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Carmen Messerlian, Ph.D.

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Biography
2014 - 2017
Post-Doctoral Fellowship Award, Canadian Institutes of Health Research
2014 - 2016
Bisby Fellowship Prize, Canadian Institutes of Health Research
2012 - 2013
James O. Maria Meadows Fellowship, McGill University, Faculty of Medicine
2008 - 2012
Doctoral Research Award, Canadian Institutes of Health Research
2008 - 2009
Provost Graduate Fellowship, McGill University, Department of Epidemiology
2019 - 2020
SM Mentor of the Year Award
2017 - 2018
Outstanding Faculty Teaching Award

Overview
I am a passionate and curious scientist committed to understanding how the world around us impacts human reproductive health and development. My research at the Harvard Chan School of Public Health is focused on examining the extent to which environmental exposures affect a couple's ability to achieve conception, maintain pregnancy, and deliver healthy offspring. I investigate both paternal and maternal exposures to phthalates, phenols, and other emerging chemicals and their mixtures on ovarian reserve, time to pregnancy, pregnancy loss, preterm birth, birth weight, placental parameters, and child development outcomes. I have specialized in reproductive, perinatal and pediatric epidemiology, infertility, assisted reproduction, and causal methods with perinatal application. I also actively collaborate with leading bench scientists to conduct translational research to examine the underlying biological pathways that may lead to infertility and adverse pregnancy and child health outcomes.

As the Director of the Scientific Early Life Environmental Health & Development (SEED) Program, my team works to understand how the environment impacts reproductive health from the very earliest stages of life - starting from the formation of gametes and embryos - to the birth of infants and throughout childhood. My goal is to generate impactful science on the role of the environment on early life health and development across the reproductive life course. My mission is to use cutting-edge evidence to inform clinical practice, translate science into policy action, and implement prevention strategies to improve the health of mothers, fathers, and their children.

Prior to joining the Harvard Chan School, I worked as a pediatric nurse at the Montreal Children's Hospital and as a maternal-child public health consultant for local, state, and national governments. I am enthusiastic teacher and mentor, and a lifelong learner. I strive to learn and grow from every person I encounter; my motivation is always one of understanding and giving, equally in my pursuit of science as in humanity.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (MESSERLIAN, CARMEN) Nov 22, 2020 - May 22, 2022
    The Dean’s Fund for Scientific Advancement Activation Award
    The Preconception Intervention for Health Reproduction (PIPER) Study
    Role: Principal Investigator
  2. R01ES031657 (MESSERLIAN, CARMEN) May 11, 2020 - Feb 28, 2025
    NIH
    The Impact of Maternal and Paternal Preconception Perfluoroalkyl Substance (PFAS) Exposure on Reproductive and Perinatal Outcomes
    Role: Principal Investigator
  3. P42ES027706-03 (LOHMANN/GRANDJEAN) Apr 1, 2017 - Mar 31, 2022
    NIEHS
    STEEP Project 2: Sources, Transport, Exposure and Effects of Perfluoroalkyl Substances (STEEP) Center
    Role Description: NIEHS Superfund Research Program
    Role: Co-Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu C, Messerlian C, Chen YJ, Mustieles V, Huang LL, Sun Y, Deng YL, Cheng YH, Liu J, Liu AM, Lu WQ, Wang YX. Trimester-specific associations of maternal exposure to disinfection by-products, oxidative stress, and neonatal neurobehavioral development. Environ Int. 2021 Aug 25; 157:106838. PMID: 34450548.
    Citations:    Fields:    
  2. Zhang Y, Mustieles V, Williams PL, Yland J, Souter I, Braun JM, Calafat AM, Hauser R, Messerlian C. Prenatal urinary concentrations of phenols and risk of preterm birth: exploring windows of vulnerability. Fertil Steril. 2021 Sep; 116(3):820-832. PMID: 34238571.
    Citations:    Fields:    
  3. Sun Y, Chen C, Mustieles V, Wang L, Zhang Y, Wang YX, Messerlian C. Association of Blood Trihalomethane Concentrations with Risk of All-Cause and Cause-Specific Mortality in U.S. Adults: A Prospective Cohort Study. Environ Sci Technol. 2021 07 06; 55(13):9043-9051. PMID: 34152769.
