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Michael David Hughes, Ph.D.

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Other Positions
Title
Institution
Department

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. UM1AI068634 (HUGHES, MICHAEL DAVID) Jun 29, 2006 - Nov 30, 2020
    NIH/NIAID
    Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)
    Role: Principal Investigator
  2. U01AI068634 (HUGHES, MICHAEL DAVID) Jun 29, 2006 - May 31, 2013
    NIH/NIAID
    Statistical and Data Management Center for the AIDS Clinical Trials Group
    Role: Principal Investigator
  3. U01AI041110 (FENTON, TERRENCE) Mar 1, 1997 - Feb 28, 2007
    NIH/NIAID
    Statistical/Data Management Center-Pediatric AIDS CTG
    Role: Co-Principal Investigator
  4. U01AI038855 (HUGHES, MICHAEL DAVID) Jan 1, 1996 - Dec 31, 2006
    NIH/NIAID
    STATISTICAL AND DATA MANAGEMENT CENTER
    Role: Principal Investigator
  5. R01AI024643 (HUGHES, MICHAEL DAVID) Apr 1, 1987 - Jun 30, 2015
    NIH/NIAID
    Statistical Methods in AIDS Research
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gupta A, Swindells S, Kim S, Hughes MD, Naini L, Wu X, Dawson R, Mave V, Sanchez J, Mendoza A, Gonzales P, Kumarasamy N, Comins K, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo UG, Ferreira ACG, Mugah C, Harrington M, Jones L, Cox S, Smith B, Shah NS, Hesseling AC, Churchyard G. Feasibility of Identifying Household Contacts of Rifampin- and Multidrug-Resistant Tuberculosis Cases at High Risk of Progression to Tuberculosis Disease. Clin Infect Dis. 2019 Mar 28. PMID: 30942853.
    Citations:    
  2. Suryavanshi N, Murrill M, Gupta A, Hughes M, Hesseling A, Kim S, Naini L, Jones L, Smith B, Gupte N, Dawson R, Mave V, Meshram S, Mendoza-Ticona A, Sanchez J, Kumarasamy N, Comins K, Conradie F, Shenje J, Nerette Fontain S, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo U, Ferreira ACG, Okeyo E, Swindells S, Churchyard G, Shah NS. Willingness to Take Multidrug-Resistant Tuberculosis (MDR-TB) Preventive Therapy among Adult and Adolescent Household Contacts of MDR-TB Index Cases: An International Multi-Site Cross-Sectional Study. Clin Infect Dis. 2019 Mar 28. PMID: 30919881.
    Citations:    
  3. Griffin LE, Fausnacht DW, Tuzo JL, Addington AK, Racine KC, Zhang H, Hughes MD, England KM, Bruno RS, O'Keefe SF, Neilson AP, Stewart AC. Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet. Nutr Res. 2019 Mar 21; 66:32-47. PMID: 31051320.
    Citations:    
  4. Chatham-Stephens K, Medalla F, Hughes M, Appiah GD, Aubert RD, Caidi H, Angelo KM, Walker AT, Hatley N, Masani S, Nash J, Belko J, Ryan ET, Mintz E, Friedman CR. Emergence of Extensively Drug-Resistant Salmonella Typhi Infections Among Travelers to or from Pakistan - United States, 2016-2018. MMWR Morb Mortal Wkly Rep. 2019 Jan 11; 68(1):11-13. PMID: 30629573.
    Citations:    Fields:    Translation:HumansCells
  5. Opollo VS, Wu X, Hughes MD, Swindells S, Gupta A, Hesseling A, Churchyard G, Kim S, Lando R, Dawson R, Mave V, Mendoza A, Gonzales P, Kumarasamy N, von Groote-Bidlingmaier F, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Mngqibisa R, Garcia Ferreira AC, Okeyo E, Naini L, Jones L, Smith B, Shah NS. HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries. Int J Tuberc Lung Dis. 2018 Dec 01; 22(12):1443-1449. PMID: 30606316.
    Citations:    Fields:    
  6. Swindells S, Gupta A, Kim S, Hughes MD, Sanchez J, Mave V, Dawson R, Kumarasamy N, Comins K, Smith B, Rustomjee R, Naini L, Shah NS, Hesseling A, Churchyard G. Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). Int J Tuberc Lung Dis. 2018 09 01; 22(9):1016-1022. PMID: 30092866.
    Citations:    Fields:    
  7. Hughes M, Pauling JD. Exploring the patient experience of digital ulcers in systemic sclerosis. Semin Arthritis Rheum. 2019 04; 48(5):888-894. PMID: 30205981.
    Citations:    Fields:    
  8. MacBrayne CE, Marks KM, Fierer DS, Naggie S, Chung RT, Hughes MD, Kim AY, Peters MG, Brainard DM, Seifert SM, Castillo-Mancilla JR, Bushman LR, Anderson PL, Kiser JJ. Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate. J Antimicrob Chemother. 2018 Aug 01; 73(8):2112-2119. PMID: 29746648.
    Citations:    Fields:    
  9. Shalan A, Hughes M, Nicholls M, Thompson A. A Challenging Case of Fibromuscular Dysplasia in a Transgender Patient: Is There a Hormonal Link? EJVES Short Rep. 2018; 39:16-19. PMID: 29988870.
    Citations:    
  10. Ibrahim M, Maswabi K, Ajibola G, Moyo S, Hughes MD, Batlang O, Sakoi M, Auletta-Young C, Vaughan L, Lockman S, Jean-Philippe P, Yu X, Lichterfeld M, Kuritzkes DR, Makhema J, Shapiro RL. Targeted HIV testing at birth supported by low and predictable mother-to-child transmission risk in Botswana. J Int AIDS Soc. 2018 05; 21(5):e25111. PMID: 29852062.
    Citations: 1     Fields:    
  11. Ngongondo M, Miyahara S, Hughes MD, Sun X, Bisson GP, Gupta A, Kumwenda J, Lavenberg JA, Torres TS, Nyirenda M, Kidonge KK, Hosseinipour MC. Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial. J Acquir Immune Defic Syndr. 2018 05 01; 78(1):54-61. PMID: 29406428.
    Citations: 1     Fields:    
  12. Powis KM, Lockman S, Ajibola G, Hughes MD, Bennett K, Leidner J, Batlang O, Botebele K, Moyo S, van Widenfelt E, Makhema J, Petlo C, Jibril HB, McIntosh K, Essex M, Shapiro RL. Similar HIV protection from four weeks of zidovudine versus nevirapine prophylaxis among formula-fed infants in Botswana. South Afr J HIV Med. 2018; 19(1):751. PMID: 29707385.
    Citations:    
  13. Torres TS, Harrison LJ, La Rosa AM, Cardoso SW, Zheng L, Ngongondo M, Some F, Lalloo UG, Mwelase T, Collier AC, Hughes MD. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS. 2018 03 13; 32(5):583-593. PMID: 29334547.
    Citations: 1     Fields:    
  14. Angelidou K, Palumbo P, Lindsey J, Violary A, Archary M, Barlow L, Claggett B, Hughes M, Wei LJ. Defining Study Outcomes That Better Reflect Individual Response to Treatment. Pediatr Infect Dis J. 2018 03; 37(3):258-262. PMID: 29189677.
    Citations:    Fields:    Translation:HumansCells
  15. Kearney MF, Spindler J, Wiegand A, Shao W, Haubrich R, Riddler S, Lalama CM, Hughes MD, Coffin JM, Mellors JW. Lower pre-ART intra-participant HIV-1 pol diversity may not be associated with virologic failure in adults. PLoS One. 2018; 13(1):e0190438. PMID: 29370196.
    Citations:    Fields:    Translation:HumansCells
  16. Torres TS, Harrison LJ, La Rosa AM, Lavenberg JA, Zheng L, Safren SA, Ngongondo M, Poongulali S, Matoga M, Samaneka W, Collier AC, Hughes MD. Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings. AIDS Care. 2018 Aug; 30(8):954-962. PMID: 29343078.
