Harvard Catalyst Profiles

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Jing-Ruey Joanna Yeh, Ph.D.

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Biography
2008
Claflin Dinstinguished Scholar Award

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA215410 (YEH, JING-RUEY JOANNA) Jan 1, 2018 - Dec 31, 2022
    NIH/NCI
    Targeting ROS production in OXPHOS-defective and OXPHOS-competent tumors
    Role: Principal Investigator
  2. U01MH105027 (YEH, JING-RUEY JOANNA) Aug 1, 2014 - Jul 31, 2017
    NIH/NIMH
    Scalable in vivo tools for annotating and manipulating the druggable genome
    Role: Co-Principal Investigator
  3. R01CA140188 (YEH, JING-RUEY JOANNA) Jul 1, 2010 - Apr 30, 2015
    NIH/NCI
    Discovering chemical tools for acute myelogenous leukemia
    Role: Principal Investigator
  4. K01AG031300 (YEH, JING-RUEY JOANNA) Aug 1, 2008 - Oct 31, 2013
    NIH/NIA
    Age factors, mutations, and chemical suppressors of acute myelogenous leukemia
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kokel D, Dunn TW, Ahrens MB, Alshut R, Cheung CY, Saint-Amant L, Bruni G, Mateus R, van Ham TJ, Shiraki T, Fukada Y, Kojima D, Yeh JR, Mikut R, von Lintig J, Engert F, Peterson RT. Identification of nonvisual photomotor response cells in the vertebrate hindbrain. J Neurosci. 2013 Feb 27; 33(9):3834-43. PMID: 23447595.
    Citations: 27     Fields:    Translation:AnimalsCells
  2. Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, Zheng W, Liu P. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFß interaction. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14592-7. PMID: 22912405.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  3. Helenius IT, Yeh JR. Small zebrafish in a big chemical pond. J Cell Biochem. 2012 Jul; 113(7):2208-16. PMID: 22396148.
    Citations: 4     Fields:    Translation:Animals
  4. Zhang Y, Yeh JR. In vivo chemical screening for modulators of hematopoiesis and hematological diseases. Adv Hematol. 2012; 2012:851674. PMID: 22778745.
    Citations: 3     
  5. Cade L, Reyon D, Hwang WY, Tsai SQ, Patel S, Khayter C, Joung JK, Sander JD, Peterson RT, Yeh JR. Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic Acids Res. 2012 Sep; 40(16):8001-10. PMID: 22684503.
    Citations: 93     Fields:    Translation:AnimalsCells
  6. Yeh JR. A Wnt inhibitor with a twist. Chem Biol. 2011 Dec 23; 18(12):1518-20. PMID: 22195553.
    Citations:    Fields:    
  7. Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR. Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat Biotechnol. 2011 Aug 05; 29(8):697-8. PMID: 21822241.
    Citations: 208     Fields:    Translation:Humans
  8. Sander JD, Yeh JR, Peterson RT, Joung JK. Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods Cell Biol. 2011; 104:51-8. PMID: 21924156.
    Citations: 18     Fields:    Translation:AnimalsCells
  9. Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods. 2011 Jan; 8(1):67-9. PMID: 21151135.
    Citations: 175     Fields:    Translation:AnimalsCells
  10. Yeh JR, Munson KM. Zebrafish small molecule screen in reprogramming/cell fate modulation. Methods Mol Biol. 2010; 636:317-27. PMID: 20336532.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Foley JE, Yeh JR, Maeder ML, Reyon D, Sander JD, Peterson RT, Joung JK. Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 2009; 4(2):e4348. PMID: 19198653.
    Citations: 99     Fields:    Translation:AnimalsCells
  12. Yeh JR, Peterson RT. Novel Wnt antagonists target porcupine and Axin. Nat Chem Biol. 2009 Feb; 5(2):74-5. PMID: 19148172.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  13. Yeh JR, Munson KM, Elagib KE, Goldfarb AN, Sweetser DA, Peterson RT. Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nat Chem Biol. 2009 Apr; 5(4):236-43. PMID: 19172146.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  14. Foley JE, Maeder ML, Pearlberg J, Joung JK, Peterson RT, Yeh JR. Targeted mutagenesis in zebrafish using customized zinc-finger nucleases. Nat Protoc. 2009; 4(12):1855-67. PMID: 20010934.
    Citations: 39     Fields:    Translation:AnimalsCells
  15. Sachidanandan C, Yeh JR, Peterson QP, Peterson RT. Identification of a novel retinoid by small molecule screening with zebrafish embryos. PLoS One. 2008 Apr 09; 3(4):e1947. PMID: 18398471.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  16. Dayyani F, Wang J, Yeh JR, Ahn EY, Tobey E, Zhang DE, Bernstein ID, Peterson RT, Sweetser DA. Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival. Blood. 2008 Apr 15; 111(8):4338-47. PMID: 18258796.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  17. Yeh JR, Munson KM, Chao YL, Peterson QP, Macrae CA, Peterson RT. AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development. 2008 Jan; 135(2):401-10. PMID: 18156164.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  18. Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM. A chemical and genetic approach to the mode of action of fumagillin. Chem Biol. 2006 Sep; 13(9):1001-9. PMID: 16984890.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  19. Yeh JJ, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10379-10384. PMID: 16790550.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  20. Yeh JR, Crews CM. Chemical genetics: adding to the developmental biology toolbox. Dev Cell. 2003 Jul; 5(1):11-9. PMID: 12852848.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  21. Yeh JR, Mohan R, Crews CM. The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2000 Nov 07; 97(23):12782-7. PMID: 11070090.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.