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Sara I Pai, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DE025340 (PAI, SARA ISABEL) Jul 1, 2015 - Jun 30, 2018
    NIH/NIDCR
    Immune Checkpoints and HPV-associated Head and Neck Cancers
    Role: Principal Investigator
  2. R21CA176332 (PAI, SARA ISABEL) Apr 1, 2013 - Mar 31, 2015
    NIH/NCI
    Oral Biomarkers for HPV-related Head and Neck Cancer
    Role: Principal Investigator
  3. P50DE019032 (SIDRANSKY, DAVID) Jun 1, 2007 - Jul 31, 2017
    NIH/NIDCR
    Spore in Head and Neck Cancer
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54. PMID: 30029671.
    View in: PubMed
  2. Rosenbaum MW, Gigliotti BJ, Pai SI, Parangi S, Wachtel H, Mino-Kenudson M, Gunda V, Faquin WC. PD-L1 and IDO1 Are Expressed in Poorly Differentiated Thyroid Carcinoma. Endocr Pathol. 2018 Mar; 29(1):59-67. PMID: 29372535.
    View in: PubMed
  3. Pai SI, Jack Lee J, Carey TE, Westra WH, Ferrone S, Moore C, Mosunjac MB, Shin DM, Ferris RL. HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers. Oral Oncol. 2018 Feb; 77:92-97. PMID: 29362132.
    View in: PubMed
  4. Gleber-Netto FO, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, Kadara H, Zhang J, Wang J, William WN, Lee JJ, Nguyen ML, Pai SI, Walline HM, Shin DM, Ferris RL, Carey TE, Myers JN, Pickering CR. Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer. 2018 Jan 01; 124(1):84-94. PMID: 29053175.
    View in: PubMed
  5. Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI. PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs. Cancer Res. 2017 11 15; 77(22):6365-6374. PMID: 28947422.
    View in: PubMed
  6. Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J, Pai SI, Sidransky D, Westra WH, William WN, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM. Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma. Head Neck. 2017 12; 39(12):2433-2443. PMID: 28945296.
    View in: PubMed
  7. Pai SI, Faquin WC. Programmed cell death ligand 1 as a biomarker in head and neck cancer. Cancer Cytopathol. 2017 Jul; 125(7):529-533. PMID: 28472542.
    View in: PubMed
  8. Osho AA, Azzoli CJ, Pai S, Mino-Kenudson M, Faquin WC, Huynh TG, Lanuti M, Mathisen DJ, Muniappan A. Successful Treatment of an Aggressive Tracheal Malignancy With Immunotherapy. Ann Thorac Surg. 2017 Feb; 103(2):e123-e125. PMID: 28109369.
    View in: PubMed
  9. Mohan S, Pai SI, Bhattacharyya N. Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity. Laryngoscope. 2017 06; 127(6):1334-1338. PMID: 28150306.
    View in: PubMed
  10. Walline HM, Carey TE, Goudsmit CM, Bellile EL, D'Souza G, Peterson LA, McHugh JB, Pai SI, Lee JJ, Shin DM, Ferris RL. High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res. 2017 02; 15(2):179-188. PMID: 27899422.
    View in: PubMed
  11. Pai SI, Zandberg DP, Strome SE. The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment. Oral Oncol. 2016 10; 61:152-8. PMID: 27503244.
    View in: PubMed
  12. Brotherton JM, Jit M, Gravitt PE, Brisson M, Kreimer AR, Pai SI, Fakhry C, Monsonego J, Franceschi S. Eurogin Roadmap 2015: How has HPV knowledge changed our practice: Vaccines. Int J Cancer. 2016 08 01; 139(3):510-7. PMID: 26916230.
    View in: PubMed
  13. Peng S, Mattox A, Best SR, Barbu AM, Burns JA, Akpeng B, Jeang J, Yang B, Ishida E, Hung CF, Wu TC, Pai SI. Identification of the murine H-2D(b) and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes. Cancer Immunol Immunother. 2016 Mar; 65(3):261-71. PMID: 26759151.
    View in: PubMed
  14. Anderson KS, Gerber JE, D'Souza G, Pai SI, Cheng JN, Alam R, Kesiraju S, Chowell D, Gross ND, Haddad R, Gillison ML, Posner M. Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study. Oral Oncol. 2015 Aug; 51(8):751-8. PMID: 26094591; PMCID: PMC4982366.
  15. Peng S, Wang JW, Karanam B, Wang C, Huh WK, Alvarez RD, Pai SI, Hung CF, Wu TC, Roden RB. Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer. PLoS One. 2015; 10(1):e116389. PMID: 25560237; PMCID: PMC4283968.
  16. Pierce RH, Campbell JS, Pai SI, Brody JD, Kohrt HE. In-situ tumor vaccination: Bringing the fight to the tumor. Hum Vaccin Immunother. 2015; 11(8):1901-9. PMID: 26055074; PMCID: PMC4635874.
  17. Ahn J, Bishop JA, Akpeng B, Pai SI, Best SR. Xenograft model for therapeutic drug testing in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2015 Feb; 124(2):110-5. PMID: 25124839.
