Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileClaudio F. Perez, Ph.D.

TitleAssistant Professor of Anaesthesia
InstitutionBrigham and Women's Hospital
AddressBrigham and Women's Hospital
75 Francis St
Boston MA 02115
vCardDownload vCard (login for email)
Profile Picture

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AR067738     (PEREZ, CLAUDIO F)Feb 16, 2016 - Jan 31, 2021
Structural and molecular requirements for DHPR and RyR1 bidirectional signaling
Role: Co-Principal Investigator

R03AR066359     (PEREZ, CLAUDIO F)Apr 1, 2014 - Mar 31, 2017
Ca2+ regulation in muscle by a new class of Ca2+-binding domain of RyRs
Role: Principal Investigator

K01AR054818     (PEREZ, CLAUDIO F)Jun 1, 2008 - May 31, 2013
Structural/functional interaction between RyR1 and DHPR alpha1s and Beta1a isofor
Role: Principal Investigator

F05TW005455     (PEREZ, CLAUDIO F)May 1, 2000
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Perez CF, Eltit JM, Lopez JR, Bodnár D, Dulhunty AF, Aditya S, Casarotto MG. Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-ß1a subunit (CACNB1). Am J Physiol Cell Physiol. 2018 Mar 01; 314(3):C323-C333. PMID: 29212769.
    View in: PubMed
  2. Cho CH, Woo JS, Perez CF, Lee EH. A focus on extracellular Ca2+ entry into skeletal muscle. Exp Mol Med. 2017 Sep 15; 49(9):e378. PMID: 28912570.
    View in: PubMed
  3. Mahalingam M, Perez CF, Fessenden JD. Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor a1S Subunit Reveals Conformational Differences Induced by Binding of the ß1a Subunit. J Biol Chem. 2016 Jun 24; 291(26):13762-70. PMID: 27129199; PMCID: PMC4919458 [Available on 06/24/17].
  4. Eltit JM, Franzini-Armstrong C, Perez CF. Amino acid residues 489-503 of dihydropyridine receptor (DHPR) ß1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor. J Biol Chem. 2014 Dec 26; 289(52):36116-24. PMID: 25384984; PMCID: PMC4276875.
  5. Altamirano F, Perez CF, Liu M, Widrick J, Barton ER, Allen PD, Adams JA, Lopez JR. Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. PLoS One. 2014; 9(9):e106590. PMID: 25181488; PMCID: PMC4152333.
  6. Chen Y, Xue S, Zou J, Lopez JR, Yang JJ, Perez CF. Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor. Biochem J. 2014 Jun 01; 460(2):261-71. PMID: 24635445; PMCID: PMC4019983.
  7. Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam KG, Samsó M. Three-dimensional localization of the a and ß subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel. J Biol Chem. 2012 Dec 21; 287(52):43853-61. PMID: 23118233; PMCID: PMC3527968.
  8. Boncompagni S, Thomas M, Lopez JR, Allen PD, Yuan Q, Kranias EG, Franzini-Armstrong C, Perez CF. Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. PLoS One. 2012; 7(7):e39962. PMID: 22768324; PMCID: PMC3388061.
  9. Perez CF. On the footsteps of Triadin and its role in skeletal muscle. World J Biol Chem. 2011 Aug 26; 2(8):177-83. PMID: 21909459; PMCID: PMC3165967.
  10. Eltit JM, Szpyt J, Li H, Allen PD, Perez CF. Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction. Cell Calcium. 2011 Feb; 49(2):128-35. PMID: 21310482; PMCID: PMC3052628.
  11. Eltit JM, Feng W, Lopez JR, Padilla IT, Pessah IN, Molinski TF, Fruen BR, Allen PD, Perez CF. Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+. J Biol Chem. 2010 Dec 03; 285(49):38453-62. PMID: 20926377; PMCID: PMC2992278.
