Harvard Catalyst Profiles

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Sara I Pai, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01CA240239 (PAI, SARA ISABEL) Sep 19, 2019 - Aug 31, 2024
    NIH/NCI
    Strategies to Overcome Immune Resistance in Head and Neck Cancers
    Role: Principal Investigator
  2. R01FD006341 (PAI, SARA ISABEL) Sep 1, 2019 - Aug 31, 2022
    FDA
    Phase II Trial of Anti-PD1 Therapy for HPV-associated Recurrent Respiratory Papillomatosis (IND#128874)
    Role: Principal Investigator
  3. R01DE025340 (PAI, SARA ISABEL) Jul 1, 2015 - Jun 30, 2018
    NIH/NIDCR
    Immune Checkpoints and HPV-associated Head and Neck Cancers
    Role: Principal Investigator
  4. R21CA176332 (PAI, SARA ISABEL) Apr 1, 2013 - Mar 31, 2015
    NIH/NCI
    Oral Biomarkers for HPV-related Head and Neck Cancer
    Role: Principal Investigator
  5. P50DE019032 (SIDRANSKY, DAVID) Jun 1, 2007 - Jul 31, 2017
    NIH/NIDCR
    Spore in Head and Neck Cancer
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wolkow N, Jakobiec FA, Afrogheh AH, Kidd M, Eagle RC, Pai SI, Faquin WC. PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications. Ophthalmic Plast Reconstr Surg. 2020 Sep/Oct; 36(5):444-450. PMID: 31990894.
    Citations:    
  2. Pai SI, Faquin WC, Sadow PM, Pittet MJ, Weissleder R. New technology on the horizon: Fast analytical screening technique FNA (FAST-FNA) enables rapid, multiplex biomarker analysis in head and neck cancers. Cancer Cytopathol. 2020 Aug 25. PMID: 32841527.
    Citations:    
  3. Mahmood U, Bang A, Chen YH, Mak RH, Lorch JH, Hanna GJ, Nishino M, Manuszak C, Thrash EM, Severgnini M, Sanborn M, Sridharan V, Margalit DN, Tishler RB, Busse PM, Willers H, Mamon HJ, Yoo HJ, Pai SI, Wirth LJ, Haddad RI, Chau NG, Schoenfeld JD. A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma. Int J Radiat Oncol Biol Phys. 2020 Aug 08. PMID: 32781104.
    Citations:    
  4. Wolkow N, Jakobiec FA, Afrogheh AH, Pai SI, Faquin WC. High Expression of PD-L1 and PD-L2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors. Am J Ophthalmol. 2020 Jul 27. PMID: 32730911.
    Citations:    
  5. Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nat Biotechnol. 2020 04; 38(4):420-425. PMID: 32042168.
    Citations:    
  6. Pai SI, Cesano A, Marincola FM. The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier. Cancer Treat Res. 2020; 180:173-195. PMID: 32215870.
    Citations:    
  7. Pai SI, Cohen EEW, Lin D, Fountzilas G, Kim ES, Mehlhorn H, Baste N, Clayburgh D, Lipworth L, Resteghini C, Shara N, Fujii T, Zhang J, Stokes M, Wang H, Twumasi-Ankrah P, Wildsmith S, Khaliq A, Melillo G, Shire N. SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. J Transl Med. 2019 12 26; 17(1):429. PMID: 31878938.
    Citations:    
  8. Pai SI, Marincola FM. Peripheral Circulating CD45RA-FOXP3hi T Regulatory (TReg) II Cells Provide a Window into the Activity of Intratumoral TReg Cells. Trends Cancer. 2020 Jan; 6(1):3-6. PMID: 31952778.
    Citations:    
  9. Banik G, Betts CB, Liudahl SM, Sivagnanam S, Kawashima R, Cotechini T, Larson W, Goecks J, Pai SI, Clayburgh DR, Tsujikawa T, Coussens LM. High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers. Methods Enzymol. 2020; 635:1-20. PMID: 32122539.
