Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Michael S. Lawrence, Ph.D.

Concepts

This page shows the publications Michael Lawrence has written about Genome, Human.
Connection Strength

1.207
  1. Huge whole-genome study of human metastatic cancers. Nature. 2019 11; 575(7781):60-61.
    View in: PubMed
    Score: 0.310
  2. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2020 02; 578(7793):102-111.
    View in: PubMed
    Score: 0.079
  3. Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nat Genet. 2016 06; 48(6):607-16.
    View in: PubMed
    Score: 0.061
  4. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5564-73.
    View in: PubMed
    Score: 0.055
  5. Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing. Genome Res. 2014 Jul; 24(7):1053-63.
    View in: PubMed
    Score: 0.053
  6. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 2014 Jan 23; 505(7484):495-501.
    View in: PubMed
    Score: 0.052
  7. Landscape of genomic alterations in cervical carcinomas. Nature. 2014 Feb 20; 506(7488):371-5.
    View in: PubMed
    Score: 0.052
  8. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Jul 11; 499(7457):214-218.
    View in: PubMed
    Score: 0.050
  9. Punctuated evolution of prostate cancer genomes. Cell. 2013 Apr 25; 153(3):666-77.
    View in: PubMed
    Score: 0.049
  10. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet. 2013 May; 45(5):478-86.
    View in: PubMed
    Score: 0.049
  11. ggbio: an R package for extending the grammar of graphics for genomic data. Genome Biol. 2012 Aug 31; 13(8):R77.
    View in: PubMed
    Score: 0.047
  12. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. 2012 Aug 02; 488(7409):106-10.
    View in: PubMed
    Score: 0.047
  13. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 2012 May 09; 485(7399):502-6.
    View in: PubMed
    Score: 0.046
  14. Initial genome sequencing and analysis of multiple myeloma. Nature. 2011 Mar 24; 471(7339):467-72.
    View in: PubMed
    Score: 0.043
  15. The genomic complexity of primary human prostate cancer. Nature. 2011 Feb 10; 470(7333):214-20.
    View in: PubMed
    Score: 0.042
  16. Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2020 02 05; 11(1):729.
    View in: PubMed
    Score: 0.020
  17. Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair. Nat Commun. 2018 05 01; 9(1):1746.
    View in: PubMed
    Score: 0.017
  18. Altered biochemical specificity of G-quadruplexes with mutated tetrads. Nucleic Acids Res. 2016 12 15; 44(22):10789-10803.
    View in: PubMed
    Score: 0.016
  19. Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair. Cell. 2016 Jan 28; 164(3):538-49.
    View in: PubMed
    Score: 0.015
  20. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun. 2015 Dec 07; 6:8866.
    View in: PubMed
    Score: 0.015
  21. SomaticSignatures: inferring mutational signatures from single-nucleotide variants. Bioinformatics. 2015 Nov 15; 31(22):3673-5.
    View in: PubMed
    Score: 0.014
  22. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature. 2015 Feb 19; 518(7539):360-364.
    View in: PubMed
    Score: 0.014
  23. Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair. Nat Biotechnol. 2014 Jan; 32(1):71-5.
    View in: PubMed
    Score: 0.013
  24. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet. 2013 Sep; 45(9):970-6.
    View in: PubMed
    Score: 0.013
  25. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol. 2013 Mar; 31(3):213-9.
    View in: PubMed
    Score: 0.012
  26. The genetic landscape of high-risk neuroblastoma. Nat Genet. 2013 Mar; 45(3):279-84.
    View in: PubMed
    Score: 0.012
  27. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet. 2011 Sep 04; 43(10):964-968.
    View in: PubMed
    Score: 0.011
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.