Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Michael S. Lawrence, Ph.D.

Concepts

This page shows the publications Michael Lawrence has written about Humans.
Connection Strength

0.254
  1. An extended APOBEC3A mutation signature in cancer. Nat Commun. 2021 03 11; 12(1):1602.
    View in: PubMed
    Score: 0.011
  2. Huge whole-genome study of human metastatic cancers. Nature. 2019 11; 575(7781):60-61.
    View in: PubMed
    Score: 0.010
  3. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science. 2019 06 28; 364(6447).
    View in: PubMed
    Score: 0.010
  4. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 2014 Jan 23; 505(7484):495-501.
    View in: PubMed
    Score: 0.007
  5. Software for computing and annotating genomic ranges. PLoS Comput Biol. 2013; 9(8):e1003118.
    View in: PubMed
    Score: 0.006
  6. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Jul 11; 499(7457):214-218.
    View in: PubMed
    Score: 0.006
  7. ggbio: an R package for extending the grammar of graphics for genomic data. Genome Biol. 2012 Aug 31; 13(8):R77.
    View in: PubMed
    Score: 0.006
  8. HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures. Carcinogenesis. 2021 02 11; 42(1):14-20.
    View in: PubMed
    Score: 0.003
  9. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2021 04 15; 28(4):503-514.e12.
    View in: PubMed
    Score: 0.003
  10. Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile. Mod Pathol. 2021 02; 34(2):264-279.
    View in: PubMed
    Score: 0.003
  11. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. Nat Commun. 2020 06 12; 11(1):2971.
    View in: PubMed
    Score: 0.003
  12. Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Adv. 2020 05 12; 4(9):1859-1866.
    View in: PubMed
    Score: 0.003
  13. MET Alterations Are a Recurring and Actionable Resistance Mechanism in ALK-Positive Lung Cancer. Clin Cancer Res. 2020 06 01; 26(11):2535-2545.
    View in: PubMed
    Score: 0.003
  14. A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol. 2020 02 10; 21(1):33.
    View in: PubMed
    Score: 0.003
  15. Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2020 02 05; 11(1):729.
    View in: PubMed
    Score: 0.003
  16. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2020 02; 578(7793):102-111.
    View in: PubMed
    Score: 0.003
  17. Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers. Sci Adv. 2020 01; 6(5):eaay2611.
    View in: PubMed
    Score: 0.002
  18. Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification. Cancer Discov. 2020 02; 10(2):306-325.
    View in: PubMed
    Score: 0.002
  19. Passenger Hotspot Mutations in Cancer. Cancer Cell. 2019 09 16; 36(3):288-301.e14.
    View in: PubMed
    Score: 0.002
  20. GTP-Dependent Formation of Multimeric G-Quadruplexes. ACS Chem Biol. 2019 09 20; 14(9):1951-1963.
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    Score: 0.002
  21. Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing. J Biol Chem. 2019 10 11; 294(41):15037-15051.
    View in: PubMed
    Score: 0.002
  22. Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer. Cancer Discov. 2019 10; 9(10):1372-1387.
    View in: PubMed
    Score: 0.002
  23. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019 06 27; 178(1):160-175.e27.
    View in: PubMed
    Score: 0.002
  24. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019 05; 569(7757):503-508.
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    Score: 0.002
  25. A Code of Mono-phosphorylation Modulates the Function of RB. Mol Cell. 2019 03 07; 73(5):985-1000.e6.
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    Score: 0.002
  26. Increasing body mass index and abdominal subcutaneous fat thickness are associated with increased skin-to-epidural space distance in pregnant women. Int J Obstet Anesth. 2019 05; 38:59-65.
    View in: PubMed
    Score: 0.002
  27. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 2018 08 09; 174(4):803-817.e16.
    View in: PubMed
    Score: 0.002
  28. Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair. Nat Commun. 2018 05 01; 9(1):1746.
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    Score: 0.002
  29. Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer. Cancer Discov. 2018 06; 8(6):714-729.
    View in: PubMed
    Score: 0.002
  30. Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. Cell. 2018 04 05; 173(2):291-304.e6.
    View in: PubMed
    Score: 0.002
  31. Comprehensive Characterization of Cancer Driver Genes and Mutations. Cell. 2018 04 05; 173(2):371-385.e18.
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    Score: 0.002
  32. SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors. Nat Med. 2018 05; 24(4):512-517.
    View in: PubMed
    Score: 0.002
  33. Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2467-2472.
    View in: PubMed
    Score: 0.002
  34. NetSig: network-based discovery from cancer genomes. Nat Methods. 2018 01; 15(1):61-66.
    View in: PubMed
    Score: 0.002
  35. Analysis of somatic microsatellite indels identifies driver events in human tumors. Nat Biotechnol. 2017 Oct; 35(10):951-959.