    Citations:    
  10. Ishida E, Lee J, Campbell JS, Chakravarty PD, Katori Y, Ogawa T, Johnson L, Mukhopadhyay A, Faquin WC, Lin DT, Wirth LJ, Pierce RH, Pai SI. Intratumoral delivery of an HPV vaccine elicits a broad anti-tumor immune response that translates into a potent anti-tumor effect in a preclinical murine HPV model. Cancer Immunol Immunother. 2019 Aug; 68(8):1273-1286. PMID: 31243491.
    Citations:    
  11. Pai SI, Faivre S, Licitra L, Machiels JP, Vermorken JB, Bruzzi P, Gruenwald V, Giglio RE, Leemans CR, Seiwert TY, Soulieres D. Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040). J Immunother Cancer. 2019 04 03; 7(1):96. PMID: 30944020.
    Citations:    
  12. Wolkow N, Jakobiec FA, Afrogheh AH, Eagle RC, Pai SI, Faquin WC. Programmed Cell Death 1 Ligand 1 and Programmed Cell Death 1 Ligand 2 Are Expressed in Conjunctival Invasive Squamous Cell Carcinoma: Therapeutic Implications. Am J Ophthalmol. 2019 04; 200:226-241. PMID: 30633894.
    Citations:    Fields:    
  13. Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-? and IL-12. Immunity. 2018 12 18; 49(6):1148-1161.e7. PMID: 30552023.
    Citations:    Fields:    
  14. Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54. PMID: 30029671.
    Citations:    Fields:    Translation:HumansAnimalsCells
  15. Rosenbaum MW, Gigliotti BJ, Pai SI, Parangi S, Wachtel H, Mino-Kenudson M, Gunda V, Faquin WC. PD-L1 and IDO1 Are Expressed in Poorly Differentiated Thyroid Carcinoma. Endocr Pathol. 2018 Mar; 29(1):59-67. PMID: 29372535.
    Citations: 1     Fields:    Translation:Humans
  16. Pai SI, Jack Lee J, Carey TE, Westra WH, Ferrone S, Moore C, Mosunjac MB, Shin DM, Ferris RL. HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers. Oral Oncol. 2018 02; 77:92-97. PMID: 29362132.
    Citations:    Fields:    
  17. Gleber-Netto FO, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, Kadara H, Zhang J, Wang J, William WN, Lee JJ, Nguyen ML, Pai SI, Walline HM, Shin DM, Ferris RL, Carey TE, Myers JN, Pickering CR. Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer. 2018 Jan 01; 124(1):84-94. PMID: 29053175.
    Citations: 3     Fields:    Translation:HumansCells
  18. Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI. PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs. Cancer Res. 2017 11 15; 77(22):6365-6374. PMID: 28947422.
    Citations: 1     Fields:    Translation:HumansCells
  19. Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J, Pai SI, Sidransky D, Westra WH, William WN, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM. Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma. Head Neck. 2017 12; 39(12):2433-2443. PMID: 28945296.
    Citations:    Fields:    Translation:Humans
  20. Pai SI, Faquin WC. Programmed cell death ligand 1 as a biomarker in head and neck cancer. Cancer Cytopathol. 2017 07; 125(7):529-533. PMID: 28472542.
    Citations:    Fields:    Translation:Humans
  21. Osho AA, Azzoli CJ, Pai S, Mino-Kenudson M, Faquin WC, Huynh TG, Lanuti M, Mathisen DJ, Muniappan A. Successful Treatment of an Aggressive Tracheal Malignancy With Immunotherapy. Ann Thorac Surg. 2017 Feb; 103(2):e123-e125. PMID: 28109369.
    Citations:    Fields:    Translation:Humans
  22. Mohan S, Pai SI, Bhattacharyya N. Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity. Laryngoscope. 2017 06; 127(6):1334-1338. PMID: 28150306.
    Citations:    Fields:    Translation:Humans
  23. Walline HM, Carey TE, Goudsmit CM, Bellile EL, D'Souza G, Peterson LA, McHugh JB, Pai SI, Lee JJ, Shin DM, Ferris RL. High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res. 2017 02; 15(2):179-188. PMID: 27899422.
    Citations: 2     Fields:    Translation:HumansCells
  24. Pai SI, Zandberg DP, Strome SE. The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment. Oral Oncol. 2016 10; 61:152-8. PMID: 27503244.
