Harvard Catalyst Profiles

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Xingbin Ai, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL154549 (AI, XINGBIN) Jul 9, 2021 - Jun 30, 2025
    Age-related mechanisms of T helper 2 memory in the early lung
    Role: Principal Investigator
  2. R01HL132991 (AI, XINGBIN) May 1, 2017 - Apr 30, 2021
    Development of PNEC innervation and neuroplasticity after early life insult
    Role: Principal Investigator
  3. R01HL116163 (FINE, ALAN FINE) Aug 5, 2013 - May 31, 2019
    The Fetal Lung Mesothelial Differentiation Program
    Role: Principal Investigator
  4. R21HL112619 (FINE, ALAN FINE) Jan 1, 2012 - Dec 31, 2015
    Identifying Molecular Phenotype of Normal and Asthmatic Bronchial Smooth Muscle
    Role: Principal Investigator
  5. R01AG034939 (AI, XINGBIN) Mar 15, 2010 - Jan 31, 2016
    Identification of Sulfs as therapeutic targets for the treatment of age-impaired skeletal muscle regeneration
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Krishnamoorthy N, Walker KH, Brüggemann TR, Tavares LP, Smith EW, Nijmeh J, Bai Y, Ai X, Cagnina RE, Duvall MG, Lehoczky JA, Levy BD. The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation. Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2):e2206480120. PMID: 36595677.
    Citations:    Fields:    Translation:AnimalsCells
  2. Amonkar GM, Wagner R, Bankoti K, Shui JE, Ai X, Lerou PH. Primary culture of tracheal aspirate-derived human airway basal stem cells. STAR Protoc. 2022 06 17; 3(2):101390. PMID: 35600918; PMCID: PMC9117922.
    Citations:    Fields:    Translation:HumansCells
  3. Bai Y, Ai X. Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle. J Vis Exp. 2022 05 05; (183). PMID: 35604150.
    Citations:    Fields:    Translation:AnimalsCells
  4. Bai Y, Guedes AGP, Krishnan R, Ai X. CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility. J Allergy Clin Immunol. 2022 05; 149(5):1643-1654.e8. PMID: 34800431; PMCID: PMC9081122.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Matute JD, Finander B, Pepin D, Ai X, Smith NP, Li JZ, Edlow AG, Villani AC, Lerou PH, Kalish BT. Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation. Pediatr Res. 2022 04; 91(5):1090-1098. PMID: 34750520; PMCID: PMC8573077.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  6. Wang W, Ai X. Primary culture of immature, naïve mouse CD4+ T cells. STAR Protoc. 2021 09 17; 2(3):100756. PMID: 34430922; PMCID: PMC8369069.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347. PMID: 34260916; PMCID: PMC8346236.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  8. Shui JE, Wang W, Liu H, Stepanova A, Liao G, Qian J, Ai X, Ten V, Lu J, Cardoso WV. Prematurity alters the progenitor cell program of the upper respiratory tract of neonates. Sci Rep. 2021 05 24; 11(1):10799. PMID: 34031475; PMCID: PMC8144386.
    Citations:    Fields:    Translation:HumansCells
  9. Jiang M, Fang Y, Li Y, Huang H, Wei Z, Gao X, Sung HK, Hu J, Qiang L, Ruan J, Chen Q, Jiang D, Whitsett JA, Ai X, Que J. VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway. Dev Cell. 2021 06 07; 56(11):1646-1660.e5. PMID: 34010630; PMCID: PMC8187331.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 04 20; 35(3):109011. PMID: 33882306; PMCID: PMC8140387.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Lu RA, Zeki AA, Ram-Mohan S, Nguyen N, Bai Y, Chmiel K, Pecic S, Ai X, Krishnan R, Ghosh CC. Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins. Front Pharmacol. 2020; 11:469. PMID: 32435188; PMCID: PMC7218099.
  12. Li G, Cohen JA, Martines C, Ram-Mohan S, Brain JD, Krishnan R, Ai X, Bai Y. Preserving Airway Smooth Muscle Contraction in Precision-Cut Lung Slices. Sci Rep. 2020 04 15; 10(1):6480. PMID: 32296115.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Ram-Mohan S, Bai Y, Schaible N, Ehrlicher AJ, Cook DP, Suki B, Stoltz DA, Solway J, Ai X, Krishnan R. Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2020 02 01; 318(2):L323-L330. PMID: 31774304.