    View in: PubMed
    Score: 0.002
  36. A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Nat Genet. 2017 Oct; 49(10):1476-1486.
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    Score: 0.002
  37. APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition. Cancer Res. 2017 09 01; 77(17):4567-4578.
    View in: PubMed
    Score: 0.002
  38. Recurrent and functional regulatory mutations in breast cancer. Nature. 2017 07 06; 547(7661):55-60.
    View in: PubMed
    Score: 0.002
  39. Exploring the Effects of Using an Oral Appliance to Reduce Movement Dysfunction in an Individual With Parkinson Disease: A Single-Subject Design Study. J Neurol Phys Ther. 2017 Jan; 41(1):52-58.
    View in: PubMed
    Score: 0.002
  40. Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias. Nat Genet. 2017 01; 49(1):10-16.
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    Score: 0.002
  41. Altered biochemical specificity of G-quadruplexes with mutated tetrads. Nucleic Acids Res. 2016 12 15; 44(22):10789-10803.
    View in: PubMed
    Score: 0.002
  42. Influenza immunization rates for Louisiana Medicare beneficiaries (1993-1995): a need for interventions. J La State Med Soc. 1996 Oct; 148(10):423-9.
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    Score: 0.002
  43. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. Nat Genet. 2016 08; 48(8):848-55.
    View in: PubMed
    Score: 0.002
  44. Prediction and Quantification of Splice Events from RNA-Seq Data. PLoS One. 2016; 11(5):e0156132.
    View in: PubMed
    Score: 0.002
  45. Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome. EBioMedicine. 2016 Jul; 9:257-277.
    View in: PubMed
    Score: 0.002
  46. Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nat Genet. 2016 06; 48(6):607-16.
    View in: PubMed
    Score: 0.002
  47. Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles. Cancer Discov. 2016 07; 6(7):714-26.
    View in: PubMed
    Score: 0.002
  48. Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair. Cell. 2016 Jan 28; 164(3):538-49.
    View in: PubMed
    Score: 0.002
  49. Complex regulation of ADAR-mediated RNA-editing across tissues. BMC Genomics. 2016 Jan 15; 17:61.
    View in: PubMed
    Score: 0.002
  50. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun. 2015 Dec 07; 6:8866.
    View in: PubMed
    Score: 0.002
  51. Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes. Nat Biotechnol. 2015 Nov; 33(11):1152-8.
    View in: PubMed
    Score: 0.002
  52. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177.
    View in: PubMed
    Score: 0.002
  53. Comprehensive assessment of cancer missense mutation clustering in protein structures. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):E5486-95.
    View in: PubMed
    Score: 0.002
  54. Paired exome analysis of Barrett's esophagus and adenocarcinoma. Nat Genet. 2015 Sep; 47(9):1047-55.
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    Score: 0.002
  55. SomaticSignatures: inferring mutational signatures from single-nucleotide variants. Bioinformatics. 2015 Nov 15; 31(22):3673-5.
    View in: PubMed
    Score: 0.002
  56. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med. 2015 Jun 25; 372(26):2481-98.
    View in: PubMed
    Score: 0.002
  57. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. 2015 May 07; 161(4):933-45.
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    Score: 0.002
  58. Oncotator: cancer variant annotation tool. Hum Mutat. 2015 Apr; 36(4):E2423-9.
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    Score: 0.002
  59. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature. 2015 Feb 19; 518(7539):360-364.
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    Score: 0.002
  60. Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women. Int J Cancer. 2015 Aug 15; 137(4):776-83.
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    Score: 0.002
  61. Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014 Dec 24; 2:167.
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    Score: 0.002
  62. Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat Genet. 2015 Feb; 47(2):106-14.
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    Score: 0.002
  63. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5564-73.
    View in: PubMed
    Score: 0.002
  64. RNF43 is frequently mutated in colorectal and endometrial cancers. Nat Genet. 2014 Dec; 46(12):1264-6.
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    Score: 0.002
  65. The genomic landscape of pediatric Ewing sarcoma. Cancer Discov. 2014 Nov; 4(11):1326-41.
    View in: PubMed
    Score: 0.002
  66. Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma. Cancer Discov. 2014 Oct; 4(10):1140-53.
    View in: PubMed
    Score: 0.002
  67. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res. 2015 Feb 01; 21(3):632-41.
    View in: PubMed
    Score: 0.002
  68. Assessing the clinical utility of cancer genomic and proteomic data across tumor types. Nat Biotechnol. 2014 Jul; 32(7):644-52.
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    Score: 0.002
  69. Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. Mol Cancer. 2014 Jun 04; 13:141.
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    Score: 0.002
  70. Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat Med. 2014 Jun; 20(6):682-8.
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    Score: 0.002
  71. Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing. Genome Res. 2014 Jul; 24(7):1053-63.
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    Score: 0.002
  72. Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. Nat Commun. 2014 May 08; 5:3830.
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    Score: 0.002
  73. A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events. PLoS One. 2014; 9(1):e87361.
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    Score: 0.002
  74. Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell. 2014 Jan 13; 25(1):91-101.
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    Score: 0.002
  75. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet. 2014 Feb; 46(2):161-5.
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    Score: 0.002
  76. Peribulbar versus retrobulbar anesthesia. Int Ophthalmol Clin. 1994; 34(3):33-42.
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    Score: 0.002
  77. Landscape of genomic alterations in cervical carcinomas. Nature. 2014 Feb 20; 506(7488):371-5.
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    Score: 0.002
  78. Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair. Nat Biotechnol. 2014 Jan; 32(1):71-5.
