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Michael David Hughes, Ph.D.

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Overview
Dr. Hughes' research program focuses on statistical methods related to the design and analysis of clinical trials and observational studies, particularly in the context of HIV research. He is well-known for his work on the development of methods for evaluating surrogate markers using meta-analysis of results from a number of clinical trials. An an important early application of this work was the assessment of the value of treatment-induced changes in CD4 cell counts and viral load as surrogate markers for the development of AIDS.

Dr. Hughes is the Principal Investigator of the Statistical and Data Management Center (SDMC) of the AIDS Clinical Trials Group (ACTG) funded by the National Institutes of Health. The ACTG undertakes numerous studies of interventions for the treatment of people infected with HIV, including co-infections such as tuberculosis and hepatitis B and C, both in the United States and internationally. He was previously the Principal Investigator for the SDMC of the Pediatric ACTG and has ongoing HIV research interests in the treatment of children infected with HIV, and the prevention of mother-to-child transmission of HIV. A particular focus of this work concerns studies evaluating the impact of prophylaxes for the prevention of transmission on restricted future treatment options for the mother due to viral resistance.

Dr. Hughes' statistical research is strongly motivated by problems encountered in his collaborative research. Ongoing research interests include the design and analysis of phase I/II clinical trials, and of bridging trials from one population to another population. One example concerns the design of studies that seek to identify the dose of a drug that maximizes the success of treatment (i.e. is both safe and effective) rather than just find the maximal tolerated dose. A second example involves the development of methodology for the design of dose-finding bridging studies in "special populations", such as infants or pregnant women, which are efficient in identifying a dose which minimizes the proportion of people who might be exposed to sub-therapeutic doses.

Another area of interest concerns statistical methods for the design and analysis of studies evaluating diagnostic and other biomarkers. For example, he is interested in the problem of comparing the performance of two biomarkers for determining when to start treatment in HIV-infected subjects, or when to change treatments. This work is motivated by the need to identify less expensive and more practically accessible technologies for addressing these questions in resource-limited countries.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. UM1AI068634 (HUGHES, MICHAEL DAVID) Jun 29, 2006 - Nov 30, 2027
    NIH
    Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)
    Role: Principal Investigator
  2. U01AI068634 (HUGHES, MICHAEL DAVID) Jun 29, 2006 - May 31, 2013
    NIH
    Statistical and Data Management Center for the AIDS Clinical Trials Group
    Role: Principal Investigator
  3. U01AI041110 (FENTON, TERRENCE) Mar 1, 1997 - Feb 28, 2007
    NIH
    Statistical/Data Management Center-Pediatric AIDS CTG
    Role: Co-Principal Investigator
  4. U01AI038855 (HUGHES, MICHAEL DAVID) Jan 1, 1996 - Dec 31, 2006
    NIH
    STATISTICAL AND DATA MANAGEMENT CENTER
    Role: Principal Investigator
  5. T32AI007358 (HUGHES, MICHAEL DAVID) Sep 1, 1989 - Jun 30, 2024
    NIH
    Biostatistics/Epidemiology Training Grants in AIDS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mitchell CM, Davy BM, Ponder MA, McMillan RP, Hughes MD, Hulver MW, Neilson AP, Davy KP. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients. 2021 Sep 17; 13(9). PMID: 34579112.
    Citations:    Fields:    
  2. Choudhary MC, Chew KW, Deo R, Flynn JP, Regan J, Crain CR, Moser C, Hughes M, Ritz J, Ribeiro RM, Ke R, Dragavon JA, Javan AC, Nirula A, Klekotka P, Greninger AL, Fletcher CV, Daar ES, Wohl DA, Eron JJ, Currier JS, Parikh UM, Sieg SF, Perelson AS, Coombs RW, Smith DM, Li JZ. Emergence of SARS-CoV-2 Resistance with Monoclonal Antibody Therapy. medRxiv. 2021 Sep 15. PMID: 34545376.
    Citations:    
  3. Baliashvili D, Gandhi NR, Kim S, Hughes M, Mave V, Mendoza-Ticona A, Gonzales P, Narunsky K, Selvamuthu P, Badal-Faesen S, Upton C, Naini L, Smith E, Gupta A, Churchyard G, Swindells S, Hesseling A, Shah NS. Resistance to Mycobacterium tuberculosis Infection Among Household Contacts: A Multinational Study. Clin Infect Dis. 2021 09 15; 73(6):1037-1045. PMID: 33772550.
