Harvard Catalyst Profiles

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Elizabeth Anne Proctor, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F31AG039266 (PROCTOR, ELIZABETH A) Dec 1, 2010 - Nov 30, 2013
    NIH/NIA
    Identification of drug leads targeting SOD1 dissociation for the treatment of ALS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR. Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model. J Thromb Haemost. 2020 Aug; 18(8):1900-1910. PMID: 32367690.
    Citations:    
  2. Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020 Jul 07; 32(1):44-55.e6. PMID: 32402267.
    Citations:    
  3. Nesterova DS, Midya V, Zacharia BE, Proctor EA, Lee SY, Stetson LC, Lathia JD, Rubin JB, Waite KA, Berens ME, Barnholtz-Sloan JS, Connor JR. Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa001. PMID: 32642673.
    Citations:    
  4. Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS. Fatty Acid Metabolites Combine with Reduced ß Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Cell Metab. 2019 09 03; 30(3):447-461.e5. PMID: 31378464.
    Citations:    
  5. Proctor EA, Mowrey DD, Dokholyan NV. ß-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology. PLoS Comput Biol. 2019 07; 15(7):e1007225. PMID: 31323035.
    Citations:    
  6. Brubaker DK, Proctor EA, Haigis KM, Lauffenburger DA. Computational translation of genomic responses from experimental model systems to humans. PLoS Comput Biol. 2019 01; 15(1):e1006286. PMID: 30629591.
    Citations:    Fields:    
  7. Belkina AC, Starchenko A, Drake KA, Proctor EA, Pihl RMF, Olson A, Lauffenburger DA, Lin N, Snyder-Cappione JE. Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging. Front Immunol. 2018; 9:2783. PMID: 30568654.
    Citations:    
  8. Wang C, Aleksandrov AA, Yang Z, Forouhar F, Proctor EA, Kota P, An J, Kaplan A, Khazanov N, Boël G, Stockwell BR, Senderowitz H, Dokholyan NV, Riordan JR, Brouillette CG, Hunt JF. Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2018 11 16; 293(46):17685-17704. PMID: 29903914.
    Citations:    Fields:    
  9. Fleury M, Belkina AC, Proctor EA, Zammitti C, Simms RW, Lauffenburger DA, Snyder-Cappione JE, Lafyatis R, Dooms H. Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis. Arthritis Rheumatol. 2018 04; 70(4):566-577. PMID: 29245183.
    Citations: 1     Fields:    
  10. Liebenberg LJ, Masson L, Arnold KB, Mckinnon LR, Werner L, Proctor E, Archary D, Mansoor LE, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS. Genital-Systemic Chemokine Gradients and the Risk of HIV Acquisition in Women. . 2017 Mar 01; 74(3):318-325. PMID: 28187085.
    Citations: 3     Fields:    
  11. Nicholas D, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA, Nikolajczyk BS. Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis. PLoS One. 2017; 12(2):e0170975. PMID: 28178278.
    Citations:    Fields:    Translation:HumansCells
  12. Liebenberg LJ, Masson L, Arnold KB, Mckinnon LR, Werner L, Proctor E, Archary D, Mansoor LE, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS. Genital - Systemic chemokine gradients and the risk of HIV acquisition in women. J Acquir Immune Defic Syndr. 2016 Oct 24. PMID: 27787345.
    Citations:    Fields:    
  13. Fay JM, Zhu C, Proctor EA, Tao Y, Cui W, Ke H, Dokholyan NV. A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation. Structure. 2016 11 01; 24(11):1898-1906. PMID: 27667694.
    Citations: 5     Fields:    Translation:HumansCells
  14. Hadi-Alijanvand H, Proctor EA, Ding F, Dokholyan NV, Moosavi-Movahedi AA. A hidden aggregation-prone structure in the heart of hypoxia inducible factor prolyl hydroxylase. Proteins. 2016 May; 84(5):611-23. PMID: 26868435.
    Citations:    Fields:    Translation:HumansCells
  15. Proctor EA, Fee L, Tao Y, Redler RL, Fay JM, Zhang Y, Lv Z, Mercer IP, Deshmukh M, Lyubchenko YL, Dokholyan NV. Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):614-9. PMID: 26719414.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Proctor EA, Dokholyan NV. Applications of Discrete Molecular Dynamics in biology and medicine. Curr Opin Struct Biol. 2016 Apr; 37:9-13. PMID: 26638022.
    Citations: 2     Fields:    Translation:Cells
  17. Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Sci Rep. 2015 Nov 13; 5:16622. PMID: 26564777.