    Citations:    Fields:    
  17. Balasubramanian R, Fowler MG, Dominguez K, Lockman S, Tookey PA, Huong NNG, Nesheim S, Hughes MD, Lallemant M, Tosswill J, Shaffer N, Sherman G, Palumbo P, Shapiro DE. Time to first positive HIV-1 DNA PCR may differ with antiretroviral regimen in infants infected with non-B subtype HIV-1. AIDS. 2017 11 28; 31(18):2465-2474. PMID: 28926397.
    Citations:    Fields:    Translation:HumansCells
  18. Powis KM, Souda S, Lockman S, Ajibola G, Bennett K, Leidner J, Hughes MD, Moyo S, van Widenfelt E, Jibril HB, Makhema J, Essex M, Shapiro RL. Cotrimoxazole prophylaxis was associated with enteric commensal bacterial resistance among HIV-exposed infants in a randomized controlled trial, Botswana. J Int AIDS Soc. 2017 11; 20(3). PMID: 29119726.
    Citations:    Fields:    Translation:HumansCells
  19. Beigel JH, Bao Y, Beeler J, Manosuthi W, Slandzicki A, Dar SM, Panuto J, Beasley RL, Perez-Patrigeon S, Suwanpimolkul G, Losso MH, McClure N, Bozzolo DR, Myers C, Holley HP, Hoopes J, Lane HC, Hughes MD, Davey RT. Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial. Lancet Infect Dis. 2017 12; 17(12):1255-1265. PMID: 28958678.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  20. Beigel JH, Tebas P, Elie-Turenne MC, Bajwa E, Bell TE, Cairns CB, Shoham S, Deville JG, Feucht E, Feinberg J, Luke T, Raviprakash K, Danko J, O'Neil D, Metcalf JA, King K, Burgess TH, Aga E, Lane HC, Hughes MD, Davey RT. Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study. Lancet Respir Med. 2017 06; 5(6):500-511. PMID: 28522352.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  21. Lockman S, Hughes M, Powis K, Ajibola G, Bennett K, Moyo S, van Widenfelt E, Leidner J, McIntosh K, Mazhani L, Makhema J, Essex M, Shapiro R. Effect of co-trimoxazole on mortality in HIV-exposed but uninfected children in Botswana (the Mpepu Study): a double-blind, randomised, placebo-controlled trial. Lancet Glob Health. 2017 05; 5(5):e491-e500. PMID: 28395844.
    Citations: 2     Fields:    Translation:HumansCells
  22. Naggie S, Marks KM, Hughes M, Fierer DS, Macbrayne C, Kim A, Hollabaugh K, Roa J, Symonds B, Brainard DM, McHutchison JG, Peters MG, Kiser JJ, Chung R. Sofosbuvir Plus Ribavirin Without Interferon for Treatment of Acute Hepatitis C Virus Infection in HIV-1-Infected Individuals: SWIFT-C. Clin Infect Dis. 2017 04 15; 64(8):1035-1042. PMID: 28329053.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  23. Lok JJ, Yang S, Sharkey B, Hughes MD. Estimation of the cumulative incidence function under multiple dependent and independent censoring mechanisms. Lifetime Data Anal. 2018 04; 24(2):201-223. PMID: 28238045.
    Citations:    Fields:    
  24. Matoga MM, Hosseinipour MC, Aga E, Ribaudo HJ, Kumarasamy N, Bartlett J, Hughes MD. Hyperlipidaemia in HIV-infected patients on lopinavir/ritonavir monotherapy in resource-limited settings. Antivir Ther. 2017; 22(3):205-213. PMID: 27740537.
    Citations: 2     Fields:    Translation:Humans
  25. Singini I, Campbell TB, Smeaton LM, Kumarasamy N, La Rosa A, Taejareonkul S, Safren SA, Flanigan TP, Hakim JG, Hughes MD. Predictors of late virologic failure after initial successful suppression of HIV replication on efavirenz-based antiretroviral therapy. HIV Clin Trials. 2016; 17(5):173-180. PMID: 27472067.
    Citations: 1     Fields:    
  26. Dawood FS, Jara J, Gonzalez R, Castillo JM, De León T, Estripeaut D, Luciani K, Sujey Brizuela Y, Barahona A, Cazares RA, Lawson AM, Rodriguez M, de Viana D, Franco D, Castillo M, Fry AM, Gubareva L, Tamura D, Hughes M, Gargiullo P, Clara W, Azziz-Baumgartner E, Widdowson MA. A randomized, double-blind, placebo-controlled trial evaluating the safety of early oseltamivir treatment among children 0-9 years of age hospitalized with influenza in El Salvador and Panama. Antiviral Res. 2016 09; 133:85-94. PMID: 27451343.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  27. Hughes M, Wilkinson J, Moore T, Manning J, New P, Dinsdale G, Murray A, Herrick AL. Thermographic Abnormalities are Associated with Future Digital Ulcers and Death in Patients with Systemic Sclerosis. J Rheumatol. 2016 08; 43(8):1519-22. PMID: 27307532.
    Citations: 2     Fields:    Translation:Humans
  28. Hughes M, Yang GZ. Line-scanning fiber bundle endomicroscopy with a virtual detector slit. Biomed Opt Express. 2016 Jun 01; 7(6):2257-68. PMID: 27375942.
    Citations: 2     
  29. Hughes MD, Borca-Tasciuc DA, Kaminski DA. Method for modeling radiative transport in luminescent particulate media. Appl Opt. 2016 Apr 20; 55(12):3251-60. PMID: 27140095.
    Citations:    Fields:    
  30. Borges ÁH, Lundh A, Tendal B, Bartlett JA, Clumeck N, Costagliola D, Daar ES, Echeverría P, Gisslén M, Huedo-Medina TB, Hughes MD, Huppler Hullsiek K, Khabo P, Komati S, Kumar P, Lockman S, MacArthur RD, Maggiolo F, Matteelli A, Miro JM, Oka S, Petoumenos K, Puls RL, Riddler SA, Sax PE, Sierra-Madero J, Torti C, Lundgren JD. Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials. Clin Infect Dis. 2016 07 15; 63(2):268-80. PMID: 27090986.
    Citations:    
  31. Lok JJ, Hughes MD. Evaluating predictors of competing risk outcomes when censoring depends on time-dependent covariates, with application to safety and efficacy of HIV treatment. Stat Med. 2016 06 15; 35(13):2183-94. PMID: 26763556.
    Citations:    Fields:    Translation:Humans
  32. Powis KM, Smeaton L, Hughes MD, Tumbare EA, Souda S, Jao J, Wirth KE, Makhema J, Lockman S, Fawzi W, Essex M, Shapiro RL. In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana. AIDS. 2016 Jan; 30(2):211-20. PMID: 26684818.
    Citations: 6     Fields:    Translation:Humans
  33. Pei PP, Weinstein MC, Li XC, Hughes MD, Paltiel AD, Hou T, Parker RA, Gaynes MR, Sax PE, Freedberg KA, Schackman BR, Walensky RP. Prioritizing HIV comparative effectiveness trials based on value of information: generic versus brand-name ART in the US. HIV Clin Trials. 2015 Nov; 16(6):207-18. PMID: 26651525.
    Citations:    Fields:    Translation:Humans
  34. Leung MH, Hughes M, Lane J, Basu S, Ryan K, Jones AK. Severe Disability in a Patient With Rheumatoid Arthritis and Sickle Cell Anemia: An Underreported, But Yet a Potentially Treatable Combination of Diseases. J Clin Rheumatol. 2015 Dec; 21(8):458-9. PMID: 26587862.
    Citations: 3     Fields:    Translation:Humans
  35. Blevins CE, Wusik MF, Sullivan CP, Jones RT, Hughes M. Do Negative Changes in Worldview Mediate Links Between Mass Trauma and Reckless Behavior? A Longitudinal Exploratory Study. Community Ment Health J. 2016 Jan; 52(1):10-7. PMID: 26148489.