    Citations:    Fields:    Translation:HumansCells
  4. Cox M, Hughes M. Osteomyelitis Complicating Digital Ulcer Disease. J Clin Rheumatol. 2021 Sep 01; 27(6):e230-e231. PMID: 31977650.
    Citations: 1     Fields:    Translation:Humans
  5. Ajibola G, Garcia-Broncano P, Maswabi K, Bennett K, Hughes MD, Moyo S, Mohammed T, Jean-Philippe P, Sakoi M, Batlang O, Lockman S, Makhema J, Kuritzkes DR, Lichterfeld M, Shapiro RL. Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression. Clin Infect Dis. 2021 08 16; 73(4):e997-e1003. PMID: 33605999.
    Citations: 1     Fields:    Translation:HumansCells
  6. Apornpong T, Grinsztejn B, Hughes M, Ritz J, Kerr SJ, Fletcher CV, Ruxrungtham K, Godfrey C, Gross R, Hogg E, Wallis CL, Badal-Faesen S, Hosseinipour MC, Mngqbisa R, Santos BR, Shah S, Hovind LJ, Mawlana S, Van Schalkwyk M, Chotirosniramit N, Kanyama C, Kumarasamy N, Salata R, Collier AC, Gandhi M. Antiretroviral hair levels, self-reported adherence, and virologic failure in second-line regimen patients in resource-limited settings. AIDS. 2021 07 15; 35(9):1439-1449. PMID: 33831905.
    Citations:    Fields:    Translation:Humans
  7. Harn HI, Wang SP, Lai YC, Van Handel B, Liang YC, Tsai S, Schiessl IM, Sarkar A, Xi H, Hughes M, Kaemmer S, Tang MJ, Peti-Peterdi J, Pyle AD, Woolley TE, Evseenko D, Jiang TX, Chuong CM. Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nat Commun. 2021 05 10; 12(1):2595. PMID: 33972536.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Murphy SL, Lescoat A, Alore M, Hughes M, Pauling JD, Sabbagh M, Khanna D. Correction to: How do patients define Raynaud's phenomenon? Differences between primary and secondary disease. Clin Rheumatol. 2021 Apr; 40(4):1617-1620. PMID: 33547561.
    Citations:    Fields:    
  9. Demers AM, Kim S, McCallum S, Eisenach K, Hughes M, Naini L, Mendoza-Ticona A, Pradhan N, Narunsky K, Poongulali S, Badal-Faesen S, Upton C, Smith E, Shah NS, Churchyard G, Gupta A, Hesseling A, Swindells S. Drug susceptibility patterns of Mycobacterium tuberculosis from adults with multidrug-resistant tuberculosis and implications for a household contact preventive therapy trial. BMC Infect Dis. 2021 Feb 24; 21(1):205. PMID: 33627075.
    Citations:    Fields:    Translation:HumansCells
  10. Suliman YA, Bruni C, Hughes M, Matucci-Cerinic M, Furst DE. Ultrasonographic imaging of systemic sclerosis digital ulcers: A systematic literature review and validation steps. Semin Arthritis Rheum. 2021 04; 51(2):425-429. PMID: 33677309.
    Citations: 1     Fields:    Translation:Humans
  11. Iglesias-Carres L, Hughes MD, Steele CN, Ponder MA, Davy KP, Neilson AP. Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation. J Nutr Biochem. 2021 05; 91:108600. PMID: 33577949.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Maswabi K, Ajibola G, Bennett K, Capparelli EV, Jean-Philippe P, Moyo S, Mohammed T, Batlang O, Sakoi M, Lockman S, Makhema J, Lichterfeld M, Kuritzkes DR, Hughes MD, Shapiro RL. Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life. Clin Infect Dis. 2021 02 01; 72(3):388-393. PMID: 31927562.
    Citations: 1     Fields:    Translation:Humans
  13. Murphy SL, Lescoat A, Alore M, Hughes M, Pauling JD, Sabbagh M, Khanna D. How do patients define Raynaud's phenomenon? Differences between primary and secondary disease. Clin Rheumatol. 2021 Apr; 40(4):1611-1616. PMID: 33486597.
    Citations:    Fields:    Translation:Humans
  14. Torres TS, Harrison LJ, La Rosa AM, Zheng L, Cardoso SW, Ulaya G, Akoojee N, Kadam D, Collier AC, Hughes MD. Poor quality of life and incomplete self-reported adherence predict second-line ART virological failure in resource-limited settings. AIDS Care. 2021 10; 33(10):1340-1349. PMID: 33487029.