    Citations: 7     Fields:    Translation:HumansCells
  18. Proctor EA, Kota P, Aleksandrov AA, He L, Riordan JR, Dokholyan NV. Rational Coupled Dynamics Network Manipulation Rescues Disease-Relevant Mutant Cystic Fibrosis Transmembrane Conductance Regulator. Chem Sci. 2015 Feb; 6(2):1237-1246. PMID: 25685315.
    Citations: 7     
  19. Hasan SS, Proctor EA, Yamashita E, Dokholyan NV, Cramer WA. Traffic within the cytochrome b6f lipoprotein complex: gating of the quinone portal. Biophys J. 2014 Oct 07; 107(7):1620-8. PMID: 25296314.
    Citations: 3     Fields:    Translation:Cells
  20. Nedd S, Redler RL, Proctor EA, Dokholyan NV, Alexandrova AN. Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive. J Mol Biol. 2014 Dec 12; 426(24):4112-4124. PMID: 25083917.
    Citations: 4     Fields:    Translation:Cells
  21. Redler RL, Shirvanyants D, Dagliyan O, Ding F, Kim DN, Kota P, Proctor EA, Ramachandran S, Tandon A, Dokholyan NV. Computational approaches to understanding protein aggregation in neurodegeneration. J Mol Cell Biol. 2014 Apr; 6(2):104-15. PMID: 24620031.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  22. Barison N, Cendron L, Loconte V, Proctor EA, Dokholyan NV, Zanotti G. Protein HP1028 from the human pathogen Helicobacter pylori belongs to the lipocalin family. Acta Crystallogr D Biol Crystallogr. 2013 Aug; 69(Pt 8):1387-94. PMID: 23897462.
    Citations: 1     Fields:    Translation:Cells
  23. Proctor EA, Kota P, Demarest SJ, Caravella JA, Dokholyan NV. Highly covarying residues have a functional role in antibody constant domains. Proteins. 2013 May; 81(5):884-95. PMID: 23280585.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Proctor EA, Kota P, Demarest SJ, Caravella JA, Dokholyan NV. Metric to distinguish closely related domain families using sequence information. J Mol Biol. 2013 Feb 08; 425(3):475-8. PMID: 23219465.
    Citations:    Fields:    Translation:Cells
  25. Hadi-Alijanvand H, Proctor EA, Goliaei B, Dokholyan NV, Moosavi-Movahedi AA. Thermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approaches. PLoS One. 2012; 7(10):e47061. PMID: 23077544.
    Citations:    Fields:    Translation:HumansCells
  26. Proctor EA, Yin S, Tropsha A, Dokholyan NV. Discrete molecular dynamics distinguishes nativelike binding poses from decoys in difficult targets. Biophys J. 2012 Jan 04; 102(1):144-51. PMID: 22225808.
    Citations: 9     Fields:    Translation:Cells
  27. Dagliyan O, Proctor EA, D'Auria KM, Ding F, Dokholyan NV. Structural and dynamic determinants of protein-peptide recognition. Structure. 2011 Dec 07; 19(12):1837-45. PMID: 22153506.
    Citations: 25     Fields:    Translation:Cells
  28. Redler RL, Wilcox KC, Proctor EA, Fee L, Caplow M, Dokholyan NV. Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers. Biochemistry. 2011 Aug 16; 50(32):7057-66. PMID: 21739997.
    Citations: 23     Fields:    Translation:Cells
  29. Proctor EA, Ding F, Dokholyan NV. Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase. J Mol Biol. 2011 May 06; 408(3):555-67. PMID: 21396374.
    Citations: 14     Fields:    Translation:HumansCells
  30. Hadi-Alijanvand H, Rouhani M, Proctor EA, Dokholyan NV, Moosavi-Movahedi AA. A folding pathway-dependent score to recognize membrane proteins. PLoS One. 2011 Mar 01; 6(3):e16778. PMID: 21390303.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  31. Yin S, Proctor EA, Lugovskoy AA, Dokholyan NV. Fast screening of protein surfaces using geometric invariant fingerprints. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16622-6. PMID: 19805347.
    Citations: 11     Fields:    Translation:Cells
  32. Seu KJ, Pandey AP, Haque F, Proctor EA, Ribbe AE, Hovis JS. Effect of surface treatment on diffusion and domain formation in supported lipid bilayers. Biophys J. 2007 Apr 01; 92(7):2445-50. PMID: 17218468.
    Citations: 24     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.