    Citations: 6     Fields:    Translation:Humans
  25. Brotherton JM, Jit M, Gravitt PE, Brisson M, Kreimer AR, Pai SI, Fakhry C, Monsonego J, Franceschi S. Eurogin Roadmap 2015: How has HPV knowledge changed our practice: Vaccines. Int J Cancer. 2016 08 01; 139(3):510-7. PMID: 26916230.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  26. Peng S, Mattox A, Best SR, Barbu AM, Burns JA, Akpeng B, Jeang J, Yang B, Ishida E, Hung CF, Wu TC, Pai SI. Identification of the murine H-2D(b) and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes. Cancer Immunol Immunother. 2016 Mar; 65(3):261-71. PMID: 26759151.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  27. Anderson KS, Gerber JE, D'Souza G, Pai SI, Cheng JN, Alam R, Kesiraju S, Chowell D, Gross ND, Haddad R, Gillison ML, Posner M. Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study. Oral Oncol. 2015 Aug; 51(8):751-8. PMID: 26094591.
    Citations: 8     Fields:    Translation:HumansCells
  28. Peng S, Wang JW, Karanam B, Wang C, Huh WK, Alvarez RD, Pai SI, Hung CF, Wu TC, Roden RB. Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer. PLoS One. 2015; 10(1):e116389. PMID: 25560237.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  29. Pierce RH, Campbell JS, Pai SI, Brody JD, Kohrt HE. In-situ tumor vaccination: Bringing the fight to the tumor. Hum Vaccin Immunother. 2015; 11(8):1901-9. PMID: 26055074.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  30. Ahn J, Bishop JA, Akpeng B, Pai SI, Best SR. Xenograft model for therapeutic drug testing in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2015 Feb; 124(2):110-5. PMID: 25124839.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  31. Gooi Z, Ward BK, Mener DJ, Ozgursoy OB, Pai SI. A staged thyroidectomy approach for gastric bypass patients. Laryngoscope. 2015 Apr; 125(4):1028-30. PMID: 25043176.
    Citations:    Fields:    Translation:Humans
  32. Xing M, Liu R, Liu X, Murugan AK, Zhu G, Zeiger MA, Pai S, Bishop J. BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol. 2014 Sep 01; 32(25):2718-26. PMID: 25024077.
    Citations: 80     Fields:    Translation:HumansCells
  33. Marcus C, Whitworth PW, Surasi DS, Pai SI, Subramaniam RM. PET/CT in the management of thyroid cancers. AJR Am J Roentgenol. 2014 Jun; 202(6):1316-29. PMID: 24848831.
    Citations: 8     Fields:    Translation:Humans
  34. D'Souza G, Gross ND, Pai SI, Haddad R, Anderson KS, Rajan S, Gerber J, Gillison ML, Posner MR. Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners. J Clin Oncol. 2014 Aug 10; 32(23):2408-15. PMID: 24778397.
    Citations: 27     Fields:    Translation:HumansCells
  35. D'souza G, Carey TE, William WN, Nguyen ML, Ko EC, Riddell J, Pai SI, Gupta V, Walline HM, Lee JJ, Wolf GT, Shin DM, Grandis JR, Ferris RL. Epidemiology of head and neck squamous cell cancer among HIV-infected patients. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):603-10. PMID: 24326607.
    Citations: 16     Fields:    Translation:Humans
  36. Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha PK, Koch WM, Richmon JD, Westra WH, Pai SI. Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. Oral Oncol. 2014 Jun; 50(6):600-4. PMID: 24630260.
    Citations: 4     Fields:    Translation:HumansCells
  37. Aragon Han P, Olson MT, Fazeli R, Prescott JD, Pai SI, Schneider EB, Tufano RP, Zeiger MA. The impact of molecular testing on the surgical management of patients with thyroid nodules. Ann Surg Oncol. 2014 Jun; 21(6):1862-9. PMID: 24522987.
    Citations: 5     Fields:    Translation:Humans
  38. Wu CY, Yang LH, Yang HY, Knoff J, Peng S, Lin YH, Wang C, Alvarez RD, Pai SI, Roden RB, Hung CF, Wu TC. Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors. Clin Cancer Res. 2014 Feb 01; 20(3):644-57. PMID: 24300786.