    Citations:    Fields:    Translation:Humans
  15. Ajibola G, Bennett K, Powis KM, Hughes MD, Leidner J, Kgole S, Batlang O, Mmalane M, Makhema J, Lockman S, Shapiro R. Decreased diarrheal and respiratory disease in HIV exposed uninfected children following vaccination with rotavirus and pneumococcal conjugate vaccines. PLoS One. 2020; 15(12):e0244100. PMID: 33347474.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  16. Haque A, Wyman M, Dargan D, Hughes M, Musson R, Caddick J, Giblin V. Hand Osteomyelitis in Patients With Secondary Raynaud Phenomenon. J Clin Rheumatol. 2020 Dec 14; Publish Ahead of Print. PMID: 33337814.
    Citations: 1     Fields:    
  17. Wallis CL, Hughes MD, Ritz J, Viana R, de Jesus CS, Saravanan S, van Schalkwyk M, Mngqibisa R, Salata R, Mugyenyi P, Hogg E, Hovind L, Wieclaw L, Gross R, Godfrey C, Collier AC, Grinsztejn B, Mellors JW. Diverse Human Immunodeficiency Virus-1 Drug Resistance Profiles at Screening for ACTG A5288: A Study of People Experiencing Virologic Failure on Second-line Antiretroviral Therapy in Resource-limited Settings. Clin Infect Dis. 2020 10 23; 71(7):e170-e177. PMID: 31724034.
    Citations: 1     Fields:    Translation:HumansCells
  18. Lescoat A, Murphy SL, Roofeh D, Pauling JD, Hughes M, Sandler R, Zimmermann F, Wessel R, Townsend W, Chung L, Denton CP, Merkel PA, Steen V, Allanore Y, Del Galdo F, Godard D, Cella D, Farrington S, Buch MH, Khanna D. Considerations for a combined index for limited cutaneous systemic sclerosis to support drug development and improve outcomes. J Scleroderma Relat Disord. 2021 Feb 01; 6(1):66-76. PMID: 34316516.
    Citations:    
  19. Sandler RD, Smith R, Kitsanta P, Hughes M. Paradoxical New Diagnosis of Giant Cell Arteritis While Receiving Ustekinumab. J Clin Rheumatol. 2020 Oct; 26(7):e215-e216. PMID: 31145223.
    Citations:    Fields:    Translation:Humans
  20. Hughes M, Pauling JD, Jones J, Denton CP, Domsic RT, Frech TM, Herrick AL, Khanna D, Matucci-Cerinic M, McKenzie L, Saketkoo LA, Gooberman-Hill R, Moore A. Patient experiences of digital ulcer development and evolution in systemic sclerosis. Rheumatology (Oxford). 2020 08 01; 59(8):2156-2158. PMID: 32031630.
    Citations: 1     Fields:    Translation:Humans
  21. Swindells S, Hughes M, Chaisson RE. Trials of Tuberculosis-Preventive Therapy in People with HIV Infection. Am J Respir Crit Care Med. 2020 07 15; 202(2):304-305. PMID: 32282226.
    Citations:    Fields:    Translation:Humans
  22. McAteer J, Derado G, Hughes M, Bhatnagar A, Medalla F, Chatham-Stevens K, Appiah GD, Mintz E. Typhoid Fever in the US Pediatric Population, 1999-2015: Opportunities for Improvement. Clin Infect Dis. 2020 Jul 07. PMID: 33247585.
    Citations:    Fields:    
  23. Davey S, Ajibola G, Maswabi K, Sakoi M, Bennett K, Hughes MD, Isaacson A, Diseko M, Zash R, Batlang O, Moyo S, Lockman S, Lichterfeld M, Kuritzkes DR, Makhema J, Shapiro R. Mother-to-Child HIV Transmission With In Utero Dolutegravir vs. Efavirenz in Botswana. J Acquir Immune Defic Syndr. 2020 07 01; 84(3):235-241. PMID: 32195745.
    Citations:    Fields:    Translation:Humans
  24. Rogers S, Hughes M. Digital artery vasospasm in primary Raynaud's phenomenon. Eur J Rheumatol. 2020 Jun 08. PMID: 32525479.
    Citations: 1     
  25. Godfrey C, Hughes MD, Ritz J, Coelho L, Gross R, Salata R, Mngqibisa R, Wallis CL, Mumbi ME, Matoga M, Poongulali S, Van Schalkwyk M, Hogg E, Fletcher CV, Grinsztejn B, Collier AC. Brief Report: Sex Differences in Outcomes for Individuals Presenting for Third-Line Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2020 06 01; 84(2):203-207. PMID: 32049773.