  12. Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B, Cattolica RA, Perez CF, Hlaing T, Knollmann-Ritschel BE, Jones LR, Pessah IN, Allen PD, Franzini-Armstrong C, Knollmann BC. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7636-41. PMID: 19383796; PMCID: PMC2678594.
  13. Pessah IN, Lehmler HJ, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem Res Toxicol. 2009 Jan; 22(1):201-7. PMID: 18954145; PMCID: PMC2662366.
  14. Voss AA, Allen PD, Pessah IN, Perez CF. Allosterically coupled calcium and magnesium binding sites are unmasked by ryanodine receptor chimeras. Biochem Biophys Res Commun. 2008 Feb 22; 366(4):988-93. PMID: 18096513; PMCID: PMC2693413.
  15. Shen X, Franzini-Armstrong C, Lopez JR, Jones LR, Kobayashi YM, Wang Y, Kerrick WG, Caswell AH, Potter JD, Miller T, Allen PD, Perez CF. Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem. 2007 Dec 28; 282(52):37864-74. PMID: 17981799.
    View in: PubMed
  16. Sheridan DC, Takekura H, Franzini-Armstrong C, Beam KG, Allen PD, Perez CF. Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19760-5. PMID: 17172444; PMCID: PMC1750873.
  17. Liu Q, Perez CF, Wang Y. Efficient site-specific integration of large transgenes by an enhanced herpes simplex virus/adeno-associated virus hybrid amplicon vector. J Virol. 2006 Feb; 80(4):1672-9. PMID: 16439524; PMCID: PMC1367150.
  18. Perez CF, López JR, Allen PD. Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle. Am J Physiol Cell Physiol. 2005 Mar; 288(3):C640-9. PMID: 15548569.
    View in: PubMed
  19. Perez CF, Mukherjee S, Allen PD. Amino acids 1-1,680 of ryanodine receptor type 1 hold critical determinants of skeletal type for excitation-contraction coupling. Role of divergence domain D2. J Biol Chem. 2003 Oct 10; 278(41):39644-52. PMID: 12900411.
    View in: PubMed
  20. Fessenden JD, Perez CF, Goth S, Pessah IN, Allen PD. Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol. J Biol Chem. 2003 Aug 01; 278(31):28727-35. PMID: 12761215.
    View in: PubMed
  21. Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. 2003 Jun 20; 278(25):22600-8. PMID: 12704193.
    View in: PubMed
  22. Perez CF, Voss A, Pessah IN, Allen PD. RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling. Biophys J. 2003 Apr; 84(4):2655-63. PMID: 12668474; PMCID: PMC1302832.
  23. Hidalgo C, Bull R, Marengo JJ, Perez CF, Donoso P. SH oxidation stimulates calcium release channels (ryanodine receptors) from excitable cells. Biol Res. 2000; 33(2):113-24. PMID: 15693278.
    View in: PubMed
  24. Pérez CF, Marengo JJ, Bull R, Hidalgo C. Cyclic ADP-ribose activates caffeine-sensitive calcium channels from sea urchin egg microsomes. Am J Physiol. 1998 Feb; 274(2 Pt 1):C430-9. PMID: 9486133.
    View in: PubMed
  25. Barros C, Capote C, Perez C, Crosby JA, Becker MI, De Ioannes A. Immunodetection of acrosin during the acrosome reaction of hamster, guinea-pig and human spermatozoa. Biol Res. 1992; 25(1):31-40. PMID: 1341578.
    View in: PubMed
  26. Perez C, Roco M, Castro A, Dupre E, Schatten G, Barros C. Localization of microfilaments and a tubulin-like protein in crustacean (Rhynchocinetes typus) spermatozoon. Mol Reprod Dev. 1991 Apr; 28(4):373-9. PMID: 2064780.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at For faculty personal and demographic information, contact HMS Office for Faculty Affairs at
Perez's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
Co-Authors Expand Description
Similar People Expand Description
Same Department Expand Description
Physical Neighbors Expand Description