    Citations:    
  36. Erlandson KM, Taejaroenkul S, Smeaton L, Gupta A, Singini IL, Lama JR, Mngqibisa R, Firnhaber C, Cardoso SW, Kanyama C, Machado da Silva AL, Hakim JG, Kumarasamy N, Campbell TB, Hughes MD. A Randomized Comparison of Anthropomorphic Changes With Preferred and Alternative Efavirenz-Based Antiretroviral Regimens in Diverse Multinational Settings. Open Forum Infect Dis. 2015 Sep; 2(3):ofv095. PMID: 26213694.
    Citations: 6     
  37. Hughes M, Snapir A, Wilkinson J, Snapir D, Wigley FM, Herrick AL. Prediction and impact of attacks of Raynaud's phenomenon, as judged by patient perception. Rheumatology (Oxford). 2015 Aug; 54(8):1443-7. PMID: 25752312.
    Citations: 2     Fields:    Translation:Humans
  38. Dryden-Peterson S, Bennett K, Hughes MD, Veres A, John O, Pradhananga R, Boyer M, Brown C, Sakyi B, van Widenfelt E, Keapoletswe K, Mine M, Moyo S, Asmelash A, Siedner M, Mmalane M, Shapiro RL, Lockman S. An augmented SMS intervention to improve access to antenatal CD4 testing and ART initiation in HIV-infected pregnant women: a cluster randomized trial. PLoS One. 2015; 10(2):e0117181. PMID: 25693050.
    Citations: 9     Fields:    Translation:Humans
  39. Rhee JJ, Sampson L, Cho E, Hughes MD, Hu FB, Willett WC. Comparison of methods to account for implausible reporting of energy intake in epidemiologic studies. Am J Epidemiol. 2015 Feb 15; 181(4):225-33. PMID: 25656533.
    Citations: 18     Fields:    Translation:Humans
  40. Katz IT, Leister E, Kacanek D, Hughes MD, Bardeguez A, Livingston E, Stek A, Shapiro DE, Tuomala R. Factors associated with lack of viral suppression at delivery among highly active antiretroviral therapy-naive women with HIV: a cohort study. Ann Intern Med. 2015 Jan 20; 162(2):90-9. PMID: 25599347.
    Citations: 8     Fields:    Translation:HumansCells
  41. Hughes M, Cooper GJ, Wilkinson J, New P, Guy JM, Herrick AL. Abnormalities of selenium but not of copper homeostasis may drive tissue fibrosis in patients with systemic sclerosis. Rheumatology (Oxford). 2015 Apr; 54(4):747-8. PMID: 25602061.
    Citations: 1     Fields:    Translation:Humans
  42. Rhee JJ, Mattei J, Hughes MD, Hu FB, Willett WC. Dietary diabetes risk reduction score, race and ethnicity, and risk of type 2 diabetes in women. Diabetes Care. 2015 Apr; 38(4):596-603. PMID: 25592193.
    Citations: 4     Fields:    Translation:Humans
  43. Hsu CK, Tzeng SY, Yang CC, Lee JY, Huang LL, Chen WR, Hughes M, Chen YW, Liao YK, Tseng SH. Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy. Biomed Opt Express. 2015 Feb 01; 6(2):390-404. PMID: 25780731.
    Citations: 5     
  44. Powis K, Lockman S, Smeaton L, Hughes MD, Fawzi W, Ogwu A, Moyo S, van Widenfelt E, von Oettingen J, Makhema J, Essex M, Shapiro RL. Vitamin D insufficiency in HIV-infected pregnant women receiving antiretroviral therapy is not associated with morbidity, mortality or growth impairment in their uninfected infants in Botswana. Pediatr Infect Dis J. 2014 Nov; 33(11):1141-7. PMID: 25037041.
    Citations: 1     Fields:    Translation:HumansCells
  45. Smith AJ, Donlon K, Anderson SR, Hughes M, Jones RT. When seeking influences believing and promotes posttraumatic adaptation. Anxiety Stress Coping. 2015; 28(3):340-56. PMID: 25264559.
    Citations:    
  46. Lindsey JC, Hughes MD, Violari A, Eshleman SH, Abrams EJ, Bwakura-Dangarembizi M, Barlow-Mosha L, Kamthunzi P, Sambo PM, Cotton MF, Moultrie H, Khadse S, Schimana W, Bobat R, Zimmer B, Petzold E, Mofenson LM, Jean-Philippe P, Palumbo P. Predictors of virologic and clinical response to nevirapine versus lopinavir/ritonavir-based antiretroviral therapy in young children with and without prior nevirapine exposure for the prevention of mother-to-child HIV transmission. Pediatr Infect Dis J. 2014 Aug; 33(8):846-54. PMID: 25222305.
    Citations: 5     Fields:    Translation:HumansCells
  47. Uno H, Claggett B, Tian L, Inoue E, Gallo P, Miyata T, Schrag D, Takeuchi M, Uyama Y, Zhao L, Skali H, Solomon S, Jacobus S, Hughes M, Packer M, Wei LJ. Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. J Clin Oncol. 2014 Aug 01; 32(22):2380-5. PMID: 24982461.
    Citations: 36     Fields:    Translation:Humans
  48. Asmelash A, Zheng Y, Kaloustian KW, Shaffer D, Sawe F, Ogwu A, Salata R, Currier J, Hughes MD, Lockman S. Predictors of suboptimal CD4 response among women achieving virologic suppression in a randomized antiretroviral treatment trial, Africa. BMC Infect Dis. 2014 Jun 17; 14:331. PMID: 24938526.
    Citations: 1     Fields:    Translation:HumansCells
  49. Gaughan DM, Siegel PD, Hughes MD, Chang CY, Law BF, Campbell CR, Richards JC, Kales SF, Chertok M, Kobzik L, Nguyen PS, O'Donnell CR, Kiefer M, Wagner GR, Christiani DC. Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters. Am J Ind Med. 2014 Jul; 57(7):748-56. PMID: 24909863.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  50. Shaffer D, Hughes MD, Sawe F, Bao Y, Moses A, Hogg E, Lockman S, Currier J. Cardiovascular disease risk factors in HIV-infected women after initiation of lopinavir/ritonavir- and nevirapine-based antiretroviral therapy in Sub-Saharan Africa: A5208 (OCTANE). J Acquir Immune Defic Syndr. 2014 Jun 01; 66(2):155-63. PMID: 24562349.
    Citations: 6     Fields:    Translation:HumansCells
  51. Gu X, Shapiro D, Hughes MD, Balasubramanian R. Stratified Weibull Regression Model for Interval-Censored Data. R J. 2014 Jun; 6(1):31-40. PMID: 26835159.
    Citations: 1     
  52. Zheng Y, Hughes MD, Lockman S, Benson CA, Hosseinipour MC, Campbell TB, Gulick RM, Daar ES, Sax PE, Riddler SA, Haubrich R, Salata RA, Currier JS. Antiretroviral therapy and efficacy after virologic failure on first-line boosted protease inhibitor regimens. Clin Infect Dis. 2014 Sep 15; 59(6):888-96. PMID: 24842909.
    Citations: 7     Fields:    Translation:HumansCells
  53. Mwafongo A, Nkanaunena K, Zheng Y, Hogg E, Samaneka W, Mulenga L, Siika A, Currier J, Lockman S, Hughes MD, Hosseinipour M. Renal events among women treated with tenofovir/emtricitabine in combination with either lopinavir/ritonavir or nevirapine. AIDS. 2014 May 15; 28(8):1135-42. PMID: 24445367.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  54. Munoz-Price LS, Carling P, Cleary T, Fajardo-Aquino Y, DePascale D, Jimenez A, Hughes M, Namias N, Pizano L, Kett DH, Arheart K. Control of a two-decade endemic situation with carbapenem-resistant Acinetobacter baumannii: electronic dissemination of a bundle of interventions. Am J Infect Control. 2014 May; 42(5):466-71. PMID: 24773784.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  55. Boltz VF, Bao Y, Lockman S, Halvas EK, Kearney MF, McIntyre JA, Schooley RT, Hughes MD, Coffin JM, Mellors JW. Low-frequency nevirapine (NVP)-resistant HIV-1 variants are not associated with failure of antiretroviral therapy in women without prior exposure to single-dose NVP. J Infect Dis. 2014 Mar 01; 209(5):703-10. PMID: 24443547.