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    Score: 0.002
  79. Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients. J Clin Oncol. 2014 Jan 10; 32(2):121-8.
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    Score: 0.002
  80. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6.
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    Score: 0.002
  81. Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep. 2013 Oct 02; 3:2650.
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    Score: 0.002
  82. Pan-cancer patterns of somatic copy number alteration. Nat Genet. 2013 Oct; 45(10):1134-40.
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    Score: 0.002
  83. Monitoring the health-related labelling of foods and non-alcoholic beverages in retail settings. Obes Rev. 2013 Oct; 14 Suppl 1:70-81.
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    Score: 0.002
  84. Identification of driver genes in hepatocellular carcinoma by exome sequencing. Hepatology. 2013 Nov; 58(5):1693-702.
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    Score: 0.002
  85. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet. 2013 Sep; 45(9):970-6.
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    Score: 0.002
  86. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8188-93.
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    Score: 0.002
  87. Punctuated evolution of prostate cancer genomes. Cell. 2013 Apr 25; 153(3):666-77.
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    Score: 0.002
  88. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet. 2013 May; 45(5):478-86.
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    Score: 0.002
  89. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013 Feb 14; 152(4):714-26.
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    Score: 0.002
  90. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol. 2013 Mar; 31(3):213-9.
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    Score: 0.002
  91. The genetic landscape of high-risk neuroblastoma. Nat Genet. 2013 Mar; 45(3):279-84.
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    Score: 0.002
  92. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. J Clin Invest. 2013 Jan; 123(1):517-25.
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    Score: 0.002
  93. Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability. Genome Res. 2013 Feb; 23(2):228-35.
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    Score: 0.002
  94. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell. 2012 Sep 14; 150(6):1107-20.
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    Score: 0.001
  95. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. 2012 Aug 02; 488(7409):106-10.
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    Score: 0.001
  96. A landscape of driver mutations in melanoma. Cell. 2012 Jul 20; 150(2):251-63.
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    Score: 0.001
  97. A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest. 2012 Aug; 122(8):2983-8.
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    Score: 0.001
  98. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 2012 Jun 20; 486(7403):405-9.
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    Score: 0.001
  99. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet. 2012 May 20; 44(6):685-9.
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    Score: 0.001
  100. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 2012 May 09; 485(7399):502-6.
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    Score: 0.001
  101. Is image registration of fluorodeoxyglucose-positron emission tomography/computed tomography for head-and-neck cancer treatment planning necessary? Int J Radiat Oncol Biol Phys. 2012 Nov 01; 84(3):748-54.
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    Score: 0.001
  102. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3879-84.
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    Score: 0.001
  103. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011 Dec 29; 365(26):2497-506.
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    Score: 0.001
  104. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet. 2011 Sep 04; 43(10):964-968.
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    Score: 0.001
  105. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26; 333(6046):1157-60.
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    Score: 0.001
  106. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011 Jun; 1(1):78-89.
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    Score: 0.001
  107. Initial genome sequencing and analysis of multiple myeloma. Nature. 2011 Mar 24; 471(7339):467-72.
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    Score: 0.001
  108. The genomic complexity of primary human prostate cancer. Nature. 2011 Feb 10; 470(7333):214-20.
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    Score: 0.001
  109. The landscape of somatic copy-number alteration across human cancers. Nature. 2010 Feb 18; 463(7283):899-905.
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    Score: 0.001
  110. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010 Jan 19; 17(1):98-110.
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    Score: 0.001
  111. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008 Oct 23; 455(7216):1069-75.
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    Score: 0.001
  112. Impact of audit on preventive measures. Br Med J (Clin Res Ed). 1983 Dec 17; 287(6408):1852-4.
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    Score: 0.001
  113. An evaluation of recorded information about preventive measures in 38 practices. J R Coll Gen Pract. 1981 Oct; 31(231):615-20.
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    Score: 0.001
  114. Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1. Am J Med Genet. 2000 Nov 13; 95(2):108-17.
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    Score: 0.001
  115. Systematic review of the epidemiological evidence on Helicobacter pylori infection and nonulcer or uninvestigated dyspepsia. Arch Intern Med. 2000 Apr 24; 160(8):1192-8.
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    Score: 0.001
  116. Comparison of powder and aerosol formulations of salmeterol in the treatment of asthma. Ann Allergy Asthma Immunol. 2000 Mar; 84(3):334-40.
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    Score: 0.001
  117. Renal hypertension. Diagnosis and surgical treatment. N Engl J Med. 1967 Mar 02; 276(9):479-85.
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    Score: 0.000
  118. Developmental chest wall defects. Ann Thorac Surg. 1966 May; 2(3):384-98.
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    Score: 0.000
  119. List size, screening methods, and other characteristics of practices in relation to preventive care. Br Med J (Clin Res Ed). 1985 Sep 28; 291(6499):869-72.
    View in: PubMed
    Score: 0.000
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.