    Citations:    Fields:    Translation:HumansPHPublic Health
  4. Blomberg AJ, Shih YH, Messerlian C, Jørgensen LH, Weihe P, Grandjean P. Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort. Environ Res. 2021 09; 200:111400. PMID: 34081971.
    Citations:    Fields:    
  5. Zhang Y, Mustieles V, Williams PL, Wylie BJ, Souter I, Calafat AM, Demokritou M, Lee A, Vagios S, Hauser R, Messerlian C. Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth. Environ Int. 2021 06; 151:106440. PMID: 33640694.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  6. Wang LM, Luo D, Li X, Hu LQ, Chen JX, Tu ZZ, Sun B, Chen HG, Liu L, Yu M, Li YP, Pan A, Messerlian C, Mei SR, Wang YX. Temporal variability of organophosphate flame retardant metabolites in spot, first morning, and 24-h urine samples among healthy adults. Environ Res. 2021 05; 196:110373. PMID: 33190805.
    Citations:    Fields:    Translation:Humans
  7. Sun Y, Wang YX, Liu C, Chen YJ, Lu WQ, Messerlian C. Trimester-Specific Blood Trihalomethane and Urinary Haloacetic Acid Concentrations and Adverse Birth Outcomes: Identifying Windows of Vulnerability during Pregnancy. Environ Health Perspect. 2020 10; 128(10):107001. PMID: 33026246.
    Citations:    Fields:    Translation:HumansPHPublic Health
  8. Qiu X, Fong KC, Shi L, Papatheodorou S, Di Q, Just A, Kosheleva A, Messerlian C, Schwartz JD. Prenatal exposure to particulate air pollution and gestational age at delivery in Massachusetts neonates 2001-2015: A perspective of causal modeling and health disparities. Environ Epidemiol. 2020 Oct; 4(5):e113. PMID: 33154990.
    Citations:    
  9. Jones NM, McDonnell M, Sparer-Fine E, Rosner B, Dennerlein JT, Kales S, Messerlian C. Associations Between the Breakroom Built Environment, Worker Health Habits, and Worker Health Outcomes: A Pilot Study Among Public Transit Rail Operators. J Occup Environ Med. 2020 08; 62(8):e398-e406. PMID: 32404827.
    Citations:    Fields:    Translation:Humans
  10. Zhang Y, Mustieles V, Yland J, Braun JM, Williams PL, Attaman JA, Ford JB, Calafat AM, Hauser R, Messerlian C. Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes With Preterm Birth. JAMA Netw Open. 2020 04 01; 3(4):e202159. PMID: 32259265.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  11. Mustieles V, Zhang Y, Yland J, Braun JM, Williams PL, Wylie BJ, Attaman JA, Ford JB, Azevedo A, Calafat AM, Hauser R, Messerlian C. Maternal and paternal preconception exposure to phenols and preterm birth. Environ Int. 2020 04; 137:105523. PMID: 32120140.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  12. Sévère M, Ng P, Messerlian C, Andersen J, Buckley D, Fehlings D, Kirton A, Koclas L, Pigeon N, Van Rensburg E, Wood E, Shevell M, Oskoui M. Congenital Malformations in Children With Cerebral Palsy: Is Prematurity Protective? Pediatr Neurol. 2020 07; 108:70-76. PMID: 32386793.
    Citations:    Fields:    Translation:Humans
  13. Liu C, Wang YX, Chen YJ, Sun Y, Huang LL, Cheng YH, Liu EN, Lu WQ, Messerlian C. Blood and urinary biomarkers of prenatal exposure to disinfection byproducts and oxidative stress: A repeated measurement analysis. Environ Int. 2020 04; 137:105518. PMID: 32018134.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  14. Skarha J, Messerlian C, Bellinger D, Mínguez-Alarcón L, Romano ME, Ford JB, Williams PL, Calafat AM, Hauser R, Braun JM. Parental preconception and prenatal urinary bisphenol A and paraben concentrations and child behavior. Environ Epidemiol. 2020 Feb; 4(1):e082. PMID: 33778347.