    Citations: 10     Fields:    Translation:HumansCells
  56. Gaughan DM, Piacitelli CA, Chen BT, Law BF, Virji MA, Edwards NT, Enright PL, Schwegler-Berry DE, Leonard SS, Wagner GR, Kobzik L, Kales SN, Hughes MD, Christiani DC, Siegel PD, Cox-Ganser JM, Hoover MD. Exposures and cross-shift lung function declines in wildland firefighters. J Occup Environ Hyg. 2014; 11(9):591-603. PMID: 24568319.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  57. Périssé AR, Smeaton L, Chen Y, La Rosa A, Walawander A, Nair A, Grinsztejn B, Santos B, Kanyama C, Hakim J, Nyirenda M, Kumarasamy N, Lalloo UG, Flanigan T, Campbell TB, Hughes MD. Outcomes among HIV-1 infected individuals first starting antiretroviral therapy with concurrent active TB or other AIDS-defining disease. PLoS One. 2013; 8(12):e83643. PMID: 24391801.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  58. Attfield KR, Hughes MD, Spengler JD, Lu C. Within- and between-child variation in repeated urinary pesticide metabolite measurements over a 1-year period. Environ Health Perspect. 2014 Feb; 122(2):201-6. PMID: 24325925.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  59. Dryden-Peterson S, Jayeoba O, Hughes MD, Jibril H, McIntosh K, Modise TA, Asmelash A, Powis KM, Essex M, Shapiro RL, Lockman S. Cotrimoxazole prophylaxis and risk of severe anemia or severe neutropenia in HAART-exposed, HIV-uninfected infants. PLoS One. 2013; 8(9):e74171. PMID: 24086319.
    Citations: 1     Fields:    Translation:Humans
  60. Gaughan DM, Christiani DC, Hughes MD, Baur DM, Kobzik L, Wagner GR, Kales SN. High hsCRP is associated with reduced lung function in structural firefighters. Am J Ind Med. 2014 Jan; 57(1):31-7. PMID: 24115029.
    Citations:    Fields:    Translation:HumansPHPublic Health
  61. Huang JS, Hughes MD, Riddler SA, Haubrich RH. Bone mineral density effects of randomized regimen and nucleoside reverse transcriptase inhibitor selection from ACTG A5142. HIV Clin Trials. 2013 Sep-Oct; 14(5):224-34. PMID: 24144899.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  62. Shapiro RL, Kitch D, Ogwu A, Hughes MD, Lockman S, Powis K, Souda S, Moffat C, Moyo S, McIntosh K, van Widenfelt E, Zwerski S, Mazhani L, Makhema J, Essex M. HIV transmission and 24-month survival in a randomized trial of HAART to prevent MTCT during pregnancy and breastfeeding in Botswana. AIDS. 2013 Jul 31; 27(12):1911-20. PMID: 24180000.
    Citations: 10     Fields:    Translation:Humans
  63. Boeke CE, Mantzoros CS, Hughes MD, L Rifas-Shiman S, Villamor E, Zera CA, Gillman MW. Differential associations of leptin with adiposity across early childhood. Obesity (Silver Spring). 2013 Jul; 21(7):1430-7. PMID: 23408391.
    Citations: 16     Fields:    Translation:Humans
  64. Powis KM, McElrath TF, Hughes MD, Ogwu A, Souda S, Datwyler SA, von Widenfelt E, Moyo S, Nádas M, Makhema J, Machakaire E, Lockman S, Essex M, Shapiro RL. High viral load and elevated angiogenic markers associated with increased risk of preeclampsia among women initiating highly active antiretroviral therapy in pregnancy in the Mma Bana study, Botswana. J Acquir Immune Defic Syndr. 2013 Apr 15; 62(5):517-24. PMID: 23344545.
    Citations: 5     Fields:    Translation:HumansCells
  65. Fiscus SA, Cu-Uvin S, Eshete AT, Hughes MD, Bao Y, Hosseinipour M, Grinsztejn B, Badal-Faesen S, Dragavon J, Coombs RW, Braun K, Moran L, Hakim J, Flanigan T, Kumarasamy N, Campbell TB. Changes in HIV-1 subtypes B and C genital tract RNA in women and men after initiation of antiretroviral therapy. Clin Infect Dis. 2013 Jul; 57(2):290-7. PMID: 23532477.
    Citations: 6     Fields:    Translation:HumansCells
  66. Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, Nattermann J, Lampe FC, Bucher HC, Sterling TR, Crane HM, Kitahata MM, May M, Sterne JA. An internationally generalizable risk index for mortality after one year of antiretroviral therapy. AIDS. 2013 Feb 20; 27(4):563-72. PMID: 23095314.
    Citations: 48     Fields:    Translation:Humans
  67. Boeke CE, Gillman MW, Hughes MD, Rifas-Shiman SL, Villamor E, Oken E. Choline intake during pregnancy and child cognition at age 7 years. Am J Epidemiol. 2013 Jun 15; 177(12):1338-47. PMID: 23425631.
    Citations: 19     Fields:    Translation:Humans
  68. Zheng L, Rosenkranz SL, Taiwo B, Para MF, Eron JJ, Hughes MD. The design of single-arm clinical trials of combination antiretroviral regimens for treatment-naive HIV-infected patients. AIDS Res Hum Retroviruses. 2013 Apr; 29(4):652-7. PMID: 23228206.
    Citations: 3     Fields:    Translation:HumansCells
  69. McMahon DK, Zheng L, Hitti J, Chan ES, Halvas EK, Hong F, Kabanda J, Taulo F, Kumarasamy N, Bonhomme J, Wallis CL, Klingman KL, Hughes MD, Mellors JW. Greater suppression of nevirapine resistance with 21- vs 7-day antiretroviral regimens after intrapartum single-dose nevirapine for prevention of mother-to-child transmission of HIV. Clin Infect Dis. 2013 Apr; 56(7):1044-51. PMID: 23300238.
    Citations: 6     Fields:    Translation:HumansCells
  70. Noubary F, Hughes MD. Factors affecting timing of antiretroviral treatment initiation based on monitoring CD4 counts. J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):326-33. PMID: 22878419.
    Citations:    Fields:    Translation:Humans
  71. Persaud D, Palumbo PE, Ziemniak C, Hughes MD, Alvero CG, Luzuriaga K, Yogev R, Capparelli EV, Chadwick EG. Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age. AIDS. 2012 Jul 31; 26(12):1483-90. PMID: 22555165.
    Citations: 37     Fields:    Translation:HumansCells
  72. Violari A, Lindsey JC, Hughes MD, Mujuru HA, Barlow-Mosha L, Kamthunzi P, Chi BH, Cotton MF, Moultrie H, Khadse S, Schimana W, Bobat R, Purdue L, Eshleman SH, Abrams EJ, Millar L, Petzold E, Mofenson LM, Jean-Philippe P, Palumbo P. Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children. N Engl J Med. 2012 Jun 21; 366(25):2380-9. PMID: 22716976.
    Citations: 71     Fields:    Translation:HumansCells
  73. Lockman S, Hughes M, Sawe F, Zheng Y, McIntyre J, Chipato T, Asmelash A, Rassool M, Kimaiyo S, Shaffer D, Hosseinipour M, Mohapi L, Ssali F, Chibowa M, Amod F, Halvas E, Hogg E, Alston-Smith B, Smith L, Schooley R, Mellors J, Currier J. Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial. PLoS Med. 2012; 9(6):e1001236. PMID: 22719231.
