Title Assistant Professor of Medicine Institution Dana-Farber Cancer Institute Address Dana-Farber Cancer Institute Medical Oncology 450 Brookline Ave Boston MA 02215
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Biography
Stanford University | BA | 06/1999 | Economics |
Stanford University | MS | 03/2001 | Computer Science |
Johns Hopkins School of Public Health | MPH | 06/2010 | Biostatistics and Epidemiology |
Johns Hopkins University School of Medicine | MD | 05/2011 | Medicine |
Johns Hopkins Hospital | | 06/2014 | Internal Medicine Residency |
Dana-Farber Cancer Institute/Harvard CancerCare | | 08/2018 | Hematology/Oncology Fellowship |
2002 - 2004
Amazon.com Innovation Awards (x3), US Patent 7,536,322
2010
JHSPH MPH Capstone Award
2012
JHUSOM Medical Student Teaching Award
2015
John R. Svenson Fellowship in Genomic Research
2018
Damon Runyon Physician-Scientist Training Grant
2018
ASCO Young Investigator Award
2018
SITC Cancer Immunotherapy Translational Fellowship
2020
ASCI Young Physician-Scientist

Overview
Dr. Liu is a medical oncologist and computational biologist at the Dana-Farber Cancer Institute and Brigham & Women's Hospital, with a background in computer science, biostatistics, and epidemiology. The Liu lab bridges multiple disciplines, and operates at the intersection of clinical oncology, cancer biology, and computational biology, developing computational approaches to dissect therapeutic resistance and susceptibility to chemo-, targeted-, and immuno-therapies in patient tumors. A focus is on development of rigorous methodologies using statistics and machine-learning techniques applied to specific clinical contexts to discover biologically relevant molecular correlates of response/resistance (for novel therapeutic targets and rational combination therapies) and build clinically relevant predictive models of therapeutic response/resistance. Examples of past work include
(1) development of predictive models of response to PD-1 immune checkpoint blockade in metastatic melanoma integrating clinical, genomic, and transcriptomic features (Liu, Schilling et al Nat Medicine 2019)
(2) validation of mutations in ERCC2 (gene necessary for nucleotide excision DNA repair) as marker of susceptibility to cisplatin-based chemotherapy in muscle-invasive bladder cancer, leading to clinical trials in progress (Liu et al JAMA Onc 2016; Li et al Clin Canc Res 2019)
(3) discovering a novel class of chromatin-modulating gene mutations as drivers of oncogenesis in a standardized meta-analysis of over 1000 prostate cancers (Armenia*, Wankowic*, Liu* et al Nat Gen 2018) *co-first author
(4) de novo discovery of a cisplatin-induced mutational signature in pre- and post-cisplatin treated bladder cancers, later validated in platinum-treated lung and ovarian cancers (Liu et al Nat Comm 2017)
(5) in the same cohort, discovery of intratumoral heterogeneity and multiple gene mutations as molecular correlates of survival and therapeutic resistance (Liu et al Nat Comm 2017)
(6) dissection of immunological correlates to a signature of mismatch repair deficiency in prostate cancer (Nava Rodrigues*, Rescigno*, Liu* et al JCI 2018) *co-first author
(7) elucidating evolution of therapeutic resistance and tumor heterogeneity from 23 tumor samples from a melanoma delayed exceptional responder to sequential immune checkpoint blockade collected over 6 years (Liu et al, under review)
Two broad areas of inquiry exist in the lab:
1. Development of parsimonious, biologically-informed predictive models utilizing statistical and machine learning approaches and integrating clinical and molecular data to guide clinical management.
2. Mapping of clinical tumor heterogeneity and evolution of resistance and metastasis, using longitudinally collected tumor samples from patients over time, treatments, development of resistance, and from different metastatic sites to develop insight into drivers of resistance and metastasis.
Current list of publications:
https://www.ncbi.nlm.nih.gov/myncbi/david.liu.4/bibliography/public/

Research
The research activities and funding listed below are automatically derived from
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(David Liu)
Jul 1, 2020 - Jun 30, 2023
Doris Duke Charitable Foundation
Dissecting Tumor and Immune Evolution in Stage III Melanoma
Role: Principal Investigator
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(BOLAND, GENEVIEVE)
Mar 1, 2019 - Feb 28, 2021
Melanoma Research Foundation
Characterizing the Role of the Hippo Pathway during Melanoma Immunotherapy
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K08CA234458
(LIU, DAVID)
Sep 18, 2018 - Aug 31, 2023
Dissecting Therapeutic Resistance and Progression in Metastatic Melanoma Through Clinical Computational Oncology
Role: Principal Investigator
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(LIU, DAVID)
Jul 1, 2018 - Jun 30, 2021
Society for Immunotherapy of Cancer - BMS
Dissecting Differential Response to Immunotherapy in Melanoma through Clinical Computational Oncology
Role: Principal Investigator
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(LIU, DAVID)
Jul 1, 2018 - Jun 30, 2019
Conquer Cancer Foundation/ASCO
Dissecting Response and Resistance to Immune and Targeted Therapies in Metastatic Melanoma Through Clinical Computational Oncology
Role: Principal Investigator

Bibliographic
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