    Citations:    
  15. Chen HG, Sun B, Chen YJ, Chavarro JE, Hu SH, Xiong CL, Pan A, Meng TQ, Wang YX, Messerlian C. Sleep duration and quality in relation to semen quality in healthy men screened as potential sperm donors. Environ Int. 2020 02; 135:105368. PMID: 31830732.
    Citations: 1     Fields:    Translation:Humans
  16. Sun B, Messerlian C, Sun ZH, Duan P, Chen HG, Chen YJ, Wang P, Wang L, Meng TQ, Wang Q, Arvizu M, Chavarro JE, Wang YX, Xiong CL, Pan A. Physical activity and sedentary time in relation to semen quality in healthy men screened as potential sperm donors. Hum Reprod. 2019 12 01; 34(12):2330-2339. PMID: 31858122.
    Citations: 3     Fields:    Translation:Humans
  17. Chen YJ, Duan P, Meng TQ, Chen HG, Chavarro JE, Xiong CL, Pan A, Wang YX, Lu WQ, Messerlian C. Associations of blood trihalomethanes with semen quality among 1199 healthy Chinese men screened as potential sperm donors. Environ Int. 2020 01; 134:105335. PMID: 31783240.
    Citations:    Fields:    Translation:HumansCells
  18. Yland J, Messerlian C, Mínguez-Alarcón L, Ford JB, Hauser R, Williams PL. Methodological approaches to analyzing IVF data with multiple cycles. Hum Reprod. 2019 03 01; 34(3):549-557. PMID: 30576499.
    Citations: 6     Fields:    Translation:Humans
  19. Mínguez-Alarcón L, Messerlian C, Bellavia A, Gaskins AJ, Chiu YH, Ford JB, Azevedo AR, Petrozza JC, Calafat AM, Hauser R, Williams PL. Urinary concentrations of bisphenol A, parabens and phthalate metabolite mixtures in relation to reproductive success among women undergoing in vitro fertilization. Environ Int. 2019 05; 126:355-362. PMID: 30826614.
    Citations: 16     Fields:    Translation:Humans
  20. Mustieles V, Mínguez-Alarcón L, Christou G, Ford JB, Dimitriadis I, Hauser R, Souter I, Messerlian C. Placental weight in relation to maternal and paternal preconception and prenatal urinary phthalate metabolite concentrations among subfertile couples. Environ Res. 2019 02; 169:272-279. PMID: 30497002.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  21. Oskoui M, Messerlian C. How socio-economic disadvantage modifies health outcomes in children with cerebral palsy. Dev Med Child Neurol. 2019 05; 61(5):509. PMID: 30444270.
    Citations:    Fields:    Translation:Humans
  22. Messerlian C, Williams PL, Mínguez-Alarcón L, Carignan CC, Ford JB, Butt CM, Meeker JD, Stapleton HM, Souter I, Hauser R. Organophosphate flame-retardant metabolite concentrations and pregnancy loss among women conceiving with assisted reproductive technology. Fertil Steril. 2018 11; 110(6):1137-1144.e1. PMID: 30396558.
    Citations: 6     Fields:    Translation:Humans
  23. Mínguez-Alarcón L, Gaskins AJ, Chiu YH, Messerlian C, Williams PL, Ford JB, Souter I, Hauser R, Chavarro JE. Type of underwear worn and markers of testicular function among men attending a fertility center. Hum Reprod. 2018 09 01; 33(9):1749-1756. PMID: 30102388.
    Citations: 8     Fields:    Translation:Humans
  24. Korevaar TIM, Mínguez-Alarcón L, Messerlian C, de Poortere RA, Williams PL, Broeren MA, Hauser R, Souter IC. Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care. Thyroid. 2018 10; 28(10):1349-1358. PMID: 29943679.
    Citations: 7     Fields:    Translation:Humans
  25. Mustieles V, Williams PL, Fernandez MF, Mínguez-Alarcón L, Ford JB, Calafat AM, Hauser R, Messerlian C. Maternal and paternal preconception exposure to bisphenols and size at birth. Hum Reprod. 2018 08 01; 33(8):1528-1537. PMID: 29982563.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  26. James-Todd TM, Chiu YH, Messerlian C, Mínguez-Alarcón L, Ford JB, Keller M, Petrozza J, Williams PL, Ye X, Calafat AM, Hauser R. Trimester-specific phthalate concentrations and glucose levels among women from a fertility clinic. Environ Health. 2018 06 14; 17(1):55. PMID: 29898728.
