Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Michael S. Lawrence, Ph.D.

Concepts

This page shows the publications Michael Lawrence has written about Mutation.
Connection Strength

1.258
  1. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Jul 11; 499(7457):214-218.
    View in: PubMed
    Score: 0.092
  2. An extended APOBEC3A mutation signature in cancer. Nat Commun. 2021 03 11; 12(1):1602.
    View in: PubMed
    Score: 0.040
  3. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. Nat Commun. 2020 06 12; 11(1):2971.
    View in: PubMed
    Score: 0.038
  4. Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2020 02 05; 11(1):729.
    View in: PubMed
    Score: 0.037
  5. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2020 02; 578(7793):102-111.
    View in: PubMed
    Score: 0.037
  6. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science. 2019 06 28; 364(6447).
    View in: PubMed
    Score: 0.035
  7. Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair. Nat Commun. 2018 05 01; 9(1):1746.
    View in: PubMed
    Score: 0.032
  8. Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer. Cancer Discov. 2018 06; 8(6):714-729.
    View in: PubMed
    Score: 0.032
  9. A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Nat Genet. 2017 Oct; 49(10):1476-1486.
    View in: PubMed
    Score: 0.031
  10. Recurrent and functional regulatory mutations in breast cancer. Nature. 2017 07 06; 547(7661):55-60.
    View in: PubMed
    Score: 0.031
  11. Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias. Nat Genet. 2017 01; 49(1):10-16.
    View in: PubMed
    Score: 0.029
  12. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. Nat Genet. 2016 08; 48(8):848-55.
    View in: PubMed
    Score: 0.029
  13. Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes. Nat Biotechnol. 2015 Nov; 33(11):1152-8.
    View in: PubMed
    Score: 0.027
  14. SomaticSignatures: inferring mutational signatures from single-nucleotide variants. Bioinformatics. 2015 Nov 15; 31(22):3673-5.
    View in: PubMed
    Score: 0.027
  15. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med. 2015 Jun 25; 372(26):2481-98.
    View in: PubMed
    Score: 0.027
  16. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature. 2015 Feb 19; 518(7539):360-364.
    View in: PubMed
    Score: 0.026
  17. RNF43 is frequently mutated in colorectal and endometrial cancers. Nat Genet. 2014 Dec; 46(12):1264-6.
    View in: PubMed
    Score: 0.025
  18. Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma. Cancer Discov. 2014 Oct; 4(10):1140-53.
    View in: PubMed
    Score: 0.025
  19. Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. Mol Cancer. 2014 Jun 04; 13:141.
    View in: PubMed
    Score: 0.025
  20. A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events. PLoS One. 2014; 9(1):e87361.
    View in: PubMed
    Score: 0.024
  21. Landscape of genomic alterations in cervical carcinomas. Nature. 2014 Feb 20; 506(7488):371-5.
    View in: PubMed
    Score: 0.024
  22. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6.
    View in: PubMed
    Score: 0.024
  23. Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep. 2013 Oct 02; 3:2650.
    View in: PubMed
    Score: 0.024
  24. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet. 2013 May; 45(5):478-86.
    View in: PubMed
    Score: 0.023
  25. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013 Feb 14; 152(4):714-26.
    View in: PubMed
    Score: 0.023
  26. The genetic landscape of high-risk neuroblastoma. Nat Genet. 2013 Mar; 45(3):279-84.
    View in: PubMed
    Score: 0.022
  27. Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability. Genome Res. 2013 Feb; 23(2):228-35.
    View in: PubMed
    Score: 0.022
  28. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14476-81.
    View in: PubMed
    Score: 0.022
  29. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. 2012 Aug 02; 488(7409):106-10.
    View in: PubMed
    Score: 0.022
  30. A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest. 2012 Aug; 122(8):2983-8.
    View in: PubMed
    Score: 0.022
  31. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 2012 Jun 20; 486(7403):405-9.
    View in: PubMed
    Score: 0.022
  32. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet. 2012 May 20; 44(6):685-9.
    View in: PubMed
    Score: 0.021
  33. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 2012 May 09; 485(7399):502-6.
    View in: PubMed
    Score: 0.021
  34. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3879-84.