    Citations: 18     Fields:    Translation:HumansCells
  74. Lorenzana SB, Hughes MD, Grinsztejn B, Collier AC, Luz PM, Freedberg KA, Wood R, Levison JH, Mugyenyi PN, Salata R, Wallis CL, Weinstein MC, Schooley RT, Walensky RP. Genotype assays and third-line ART in resource-limited settings: a simulation and cost-effectiveness analysis of a planned clinical trial. AIDS. 2012 Jun 01; 26(9):1083-93. PMID: 22343964.
    Citations: 8     Fields:    Translation:Humans
  75. Dong BJ, Zheng Y, Hughes MD, Frymoyer A, Verotta D, Lizak P, Sawe F, Currier JS, Lockman S, Aweeka FT. Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African women. AIDS. 2012 Apr 24; 26(7):833-41. PMID: 22301417.
    Citations: 18     Fields:    Translation:HumansCTClinical Trials
  76. You JJ, Singer DE, Howard PA, Lane DA, Eckman MH, Fang MC, Hylek EM, Schulman S, Go AS, Hughes M, Spencer FA, Manning WJ, Halperin JL, Lip GYH. Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb; 141(2 Suppl):e531S-e575S. PMID: 22315271.
    Citations: 191     Fields:    Translation:Humans
  77. Porter KA, Cole SR, Eron JJ, Zheng Y, Hughes MD, Lockman S, Poole C, Skinner-Adams TS, Hosseinipour M, Shaffer D, D'Amico R, Sawe FK, Siika A, Stringer E, Currier JS, Chipato T, Salata R, McCarthy JS, Meshnick SR. HIV-1 protease inhibitors and clinical malaria: a secondary analysis of the AIDS Clinical Trials Group A5208 study. Antimicrob Agents Chemother. 2012 Feb; 56(2):995-1000. PMID: 22123685.
    Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
  78. Dryden-Peterson S, Jayeoba O, Hughes MD, Jibril H, Keapoletswe K, Tlale J, Modise TA, Asmelash A, Moyo S, van Widenfelt E, Makhema J, Essex M, Shapiro RL, Lockman S. Highly active antiretroviral therapy versus zidovudine for prevention of mother-to-child transmission in a programmatic setting, Botswana. J Acquir Immune Defic Syndr. 2011 Nov 01; 58(3):353-7. PMID: 21792062.
    Citations: 11     Fields:    Translation:Humans
  79. Lima XT, Janakiraman V, Hughes MD, Kimball AB. The impact of psoriasis on pregnancy outcomes. J Invest Dermatol. 2012 Jan; 132(1):85-91. PMID: 21918537.
    Citations: 7     Fields:    Translation:Humans
  80. Powis KM, Kitch D, Ogwu A, Hughes MD, Lockman S, Leidner J, van Widenfelt E, Moffat C, Moyo S, Makhema J, Essex M, Shapiro RL. Increased risk of preterm delivery among HIV-infected women randomized to protease versus nucleoside reverse transcriptase inhibitor-based HAART during pregnancy. J Infect Dis. 2011 Aug 15; 204(4):506-14. PMID: 21791651.
    Citations: 40     Fields:    Translation:Humans
  81. Boltz VF, Zheng Y, Lockman S, Hong F, Halvas EK, McIntyre J, Currier JS, Chibowa MC, Kanyama C, Nair A, Owino-Ong'or W, Hughes M, Coffin JM, Mellors JW. Role of low-frequency HIV-1 variants in failure of nevirapine-containing antiviral therapy in women previously exposed to single-dose nevirapine. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9202-7. PMID: 21576473.
    Citations: 29     Fields:    Translation:HumansCells
  82. Dryden-Peterson S, Shapiro RL, Hughes MD, Powis K, Ogwu A, Moffat C, Moyo S, Makhema J, Essex M, Lockman S. Increased risk of severe infant anemia after exposure to maternal HAART, Botswana. J Acquir Immune Defic Syndr. 2011 Apr 15; 56(5):428-36. PMID: 21266910.
    Citations: 11     Fields:    Translation:HumansCells
  83. Brehm JH, Lalama CM, Hughes MD, Haubrich R, Riddler SA, Sluis-Cremer N, Mellors JW. Failure of initial therapy with two nucleosides and efavirenz is not associated with early emergence of mutations in the C-terminus of HIV-1 reverse transcriptase. J Acquir Immune Defic Syndr. 2011 Apr; 56(4):344-8. PMID: 21350368.
    Citations: 3     Fields:    Translation:HumansCells
  84. Chadwick EG, Yogev R, Alvero CG, Hughes MD, Hazra R, Pinto JA, Robbins BL, Heckman BE, Palumbo PE, Capparelli EV. Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy. AIDS. 2011 Mar 13; 25(5):643-9. PMID: 21297419.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  85. Robinson EB, Munir K, Munafò MR, Hughes M, McCormick MC, Koenen KC. Stability of autistic traits in the general population: further evidence for a continuum of impairment. J Am Acad Child Adolesc Psychiatry. 2011 Apr; 50(4):376-84. PMID: 21421177.
    Citations: 28     Fields:    Translation:Humans
  86. Ciaranello AL, Lockman S, Freedberg KA, Hughes M, Chu J, Currier J, Wood R, Holmes CB, Pillay S, Conradie F, McIntyre J, Losina E, Walensky RP. First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trial. AIDS. 2011 Feb 20; 25(4):479-92. PMID: 21293199.
    Citations: 12     Fields:    Translation:Humans
  87. Babiker A, Castro nee Green H, Compagnucci A, Fiscus S, Giaquinto C, Gibb DM, Harper L, Harrison L, Hughes M, McKinney R, Melvin A, Mofenson L, Saidi Y, Smith ME, Tudor-Williams G, Walker AS. First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial. Lancet Infect Dis. 2011 Apr; 11(4):273-83. PMID: 21288774.
    Citations: 54     Fields:    Translation:HumansCTClinical Trials
  88. Cervia JS, Chantry CJ, Hughes MD, Alvero C, Meyer WA, Hodge J, Borum P, Moye J, Spector SA. Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy. Pediatr Infect Dis J. 2010 Dec; 29(12):1118-22. PMID: 20631646.
    Citations: 8     Fields:    Translation:HumansCells
  89. Lockman S, Hughes MD, McIntyre J, Zheng Y, Chipato T, Conradie F, Sawe F, Asmelash A, Hosseinipour MC, Mohapi L, Stringer E, Mngqibisa R, Siika A, Atwine D, Hakim J, Shaffer D, Kanyama C, Wools-Kaloustian K, Salata RA, Hogg E, Alston-Smith B, Walawander A, Purcelle-Smith E, Eshleman S, Rooney J, Rahim S, Mellors JW, Schooley RT, Currier JS. Antiretroviral therapies in women after single-dose nevirapine exposure. N Engl J Med. 2010 Oct 14; 363(16):1499-509. PMID: 20942666.
    Citations: 55     Fields:    Translation:HumansCells
  90. Palumbo P, Lindsey JC, Hughes MD, Cotton MF, Bobat R, Meyers T, Bwakura-Dangarembizi M, Chi BH, Musoke P, Kamthunzi P, Schimana W, Purdue L, Eshleman SH, Abrams EJ, Millar L, Petzold E, Mofenson LM, Jean-Philippe P, Violari A. Antiretroviral treatment for children with peripartum nevirapine exposure. N Engl J Med. 2010 Oct 14; 363(16):1510-20. PMID: 20942667.
    Citations: 89     Fields:    Translation:HumansCells
  91. Gilbert-Diamond D, Baylin A, Mora-Plazas M, Marin C, Arsenault JE, Hughes MD, Willett WC, Villamor E. Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study. Am J Clin Nutr. 2010 Dec; 92(6):1446-51. PMID: 20926524.