    Citations: 4     Fields:    Translation:HumansCells
  26. Ajibola G, Moyo S, Mohammed T, Moseki S, Jack D, Sakoi M, Batlang O, Maswabi K, Bennett K, Hughes MD, Lockman S, Makhema JM, Lichterfeld M, Kuritzkes DR, Shapiro RL. HIV diagnostic algorithm requires confirmatory testing for initial indeterminate or positive screens in the first week of life. AIDS. 2020 06 01; 34(7):1029-1035. PMID: 32287064.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  27. Beigel JH, Manosuthi W, Beeler J, Bao Y, Hoppers M, Ruxrungtham K, Beasley RL, Ison M, Avihingsanon A, Losso MH, Langlois N, Hoopes J, Lane HC, Holley HP, Myers CA, Hughes MD, Davey RT. Effect of Oral Oseltamivir on Virological Outcomes in Low-risk Adults With Influenza: A Randomized Clinical Trial. Clin Infect Dis. 2020 05 23; 70(11):2317-2324. PMID: 31541242.
    Citations: 2     Fields:    Translation:Humans
  28. Hughes M, Pauling JD, Jones J, Denton CP, Domsic RT, Frech TM, Herrick AL, Khanna D, Matucci-Cerinic M, McKenzie L, Saketkoo LA, Gooberman-Hill R, Moore A. Multicenter Qualitative Study Exploring the Patient Experience of Digital Ulcers in Systemic Sclerosis. Arthritis Care Res (Hoboken). 2020 05; 72(5):723-733. PMID: 31841265.
    Citations: 2     Fields:    Translation:Humans
  29. Rogers SK, Hughes M. Forgetting "routine" deep venous thrombosis and stroke during COVID-19 is a parallel pandemic that will be costly if ignored. J Vasc Surg. 2020 Aug; 72(2):761-763. PMID: 32360375.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  30. Condon S, Patel A, Shah N, Stocker A, Hughes M, Farmer R, Abell T. Gastric Electrical Stimulators Causing Erosion Through the Colonic Wall. ACG Case Rep J. 2020 Feb; 7(2):e00313. PMID: 32440521.
    Citations:    
  31. Hughes M, Pauling JD, Armstrong-James L, Denton CP, Galdas P, Flurey C. Gender-related differences in systemic sclerosis. Autoimmun Rev. 2020 Apr; 19(4):102494. PMID: 32062031.
    Citations: 4     Fields:    Translation:Humans
  32. Karda R, Rahim AA, Wong AMS, Suff N, Diaz JA, Perocheau DP, Tijani M, Ng J, Baruteau J, Martin NP, Hughes M, Delhove JMKM, Counsell JR, Cooper JD, Henckaerts E, Mckay TR, Buckley SMK, Waddington SN. Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors. Sci Rep. 2020 02 07; 10(1):2121. PMID: 32034258.
    Citations: 1     Fields:    Translation:AnimalsCells
  33. Kennedy-Shaffer L, Hughes MD. Sample size estimation for stratified individual and cluster randomized trials with binary outcomes. Stat Med. 2020 05 15; 39(10):1489-1513. PMID: 32003492.
    Citations: 2     Fields:    Translation:Humans
  34. Gupta A, Swindells S, Kim S, Hughes MD, Naini L, Wu X, Dawson R, Mave V, Sanchez J, Mendoza A, Gonzales P, Kumarasamy N, Comins K, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo UG, Ferreira ACG, Mugah C, Harrington M, Jones L, Cox SR, Smith B, Shah NS, Hesseling AC, Churchyard G. Feasibility of Identifying Household Contacts of Rifampin-and Multidrug-resistant Tuberculosis Cases at High Risk of Progression to Tuberculosis Disease. Clin Infect Dis. 2020 01 16; 70(3):425-435. PMID: 30942853.
    Citations: 5     Fields:    Translation:Humans
  35. Suryavanshi N, Murrill M, Gupta A, Hughes M, Hesseling A, Kim S, Naini L, Jones L, Smith B, Gupte N, Dawson R, Mave V, Meshram S, Mendoza-Ticona A, Sanchez J, Kumarasamy N, Comins K, Conradie F, Shenje J, Nerette Fontain S, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo U, Cristina Garcia Ferreira A, Okeyo E, Swindells S, Churchyard G, Shah NS. Willingness to Take Multidrug-resistant Tuberculosis (MDR-TB) Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases: An International Multisite Cross-sectional Study. Clin Infect Dis. 2020 01 16; 70(3):436-445. PMID: 30919881.