    Citations: 15     Fields:    Translation:AnimalsCells
  39. Jara SM, Carson KA, Pai SI, Agrawal N, Richmon JD, Prescott JD, Dackiw A, Zeiger MA, Bishop JA, Tufano RP. The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma. Surgery. 2013 Dec; 154(6):1272-80; discussion 1280-2. PMID: 24238047.
    Citations: 9     Fields:    Translation:Humans
  40. Sanguineti G, Pai S, Agbahiwe H, Ricchetti F, Westra W, Sormani MP, Clemente S, Califano J. HPV-related oropharyngeal carcinoma with Overt Level II and/or III metastases at presentation: The risk of subclinical disease in ipsilateral levels IB, IV and V. Acta Oncol. 2014 May; 53(5):662-8. PMID: 24274389.
    Citations:    Fields:    Translation:Humans
  41. Lin BM, Wang H, D'Souza G, Zhang Z, Fakhry C, Joseph AW, Drake VE, Sanguineti G, Westra WH, Pai SI. Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma. Cancer. 2013 Oct 01; 119(19):3462-71. PMID: 23861037.
    Citations: 14     Fields:    Translation:HumansCells
  42. Liu X, Bishop J, Shan Y, Pai S, Liu D, Murugan AK, Sun H, El-Naggar AK, Xing M. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer. 2013 Aug; 20(4):603-10. PMID: 23766237.
    Citations: 101     Fields:    Translation:HumansCells
  43. Gross ND, Pai SI, Haddad RI, Gillison ML, Posner MR. Oral HPV infection in HPV-positive oropharyngeal cancer cases and their spouses. J Clin Oncol. 2013 Jun 20; 31(18_suppl):CRA6031. PMID: 28136081.
    Citations:    
  44. Bishop JA, Ogawa T, Stelow EB, Moskaluk CA, Koch WM, Pai SI, Westra WH. Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Am J Surg Pathol. 2013 Jun; 37(6):836-44. PMID: 23598962.
    Citations: 23     Fields:    Translation:Humans
  45. Pai SI. Mission impossible: how HPV-associated head and neck cancers escape a primed immune response. Oral Oncol. 2013 Aug; 49(8):723-5. PMID: 23643070.
    Citations: 1     Fields:    Translation:HumansCells
  46. Pai SI. Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma. Oncoimmunology. 2013 May 01; 2(5):e24065. PMID: 23762795.
    Citations: 4     
  47. Xing M, Alzahrani AS, Carson KA, Viola D, Elisei R, Bendlova B, Yip L, Mian C, Vianello F, Tuttle RM, Robenshtok E, Fagin JA, Puxeddu E, Fugazzola L, Czarniecka A, Jarzab B, O'Neill CJ, Sywak MS, Lam AK, Riesco-Eizaguirre G, Santisteban P, Nakayama H, Tufano RP, Pai SI, Zeiger MA, Westra WH, Clark DP, Clifton-Bligh R, Sidransky D, Ladenson PW, Sykorova V. Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA. 2013 Apr 10; 309(14):1493-501. PMID: 23571588.
    Citations: 171     Fields:    Translation:Humans
  48. Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH. Human papillomavirus-related carcinomas of the sinonasal tract. Am J Surg Pathol. 2013 Feb; 37(2):185-92. PMID: 23095507.
    Citations: 41     Fields:    Translation:HumansCells
  49. Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res. 2013 Mar 15; 73(6):1733-41. PMID: 23288508.
    Citations: 160     Fields:    Translation:HumansCells
  50. Joseph AW, Ogawa T, Bishop JA, Lyford-Pike S, Chang X, Phelps TH, Westra WH, Pai SI. Molecular etiology of second primary tumors in contralateral tonsils of human papillomavirus-associated index tonsillar carcinomas. Oral Oncol. 2013 Mar; 49(3):244-8. PMID: 23062994.
    Citations: 7     Fields:    Translation:HumansCells
  51. Peng S, Lyford-Pike S, Akpeng B, Wu A, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI. Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine. Cancer Immunol Immunother. 2013 Jan; 62(1):171-82. PMID: 23011589.
    Citations: 22     Fields:    Translation:AnimalsCells
  52. Best SR, Niparko KJ, Pai SI. Biology of human papillomavirus infection and immune therapy for HPV-related head and neck cancers. Otolaryngol Clin North Am. 2012 Aug; 45(4):807-22. PMID: 22793854.