    Citations: 31     Fields:    Translation:Humans
  92. Noubary F, Hughes MD. Assessing agreement in the timing of treatment initiation determined by repeated measurements of novel versus gold standard technologies with application to the monitoring of CD4 counts in HIV-infected patients. Stat Med. 2010 Aug 15; 29(18):1932-46. PMID: 20680986.
    Citations: 7     Fields:    Translation:Humans
  93. Wilkin TJ, Su Z, Krambrink A, Long J, Greaves W, Gross R, Hughes MD, Flexner C, Skolnik PR, Coakley E, Godfrey C, Hirsch M, Kuritzkes DR, Gulick RM. Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients. J Acquir Immune Defic Syndr. 2010 Aug; 54(5):470-6. PMID: 20672447.
    Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
  94. Lok JJ, Bosch RJ, Benson CA, Collier AC, Robbins GK, Shafer RW, Hughes MD. Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection. AIDS. 2010 Jul 31; 24(12):1867-76. PMID: 20467286.
    Citations: 31     Fields:    Translation:HumansCells
  95. Shapiro RL, Hughes MD, Ogwu A, Kitch D, Lockman S, Moffat C, Makhema J, Moyo S, Thior I, McIntosh K, van Widenfelt E, Leidner J, Powis K, Asmelash A, Tumbare E, Zwerski S, Sharma U, Handelsman E, Mburu K, Jayeoba O, Moko E, Souda S, Lubega E, Akhtar M, Wester C, Tuomola R, Snowden W, Martinez-Tristani M, Mazhani L, Essex M. Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med. 2010 Jun 17; 362(24):2282-94. PMID: 20554983.
    Citations: 154     Fields:    Translation:HumansCells
  96. Katz IT, Shapiro R, Li D, Govindarajulu U, Thompson B, Watts DH, Hughes MD, Tuomala R. Risk factors for detectable HIV-1 RNA at delivery among women receiving highly active antiretroviral therapy in the women and infants transmission study. J Acquir Immune Defic Syndr. 2010 May 01; 54(1):27-34. PMID: 20065861.
    Citations: 13     Fields:    Translation:HumansCells
  97. Crawford KW, Li C, Keung A, Su Z, Hughes MD, Greaves W, Kuritzkes D, Gulick R, Flexner C. Pharmacokinetic/pharmacodynamic modeling of the antiretroviral activity of the CCR5 antagonist Vicriviroc in treatment experienced HIV-infected subjects (ACTG protocol 5211). J Acquir Immune Defic Syndr. 2010 Apr; 53(5):598-605. PMID: 20071999.
    Citations: 4     Fields:    Translation:HumansCells
  98. Chantry CJ, Cervia JS, Hughes MD, Alvero C, Hodge J, Borum P, Moye J. Predictors of growth and body composition in HIV-infected children beginning or changing antiretroviral therapy. HIV Med. 2010 Oct 01; 11(9):573-83. PMID: 20345880.
    Citations: 5     Fields:    Translation:Humans
  99. O'Quigley J, Hughes MD, Fenton T, Pei L. Dynamic calibration of pharmacokinetic parameters in dose-finding studies. Biostatistics. 2010 Jul; 11(3):537-45. PMID: 20203258.
    Citations: 3     Fields:    Translation:Humans
  100. Williams PL, Marino M, Malee K, Brogly S, Hughes MD, Mofenson LM. Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants. Pediatrics. 2010 Feb; 125(2):e250-60. PMID: 20083530.
    Citations: 24     Fields:    Translation:HumansCells
  101. Su Z, Gulick RM, Krambrink A, Coakley E, Hughes MD, Han D, Flexner C, Wilkin TJ, Skolnik PR, Greaves WL, Kuritzkes DR, Reeves JD. Response to vicriviroc in treatment-experienced subjects, as determined by an enhanced-sensitivity coreceptor tropism assay: reanalysis of AIDS clinical trials group A5211. J Infect Dis. 2009 Dec 01; 200(11):1724-8. PMID: 19874179.
    Citations: 32     Fields:    Translation:HumansCells
  102. Patterson KB, Cohn SE, Uyanik J, Hughes M, Smurzynski M, Eron JJ. Treatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group Studies. Clin Infect Dis. 2009 Aug 01; 49(3):473-6. PMID: 19555288.
    Citations: 7     Fields:    Translation:HumansCells
  103. Winter HS, Oleske JM, Hughes MD, McKinney RE, Elgie C, Powell C, Purdue L, Puga AM, Jimenez E, Scott GB, Cruz ML, Moye J. Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus. J Pediatr Gastroenterol Nutr. 2009 Aug; 49(2):222-32. PMID: 19543114.
    Citations: 2     Fields:    Translation:HumansAnimals
  104. Hosoya N, Su Z, Wilkin T, Gulick RM, Flexner C, Hughes MD, Skolnik PR, Giguel F, Greaves WL, Coakley E, Kuritzkes DR. Assessing human immunodeficiency virus type 1 tropism: Comparison of assays using replication-competent virus versus plasma-derived pseudotyped virions. J Clin Microbiol. 2009 Aug; 47(8):2604-6. PMID: 19494074.
    Citations: 4     Fields:    Translation:HumansCells
  105. Tsibris AM, Korber B, Arnaout R, Russ C, Lo CC, Leitner T, Gaschen B, Theiler J, Paredes R, Su Z, Hughes MD, Gulick RM, Greaves W, Coakley E, Flexner C, Nusbaum C, Kuritzkes DR. Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo. PLoS One. 2009 May 25; 4(5):e5683. PMID: 19479085.
    Citations: 112     Fields:    Translation:HumansCells
  106. Shipton LK, Wester CW, Stock S, Ndwapi N, Gaolathe T, Thior I, Avalos A, Moffat HJ, Mboya JJ, Widenfelt E, Essex M, Hughes MD, Shapiro RL. Safety and efficacy of nevirapine- and efavirenz-based antiretroviral treatment in adults treated for TB-HIV co-infection in Botswana. Int J Tuberc Lung Dis. 2009 Mar; 13(3):360-6. PMID: 19275797.
    Citations: 23     Fields:    Translation:HumansCells
  107. Tsibris AM, Paredes R, Chadburn A, Su Z, Henrich TJ, Krambrink A, Hughes MD, Aberg JA, Currier JS, Tashima K, Godfrey C, Greaves W, Flexner C, Skolnik PR, Wilkin TJ, Gulick RM, Kuritzkes DR. Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: results of the AIDS Clinical Trials Group A5211. Clin Infect Dis. 2009 Mar 01; 48(5):642-9. PMID: 19191652.
    Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
  108. Chadwick EG, Pinto J, Yogev R, Alvero CG, Hughes MD, Palumbo P, Robbins B, Hazra R, Serchuck L, Heckman BE, Purdue L, Browning R, Luzuriaga K, Rodman J, Capparelli E. Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacy. Pediatr Infect Dis J. 2009 Mar; 28(3):215-9. PMID: 19209098.
    Citations: 17     Fields:    Translation:HumansCellsCTClinical Trials
  109. Tassiopoulos K, Kapiga S, Sam N, Ao TT, Hughes M, Seage GR. A case-crossover analysis of predictors of condom use by female bar and hotel workers in Moshi, Tanzania. Int J Epidemiol. 2009 Apr; 38(2):552-60. PMID: 19147705.
    Citations: 8     Fields:    Translation:Humans
  110. Stewart D, Hughes M, Hope WW. Laparoscopic-assisted small bowel resection for treatment of adult small bowel intussusception: a case report. Cases J. 2008 Dec 31; 1(1):432. PMID: 19117512.
    Citations: 6     
  111. Singh KK, Hughes MD, Chen J, Phiri K, Rousseau C, Kuhn L, Coutsoudis A, Jackson JB, Guay LA, Musoke P, Mmiro F, Semba RD, Spector SA. Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals. J Acquir Immune Defic Syndr. 2008 Nov 01; 49(3):259-65. PMID: 18845960.
