Harvard Catalyst Profiles

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Claudio F. Perez, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR067738 (PEREZ, CLAUDIO F) Feb 16, 2016 - Jan 31, 2021
    Structural and molecular requirements for DHPR and RyR1 bidirectional signaling
    Role: Co-Principal Investigator
  2. R03AR066359 (PEREZ, CLAUDIO F) Apr 1, 2014 - Mar 31, 2018
    Ca2+ regulation in muscle by a new class of Ca2+-binding domain of RyRs
    Role: Principal Investigator
  3. K01AR054818 (PEREZ, CLAUDIO F) Jun 1, 2008 - May 31, 2013
    Structural/functional interaction between RyR1 and DHPR alpha1s and Beta1a isofor
    Role: Principal Investigator
  4. F05TW005455 (PEREZ, CLAUDIO F) May 1, 2000
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Perez CF, Eltit JM, Lopez JR, Bodnár D, Dulhunty AF, Aditya S, Casarotto MG. Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-ß1a subunit (CACNB1). . 2018 03 01; 314(3):C323-C333. PMID: 29212769.
    Citations:    Translation:HumansAnimalsCells
  2. Cho CH, Woo JS, Perez CF, Lee EH. A focus on extracellular Ca2+ entry into skeletal muscle. Exp Mol Med. 2017 09 15; 49(9):e378. PMID: 28912570.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  3. Mahalingam M, Perez CF, Fessenden JD. Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor a1S Subunit Reveals Conformational Differences Induced by Binding of the ß1a Subunit. J Biol Chem. 2016 Jun 24; 291(26):13762-70. PMID: 27129199.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Eltit JM, Franzini-Armstrong C, Perez CF. Amino acid residues 489-503 of dihydropyridine receptor (DHPR) ß1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor. J Biol Chem. 2014 Dec 26; 289(52):36116-24. PMID: 25384984.
    Citations: 9     Fields:    Translation:AnimalsCells
  5. Altamirano F, Perez CF, Liu M, Widrick J, Barton ER, Allen PD, Adams JA, Lopez JR. Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. PLoS One. 2014; 9(9):e106590. PMID: 25181488.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Chen Y, Xue S, Zou J, Lopez JR, Yang JJ, Perez CF. Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor. Biochem J. 2014 Jun 01; 460(2):261-71. PMID: 24635445.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam KG, Samsó M. Three-dimensional localization of the a and ß subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel. J Biol Chem. 2012 Dec 21; 287(52):43853-61. PMID: 23118233.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Boncompagni S, Thomas M, Lopez JR, Allen PD, Yuan Q, Kranias EG, Franzini-Armstrong C, Perez CF. Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. PLoS One. 2012; 7(7):e39962. PMID: 22768324.
    Citations: 23     Fields:    Translation:AnimalsCells
  9. Perez CF. On the footsteps of Triadin and its role in skeletal muscle. World J Biol Chem. 2011 Aug 26; 2(8):177-83. PMID: 21909459.
  10. Eltit JM, Szpyt J, Li H, Allen PD, Perez CF. Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction. Cell Calcium. 2011 Feb; 49(2):128-35. PMID: 21310482.
    Citations: 8     Fields:    Translation:AnimalsCells
  11. Eltit JM, Feng W, Lopez JR, Padilla IT, Pessah IN, Molinski TF, Fruen BR, Allen PD, Perez CF. Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+. J Biol Chem. 2010 Dec 03; 285(49):38453-62. PMID: 20926377.
    Citations: 14     Fields:    Translation:AnimalsCells
  12. Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B, Cattolica RA, Perez CF, Hlaing T, Knollmann-Ritschel BE, Jones LR, Pessah IN, Allen PD, Franzini-Armstrong C, Knollmann BC. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7636-41. PMID: 19383796.
    Citations: 61     Fields:    Translation:AnimalsCells
  13. Pessah IN, Lehmler HJ, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem Res Toxicol. 2009 Jan; 22(1):201-7. PMID: 18954145.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  14. Voss AA, Allen PD, Pessah IN, Perez CF. Allosterically coupled calcium and magnesium binding sites are unmasked by ryanodine receptor chimeras. Biochem Biophys Res Commun. 2008 Feb 22; 366(4):988-93. PMID: 18096513.
    Citations: 3     Fields:    Translation:Cells
  15. Shen X, Franzini-Armstrong C, Lopez JR, Jones LR, Kobayashi YM, Wang Y, Kerrick WG, Caswell AH, Potter JD, Miller T, Allen PD, Perez CF. Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem. 2007 Dec 28; 282(52):37864-74. PMID: 17981799.
    Citations: 39     Fields:    Translation:AnimalsCells
  16. Sheridan DC, Takekura H, Franzini-Armstrong C, Beam KG, Allen PD, Perez CF. Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19760-5. PMID: 17172444.
    Citations: 36     Fields:    Translation:Cells
  17. Liu Q, Perez CF, Wang Y. Efficient site-specific integration of large transgenes by an enhanced herpes simplex virus/adeno-associated virus hybrid amplicon vector. J Virol. 2006 Feb; 80(4):1672-9. PMID: 16439524.
    Citations: 6     Fields:    Translation:HumansCells
  18. Perez CF, López JR, Allen PD. Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle. . 2005 Mar; 288(3):C640-9. PMID: 15548569.
    Citations: 22     Translation:HumansAnimalsCells
  19. Perez CF, Mukherjee S, Allen PD. Amino acids 1-1,680 of ryanodine receptor type 1 hold critical determinants of skeletal type for excitation-contraction coupling. Role of divergence domain D2. J Biol Chem. 2003 Oct 10; 278(41):39644-52. PMID: 12900411.
    Citations: 20     Fields:    Translation:AnimalsCells
  20. Fessenden JD, Perez CF, Goth S, Pessah IN, Allen PD. Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol. J Biol Chem. 2003 Aug 01; 278(31):28727-35. PMID: 12761215.
    Citations: 16     Fields:    Translation:AnimalsCells
  21. Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. 2003 Jun 20; 278(25):22600-8. PMID: 12704193.
    Citations: 29     Fields:    Translation:AnimalsCells
  22. Perez CF, Voss A, Pessah IN, Allen PD. RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling. Biophys J. 2003 Apr; 84(4):2655-63. PMID: 12668474.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  23. Hidalgo C, Bull R, Marengo JJ, Perez CF, Donoso P. SH oxidation stimulates calcium release channels (ryanodine receptors) from excitable cells. Biol Res. 2000; 33(2):113-24. PMID: 15693278.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Pérez CF, Marengo JJ, Bull R, Hidalgo C. Cyclic ADP-ribose activates caffeine-sensitive calcium channels from sea urchin egg microsomes. Am J Physiol. 1998 02; 274(2):C430-9. PMID: 9486133.
    Citations: 1     Fields:    Translation:AnimalsCells
  25. Barros C, Capote C, Perez C, Crosby JA, Becker MI, De Ioannes A. Immunodetection of acrosin during the acrosome reaction of hamster, guinea-pig and human spermatozoa. Biol Res. 1992; 25(1):31-40. PMID: 1341578.
    Citations: 2     Fields:    Translation:AnimalsCells
  26. Perez C, Roco M, Castro A, Dupre E, Schatten G, Barros C. Localization of microfilaments and a tubulin-like protein in crustacean (Rhynchocinetes typus) spermatozoon. Mol Reprod Dev. 1991 Apr; 28(4):373-9. PMID: 2064780.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.