Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lei Xu, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sagers JE, Beauchamp RL, Zhang Y, Vasilijic S, Wu L, DeSouza P, Seist R, Zhou W, Xu L, Ramesh V, Stankovic KM. Combination therapy with mTOR kinase inhibitor and dasatinib as a novel therapeutic strategy for vestibular schwannoma. Sci Rep. 2020 Mar 06; 10(1):4211. PMID: 32144278.
    Citations:    
  2. Landegger LD, Vasilijic S, Fujita T, Soares VY, Seist R, Xu L, Stankovic KM. Cytokine Levels in Inner Ear Fluid of Young and Aged Mice as Molecular Biomarkers of Noise-Induced Hearing Loss. Front Neurol. 2019; 10:977. PMID: 31632328.
    Citations:    
  3. Zhang DW, Luo RH, Xu L, Yang LM, Xu XS, Bedwell GJ, Engelman AN, Zheng YT, Chang S. A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid. Antiviral Res. 2019 09; 169:104544. PMID: 31254557.
    Citations:    
  4. Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nat Protoc. 2019 02; 14(2):541-555. PMID: 30617350.
    Citations:    Fields:    
  5. Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2210-2219. PMID: 30659155.
    Citations:    Fields:    
  6. Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E2077-E2084. PMID: 29440379.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, Amoozgar Z, Seano G, Ferraro GB, Chatterjee S, Xu L, Fukumura D, Duda DG, Jain RK. A cerebellar window for intravital imaging of normal and disease states in mice. Nat Protoc. 2017 Nov; 12(11):2251-2262. PMID: 28981123.
    Citations:    Fields:    Translation:Animals
  8. Zhang N, Chen J, Ferraro GB, Wu L, Datta M, Jain RK, Plotkin SR, Stemmer-Rachamimov A, Xu L. Anti-VEGF treatment improves neurological function in tumors of the nervous system. Exp Neurol. 2018 01; 299(Pt B):326-333. PMID: 28911884.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Zhao F, Ohgaki H, Xu L, Giangaspero F, Li C, Li P, Yang Z, Wang B, Wang X, Wang Z, Ai L, Zhang J, Luo L, Liu P. Molecular subgroups of adult medulloblastoma: a long-term single-institution study. Neuro Oncol. 2016 07; 18(7):982-90. PMID: 27106407.
    Citations: 9     Fields:    Translation:Humans
  10. Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4470-5. PMID: 27044097.
    Citations: 33     Fields:    Translation:AnimalsCells
  11. Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4476-81. PMID: 27044098.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  12. Zhang N, Gao X, Zhao Y, Datta M, Liu P, Xu L. Rationally combining anti-VEGF therapy with radiation in NF2 schwannoma. J Rare Dis Res Treat. 2016; 1(2):51-55. PMID: 28191549.
    Citations: 1     
  13. Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L. Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14676-81. PMID: 26554010.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Datta M, Via LE, Chen W, Baish JW, Xu L, Barry CE, Jain RK. Mathematical Model of Oxygen Transport in Tuberculosis Granulomas. Ann Biomed Eng. 2016 Apr; 44(4):863-72. PMID: 26253038.
    Citations: 5     Fields:    Translation:Animals
  15. Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK. Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1827-32. PMID: 25624495.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  16. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015; 67(2):338-67. PMID: 25713288.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  17. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76. PMID: 23452854.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  18. Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L. TGF-ß blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16618-23. PMID: 22996328.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  19. Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011 Jul; 91(3):1071-121. PMID: 21742796.
    Citations: 349     Fields:    Translation:HumansAnimals
  20. Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L. PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clin Cancer Res. 2011 Jun 01; 17(11):3638-48. PMID: 21459800.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  21. Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin Cancer Res. 2011 Apr 15; 17(8):2074-80. PMID: 21349998.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  22. Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L. TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models. Clin Cancer Res. 2011 Mar 15; 17(6):1415-24. PMID: 21278244.