    Citations: 15     Fields:    Translation:HumansCells
  112. Chantry CJ, Hughes MD, Alvero C, Cervia JS, Hodge J, Borum P, Moye J. Insulin-like growth factor-1 and lean body mass in HIV-infected children. J Acquir Immune Defic Syndr. 2008 Aug 01; 48(4):437-43. PMID: 18614924.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  113. Chantry CJ, Hughes MD, Alvero C, Cervia JS, Meyer WA, Hodge J, Borum P, Moye J. Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapy. Pediatrics. 2008 Jul; 122(1):e129-38. PMID: 18519448.
    Citations: 19     Fields:    Translation:Humans
  114. Tsibris AM, Sagar M, Gulick RM, Su Z, Hughes M, Greaves W, Subramanian M, Flexner C, Giguel F, Leopold KE, Coakley E, Kuritzkes DR. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J Virol. 2008 Aug; 82(16):8210-4. PMID: 18495779.
    Citations: 58     Fields:    Translation:HumansCells
  115. Hughes MD, Ribaudo HR. The search for data on when to start treatment for HIV infection. J Infect Dis. 2008 Apr 15; 197(8):1084-6. PMID: 18462158.
    Citations: 6     Fields:    Translation:HumansCells
  116. Bryson YJ, Mirochnick M, Stek A, Mofenson LM, Connor J, Capparelli E, Watts DH, Huang S, Hughes MD, Kaiser K, Purdue L, Asfaw Y, Keller M, Smith E. Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353. HIV Clin Trials. 2008 Mar-Apr; 9(2):115-25. PMID: 18474496.
    Citations: 20     Fields:    Translation:Humans
  117. Hughes MD. Practical issues arising in an exploratory analysis evaluating progression-free survival as a surrogate endpoint for overall survival in advanced colorectal cancer. Stat Methods Med Res. 2008 Oct; 17(5):487-95. PMID: 18285440.
    Citations: 7     Fields:    Translation:Humans
  118. Pei L, Hughes MD. A statistical framework for quantile equivalence clinical trials with application to pharmacokinetic studies that bridge from HIV-infected adults to children. Biometrics. 2008 Dec; 64(4):1117-25. PMID: 18261161.
    Citations: 2     Fields:    Translation:Humans
  119. Hughes M, Lip GY. Stroke and thromboembolism in atrial fibrillation: a systematic review of stroke risk factors, risk stratification schema and cost effectiveness data. Thromb Haemost. 2008 Feb; 99(2):295-304. PMID: 18278178.
    Citations: 50     Fields:    Translation:Humans
  120. Chadwick EG, Capparelli EV, Yogev R, Pinto JA, Robbins B, Rodman JH, Chen J, Palumbo P, Serchuck L, Smith E, Hughes M. Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results. AIDS. 2008 Jan 11; 22(2):249-55. PMID: 18097227.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials
  121. Flynn PM, Rudy BJ, Lindsey JC, Douglas SD, Lathey J, Spector SA, Martinez J, Silio M, Belzer M, Friedman L, D'Angelo L, Smith E, Hodge J, Hughes MD. Long-term observation of adolescents initiating HAART therapy: three-year follow-up. AIDS Res Hum Retroviruses. 2007 Oct; 23(10):1208-14. PMID: 17961106.
    Citations: 25     Fields:    Translation:HumansCells
  122. McKinney RE, Rodman J, Hu C, Britto P, Hughes M, Smith ME, Serchuck LK, Kraimer J, Ortiz AA, Flynn P, Yogev R, Spector S, Draper L, Tran P, Scites M, Dickover R, Weinberg A, Cunningham C, Abrams E, Blum MR, Chittick GE, Reynolds L, Rathore M. Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021. Pediatrics. 2007 Aug; 120(2):e416-23. PMID: 17646352.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  123. Jacobson BC, Vander Vliet MB, Hughes MD, Maurer R, McManus K, Banks PA. A prospective, randomized trial of clear liquids versus low-fat solid diet as the initial meal in mild acute pancreatitis. Clin Gastroenterol Hepatol. 2007 Aug; 5(8):946-51; quiz 886. PMID: 17613280.
    Citations: 22     Fields:    Translation:Humans
  124. Hughes MD, Kapllani E, Alexander AE, Burk RD, Schoenfeld AR. HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Cancer Cell Int. 2007 Jun 28; 7:13. PMID: 17598890.
    Citations: 9     
  125. Gulick RM, Su Z, Flexner C, Hughes MD, Skolnik PR, Wilkin TJ, Gross R, Krambrink A, Coakley E, Greaves WL, Zolopa A, Reichman R, Godfrey C, Hirsch M, Kuritzkes DR. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211. J Infect Dis. 2007 Jul 15; 196(2):304-12. PMID: 17570119.
    Citations: 83     Fields:    Translation:HumansCellsCTClinical Trials
  126. Brogly SB, Ylitalo N, Mofenson LM, Oleske J, Van Dyke R, Crain MJ, Abzug MJ, Brady M, Jean-Philippe P, Hughes MD, Seage GR. In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children. AIDS. 2007 May 11; 21(8):929-38. PMID: 17457086.
    Citations: 37     Fields:    Translation:HumansCTClinical Trials
  127. Hughes MD, Williams PL. Challenges in using observational studies to evaluate adverse effects of treatment. N Engl J Med. 2007 Apr 26; 356(17):1705-7. PMID: 17460224.
    Citations: 9     Fields:    Translation:Humans
  128. Zorrilla CD, Van Dyke R, Bardeguez A, Acosta EP, Smith B, Hughes MD, Huang S, Watts DH, Heckman B, Jiménez E, McSherry G, Mofenson L. Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. Antimicrob Agents Chemother. 2007 Jun; 51(6):2208-10. PMID: 17420209.
    Citations: 4     Fields:    Translation:HumansCells
  129. Persaud D, Palumbo P, Ziemniak C, Chen J, Ray SC, Hughes M, Havens P, Purswani M, Gaur AH, Chadwick EG. Early archiving and predominance of nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 among recently infected infants born in the United States. J Infect Dis. 2007 May 15; 195(10):1402-10. PMID: 17436219.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  130. Lassere MN, Johnson KR, Boers M, Tugwell P, Brooks P, Simon L, Strand V, Conaghan PG, Ostergaard M, Maksymowych WP, Landewe R, Bresnihan B, Tak PP, Wakefield R, Mease P, Bingham CO, Hughes M, Altman D, Buyse M, Galbraith S, Wells G. Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema. J Rheumatol. 2007 Mar; 34(3):607-15. PMID: 17343307.
    Citations: 23     Fields:    Translation:Humans
  131. Lindsey JC, Malee KM, Brouwers P, Hughes MD. Neurodevelopmental functioning in HIV-infected infants and young children before and after the introduction of protease inhibitor-based highly active antiretroviral therapy. Pediatrics. 2007 Mar; 119(3):e681-93. PMID: 17296781.
    Citations: 18     Fields:    Translation:Humans
  132. Wilkin TJ, Su Z, Kuritzkes DR, Hughes M, Flexner C, Gross R, Coakley E, Greaves W, Godfrey C, Skolnik PR, Timpone J, Rodriguez B, Gulick RM. HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211. Clin Infect Dis. 2007 Feb 15; 44(4):591-5. PMID: 17243065.
    Citations: 62     Fields:    Translation:HumansCells
  133. Tassiopoulos KK, Seage G, Sam N, Kiwelu I, Shao J, Ao TT, Essex M, Coplan P, Rosenberg Z, Hughes M, Kapiga S. Predictors of herpes simplex virus type 2 prevalence and incidence among bar and hotel workers in Moshi, Tanzania. J Infect Dis. 2007 Feb 15; 195(4):493-501. PMID: 17230408.
    Citations: 19     Fields:    Translation:HumansCells
  134. Unadkat JD, Wara DW, Hughes MD, Mathias AA, Holland DT, Paul ME, Connor J, Huang S, Nguyen BY, Watts DH, Mofenson LM, Smith E, Deutsch P, Kaiser KA, Tuomala RE. Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women. Antimicrob Agents Chemother. 2007 Feb; 51(2):783-6. PMID: 17158945.
