Harvard Catalyst Profiles

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Fabien Xavier Loison, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hsu AY, Peng Z, Luo H, Loison F. Isolation of Human Neutrophils from Whole Blood and Buffy Coats. J Vis Exp. 2021 09 17; (175). PMID: 34605812.
    Citations:    Fields:    Translation:HumansCells
  2. Fan Y, Teng Y, Loison F, Pang A, Kasorn A, Shao X, Zhang C, Ren Q, Yu H, Zheng Y, Cancelas JA, Manis J, Chai L, Park SY, Zhao L, Xu Y, Feng S, Silberstein LE, Ma F, Luo HR. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Sci Transl Med. 2021 07 28; 13(604). PMID: 34321317.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Poonpanichakul T, Chan-In W, Opasawatchai A, Loison F, Matangkasombut O, Charoensawan V, Matangkasombut P. Innate Lymphoid Cells Activation and Transcriptomic Changes in Response to Human Dengue Infection. Front Immunol. 2021; 12:599805. PMID: 34079535.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  4. Umnajvijit W, Sangthong J, Loison F, Vaeteewoottacharn K, Ponglikitmongkol M. An internal class III PDZ binding motif in HPV16 E6* protein is required for Dlg degradation activity. Biochim Biophys Acta Gen Subj. 2021 05; 1865(5):129850. PMID: 33486056.
    Citations:    Fields:    Translation:HumansCells
  5. Opasawatchai A, Amornsupawat P, Jiravejchakul N, Chan-In W, Spoerk NJ, Manopwisedjaroen K, Singhasivanon P, Yingtaweesak T, Suraamornkul S, Mongkolsapaya J, Sakuntabhai A, Matangkasombut P, Loison F. Neutrophil Activation and Early Features of NET Formation Are Associated With Dengue Virus Infection in Human. Front Immunol. 2018; 9:3007. PMID: 30687301.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  6. Karatepe K, Zhu H, Zhang X, Guo R, Kambara H, Loison F, Liu P, Yu H, Ren Q, Luo X, Manis J, Cheng T, Ma F, Xu Y, Luo HR. Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow. Stem Cell Reports. 2018 11 13; 11(5):1092-1105. PMID: 30392974.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Kasorn A, Loison F, Kangsamaksin T, Jongrungruangchok S, Ponglikitmongkol M. Terrein inhibits migration of human breast cancer cells via inhibition of the Rho and Rac signaling pathways. Oncol Rep. 2018 Mar; 39(3):1378-1386. PMID: 29328460.
    Citations: 4     Fields:    Translation:HumansCells
  8. Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HR. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016 09 19; 213(10):1999-2018. PMID: 27551153.
    Citations: 19     Fields:    Translation:AnimalsCells
  9. Loison F, Zhu H, Karatepe K, Kasorn A, Liu P, Ye K, Zhou J, Cao S, Gong H, Jenne DE, Remold-O'Donnell E, Xu Y, Luo HR. Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation. J Clin Invest. 2014 Oct; 124(10):4445-58. PMID: 25180606.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  10. Jo H, Loison F, Luo HR. Microtubule dynamics regulates Akt signaling via dynactin p150. Cell Signal. 2014 Aug; 26(8):1707-16. PMID: 24726838.
    Citations: 9     Fields:    Translation:HumansCells
  11. Loison F, Xu Y, Luo HR. Proteinase 3 and Serpin B1: a novel pathway in the regulation of caspase-3 activation, neutrophil spontaneous apoptosis, and inflammation. Inflamm Cell Signal. 2014; 1(6). PMID: 26029732.
    Citations: 7     
  12. Mondal S, Ghosh-Roy S, Loison F, Li Y, Jia Y, Harris C, Williams DA, Luo HR. PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol. 2011 Dec 01; 187(11):5783-94. PMID: 22043008.
    Citations: 10     Fields:    Translation:AnimalsCells
  13. Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HR. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol. 2011 Jun 19; 12(8):752-60. PMID: 21685907.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  14. Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HR. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16; 117(24):6702-13. PMID: 21521784.
    Citations: 32     Fields:    Translation:AnimalsCells
  15. Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6486-91. PMID: 21464312.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  16. Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HR. Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One. 2010 Apr 23; 5(4):e10318. PMID: 20428237.
    Citations: 14     Fields:    Translation:HumansCells
  17. Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51. PMID: 20142487.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  18. Xu Y, Loison F, Luo HR. Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):2950-5. PMID: 20133633.
    Citations: 29     Fields:    Translation:HumansCells
  19. Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol. 2009 Jul 15; 183(2):1032-43. PMID: 19561112.
    Citations: 22     Fields:    Translation:AnimalsCells
  20. Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HR. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol. 2009 Jun 01; 182(11):7190-200. PMID: 19454716.
    Citations: 16     Fields:    Translation:AnimalsCells
  21. Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HR. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood. 2009 May 14; 113(20):4930-41. PMID: 19286998.
    Citations: 29     Fields:    Translation:AnimalsCells
  22. Luo HR, Loison F. Constitutive neutrophil apoptosis: mechanisms and regulation. Am J Hematol. 2008 Apr; 83(4):288-95. PMID: 17924549.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  23. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44. PMID: 18339802.
    Citations: 19     Fields:    Translation:AnimalsCells
  24. Hattori H, Zhang X, Jia Y, Subramanian KK, Jo H, Loison F, Newburger PE, Luo HR. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood. 2007 Jul 15; 110(2):640-50. PMID: 17420285.
    Citations: 19     Fields:    Translation:HumansCells
  25. Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HR. Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14836-41. PMID: 16988010.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  26. Loison F, Debure L, Nizard P, le Goff P, Michel D, le Dréan Y. Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes. Biochem J. 2006 Apr 01; 395(1):223-31. PMID: 16336210.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  27. Loison F, Nizard P, Sourisseau T, Le Goff P, Debure L, Le Drean Y, Michel D. A ubiquitin-based assay for the cytosolic uptake of protein transduction domains. Mol Ther. 2005 Feb; 11(2):205-14. PMID: 15668132.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  28. Debure L, Vayssiere JL, Rincheval V, Loison F, Le Drean Y, Michel D. Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration. J Cell Sci. 2003 Aug 01; 116(Pt 15):3109-21. PMID: 12799419.
    Citations: 25     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.