    Citations: 7     Fields:    Translation:HumansCells
  53. Zaboli D, Tan M, Gogineni H, Lake S, Fan K, Zahurak ML, Messing B, Ulmer K, Zinreich ES, Levine MA, Tang M, Pai SI, Blanco RG, Saunders JR, Best SR, Califano JA, Ha PK. Hyperfractionated radiotherapy with concurrent cisplatin/5-Fluorouracil for locoregional advanced head and neck cancer: analysis of 105 consecutive patients. Int J Otolaryngol. 2012; 2012:754191. PMID: 22778748.
    Citations:    
  54. Fan KY, Gogineni H, Zaboli D, Lake S, Zahurak ML, Best SR, Levine MA, Tang M, Zinreich ES, Saunders JR, Califano JA, Blanco RG, Pai SI, Messing B, Ha PK. Comparison of acute toxicities in two primary chemoradiation regimens in the treatment of advanced head and neck squamous cell carcinoma. Ann Surg Oncol. 2012 Jun; 19(6):1980-7. PMID: 22290566.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  55. Pai SI. HPV-associated head and neck cancers. Otolaryngol Clin North Am. 2012 Aug; 45(4):xi-xii. PMID: 22793861.
    Citations:    Fields:    Translation:HumansCells
  56. Bishop JA, Ogawa T, Chang X, Illei PB, Gabrielson E, Pai SI, Westra WH. HPV analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. Am J Surg Pathol. 2012 Jan; 36(1):142-8. PMID: 22173119.
    Citations: 10     Fields:    Translation:Humans
  57. Teixeira GV, Chikota H, Teixeira T, Manfro G, Pai SI, Tufano RP. Incidence of malignancy in thyroid nodules determined to be follicular lesions of undetermined significance on fine-needle aspiration. World J Surg. 2012 Jan; 36(1):69-74. PMID: 22057754.
    Citations: 13     Fields:    Translation:Humans
  58. Wu G, Fraser S, Pai SI, Farrag TY, Ladenson PW, Tufano RP. Determining the extent of lateral neck dissection necessary to establish regional disease control and avoid reoperation after previous total thyroidectomy and radioactive iodine for papillary thyroid cancer. Head Neck. 2012 Oct; 34(10):1418-21. PMID: 22052539.
    Citations: 1     Fields:    Translation:Humans
  59. Wu G, Pai SI, Agrawal N, Richmon J, Dackiw A, Tufano RP. Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgery. Otolaryngol Head Neck Surg. 2011 Nov; 145(5):727-31. PMID: 21860058.
    Citations: 1     Fields:    Translation:Humans
  60. Bishop JA, Maleki Z, Valsamakis A, Ogawa T, Chang X, Pai SI, Westra WH. Application of the hybrid capture 2 assay to squamous cell carcinomas of the head and neck: a convenient liquid-phase approach for the reliable determination of human papillomavirus status. Cancer Cytopathol. 2012 Feb 25; 120(1):18-25. PMID: 21751428.
    Citations: 8     Fields:    Translation:HumansCells
  61. Gomez NR, Kouniavsky G, Tsai HL, Somervell H, Pai SI, Tufano RP, Umbricht C, Kowalski J, Dackiw AP, Zeiger MA. Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer. J Surg Oncol. 2011 Nov 01; 104(6):613-6. PMID: 21744345.
    Citations: 5     Fields:    Translation:Humans
  62. Anderson KS, Wong J, D'Souza G, Riemer AB, Lorch J, Haddad R, Pai SI, Longtine J, McClean M, LaBaer J, Kelsey KT, Posner M. Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. Br J Cancer. 2011 Jun 07; 104(12):1896-905. PMID: 21654689.
    Citations: 22     Fields:    Translation:HumansCells
  63. Cho YG, Chang X, Park IS, Yamashita K, Shao C, Ha PK, Pai SI, Sidransky D, Kim MS. Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol. 2011 Aug; 39(2):337-44. PMID: 21617854.