    Citations: 2     Fields:    Translation:HumansAnimals
  14. Wang W, Cohen JA, Wallrapp A, Trieu KG, Barrios J, Shao F, Krishnamoorthy N, Kuchroo VK, Jones MR, Fine A, Bai Y, Ai X. Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. Immunity. 2019 12 17; 51(6):1102-1118.e7. PMID: 31757673.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  15. Levy BD, Abdulnour RE, Tavares A, Brüggemann TR, Norris PC, Bai Y, Ai X, Serhan CN. Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes. J Allergy Clin Immunol. 2020 01; 145(1):335-344. PMID: 31622689; PMCID: PMC7308163.
    Citations: 14     Fields:    Translation:HumansAnimals
  16. Barrios J, Kho AT, Aven L, Mitchel JA, Park JA, Randell SH, Miller LA, Tantisira KG, Ai X. Pulmonary Neuroendocrine Cells Secrete ?-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models. Am J Respir Cell Mol Biol. 2019 06; 60(6):687-694. PMID: 30571139; PMCID: PMC6543741.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  17. Stump B, Shrestha S, Lamattina AM, Louis PH, Cho W, Perrella MA, Ai X, Rosas IO, Wagner FF, Priolo C, Astin J, El-Chemaly S. Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways. PLoS One. 2019; 14(4):e0213831. PMID: 30964887; PMCID: PMC6456176.
    Citations: 3     Fields:    Translation:HumansCells
  18. Qiu H, Shi S, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-Hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Nat Methods. 2018 11; 15(11):889-899. PMID: 30377379; PMCID: PMC6214364.
    Citations: 31     Fields:    Translation:AnimalsCells
  19. Barrios J, Ai X. Neurotrophins in Asthma. Curr Allergy Asthma Rep. 2018 02 16; 18(2):10. PMID: 29453651.
    Citations: 10     Fields:    Translation:HumansAnimals
  20. Buttrick TS, Wang W, Yung C, Trieu KG, Patel K, Khoury SJ, Ai X, Elyaman W. Foxo1 Promotes Th9 Cell Differentiation and Airway Allergy. Sci Rep. 2018 01 16; 8(1):818. PMID: 29339772.
    Citations: 12     Fields:    Translation:AnimalsCells
  21. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876. PMID: 28920925; PMCID: PMC5617666.
    Citations: 7     Fields:    Translation:AnimalsCells
  22. Patel KR, Bai Y, Trieu KG, Barrios J, Ai X. Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma. FASEB J. 2017 10; 31(10):4335-4346. PMID: 28619712; PMCID: PMC5602904.
    Citations: 9     Fields:    Translation:Animals
  23. Jiang Z, Knudsen NH, Wang G, Qiu W, Naing ZZC, Bai Y, Ai X, Lee CH, Zhou X. Genetic Control of Fatty Acid ß-Oxidation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2017 06; 56(6):738-748. PMID: 28199134.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  24. Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 09; 31(9):4117-4128. PMID: 28566470; PMCID: PMC5572694.
    Citations: 24     Fields:    Translation:AnimalsCells
  25. Bailey E, Cui Y, Casey A, Stoler JM, Ai X, Ma D, Handin R, Sliz P, Vargas SO, El-Chemaly SY. Pulmonary Vasculopathy Associated with FIGF Gene Mutation. Am J Pathol. 2017 Jan; 187(1):25-32. PMID: 27846380; PMCID: PMC5225300.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Bai Y, Krishnamoorthy N, Patel KR, Rosas I, Sanderson MJ, Ai X. Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking. A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists. Am J Respir Cell Mol Biol. 2016 05; 54(5):656-63. PMID: 26550921; PMCID: PMC4942196.
    Citations: 22     Fields:    Translation:HumansCells
  27. Abdulnour RE, Sham HP, Douda DN, Colas RA, Dalli J, Bai Y, Ai X, Serhan CN, Levy BD. Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. Mucosal Immunol. 2016 09; 9(5):1278-87. PMID: 26647716; PMCID: PMC5107310.
    Citations: 48     Fields:    Translation:AnimalsCells
  28. Jiang Z, Cushing L, Ai X, Lü J. miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):273-83. PMID: 24617895.
    Citations: 27     Fields:    Translation:AnimalsCells
  29. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81. PMID: 24313705.
