Curr Top Dev Biol. 2012; 101:xi-xiii. PMID: 23140634.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  43. Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y. Wnt/ß-catenin signaling is differentially regulated by Ga proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20101-6. PMID: 22106277.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  44. Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell. 2011 Feb 15; 20(2):163-76. PMID: 21316585.
    Citations: 226     Fields:    Translation:AnimalsCells
  45. Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y. Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature. 2010 Jul 15; 466(7304):378-82. PMID: 20562861.
    Citations: 157     Fields:    Translation:AnimalsCells
  46. Song H, Mak KK, Topol L, Yun K, Hu J, Garrett L, Chen Y, Park O, Chang J, Simpson RM, Wang CY, Gao B, Jiang J, Yang Y. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1431-6. PMID: 20080598.
    Citations: 266     Fields:    Translation:AnimalsCells
  47. Yang Y, Kozin SH. Cell signaling regulation of vertebrate limb growth and patterning. J Bone Joint Surg Am. 2009 Jul; 91 Suppl 4:76-80. PMID: 19571072.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  48. Nemeth MJ, Mak KK, Yang Y, Bodine DM. beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells. Stem Cells. 2009 May; 27(5):1109-19. PMID: 19415781.
    Citations: 21     Fields:    Translation:AnimalsCells
  49. Yang Y. Growth and patterning in the limb: signaling gradients make the decision. Sci Signal. 2009 Jan 13; 2(53):pe3. PMID: 19141858.
    Citations: 10     Fields:    Translation:AnimalsCells
  50. Yang Y. Skeletal morphogenesis during embryonic development. Crit Rev Eukaryot Gene Expr. 2009; 19(3):197-218. PMID: 19883365.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  51. Topol L, Chen W, Song H, Day TF, Yang Y. Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus. J Biol Chem. 2009 Jan 30; 284(5):3323-3333. PMID: 19047045.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  52. Mak KK, Bi Y, Wan C, Chuang PT, Clemens T, Young M, Yang Y. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell. 2008 May; 14(5):674-88. PMID: 18477451.
    Citations: 78     Fields:    Translation:AnimalsCells
  53. Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development. 2008 Jun; 135(11):1947-56. PMID: 18434416.
    Citations: 115     Fields:    Translation:AnimalsCells
  54. Mak KK, Chen MH, Day TF, Chuang PT, Yang Y. Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development. 2006 Sep; 133(18):3695-707. PMID: 16936073.
    Citations: 80     Fields:    Translation:AnimalsCells
  55. Day TF, Guo X, Garrett-Beal L, Yang Y. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell. 2005 May; 8(5):739-50. PMID: 15866164.
    Citations: 684     Fields:    Translation:AnimalsCells
  56. Guo X, Day TF, Jiang X, Garrett-Beal L, Topol L, Yang Y. Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 2004 Oct 01; 18(19):2404-17. PMID: 15371327.
    Citations: 137     Fields:    Translation:AnimalsCells
  57. Yang Y. Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis. Birth Defects Res C Embryo Today. 2003 Nov; 69(4):305-17. PMID: 14745971.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  58. Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol. 2003 Sep 01; 162(5):899-908. PMID: 12952940.
    Citations: 301     Fields:    Translation:HumansAnimalsCells
  59. Yang Y, Topol L, Lee H, Wu J. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development. 2003 Mar; 130(5):1003-15. PMID: 12538525.
    Citations: 149     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.