    Citations:    Fields:    Translation:Humans
  36. Boltz VF, Shao W, Bale MJ, Halvas EK, Luke B, McIntyre JA, Schooley RT, Lockman S, Currier JS, Sawe F, Hogg E, Hughes MD, Kearney MF, Coffin JM, Mellors JW. Linked dual-class HIV resistance mutations are associated with treatment failure. JCI Insight. 2019 10 03; 4(19). PMID: 31487271.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  37. Beigel JH, Aga E, Elie-Turenne MC, Cho J, Tebas P, Clark CL, Metcalf JP, Ozment C, Raviprakash K, Beeler J, Holley HP, Warner S, Chorley C, Lane HC, Hughes MD, Davey RT. Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial. Lancet Respir Med. 2019 11; 7(11):941-950. PMID: 31582360.
    Citations: 32     Fields:    Translation:HumansCellsCTClinical Trials
  38. Gupta A, Hughes MD, Garcia-Prats AJ, McIntire K, Hesseling AC. Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons. PLoS Med. 2019 08; 16(8):e1002882. PMID: 31415563.
    Citations: 3     Fields:    Translation:Humans
  39. Grinsztejn B, Hughes MD, Ritz J, Salata R, Mugyenyi P, Hogg E, Wieclaw L, Gross R, Godfrey C, Cardoso SW, Bukuru A, Makanga M, Faesen S, Mave V, Wangari Ndege B, Nerette Fontain S, Samaneka W, Secours R, van Schalkwyk M, Mngqibisa R, Mohapi L, Valencia J, Sugandhavesa P, Montalban E, Avihingsanon A, Santos BR, Kumarasamy N, Kanyama C, Schooley RT, Mellors JW, Wallis CL, Collier AC. Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study. Lancet HIV. 2019 09; 6(9):e588-e600. PMID: 31371262.
    Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
  40. Naggie S, Fierer DS, Hughes MD, Kim AY, Luetkemeyer A, Vu V, Roa J, Rwema S, Brainard DM, McHutchison JG, Peters MG, Kiser JJ, Marks KM, Chung RT. Ledipasvir/Sofosbuvir for 8 Weeks to Treat Acute Hepatitis C Virus Infections in Men With Human Immunodeficiency Virus Infections: Sofosbuvir-Containing Regimens Without Interferon for Treatment of Acute HCV in HIV-1 Infected Individuals. Clin Infect Dis. 2019 07 18; 69(3):514-522. PMID: 31220220.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  41. Hughes M. Effect of Season on Internet Searches for Information on Raynaud Phenomenon. J Rheumatol. 2019 11; 46(11):1543-1544. PMID: 31308207.
    Citations: 1     Fields:    Translation:Humans
  42. Gross R, Ritz J, Hughes MD, Salata R, Mugyenyi P, Hogg E, Wieclaw L, Godfrey C, Wallis CL, Mellors JW, Mudhune VO, Badal-Faesen S, Grinsztejn B, Collier AC. Two-way mobile phone intervention compared with standard-of-care adherence support after second-line antiretroviral therapy failure: a multinational, randomised controlled trial. Lancet Digit Health. 2019 05; 1(1):e26-e34. PMID: 31528850.
    Citations: 8     Translation:Humans
  43. Griffin LE, Fausnacht DW, Tuzo JL, Addington AK, Racine KC, Zhang H, Hughes MD, England KM, Bruno RS, O'Keefe SF, Neilson AP, Stewart AC. Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet. Nutr Res. 2019 06; 66:32-47. PMID: 31051320.
    Citations:    Fields:    Translation:Animals
  44. Chatham-Stephens K, Medalla F, Hughes M, Appiah GD, Aubert RD, Caidi H, Angelo KM, Walker AT, Hatley N, Masani S, Nash J, Belko J, Ryan ET, Mintz E, Friedman CR. Emergence of Extensively Drug-Resistant Salmonella Typhi Infections Among Travelers to or from Pakistan - United States, 2016-2018. MMWR Morb Mortal Wkly Rep. 2019 Jan 11; 68(1):11-13. PMID: 30629573.