    Citations: 25     Fields:    Translation:HumansAnimals
  23. Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol. 2011 Jun; 103(2):325-32. PMID: 20821342.
    Citations: 30     Fields:    Translation:HumansCTClinical Trials
  24. Xu L, Czito BG, Willett CG. Epigenetic markers in rectal cancer. Clin Cancer Res. 2010 May 15; 16(10):2699-701. PMID: 20460492.
    Citations:    Fields:    Translation:HumansCells
  25. Xu L, Bergès A, Lu PJ, Studart AR, Schofield AB, Oki H, Davies S, Weitz DA. Drying of complex suspensions. Phys Rev Lett. 2010 Mar 26; 104(12):128303. PMID: 20366569.
    Citations: 3     Fields:    
  26. Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 2009 Oct 15; 69(20):7905-10. PMID: 19826039.
    Citations: 58     Fields:    Translation:HumansCells
  27. Xu L, Davies S, Schofield AB, Weitz DA. Dynamics of drying in 3D porous media. Phys Rev Lett. 2008 Aug 29; 101(9):094502. PMID: 18851617.
    Citations: 9     Fields:    
  28. Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 2008 May 28; 28(22):5817-26. PMID: 18509043.
    Citations: 69     Fields:    Translation:AnimalsCells
  29. Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med. 2008 Mar; 14(3):255-7. PMID: 18278052.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  30. Xu L, Zhu J, Hu X, Zhu H, Kim HT, LaBaer J, Goldberg A, Yuan J. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Mol Cell. 2007 Dec 14; 28(5):914-22. PMID: 18082613.
    Citations: 31     Fields:    Translation:HumansCells
  31. Jain RK, Xu L. alphaPlGF: a new kid on the antiangiogenesis block. Cell. 2007 Nov 02; 131(3):443-5. PMID: 17981110.
    Citations: 7     Fields:    Translation:HumansAnimals
  32. Xu L, Jain RK. Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma. Mol Cancer Res. 2007 Sep; 5(9):873-80. PMID: 17704140.
    Citations: 12     Fields:    Translation:HumansCells
  33. Xu L. Liquid drop splashing on smooth, rough, and textured surfaces. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May; 75(5 Pt 2):056316. PMID: 17677173.
    Citations: 1     Fields:    
  34. Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D. Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Res. 2006 Apr 15; 66(8):3971-7. PMID: 16618713.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  35. Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res. 2006 Apr 01; 66(7):3360-4. PMID: 16585153.
    Citations: 43     Fields:    Translation:AnimalsCells
  36. Xu L, Tong R, Cochran DM, Jain RK. Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res. 2005 Jul 01; 65(13):5711-9. PMID: 15994946.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  37. Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest. 2005 Jul; 115(7):1816-27. PMID: 15951843.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  38. Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004 Dec; 6(6):553-63. PMID: 15607960.
    Citations: 383     Fields:    Translation:HumansAnimalsCells
  39. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 2004 Mar 18; 428(6980):328-32. PMID: 15029197.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  40. Xu L, Pathak PS, Fukumura D. Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells. Clin Cancer Res. 2004 Jan 15; 10(2):701-7. PMID: 14760093.
    Citations: 27     Fields:    Translation:HumansCells
  41. Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res. 2003 Oct 31; 93(9):e88-97. PMID: 14525808.
    Citations: 76     Fields:    Translation:AnimalsCells
  42. Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D. Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts. Clin Cancer Res. 2003 Sep 15; 9(11):4221-6. PMID: 14519649.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  43. Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature. 2002 Mar 21; 416(6878):279-80. PMID: 11907566.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  44. Xu L, Fukumura D, Jain RK. Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem. 2002 Mar 29; 277(13):11368-74. PMID: 11741977.
    Citations: 68     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Xu's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (314)
Explore
_
Co-Authors (47)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.