    Citations: 10     Fields:    Translation:Humans
  27. Messerlian C, Mustieles V, Minguez-Alarcon L, Ford JB, Calafat AM, Souter I, Williams PL, Hauser R. Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study. Environ Int. 2018 05; 114:60-68. PMID: 29477955.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  28. Chiu YH, Bellavia A, James-Todd T, Correia KF, Valeri L, Messerlian C, Ford JB, Mínguez-Alarcón L, Calafat AM, Hauser R, Williams PL. Evaluating effects of prenatal exposure to phthalate mixtures on birth weight: A comparison of three statistical approaches. Environ Int. 2018 04; 113:231-239. PMID: 29453090.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  29. Messerlian C, Williams PL, Ford JB, Chavarro JE, Mínguez-Alarcón L, Dadd R, Braun JM, Gaskins AJ, Meeker JD, James-Todd T, Chiu YH, Nassan FL, Souter I, Petrozza J, Keller M, Toth TL, Calafat AM, Hauser R. The Environment and Reproductive Health (EARTH) Study: A Prospective Preconception Cohort. Hum Reprod Open. 2018 Feb; 2018(2). PMID: 29888739.
    Citations: 32     
  30. Messerlian C, Basso O. Cohort studies in the context of obstetric and gynecologic research: a methodologic overview. Acta Obstet Gynecol Scand. 2018 Apr; 97(4):371-379. PMID: 29194569.
    Citations: 3     Fields:    Translation:Humans
  31. Messerlian C, Mustieles V, Wylie BJ, Ford JB, Keller M, Ye X, Calafat AM, Williams PL, Hauser R. Ultrasound gel as an unrecognized source of exposure to phthalates and phenols among pregnant women undergoing routine scan. Int J Hyg Environ Health. 2017 11; 220(8):1285-1294. PMID: 28830670.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  32. Messerlian C, Bellinger D, Mínguez-Alarcón L, Romano ME, Ford JB, Williams PL, Calafat AM, Hauser R, Braun JM. Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior. Environ Res. 2017 10; 158:720-728. PMID: 28738300.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  33. Messerlian C, Martinez RM, Hauser R, Baccarelli AA. 'Omics' and endocrine-disrupting chemicals - new paths forward. Nat Rev Endocrinol. 2017 Dec; 13(12):740-748. PMID: 28707677.
    Citations: 13     Fields:    Translation:HumansCellsPHPublic Health
  34. Messerlian C, Braun JM, Mínguez-Alarcón L, Williams PL, Ford JB, Mustieles V, Calafat AM, Souter I, Toth T, Hauser R. Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples. Environ Int. 2017 10; 107:55-64. PMID: 28666241.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  35. Mínguez-Alarcón L, Christou G, Messerlian C, Williams PL, Carignan CC, Souter I, Ford JB, Calafat AM, Hauser R. Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic. Fertil Steril. 2017 08; 108(2):312-319. PMID: 28583664.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  36. Messerlian C, Gaskins AJ. Epidemiologic Approaches for Studying Assisted Reproductive Technologies: Design, Methods, Analysis and Interpretation. Curr Epidemiol Rep. 2017 Jun; 4(2):124-132. PMID: 29034142.
    Citations: 7     
  37. Chiu YH, Mínguez-Alarcón L, Ford JB, Keller M, Seely EW, Messerlian C, Petrozza J, Williams PL, Ye X, Calafat AM, Hauser R, James-Todd T. Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic. J Clin Endocrinol Metab. 2017 04 01; 102(4):1350-1357. PMID: 28323984.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  38. Wylie BJ, Ae-Ngibise KA, Boamah EA, Mujtaba M, Messerlian C, Hauser R, Coull B, Calafat AM, Jack D, Kinney PL, Whyatt R, Owusu-Agyei S, Asante KP. Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study. Int J Environ Res Public Health. 2017 03 29; 14(4). PMID: 28353657.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  39. Braun JM, Messerlian C, Hauser R. Fathers Matter: Why It's Time to Consider the Impact of Paternal Environmental Exposures on Children's Health. Curr Epidemiol Rep. 2017 Mar; 4(1):46-55. PMID: 28848695.