    View in: PubMed
    Score: 0.021
  35. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011 Dec 29; 365(26):2497-506.
    View in: PubMed
    Score: 0.021
  36. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26; 333(6046):1157-60.
    View in: PubMed
    Score: 0.020
  37. Initial genome sequencing and analysis of multiple myeloma. Nature. 2011 Mar 24; 471(7339):467-72.
    View in: PubMed
    Score: 0.020
  38. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008 Oct 23; 455(7216):1069-75.
    View in: PubMed
    Score: 0.017
  39. HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures. Carcinogenesis. 2021 02 11; 42(1):14-20.
    View in: PubMed
    Score: 0.010
  40. Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Adv. 2020 05 12; 4(9):1859-1866.
    View in: PubMed
    Score: 0.009
  41. GTP-Dependent Formation of Multimeric G-Quadruplexes. ACS Chem Biol. 2019 09 20; 14(9):1951-1963.
    View in: PubMed
    Score: 0.009
  42. Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing. J Biol Chem. 2019 10 11; 294(41):15037-15051.
    View in: PubMed
    Score: 0.009
  43. A Code of Mono-phosphorylation Modulates the Function of RB. Mol Cell. 2019 03 07; 73(5):985-1000.e6.
    View in: PubMed
    Score: 0.009
  44. Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. Cell. 2018 04 05; 173(2):291-304.e6.
    View in: PubMed
    Score: 0.008
  45. Comprehensive Characterization of Cancer Driver Genes and Mutations. Cell. 2018 04 05; 173(2):371-385.e18.
    View in: PubMed
    Score: 0.008
  46. NetSig: network-based discovery from cancer genomes. Nat Methods. 2018 01; 15(1):61-66.
    View in: PubMed
    Score: 0.008
  47. Analysis of somatic microsatellite indels identifies driver events in human tumors. Nat Biotechnol. 2017 Oct; 35(10):951-959.
    View in: PubMed
    Score: 0.008
  48. APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition. Cancer Res. 2017 09 01; 77(17):4567-4578.
    View in: PubMed
    Score: 0.008
  49. Altered biochemical specificity of G-quadruplexes with mutated tetrads. Nucleic Acids Res. 2016 12 15; 44(22):10789-10803.
    View in: PubMed
    Score: 0.007
  50. Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair. Cell. 2016 Jan 28; 164(3):538-49.
    View in: PubMed
    Score: 0.007
  51. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun. 2015 Dec 07; 6:8866.
    View in: PubMed
    Score: 0.007
  52. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177.
    View in: PubMed
    Score: 0.007
  53. Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women. Int J Cancer. 2015 Aug 15; 137(4):776-83.
    View in: PubMed
    Score: 0.006
  54. Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014 Dec 24; 2:167.
    View in: PubMed
    Score: 0.006
  55. Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat Genet. 2015 Feb; 47(2):106-14.
    View in: PubMed
    Score: 0.006
  56. The genomic landscape of pediatric Ewing sarcoma. Cancer Discov. 2014 Nov; 4(11):1326-41.
    View in: PubMed
    Score: 0.006
  57. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res. 2015 Feb 01; 21(3):632-41.
    View in: PubMed
    Score: 0.006
  58. Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell. 2014 Jan 13; 25(1):91-101.
    View in: PubMed
    Score: 0.006
  59. Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair. Nat Biotechnol. 2014 Jan; 32(1):71-5.
    View in: PubMed
    Score: 0.006
  60. Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients. J Clin Oncol. 2014 Jan 10; 32(2):121-8.
    View in: PubMed
    Score: 0.006
  61. Identification of driver genes in hepatocellular carcinoma by exome sequencing. Hepatology. 2013 Nov; 58(5):1693-702.
    View in: PubMed
    Score: 0.006
  62. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet. 2013 Sep; 45(9):970-6.
    View in: PubMed
    Score: 0.006
  63. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8188-93.
    View in: PubMed
    Score: 0.006
  64. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. J Clin Invest. 2013 Jan; 123(1):517-25.
    View in: PubMed
    Score: 0.006
  65. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell. 2012 Sep 14; 150(6):1107-20.
    View in: PubMed
    Score: 0.005
  66. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011 Jun; 1(1):78-89.
    View in: PubMed
    Score: 0.005
  67. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010 Jan 19; 17(1):98-110.
    View in: PubMed
    Score: 0.005
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.