    Citations: 28     Fields:    Translation:HumansCells
  45. Opollo VS, Wu X, Hughes MD, Swindells S, Gupta A, Hesseling A, Churchyard G, Kim S, Lando R, Dawson R, Mave V, Mendoza A, Gonzales P, Kumarasamy N, von Groote-Bidlingmaier F, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Mngqibisa R, Garcia Ferreira AC, Okeyo E, Naini L, Jones L, Smith B, Shah NS. HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries. Int J Tuberc Lung Dis. 2018 12 01; 22(12):1443-1449. PMID: 30606316.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  46. Swindells S, Gupta A, Kim S, Hughes MD, Sanchez J, Mave V, Dawson R, Kumarasamy N, Comins K, Smith B, Rustomjee R, Naini L, Shah NS, Hesseling A, Churchyard G. Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). Int J Tuberc Lung Dis. 2018 09 01; 22(9):1016-1022. PMID: 30092866.
    Citations:    Fields:    Translation:HumansPHPublic Health
  47. Hughes M, Pauling JD. Exploring the patient experience of digital ulcers in systemic sclerosis. Semin Arthritis Rheum. 2019 04; 48(5):888-894. PMID: 30205981.
    Citations: 2     Fields:    Translation:Humans
  48. MacBrayne CE, Marks KM, Fierer DS, Naggie S, Chung RT, Hughes MD, Kim AY, Peters MG, Brainard DM, Seifert SM, Castillo-Mancilla JR, Bushman LR, Anderson PL, Kiser JJ. Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate. J Antimicrob Chemother. 2018 08 01; 73(8):2112-2119. PMID: 29746648.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  49. Shalan A, Hughes M, Nicholls M, Thompson A. A Challenging Case of Fibromuscular Dysplasia in a Transgender Patient: Is There a Hormonal Link? EJVES Short Rep. 2018; 39:16-19. PMID: 29988870.
    Citations: 1     
  50. Ibrahim M, Maswabi K, Ajibola G, Moyo S, Hughes MD, Batlang O, Sakoi M, Auletta-Young C, Vaughan L, Lockman S, Jean-Philippe P, Yu X, Lichterfeld M, Kuritzkes DR, Makhema J, Shapiro RL. Targeted HIV testing at birth supported by low and predictable mother-to-child transmission risk in Botswana. J Int AIDS Soc. 2018 05; 21(5):e25111. PMID: 29852062.
    Citations: 6     Fields:    Translation:Humans
  51. Ngongondo M, Miyahara S, Hughes MD, Sun X, Bisson GP, Gupta A, Kumwenda J, Lavenberg JA, Torres TS, Nyirenda M, Kidonge KK, Hosseinipour MC. Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial. . 2018 05 01; 78(1):54-61. PMID: 29406428.
    Citations: 6     Translation:HumansCells
  52. Powis KM, Lockman S, Ajibola G, Hughes MD, Bennett K, Leidner J, Batlang O, Botebele K, Moyo S, van Widenfelt E, Makhema J, Petlo C, Jibril HB, McIntosh K, Essex M, Shapiro RL. Similar HIV protection from four weeks of zidovudine versus nevirapine prophylaxis among formula-fed infants in Botswana. South Afr J HIV Med. 2018; 19(1):751. PMID: 29707385.
    Citations:    
  53. Torres TS, Harrison LJ, La Rosa AM, Cardoso SW, Zheng L, Ngongondo M, Some F, Lalloo UG, Mwelase T, Collier AC, Hughes MD. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS. 2018 03 13; 32(5):583-593. PMID: 29334547.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  54. Angelidou K, Palumbo P, Lindsey J, Violary A, Archary M, Barlow L, Claggett B, Hughes M, Wei LJ. Defining Study Outcomes That Better Reflect Individual Response to Treatment. Pediatr Infect Dis J. 2018 03; 37(3):258-262. PMID: 29189677.
    Citations:    Fields:    Translation:HumansCells
  55. Kearney MF, Spindler J, Wiegand A, Shao W, Haubrich R, Riddler S, Lalama CM, Hughes MD, Coffin JM, Mellors JW. Lower pre-ART intra-participant HIV-1 pol diversity may not be associated with virologic failure in adults. PLoS One. 2018; 13(1):e0190438. PMID: 29370196.
    Citations:    Fields:    Translation:HumansCells
  56. Torres TS, Harrison LJ, La Rosa AM, Lavenberg JA, Zheng L, Safren SA, Ngongondo M, Poongulali S, Matoga M, Samaneka W, Collier AC, Hughes MD. Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings. AIDS Care. 2018 08; 30(8):954-962. PMID: 29343078.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  57. Balasubramanian R, Fowler MG, Dominguez K, Lockman S, Tookey PA, Huong NNG, Nesheim S, Hughes MD, Lallemant M, Tosswill J, Shaffer N, Sherman G, Palumbo P, Shapiro DE. Time to first positive HIV-1 DNA PCR may differ with antiretroviral regimen in infants infected with non-B subtype HIV-1. AIDS. 2017 11 28; 31(18):2465-2474. PMID: 28926397.