    Citations: 8     Fields:    Translation:HumansCells
  64. Park IS, Chang X, Loyo M, Wu G, Chuang A, Kim MS, Chae YK, Lyford-Pike S, Westra WH, Saunders JR, Sidransky D, Pai SI. Characterization of the methylation patterns in human papillomavirus type 16 viral DNA in head and neck cancers. Cancer Prev Res (Phila). 2011 Feb; 4(2):207-17. PMID: 21292634.
    Citations: 17     Fields:    Translation:HumansCells
  65. Best SR, Ha PK, Blanco RG, Saunders JR, Zinreich ES, Levine MA, Pai SI, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, Messing BP. Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head Neck. 2011 Dec; 33(12):1727-34. PMID: 21246640.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  66. Lyford-Pike S, Westra WH, Loyo M, Peng S, Hung CF, Wu AA, Flint PW, Tunkel DE, Saunders JR, Pai SI. Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis. Histopathology. 2010 Nov; 57(5):768-70. PMID: 21083608.
    Citations: 2     Fields:    Translation:Humans
  67. Wu A, Zeng Q, Kang TH, Peng S, Roosinovich E, Pai SI, Hung CF. Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer. Gene Ther. 2011 Mar; 18(3):304-12. PMID: 20981112.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  68. Kim D, Hoory T, Monie A, Wu A, Hsueh WT, Pai SI, Hung CF. Delivery of chemotherapeutic agents using drug-loaded irradiated tumor cells to treat murine ovarian tumors. J Biomed Sci. 2010 Jul 26; 17:61. PMID: 20659328.
    Citations: 3     Fields:    Translation:AnimalsCells
  69. Kang TH, Noh KH, Kim JH, Bae HC, Lin KY, Monie A, Pai SI, Hung CF, Wu TC, Kim TW. Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. Cancer Res. 2010 Apr 15; 70(8):3062-70. PMID: 20395201.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  70. Pai SI, Tufano RP. Reoperation for recurrent/persistent well-differentiated thyroid cancer. Otolaryngol Clin North Am. 2010 Apr; 43(2):353-63, ix. PMID: 20510718.
    Citations: 3     Fields:    Translation:Humans
  71. Tufano RP, Pai SI. Thyroid and parathyroid surgery. Preface. Otolaryngol Clin North Am. 2010 Apr; 43(2):xiii-xiv. PMID: 20510709.
    Citations:    Fields:    Translation:Humans
  72. Peng S, Best SR, Hung CF, Loyo M, Lyford-Pike S, Flint PW, Tunkel DE, Saunders JR, Wu TC, Pai SI. Characterization of human papillomavirus type 11-specific immune responses in a preclinical model. Laryngoscope. 2010 Mar; 120(3):504-10. PMID: 20025042.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  73. Hillel AT, Fakhry C, Pai SI, Williams MF, Blanco RG, Zinreich ES, Levine MA, Westra WH, Saunders JR, Ha PK. Selective versus comprehensive neck dissection after chemoradiation for advanced oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009 Dec; 141(6):737-42. PMID: 19932847.
    Citations: 5     Fields:    Translation:Humans
  74. Kang TH, Chung JY, Monie A, Pai SI, Hung CF, Wu TC. Enhancing DNA vaccine potency by co-administration of xenogenic MHC class-I DNA. Gene Ther. 2010 Apr; 17(4):531-40. PMID: 19940864.
    Citations: 4     Fields:    Translation:AnimalsCells
  75. Sedaghat AR, Zhang Z, Begum S, Palermo R, Best S, Ulmer KM, Levine M, Zinreich E, Messing BP, Gold D, Wu AA, Niparko KJ, Kowalski J, Hirata RM, Saunders JR, Westra WH, Pai SI. Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas. Laryngoscope. 2009 Aug; 119(8):1542-9. PMID: 19522004.
    Citations: 30     Fields:    Translation:HumansCells
  76. Best SR, Peng S, Juang CM, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI. Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery. Vaccine. 2009 Sep 04; 27(40):5450-9. PMID: 19622402.
    Citations: 45     Fields:    Translation:AnimalsCellsPHPublic Health
  77. Chuang CM, Monie A, Wu A, Pai SI, Hung CF. Combination of viral oncolysis and tumor-specific immunity to control established tumors. Clin Cancer Res. 2009 Jul 15; 15(14):4581-8. PMID: 19584165.
