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Johann Bergholz, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bergholz JS, Wang Q, Kabraji S, Zhao JJ. Integrating Immunotherapy and Targeted Therapy in Cancer Treatment: Mechanistic Insights and Clinical Implications. Clin Cancer Res. 2020 11 01; 26(21):5557-5566. PMID: 32576627.
    Citations: 1     Fields:    
  2. Fassl A, Brain C, Abu-Remaileh M, Stukan I, Butter D, Stepien P, Feit AS, Bergholz J, Michowski W, Otto T, Sheng Q, Loo A, Michael W, Tiedt R, DeAngelis C, Schiff R, Jiang B, Jovanovic B, Nowak K, Ericsson M, Cameron M, Gray N, Dillon D, Zhao JJ, Sabatini DM, Jeselsohn R, Brown M, Polyak K, Sicinski P. Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Sci Adv. 2020 Jun; 6(25):eabb2210. PMID: 32704543.
    Citations: 6     Fields:    
  3. Berrueta L, Bergholz J, Munoz D, Muskaj I, Badger GJ, Shukla A, Kim HJ, Zhao JJ, Langevin HM. Author Correction: Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model. Sci Rep. 2018 Nov 16; 8(1):17226. PMID: 30443010.
    Citations:    Fields:    
  4. Berrueta L, Bergholz J, Munoz D, Muskaj I, Badger GJ, Shukla A, Kim HJ, Zhao JJ, Langevin HM. Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model. Sci Rep. 2018 05 18; 8(1):7864. PMID: 29777149.
    Citations: 9     Fields:    Translation:Animals
  5. Bergholz JS, Roberts TM, Zhao JJ. Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer. J Clin Oncol. 2018 05 01; 36(13):1339-1342. PMID: 29517943.
    Citations: 3     Fields:    Translation:Humans
  6. Jeselsohn R, Bergholz JS, Pun M, Cornwell M, Liu W, Nardone A, Xiao T, Li W, Qiu X, Buchwalter G, Feiglin A, Abell-Hart K, Fei T, Rao P, Long H, Kwiatkowski N, Zhang T, Gray N, Melchers D, Houtman R, Liu XS, Cohen O, Wagle N, Winer EP, Zhao J, Brown M. Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations. Cancer Cell. 2018 02 12; 33(2):173-186.e5. PMID: 29438694.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  7. Yi Y, Gao L, Wu M, Ao J, Zhang C, Wang X, Lin M, Bergholz J, Zhang Y, Xiao ZJ. Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase. J Cancer. 2017; 8(13):2636-2642. PMID: 28900501.
    Citations: 4     
  8. Han A, Li J, Li Y, Wang Y, Bergholz J, Zhang Y, Li C, Xiao ZX. Correction: p63a modulates c-Myc activity via direct interaction and regulation of MM1 protein stability. Oncotarget. 2017 06 13; 8(24):39935. PMID: 28629113.
    Citations: 1     Fields:    
  9. Hu L, Liang S, Chen H, Lv T, Wu J, Chen D, Wu M, Sun S, Zhang H, You H, Ji H, Zhang Y, Bergholz J, Xiao ZJ. ?Np63a is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis. Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E3964-E3973. PMID: 28468801.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  10. Yi Y, Chen D, Ao J, Sun S, Wu M, Li X, Bergholz J, Zhang Y, Xiao ZX. Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ?Np63a Protein Expression and Inhibits Cancer Cell Viability. J Biol Chem. 2017 Mar 31; 292(13):5253-5261. PMID: 28193839.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  11. He H, Wang C, Dai Q, Li F, Bergholz J, Li Z, Li Q, Xiao ZX. p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem Cell Reports. 2016 12 13; 7(6):1087-1098. PMID: 27866875.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  12. Jiang X, Niu M, Chen D, Chen J, Cao Y, Li X, Ying H, Bergholz J, Zhang Y, Xiao ZX. Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF. Oncotarget. 2016 Aug 02; 7(31):49180-49193. PMID: 27341132.
    Citations: 3     Fields:    Translation:HumansCells
  13. Han A, Li J, Li Y, Wang Y, Bergholz J, Zhang Y, Li C, Xiao ZhX. p63a modulates c-Myc activity via direct interaction and regulation of MM1 protein stability. Oncotarget. 2016 Jul 12; 7(28):44277-44287. PMID: 27341130.
    Citations: 7     Fields:    Translation:HumansCells
  14. Hu L, Zhang H, Bergholz J, Sun S, Xiao ZX. MDM2/MDMX: Master negative regulators for p53 and RB. Mol Cell Oncol. 2016 Mar; 3(2):e1106635. PMID: 27308631.
    Citations: 4     
  15. Walsh EM, Niu M, Bergholz J, Xiao ZX. Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation. Biochem Biophys Res Commun. 2015 May 29; 461(2):293-9. PMID: 25871794.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Zhang H, Hu L, Qiu W, Deng T, Zhang Y, Bergholz J, Xiao ZX. MDMX exerts its oncogenic activity via suppression of retinoblastoma protein. Oncogene. 2015 Oct 29; 34(44):5560-9. PMID: 25703327.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  17. Tong Y, Ying H, Liu R, Li L, Bergholz J, Xiao ZX. Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage. Cell Death Dis. 2015 Feb 12; 6:e1640. PMID: 25675300.
    Citations: 11     Fields:    Translation:HumansCells
  18. Wu J, Liang S, Bergholz J, He H, Walsh EM, Zhang Y, Xiao ZX. ?Np63a activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell Death Dis. 2014 Jun 05; 5:e1280. PMID: 24901051.
    Citations: 26     Fields:    Translation:Humans
  19. Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao ZX. Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell. 2014 Aug; 13(4):669-78. PMID: 25070626.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  20. Du W, Yi Y, Zhang H, Bergholz J, Wu J, Ying H, Zhang Y, Xiao ZX. Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. PLoS One. 2013; 8(4):e63179. PMID: 23638184.
    Citations: 5     Fields:    Translation:HumansCells
  21. Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Xiao ZX. ?Np63a regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene. 2014 Jan 09; 33(2):212-24. PMID: 23246965.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  22. Bergholz J, Xiao ZX. Role of p63 in Development, Tumorigenesis and Cancer Progression. Cancer Microenviron. 2012 Dec; 5(3):311-22. PMID: 22847008.
    Citations: 36     
  23. Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX. TAp63 is a transcriptional target of NF-kappaB. J Cell Biochem. 2010 Mar 01; 109(4):702-10. PMID: 20052674.
    Citations: 8     Fields:    Translation:HumansCells
  24. Sungur C, Miller S, Bergholz J, Hoye RC, Brisbois RG, Overvoorde P. The small molecule 2-furylacrylic acid inhibits auxin-mediated responses in Arabidopsis thaliana. Plant Cell Physiol. 2007 Dec; 48(12):1693-701. PMID: 17942448.
    Citations: 4     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.