    Citations: 22     
  40. Messerlian C, Wylie BJ, Mínguez-Alarcón L, Williams PL, Ford JB, Souter IC, Calafat AM, Hauser R. Urinary Concentrations of Phthalate Metabolites and Pregnancy Loss Among Women Conceiving with Medically Assisted Reproduction. Epidemiology. 2016 11; 27(6):879-88. PMID: 27299194.
    Citations: 20     Fields:    Translation:HumansPHPublic Health
  41. Mínguez-Alarcón L, Chiu YH, Messerlian C, Williams PL, Sabatini ME, Toth TL, Ford JB, Calafat AM, Hauser R. Urinary paraben concentrations and in vitro fertilization outcomes among women from a fertility clinic. Fertil Steril. 2016 Mar; 105(3):714-721. PMID: 26654974.
    Citations: 9     Fields:    Translation:Humans
  42. Messerlian C, Souter I, Gaskins AJ, Williams PL, Ford JB, Chiu YH, Calafat AM, Hauser R. Urinary phthalate metabolites and ovarian reserve among women seeking infertility care. Hum Reprod. 2016 Jan; 31(1):75-83. PMID: 26573529.
    Citations: 21     Fields:    Translation:Humans
  43. Oskoui M, Messerlian C, Blair A, Gamache P, Shevell M. Variation in cerebral palsy profile by socio-economic status. Dev Med Child Neurol. 2016 Feb; 58(2):160-6. PMID: 26010819.
    Citations: 7     Fields:    Translation:Humans
  44. Messerlian C, Platt RW, Ata B, Tan SL, Basso O. Do the causes of infertility play a direct role in the aetiology of preterm birth? Paediatr Perinat Epidemiol. 2015 Mar; 29(2):101-12. PMID: 25644431.
    Citations: 4     Fields:    Translation:Humans
  45. Messerlian C, Platt RW, Tan SL, Gagnon R, Basso O. Low-technology assisted reproduction and the risk of preterm birth in a hospital-based cohort. Fertil Steril. 2015 Jan; 103(1):81-8.e2. PMID: 25456793.
    Citations: 4     Fields:    Translation:Humans
  46. Dayan N, Pilote L, Opatrny L, Basso O, Messerlian C, El-Messidi A, Daskalopoulou SS. Combined impact of high body mass index and in vitro fertilization on preeclampsia risk: a hospital-based cohort study. Obesity (Silver Spring). 2015 Jan; 23(1):200-6. PMID: 25293810.
    Citations: 7     Fields:    Translation:Humans
  47. Messerlian C, Fishman JR. Less is more: improving outcomes and cutting costs to Quebec's assisted reproduction program. CMAJ. 2014 Apr 01; 186(6):405-6. PMID: 24591273.
    Citations:    Fields:    Translation:Humans
  48. Messerlian C, Maclagan L, Basso O. Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis. Hum Reprod. 2013 Jan; 28(1):125-37. PMID: 23042798.
    Citations: 26     Fields:    Translation:Humans
  49. Messerlian C, Gillespie M, Derevensky JL. Beyond drugs and alcohol: Including gambling in a high-risk behavioural framework. Paediatr Child Health. 2007 Mar; 12(3):199-204. PMID: 19030359.
    Citations: 8     
  50. Messerlian C, Derevensky J. Evaluating the role of social marketing campaigns to prevent youth gambling problems: a qualitative study. Can J Public Health. 2007 Mar-Apr; 98(2):101-4. PMID: 17441531.
    Citations: 1     Fields:    Translation:Humans
  51. Messerlian C, Derevensky J, Gupta R. Youth gambling problems: a public health perspective. Health Promot Int. 2005 Mar; 20(1):69-79. PMID: 15681591.
    Citations: 46     Fields:    Translation:Humans
  52. Messerlian C, Byrne AM, Derevensky JL. Gambling, youth and the internet: should we be concerned? Can Child Adolesc Psychiatr Rev. 2004 Feb; 13(1):3-6. PMID: 19030146.
    Citations: 19     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.