    Citations: 8     Fields:    Translation:AnimalsCells
  78. Tsen SW, Wu CY, Meneshian A, Pai SI, Hung CF, Wu TC. Femtosecond laser treatment enhances DNA transfection efficiency in vivo. J Biomed Sci. 2009 Apr 01; 16:36. PMID: 19338665.
    Citations: 6     Fields:    Translation:HumansAnimals
  79. Pai SI, Westra WH. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol. 2009; 4:49-70. PMID: 18729723.
    Citations: 89     Fields:    Translation:Humans
  80. Noh KH, Kang TH, Kim JH, Pai SI, Lin KY, Hung CF, Wu TC, Kim TW. Activation of Akt as a mechanism for tumor immune evasion. Mol Ther. 2009 Mar; 17(3):439-47. PMID: 19107122.
    Citations: 30     Fields:    Translation:AnimalsCellsPHPublic Health
  81. Pai SI, Tufano RP. Central compartment neck dissection for thyroid cancer. Technical considerations. ORL J Otorhinolaryngol Relat Spec. 2008; 70(5):292-7. PMID: 18971593.
    Citations: 4     Fields:    Translation:Humans
  82. Loyo M, Pai SI. The molecular genetics of laryngeal cancer. Otolaryngol Clin North Am. 2008 Aug; 41(4):657-72, v. PMID: 18570952.
    Citations: 3     Fields:    Translation:Humans
  83. Goldenberg D, Begum S, Westra WH, Khan Z, Sciubba J, Pai SI, Califano JA, Tufano RP, Koch WM. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008 Jul; 30(7):898-903. PMID: 18383529.
    Citations: 64     Fields:    Translation:Humans
  84. Loyo M, Pai SI, Netto GJ, Tunkel DE. Aggressive recurrent respiratory papillomatosis in a neonate. Int J Pediatr Otorhinolaryngol. 2008 Jun; 72(6):917-20. PMID: 18423627.
    Citations: 1     Fields:    Translation:Humans
  85. Wu AA, Niparko KJ, Pai SI. Immunotherapy for head and neck cancer. J Biomed Sci. 2008 May; 15(3):275-89. PMID: 18392689.
    Citations: 8     Fields:    Translation:HumansCells
  86. Lin LM, Pai SI, Flint PW. A retropharyngeal pseudoabscess in a patient with paroxysmal nocturnal hemoglobinuria. Otolaryngol Head Neck Surg. 2007 Oct; 137(4):684-6. PMID: 17903595.
    Citations:    Fields:    Translation:Humans
  87. Kang TH, Lee JH, Song CK, Han HD, Shin BC, Pai SI, Hung CF, Trimble C, Lim JS, Kim TW, Wu TC. Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Res. 2007 Jan 15; 67(2):802-11. PMID: 17234792.
    Citations: 48     Fields:    Translation:AnimalsCells
  88. Pai SI, Goldstein BJ, Studeman KD, Westra WH, Tufano RP. Concurrent sporadic parathyroid adenoma and carcinoma. Am J Otolaryngol. 2006 Sep-Oct; 27(5):346-8. PMID: 16935182.
    Citations: 2     Fields:    Translation:Humans
  89. Pai SI, Lin YY, Macaes B, Meneshian A, Hung CF, Wu TC. Prospects of RNA interference therapy for cancer. Gene Ther. 2006 Mar; 13(6):464-77. PMID: 16341059.
    Citations: 61     Fields:    Translation:Humans
  90. Flint PW, Li ZB, Lehar M, Saito K, Pai SI. Laryngeal muscle surface receptors identified using random phage library. Laryngoscope. 2005 Nov; 115(11):1930-7. PMID: 16319601.
    Citations: 2     Fields:    Translation:AnimalsCells
  91. Kim TW, Hung CF, Zheng M, Boyd DA, He L, Pai SI, Wu TC. A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response. J Biomed Sci. 2004 Jul-Aug; 11(4):493-9. PMID: 15153784.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  92. Kim JW, Hung CF, Juang J, He L, Kim TW, Armstrong DK, Pai SI, Chen PJ, Lin CT, Boyd DA, Wu TC. Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther. 2004 Jun; 11(12):1011-8. PMID: 14985791.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  93. Trimble C, Lin CT, Hung CF, Pai S, Juang J, He L, Gillison M, Pardoll D, Wu L, Wu TC. Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine. 2003 Sep 08; 21(25-26):4036-42. PMID: 12922140.