    Citations: 26     Fields:    Translation:HumansCells
  135. De Gruttola V, Flexner C, Schapiro J, Hughes M, Van Der Laan M, Kuritzkes DR. Drug development strategies for salvage therapy: conflicts and solutions. AIDS Res Hum Retroviruses. 2006 Nov; 22(11):1106-9. PMID: 17147496.
    Citations:    Fields:    Translation:Humans
  136. Wruck LM, Yiannoutsos CT, Hughes MD. A sequential design to estimate sensitivity and specificity of a diagnostic or screening test. Stat Med. 2006 Oct 30; 25(20):3458-73. PMID: 16374904.
    Citations: 3     Fields:    
  137. Hulgan T, Hughes M, Sun X, Smeaton LM, Terry E, Robbins GK, Shafer RW, Clifford DB, McComsey GA, Canter JA, Morrow JD, Haas DW. Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study. J Acquir Immune Defic Syndr. 2006 Aug 01; 42(4):450-4. PMID: 16791116.
    Citations: 5     Fields:    Translation:Humans
  138. Ylitalo N, Brogly S, Hughes MD, Nachman S, Dankner W, Van Dyke R, Seage GR. Risk factors for opportunistic illnesses in children with human immunodeficiency virus in the era of highly active antiretroviral therapy. Arch Pediatr Adolesc Med. 2006 Aug; 160(8):778-87. PMID: 16894075.
    Citations: 9     Fields:    Translation:HumansCells
  139. Hughes MD. Initial treatment of HIV infection: randomized trials with clinical end points are still needed. J Infect Dis. 2006 Sep 01; 194(5):542-4. PMID: 16897649.
    Citations: 8     Fields:    Translation:Humans
  140. Tassiopoulos KK, Seage GR, Sam NE, Ao TT, Masenga EJ, Hughes MD, Kapiga SH. Sexual behavior, psychosocial and knowledge differences between consistent, inconsistent and non-users of condoms: a study of female bar and hotel workers in Moshi, Tanzania. AIDS Behav. 2006 Jul; 10(4):405-13. PMID: 16752083.
    Citations: 2     Fields:    Translation:Humans
  141. Surkan PJ, Peterson KE, Hughes MD, Gottlieb BR. The role of social networks and support in postpartum women's depression: a multiethnic urban sample. Matern Child Health J. 2006 Jul; 10(4):375-83. PMID: 16404681.
    Citations: 24     Fields:    Translation:Humans
  142. Bongiovanni CM, Hughes MD, Bomengen RW. Accelerated wound healing: multidisciplinary advances in the care of venous leg ulcers. Angiology. 2006 Mar-Apr; 57(2):139-44. PMID: 16518520.
    Citations: 3     Fields:    Translation:Humans
  143. Singh KK, Hughes MD, Chen J, Spector SA. Impact of MCP-1-2518-G allele on the HIV-1 disease of children in the United States. AIDS. 2006 Feb 14; 20(3):475-8. PMID: 16439891.
    Citations: 7     Fields:    Translation:HumansCells
  144. Lee GM, Gortmaker SL, McIntosh K, Hughes MD, Oleske JM. Quality of life for children and adolescents: impact of HIV infection and antiretroviral treatment. Pediatrics. 2006 Feb; 117(2):273-83. PMID: 16452344.
    Citations: 32     Fields:    Translation:Humans
  145. Dixon DO, Freedman RS, Herson J, Hughes M, Kim K, Silverman MH, Tangen CM. Guidelines for data and safety monitoring for clinical trials not requiring traditional data monitoring committees. Clin Trials. 2006; 3(3):314-9. PMID: 16895048.
    Citations: 9     Fields:    Translation:Humans
  146. Holohan TV, Colestro J, Grippi J, Converse J, Hughes M. Analysis of diagnostic error in paid malpractice claims with substandard care in a large healthcare system. South Med J. 2005 Nov; 98(11):1083-7. PMID: 16351028.
    Citations: 6     Fields:    Translation:Humans
  147. King JR, Nachman S, Yogev R, Hodge J, Aldrovandi G, Hughes MD, Chen J, Wiznia A, Damle B, Acosta EP. Efficacy, tolerability and pharmacokinetics of two nelfinavir-based regimens in human immunodeficiency virus-infected children and adolescents: pediatric AIDS clinical trials group protocol 403. Pediatr Infect Dis J. 2005 Oct; 24(10):880-5. PMID: 16220085.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  148. Chadwick EG, Rodman JH, Britto P, Powell C, Palumbo P, Luzuriaga K, Hughes M, Abrams EJ, Flynn PM, Borkowsky W, Yogev R. Ritonavir-based highly active antiretroviral therapy in human immunodeficiency virus type 1-infected infants younger than 24 months of age. Pediatr Infect Dis J. 2005 Sep; 24(9):793-800. PMID: 16148846.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  149. Watson FL, Püttmann-Holgado R, Thomas F, Lamar DL, Hughes M, Kondo M, Rebel VI, Schmucker D. Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science. 2005 Sep 16; 309(5742):1874-8. PMID: 16109846.
    Citations: 147     Fields:    Translation:AnimalsCells
  150. Mirochnick M, Stek A, Acevedo M, Keller M, Holland D, Capparelli E, Connor J, Huang S, Hughes M, Watts H, Mofenson L, Bryson Y. Safety and pharmacokinetics of nelfinavir coadministered with zidovudine and lamivudine in infants during the first 6 weeks of life. J Acquir Immune Defic Syndr. 2005 Jun 01; 39(2):189-94. PMID: 15905735.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  151. Singh KK, Hughes MD, Chen J, Spector SA. Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load. J Infect Dis. 2005 Jun 01; 191(11):1971-80. PMID: 15871132.
    Citations: 12     Fields:    Translation:HumansCells
  152. Church JA, Hughes M, Chen J, Palumbo P, Mofenson LM, Delora P, Smith E, Wiznia A, Hawkins E, Sista P, Cunningham CK. Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children. Pediatr Infect Dis J. 2004 Aug; 23(8):713-8. PMID: 15295220.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  153. Flynn PM, Rudy BJ, Douglas SD, Lathey J, Spector SA, Martinez J, Silio M, Belzer M, Friedman L, D'Angelo L, McNamara J, Hodge J, Hughes MD, Lindsey JC. Virologic and immunologic outcomes after 24 weeks in HIV type 1-infected adolescents receiving highly active antiretroviral therapy. J Infect Dis. 2004 Jul 15; 190(2):271-9. PMID: 15216461.
    Citations: 43     Fields:    Translation:HumansCellsCTClinical Trials
  154. Gaughan DM, Hughes MD, Oleske JM, Malee K, Gore CA, Nachman S. Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection. Pediatrics. 2004 Jun; 113(6):e544-51. PMID: 15173535.
    Citations: 28     Fields:    Translation:Humans
  155. Singh KK, Barroga CF, Hughes MD, Chen J, Raskino C, McKinney RE, Spector SA. Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States. J Acquir Immune Defic Syndr. 2004 Mar 01; 35(3):309-13. PMID: 15076247.
    Citations: 3     Fields:    Translation:Humans
  156. Acosta EP, Bardeguez A, Zorrilla CD, Van Dyke R, Hughes MD, Huang S, Pompeo L, Stek AM, Pitt J, Watts DH, Smith E, Jiménez E, Mofenson L. Pharmacokinetics of saquinavir plus low-dose ritonavir in human immunodeficiency virus-infected pregnant women. Antimicrob Agents Chemother. 2004 Feb; 48(2):430-6. PMID: 14742191.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  157. Wu H, Lathey J, Ruan P, Douglas SD, Spector SA, Lindsey J, Hughes MD, Rudy BJ, Flynn PM. Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to highly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior. J Infect Dis. 2004 Feb 15; 189(4):593-601. PMID: 14767811.
    Citations: 11     Fields: