Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lei Xu, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Lei Xu and Rakesh Jain.
Connection Strength

5.432
  1. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 2009 Oct 15; 69(20):7905-10.
    View in: PubMed
    Score: 0.442
  2. alphaPlGF: a new kid on the antiangiogenesis block. Cell. 2007 Nov 02; 131(3):443-5.
    View in: PubMed
    Score: 0.386
  3. Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma. Mol Cancer Res. 2007 Sep; 5(9):873-80.
    View in: PubMed
    Score: 0.380
  4. Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res. 2005 Jul 01; 65(13):5711-9.
    View in: PubMed
    Score: 0.328
  5. Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem. 2002 Mar 29; 277(13):11368-74.
    View in: PubMed
    Score: 0.257
  6. Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models. Sci Transl Med. 2021 Jul 14; 13(602).
    View in: PubMed
    Score: 0.249
  7. Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas. Nat Commun. 2021 05 11; 12(1):2582.
    View in: PubMed
    Score: 0.246
  8. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nat Protoc. 2019 02; 14(2):541-555.
    View in: PubMed
    Score: 0.211
  9. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2210-2219.
    View in: PubMed
    Score: 0.210
  10. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E2077-E2084.
    View in: PubMed
    Score: 0.197
  11. A cerebellar window for intravital imaging of normal and disease states in mice. Nat Protoc. 2017 Nov; 12(11):2251-2262.
    View in: PubMed
    Score: 0.192
  12. Anti-VEGF treatment improves neurological function in tumors of the nervous system. Exp Neurol. 2018 01; 299(Pt B):326-333.
    View in: PubMed
    Score: 0.191
  13. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4470-5.
    View in: PubMed
    Score: 0.173
  14. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4476-81.
    View in: PubMed
    Score: 0.173
  15. Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14676-81.
    View in: PubMed
    Score: 0.168
  16. Mathematical Model of Oxygen Transport in Tuberculosis Granulomas. Ann Biomed Eng. 2016 Apr; 44(4):863-72.
    View in: PubMed
    Score: 0.165
  17. Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1827-32.
    View in: PubMed
    Score: 0.159
  18. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76.
    View in: PubMed
    Score: 0.140
  19. TGF-ß blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16618-23.
    View in: PubMed
    Score: 0.135
  20. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011 Jul; 91(3):1071-121.
    View in: PubMed
    Score: 0.124
  21. PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clin Cancer Res. 2011 Jun 01; 17(11):3638-48.
    View in: PubMed
    Score: 0.122
  22. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin Cancer Res. 2011 Apr 15; 17(8):2074-80.
    View in: PubMed
    Score: 0.121
  23. TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models. Clin Cancer Res. 2011 Mar 15; 17(6):1415-24.
    View in: PubMed
    Score: 0.121
  24. Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Res. 2006 Apr 15; 66(8):3971-7.
    View in: PubMed
    Score: 0.087
  25. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res. 2006 Apr 01; 66(7):3360-4.
    View in: PubMed
    Score: 0.086
  26. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004 Dec; 6(6):553-63.
    View in: PubMed
    Score: 0.079
  27. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 2004 Mar 18; 428(6980):328-32.
    View in: PubMed
    Score: 0.075
  28. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res. 2003 Oct 31; 93(9):e88-97.
    View in: PubMed
    Score: 0.073
  29. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature. 2002 Mar 21; 416(6878):279-80.
    View in: PubMed
    Score: 0.065
  30. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol. 2011 Jun; 103(2):325-32.
    View in: PubMed
    Score: 0.029
  31. Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med. 2008 Mar; 14(3):255-7.
    View in: PubMed
    Score: 0.025
  32. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest. 2005 Jul; 115(7):1816-27.
    View in: PubMed
    Score: 0.020
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.