    Citations: 22     Fields:    Translation:AnimalsCells
  30. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907. PMID: 24221086.
    Citations: 31     Fields:    Translation:Animals
  31. Dixit R, Ai X, Fine A. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development. 2013 Nov; 140(21):4398-406. PMID: 24130328.
    Citations: 52     Fields:    Translation:AnimalsCells
  32. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469. PMID: 24040256.
    Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  33. Aven L, Ai X. Mechanisms of respiratory innervation during embryonic development. Organogenesis. 2013 Jul-Sep; 9(3):194-8. PMID: 23974176.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  34. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
    Citations: 38     Fields:    Translation:Humans
  35. Tran TH, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012 Sep 21; 287(39):32651-64. PMID: 22865881.
    Citations: 26     Fields:    Translation:AnimalsCells
  36. Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17; 287(8):5979-87. PMID: 22187428.
    Citations: 3     Fields:    Translation:AnimalsCells
  37. Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K, Lu J, Fine A, Ai X. A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci. 2011 Oct 26; 31(43):15407-15. PMID: 22031887.
    Citations: 50     Fields:    Translation:AnimalsCells
  38. Schumacher VA, Schlötzer-Schrehardt U, Karumanchi SA, Shi X, Zaia J, Jeruschke S, Zhang D, Pavenstädt H, Pavenstaedt H, Drenckhan A, Amann K, Ng C, Hartwig S, Ng KH, Ho J, Kreidberg JA, Taglienti M, Royer-Pokora B, Ai X. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol. 2011 Jul; 22(7):1286-96. PMID: 21719793.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  39. Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87. PMID: 21536678.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  40. Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61. PMID: 20855470.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  41. Langsdorf A, Radzikinas K, Kroten A, Jain S, Ai X. Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):293-301. PMID: 20139349.
    Citations: 18     Fields:    Translation:AnimalsCells
  42. Ambasta RK, Ai X, Emerson CP. Quail Sulf1 function requires asparagine-linked glycosylation. J Biol Chem. 2007 Nov 23; 282(47):34492-9. PMID: 17855356.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  43. Langsdorf A, Do AT, Kusche-Gullberg M, Emerson CP, Ai X. Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration. Dev Biol. 2007 Nov 15; 311(2):464-77. PMID: 17920055.
    Citations: 31     Fields:    Translation:AnimalsCells
  44. Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development. 2007 Sep; 134(18):3327-38. PMID: 17720696.
    Citations: 89     Fields:    Translation:AnimalsCells
  45. Danesin C, Agius E, Escalas N, Ai X, Emerson C, Cochard P, Soula C. Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord. J Neurosci. 2006 May 10; 26(19):5037-48. PMID: 16687495; PMCID: PMC6674256.
    Citations: 60     Fields:    Translation:AnimalsCells
  46. Riobó NA, Lu K, Ai X, Haines GM, Emerson CP. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4505-10. PMID: 16537363; PMCID: PMC1450201.
    Citations: 219     Fields:    Translation:AnimalsCells
  47. Ai X, Do AT, Kusche-Gullberg M, Lindahl U, Lu K, Emerson CP. Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2. J Biol Chem. 2006 Feb 24; 281(8):4969-76. PMID: 16377625.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  48. Braquart-Varnier C, Danesin C, Clouscard-Martinato C, Agius E, Escalas N, Benazeraf B, Ai X, Emerson C, Cochard P, Soula C. A subtractive approach to characterize genes with regionalized expression in the gliogenic ventral neuroepithelium: identification of chick sulfatase 1 as a new oligodendrocyte lineage gene. Mol Cell Neurosci. 2004 Apr; 25(4):612-28. PMID: 15080891.
    Citations: 11     Fields:    Translation:AnimalsCells
  49. Wang S, Ai X, Freeman SD, Pownall ME, Lu Q, Kessler DS, Emerson CP. QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4833-8. PMID: 15051888; PMCID: PMC387334.
    Citations: 87     Fields:    Translation:AnimalsCells
  50. Ai X, Do AT, Lozynska O, Kusche-Gullberg M, Lindahl U, Emerson CP. QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling. J Cell Biol. 2003 Jul 21; 162(2):341-51. PMID: 12860968; PMCID: PMC2172803.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.