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Rachel Bennett, Ph.D.

Title
Institution
Department
Address

Biography
Washington University in St. Louis, St. Louis, MOPh.D.05/2014Neuroscience
Arizona State University, Tempe, AZB.S.12/2007Molecular Biology

Overview
Research scientist with expertise in cell biology of the nervous system and in vivo imaging using advanced microscopy tools. Research areas include processes of neurodegerenation with a focus on pathological tau and vascular changes in Alzheimer's disease and traumatic brain injury.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99AG061259 (BENNETT, RACHEL ELISE) Jul 1, 2019 - Jun 30, 2021
    NIH/NIA
    Assessing the Functional Consequences of Tau-Related Vasculature Changes using In Vivo Imaging
    Role: Principal Investigator
  2. F31NS076047 (BENNETT, RACHEL ELISE) Mar 1, 2012 - Feb 28, 2014
    NIH/NINDS
    Contribution of Microglia to Axonal Injury following Repetitive Concussion in Mou
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT. Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathol Commun. 2020 Oct 19; 8(1):168. PMID: 33076986.
    Citations:    Fields:    
  2. Bryant AG, Hu M, Carlyle BC, Arnold SE, Frosch MP, Das S, Hyman BT, Bennett RE. Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. Front Neurol. 2020; 11:575953. PMID: 33041998.
    Citations:    
  3. Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathol Commun. 2020 08 18; 8(1):137. PMID: 32811565.
    Citations:    Fields:    
  4. Benetatos J, Bennett RE, Evans HT, Ellis SA, Hyman BT, Bodea LG, Götz J. PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy. Acta Neuropathol. 2020 07; 140(1):7-24. PMID: 32236736.
    Citations:    Fields:    
  5. Marquié M, Agüero C, Amaral AC, Villarejo-Galende A, Ramanan P, Chong MST, Sáez-Calveras N, Bennett RE, Verwer EE, Kim SJW, Dhaynaut M, Alvarez VE, Johnson KA, McKee AC, Frosch MP, Gómez-Isla T. [18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series. Acta Neuropathol Commun. 2019 10 28; 7(1):164. PMID: 31661038.
    Citations:    Fields:    Translation:Humans
  6. Hanlon KS, Meltzer JC, Buzhdygan T, Cheng MJ, Sena-Esteves M, Bennett RE, Sullivan TP, Razmpour R, Gong Y, Ng C, Nammour J, Maiz D, Dujardin S, Ramirez SH, Hudry E, Maguire CA. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression. Mol Ther Methods Clin Dev. 2019 Dec 13; 15:320-332. PMID: 31788496.
    Citations: 2     
  7. Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT. Experimental evidence for the age dependence of tau protein spread in the brain. Sci Adv. 2019 06; 5(6):eaaw6404. PMID: 31249873.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2019 Jan 16; 101(2):349. PMID: 30653936.
    Citations: 3     Fields:    
  9. Bennett RE, Bryant A, Hu M, Robbins AB, Hopp SC, Hyman BT. Partial reduction of microglia does not affect tau pathology in aged mice. J Neuroinflammation. 2018 Nov 09; 15(1):311. PMID: 30413160.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018 09 05; 99(5):925-940.e7. PMID: 30189209.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  11. DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BT. Tau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo. Brain. 2018 07 01; 141(7):2194-2212. PMID: 29733334.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. Tau protein liquid-liquid phase separation can initiate tau aggregation. EMBO J. 2018 04 03; 37(7). PMID: 29472250.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  13. Bennett RE, Robbins AB, Hu M, Cao X, Betensky RA, Clark T, Das S, Hyman BT. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):E1289-E1298. PMID: 29358399.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  14. Wegmann S, Bennett RE, Amaral AS, Hyman BT. Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. Methods Cell Biol. 2017; 141:307-322. PMID: 28882310.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Nicholls SB, DeVos SL, Commins C, Nobuhara C, Bennett RE, Corjuc DL, Maury E, Eftekharzadeh B, Akingbade O, Fan Z, Roe AD, Takeda S, Wegmann S, Hyman BT. Characterization of TauC3 antibody and demonstration of its potential to block tau propagation. PLoS One. 2017; 12(5):e0177914. PMID: 28531180.
    Citations: 6     Fields:    Translation:HumansCells
  16. Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. Enhanced Tau Aggregation in the Presence of Amyloid ß. Am J Pathol. 2017 Jul; 187(7):1601-1612. PMID: 28500862.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  17. Bennett RE, Brody DL. Array tomography for the detection of non-dilated, injured axons in traumatic brain injury. J Neurosci Methods. 2015 Apr 30; 245:25-36. PMID: 25687633.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Brody DL, Benetatos J, Bennett RE, Klemenhagen KC, Mac Donald CL. The pathophysiology of repetitive concussive traumatic brain injury in experimental models; new developments and open questions. Mol Cell Neurosci. 2015 May; 66(Pt B):91-8. PMID: 25684677.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  19. Bennett RE, Brody DL. Acute reduction of microglia does not alter axonal injury in a mouse model of repetitive concussive traumatic brain injury. J Neurotrauma. 2014 Oct 01; 31(19):1647-63. PMID: 24797413.
    Citations: 22     Fields:    Translation:AnimalsCells
  20. Bennett RE, Esparza TJ, Lewis HA, Kim E, Mac Donald CL, Sullivan PM, Brody DL. Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-ß immunoreactivity after traumatic brain injury in 3xTG-AD mice. J Neuropathol Exp Neurol. 2013 May; 72(5):396-403. PMID: 23584199.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  21. Bennett RE, Mac Donald CL, Brody DL. Diffusion tensor imaging detects axonal injury in a mouse model of repetitive closed-skull traumatic brain injury. Neurosci Lett. 2012 Apr 04; 513(2):160-5. PMID: 22343314.
    Citations: 57     Fields:    Translation:AnimalsCells
  22. Shitaka Y, Tran HT, Bennett RE, Sanchez L, Levy MA, Dikranian K, Brody DL. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity. J Neuropathol Exp Neurol. 2011 Jul; 70(7):551-67. PMID: 21666502.
    Citations: 122     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.