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profileTobias Wolfgang Giessen, Ph.D.

TitleResearch Fellow in Systems Biology (INT)
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology WAB 536
200 Longwood Ave
Boston MA 02115
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Giessen TW, Silver PA. Widespread distribution of encapsulin nanocompartments reveals functional diversity. Nat Microbiol. 2017 Mar 06; 2:17029. PMID: 28263314.
    View in: PubMed
  2. Giessen TW, Silver PA. Engineering carbon fixation with artificial protein organelles. Curr Opin Biotechnol. 2017 Jan 23; 46:42-50. PMID: 28126670.
    View in: PubMed
  3. Liu X, Lopez PA, Giessen TW, Giles M, Way JC, Silver PA. Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution. Sci Rep. 2016 Nov 29; 6:38019. PMID: 27897245.
    View in: PubMed
  4. Giessen TW, Silver PA. Microbes use encapsulin protein organelles to sequester toxic reactions. bioRxiv. 2016.
  5. Liu X, Lopez P, Giessen TW, Giles M, Way J, Silver PA. Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution. Scientific Reports. 2016.
  6. Giessen TW, Silver PA. A Catalytic Nanoreactor Based on in Vivo Encapsulation of Multiple Enzymes in an Engineered Protein Nanocompartment. Chembiochem. 2016 Oct 17; 17(20):1931-1935. PMID: 27504846.
    View in: PubMed
  7. Giessen TW, Silver PA. Converting a Natural Protein Compartment into a Nanofactory for the Size-Constrained Synthesis of Antimicrobial Silver Nanoparticles. ACS Synth Biol. 2016 12 16; 5(12):1497-1504. PMID: 27276075.
    View in: PubMed
  8. Giessen TW. Encapsulins: microbial nanocompartments with applications in biomedicine, nanobiotechnology and materials science. Curr Opin Chem Biol. 2016 Oct; 34:1-10. PMID: 27232770.
    View in: PubMed
  9. Giessen TW, Silver PA. Encapsulation as a Strategy for the Design of Biological Compartmentalization. J Mol Biol. 2016 Feb 27; 428(5 Pt B):916-27. PMID: 26403362.
    View in: PubMed
  10. Giessen TW, Marahiel MA. Rational and combinatorial tailoring of bioactive cyclic dipeptides. Front Microbiol. 2015; 6:785. PMID: 26284060; PMCID: PMC4519757.
  11. Giessen TW, Altegoer F, Nebel AJ, Steinbach RM, Bange G, Marahiel MA. A synthetic adenylation-domain-based tRNA-aminoacylation catalyst. Angew Chem Int Ed Engl. 2015 Feb 16; 54(8):2492-6. PMID: 25583137.
    View in: PubMed
  12. Giessen TW, Marahiel MA. The tRNA-dependent biosynthesis of modified cyclic dipeptides. Int J Mol Sci. 2014 Aug 21; 15(8):14610-31. PMID: 25196600; PMCID: PMC4159871.
  13. Giessen TW, von Tesmar AM, Marahiel MA. Insights into the generation of structural diversity in a tRNA-dependent pathway for highly modified bioactive cyclic dipeptides. Chem Biol. 2013 Jun 20; 20(6):828-38. PMID: 23790493.
    View in: PubMed
  14. Giessen TW, von Tesmar AM, Marahiel MA. A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines. Biochemistry. 2013 Jun 18; 52(24):4274-83. PMID: 23705796.
    View in: PubMed
  15. Fl├╝he L, Burghaus O, Wieckowski BM, Giessen TW, Linne U, Marahiel MA. Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor. J Am Chem Soc. 2013 Jan 23; 135(3):959-62. PMID: 23282011.
    View in: PubMed
  16. Giessen TW, Franke KB, Knappe TA, Kraas FI, Bosello M, Xie X, Linne U, Marahiel MA. Isolation, structure elucidation, and biosynthesis of an unusual hydroxamic acid ester-containing siderophore from Actinosynnema mirum. J Nat Prod. 2012 May 25; 75(5):905-14. PMID: 22578145.
    View in: PubMed
  17. Bosello M, Mielcarek A, Giessen TW, Marahiel MA. An enzymatic pathway for the biosynthesis of the formylhydroxyornithine required for rhodochelin iron coordination. Biochemistry. 2012 Apr 10; 51(14):3059-66. PMID: 22439765.
    View in: PubMed
  18. Giessen TW, Marahiel MA. Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity. FEBS Lett. 2012 Jul 16; 586(15):2065-75. PMID: 22273582.
    View in: PubMed
  19. Kraas FI, Giessen TW, Marahiel MA. Exploring the mechanism of lipid transfer during biosynthesis of the acidic lipopeptide antibiotic CDA. FEBS Lett. 2012 Feb 03; 586(3):283-8. PMID: 22245678.
    View in: PubMed
  20. Giessen TW, Kraas FI, Marahiel MA. A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry. 2011 Jun 28; 50(25):5680-92. PMID: 21612226.
    View in: PubMed
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