    Citations: 2     Fields:    Translation:HumansCells
  58. Powis KM, Souda S, Lockman S, Ajibola G, Bennett K, Leidner J, Hughes MD, Moyo S, van Widenfelt E, Jibril HB, Makhema J, Essex M, Shapiro RL. Cotrimoxazole prophylaxis was associated with enteric commensal bacterial resistance among HIV-exposed infants in a randomized controlled trial, Botswana. J Int AIDS Soc. 2017 11; 20(3). PMID: 29119726.
    Citations: 6     Fields:    Translation:HumansCells
  59. Beigel JH, Bao Y, Beeler J, Manosuthi W, Slandzicki A, Dar SM, Panuto J, Beasley RL, Perez-Patrigeon S, Suwanpimolkul G, Losso MH, McClure N, Bozzolo DR, Myers C, Holley HP, Hoopes J, Lane HC, Hughes MD, Davey RT. Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial. Lancet Infect Dis. 2017 12; 17(12):1255-1265. PMID: 28958678.
    Citations: 22     Fields:    Translation:HumansCTClinical Trials
  60. Jill Kiecolt K, Hughes M. Racial identity and the quality of life among blacks and whites in the U.S. Soc Sci Res. 2017 Sep; 67:59-71. PMID: 28888292.
    Citations:    Fields:    
  61. Beigel JH, Tebas P, Elie-Turenne MC, Bajwa E, Bell TE, Cairns CB, Shoham S, Deville JG, Feucht E, Feinberg J, Luke T, Raviprakash K, Danko J, O'Neil D, Metcalf JA, King K, Burgess TH, Aga E, Lane HC, Hughes MD, Davey RT. Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study. Lancet Respir Med. 2017 06; 5(6):500-511. PMID: 28522352.
    Citations: 40     Fields:    Translation:HumansCTClinical Trials
  62. Lockman S, Hughes M, Powis K, Ajibola G, Bennett K, Moyo S, van Widenfelt E, Leidner J, McIntosh K, Mazhani L, Makhema J, Essex M, Shapiro R. Effect of co-trimoxazole on mortality in HIV-exposed but uninfected children in Botswana (the Mpepu Study): a double-blind, randomised, placebo-controlled trial. Lancet Glob Health. 2017 05; 5(5):e491-e500. PMID: 28395844.
    Citations: 18     Fields:    Translation:HumansCells
  63. Naggie S, Marks KM, Hughes M, Fierer DS, Macbrayne C, Kim A, Hollabaugh K, Roa J, Symonds B, Brainard DM, McHutchison JG, Peters MG, Kiser JJ, Chung R. Sofosbuvir Plus Ribavirin Without Interferon for Treatment of Acute Hepatitis C Virus Infection in HIV-1-Infected Individuals: SWIFT-C. Clin Infect Dis. 2017 04 15; 64(8):1035-1042. PMID: 28329053.
    Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
  64. Lok JJ, Yang S, Sharkey B, Hughes MD. Estimation of the cumulative incidence function under multiple dependent and independent censoring mechanisms. Lifetime Data Anal. 2018 04; 24(2):201-223. PMID: 28238045.
    Citations: 2     Fields:    
  65. Matoga MM, Hosseinipour MC, Aga E, Ribaudo HJ, Kumarasamy N, Bartlett J, Hughes MD. Hyperlipidaemia in HIV-infected patients on lopinavir/ritonavir monotherapy in resource-limited settings. Antivir Ther. 2017; 22(3):205-213. PMID: 27740537.
    Citations: 9     Fields:    Translation:Humans
  66. Singini I, Campbell TB, Smeaton LM, Kumarasamy N, La Rosa A, Taejareonkul S, Safren SA, Flanigan TP, Hakim JG, Hughes MD. Predictors of late virologic failure after initial successful suppression of HIV replication on efavirenz-based antiretroviral therapy. HIV Clin Trials. 2016; 17(5):173-180. PMID: 27472067.