    Citations: 49     Fields:    Translation:AnimalsCells
  94. Pai SI, Limb CJ, Nicol T, Williams MF. Leiomyosarcoma of the auricle. Otolaryngol Head Neck Surg. 2003 Mar; 128(3):442-4. PMID: 12646855.
    Citations: 1     Fields:    Translation:Humans
  95. Cheng WF, Hung CF, Pai SI, Hsu KF, He L, Ling M, Wu TC. Repeated DNA vaccinations elicited qualitatively different cytotoxic T lymphocytes and improved protective antitumor effects. J Biomed Sci. 2002 Nov-Dec; 9(6 Pt 2):675-87. PMID: 12432234.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  96. Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA. Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002 May; 8(5):1203-9. PMID: 12006539.
    Citations: 38     Fields:    Translation:HumansCells
  97. Dong SM, Pai SI, Rha SH, Hildesheim A, Kurman RJ, Schwartz PE, Mortel R, McGowan L, Greenberg MD, Barnes WA, Sidransky D. Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma. Cancer Epidemiol Biomarkers Prev. 2002 Jan; 11(1):3-6. PMID: 11815394.
    Citations: 17     Fields:    Translation:HumansCells
  98. Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med. 2001 Apr 02; 193(7):839-46. PMID: 11283156.
    Citations: 236     Fields:    Translation:HumansAnimalsCells
  99. Capone RB, Pai SI, Koch WM, Gillison ML, Danish HN, Westra WH, Daniel R, Shah KV, Sidransky D. Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma. Clin Cancer Res. 2000 Nov; 6(11):4171-5. PMID: 11106228.
    Citations: 33     Fields:    Translation:HumansCells
  100. Wang TL, Ling M, Shih IM, Pham T, Pai SI, Lu Z, Kurman RJ, Pardoll DM, Wu TC. Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gene Ther. 2000 May; 7(9):726-33. PMID: 10822298.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  101. Ji H, Wang TL, Chen CH, Pai SI, Hung CF, Lin KY, Kurman RJ, Pardoll DM, Wu TC. Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors. Hum Gene Ther. 1999 Nov 20; 10(17):2727-40. PMID: 10584920.
    Citations: 52     Fields:    Translation:AnimalsCells
  102. Pai SI, Wu GS, Ozören N, Wu L, Jen J, Sidransky D, El-Deiry WS. Rare loss-of-function mutation of a death receptor gene in head and neck cancer. Cancer Res. 1998 Aug 15; 58(16):3513-8. PMID: 9721851.
    Citations: 27     Fields:    Translation:HumansCells
  103. Trink B, Pai SI, Spunt SL, Raman V, Cairns P, Jen J, Gabrielson E, Sukumar S, Sidransky D. Absence of TSG101 transcript abnormalities in human cancers. Oncogene. 1998 May 28; 16(21):2815-8. PMID: 9652749.
    Citations: 2     Fields:    Translation:HumansCells
  104. Nichols RC, Blinder J, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P. Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. Genomics. 1996 Aug 15; 36(1):210-3. PMID: 8812440.
    Citations: 1     Fields:    Translation:HumansCells
  105. Nichols RC, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P. Localization of two human autoantigen genes by PCR screening and in situ hybridization--glycyl-tRNA synthetase locates to 7p15 and alanyl-tRNA synthetase locates to 16q22. Genomics. 1995 Nov 01; 30(1):131-2. PMID: 8595897.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  106. North WG, Pai S, Friedmann A, Yu X, Fay M, Memoli V. Vasopressin gene related products are markers of human breast cancer. Breast Cancer Res Treat. 1995 Jun; 34(3):229-35. PMID: 7579487.
    Citations: 7     Fields:    Translation:Humans
  107. Friedmann AS, Malott KA, Memoli VA, Pai SI, Yu XM, North WG. Products of vasopressin gene expression in small-cell carcinoma of the lung. Br J Cancer. 1994 Feb; 69(2):260-3. PMID: 8297723.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.