    Citations: 2     Fields:    
  67. Dawood FS, Jara J, Gonzalez R, Castillo JM, De León T, Estripeaut D, Luciani K, Sujey Brizuela Y, Barahona A, Cazares RA, Lawson AM, Rodriguez M, de Viana D, Franco D, Castillo M, Fry AM, Gubareva L, Tamura D, Hughes M, Gargiullo P, Clara W, Azziz-Baumgartner E, Widdowson MA. A randomized, double-blind, placebo-controlled trial evaluating the safety of early oseltamivir treatment among children 0-9 years of age hospitalized with influenza in El Salvador and Panama. Antiviral Res. 2016 09; 133:85-94. PMID: 27451343.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  68. Hughes M, Wilkinson J, Moore T, Manning J, New P, Dinsdale G, Murray A, Herrick AL. Thermographic Abnormalities are Associated with Future Digital Ulcers and Death in Patients with Systemic Sclerosis. J Rheumatol. 2016 08; 43(8):1519-22. PMID: 27307532.
    Citations: 5     Fields:    Translation:Humans
  69. Hughes M, Yang GZ. Line-scanning fiber bundle endomicroscopy with a virtual detector slit. Biomed Opt Express. 2016 Jun 01; 7(6):2257-68. PMID: 27375942.
    Citations: 10     
  70. Hughes MD, Borca-Tasciuc DA, Kaminski DA. Method for modeling radiative transport in luminescent particulate media. Appl Opt. 2016 Apr 20; 55(12):3251-60. PMID: 27140095.
    Citations:    Fields:    
  71. Borges ÁH, Lundh A, Tendal B, Bartlett JA, Clumeck N, Costagliola D, Daar ES, Echeverría P, Gisslén M, Huedo-Medina TB, Hughes MD, Huppler Hullsiek K, Khabo P, Komati S, Kumar P, Lockman S, MacArthur RD, Maggiolo F, Matteelli A, Miro JM, Oka S, Petoumenos K, Puls RL, Riddler SA, Sax PE, Sierra-Madero J, Torti C, Lundgren JD. Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials. Clin Infect Dis. 2016 07 15; 63(2):268-80. PMID: 27090986.
    Citations: 5     Fields:    Translation:Humans
  72. Lok JJ, Hughes MD. Evaluating predictors of competing risk outcomes when censoring depends on time-dependent covariates, with application to safety and efficacy of HIV treatment. Stat Med. 2016 06 15; 35(13):2183-94. PMID: 26763556.
    Citations: 1     Fields:    Translation:Humans
  73. Powis KM, Smeaton L, Hughes MD, Tumbare EA, Souda S, Jao J, Wirth KE, Makhema J, Lockman S, Fawzi W, Essex M, Shapiro RL. In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana. AIDS. 2016 Jan; 30(2):211-20. PMID: 26684818.
    Citations: 22     Fields:    Translation:Humans
  74. Pei PP, Weinstein MC, Li XC, Hughes MD, Paltiel AD, Hou T, Parker RA, Gaynes MR, Sax PE, Freedberg KA, Schackman BR, Walensky RP. Prioritizing HIV comparative effectiveness trials based on value of information: generic versus brand-name ART in the US. HIV Clin Trials. 2015 Nov; 16(6):207-18. PMID: 26651525.
    Citations: 1     Fields:    Translation:Humans
  75. Leung MH, Hughes M, Lane J, Basu S, Ryan K, Jones AK. Severe Disability in a Patient With Rheumatoid Arthritis and Sickle Cell Anemia: An Underreported, But Yet a Potentially Treatable Combination of Diseases. J Clin Rheumatol. 2015 Dec; 21(8):458-9. PMID: 26587862.
    Citations: 4     Fields:    Translation:Humans
  76. Blevins CE, Wusik MF, Sullivan CP, Jones RT, Hughes M. Do Negative Changes in Worldview Mediate Links Between Mass Trauma and Reckless Behavior? A Longitudinal Exploratory Study. Community Ment Health J. 2016 Jan; 52(1):10-7. PMID: 26148489.
    Citations: 1     Fields:    Translation:Humans
  77. Erlandson KM, Taejaroenkul S, Smeaton L, Gupta A, Singini IL, Lama JR, Mngqibisa R, Firnhaber C, Cardoso SW, Kanyama C, Machado da Silva AL, Hakim JG, Kumarasamy N, Campbell TB, Hughes MD. A Randomized Comparison of Anthropomorphic Changes With Preferred and Alternative Efavirenz-Based Antiretroviral Regimens in Diverse Multinational Settings. Open Forum Infect Dis. 2015 Sep; 2(3):ofv095. PMID: 26213694.