    View in: PubMed
  18. Gooi Z, Ward BK, Mener DJ, Ozgursoy OB, Pai SI. A staged thyroidectomy approach for gastric bypass patients. Laryngoscope. 2015 Apr; 125(4):1028-30. PMID: 25043176.
    View in: PubMed
  19. Xing M, Liu R, Liu X, Murugan AK, Zhu G, Zeiger MA, Pai S, Bishop J. BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol. 2014 Sep 01; 32(25):2718-26. PMID: 25024077; PMCID: PMC4145183.
  20. Marcus C, Whitworth PW, Surasi DS, Pai SI, Subramaniam RM. PET/CT in the management of thyroid cancers. AJR Am J Roentgenol. 2014 Jun; 202(6):1316-29. PMID: 24848831.
    View in: PubMed
  21. D'Souza G, Gross ND, Pai SI, Haddad R, Anderson KS, Rajan S, Gerber J, Gillison ML, Posner MR. Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners. J Clin Oncol. 2014 Aug 10; 32(23):2408-15. PMID: 24778397; PMCID: PMC4263818.
  22. D'souza G, Carey TE, William WN, Nguyen ML, Ko EC, Riddell J, Pai SI, Gupta V, Walline HM, Lee JJ, Wolf GT, Shin DM, Grandis JR, Ferris RL. Epidemiology of head and neck squamous cell cancer among HIV-infected patients. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):603-10. PMID: 24326607; PMCID: PMC3999230.
  23. Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha PK, Koch WM, Richmon JD, Westra WH, Pai SI. Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. Oral Oncol. 2014 Jun; 50(6):600-4. PMID: 24630260; PMCID: PMC4318229.
  24. Aragon Han P, Olson MT, Fazeli R, Prescott JD, Pai SI, Schneider EB, Tufano RP, Zeiger MA. The impact of molecular testing on the surgical management of patients with thyroid nodules. Ann Surg Oncol. 2014 Jun; 21(6):1862-9. PMID: 24522987.
    View in: PubMed
  25. Wu CY, Yang LH, Yang HY, Knoff J, Peng S, Lin YH, Wang C, Alvarez RD, Pai SI, Roden RB, Hung CF, Wu TC. Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors. Clin Cancer Res. 2014 Feb 01; 20(3):644-57. PMID: 24300786; PMCID: PMC3946442.
  26. Jara SM, Carson KA, Pai SI, Agrawal N, Richmon JD, Prescott JD, Dackiw A, Zeiger MA, Bishop JA, Tufano RP. The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma. Surgery. 2013 Dec; 154(6):1272-80; discussion 1280-2. PMID: 24238047.
    View in: PubMed
  27. Sanguineti G, Pai S, Agbahiwe H, Ricchetti F, Westra W, Sormani MP, Clemente S, Califano J. HPV-related oropharyngeal carcinoma with Overt Level II and/or III metastases at presentation: The risk of subclinical disease in ipsilateral levels IB, IV and V. Acta Oncol. 2014 May; 53(5):662-8. PMID: 24274389; PMCID: PMC4696049.
  28. Lin BM, Wang H, D'Souza G, Zhang Z, Fakhry C, Joseph AW, Drake VE, Sanguineti G, Westra WH, Pai SI. Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma. Cancer. 2013 Oct 01; 119(19):3462-71. PMID: 23861037; PMCID: PMC3788050.
  29. Liu X, Bishop J, Shan Y, Pai S, Liu D, Murugan AK, Sun H, El-Naggar AK, Xing M. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer. 2013 Aug; 20(4):603-10. PMID: 23766237; PMCID: PMC3782569.
  30. Gross ND, Pai SI, Haddad RI, Gillison ML, Posner MR. Oral HPV infection in HPV-positive oropharyngeal cancer cases and their spouses. J Clin Oncol. 2013 Jun 20; 31(18_suppl):CRA6031. PMID: 28136081.
    View in: PubMed
  31. Bishop JA, Ogawa T, Stelow EB, Moskaluk CA, Koch WM, Pai SI, Westra WH. Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Am J Surg Pathol. 2013 Jun; 37(6):836-44. PMID: 23598962; PMCID: PMC3653997.
  32. Pai SI. Mission impossible: how HPV-associated head and neck cancers escape a primed immune response. Oral Oncol. 2013 Aug; 49(8):723-5. PMID: 23643070.
    View in: PubMed
  33. Pai SI. Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma. Oncoimmunology. 2013 May 01; 2(5):e24065. PMID: 23762795.
    View in: PubMed
  34. Xing M, Alzahrani AS, Carson KA, Viola D, Elisei R, Bendlova B, Yip L, Mian C, Vianello F, Tuttle RM, Robenshtok E, Fagin JA, Puxeddu E, Fugazzola L, Czarniecka A, Jarzab B, O'Neill CJ, Sywak MS, Lam AK, Riesco-Eizaguirre G, Santisteban P, Nakayama H, Tufano RP, Pai SI, Zeiger MA, Westra WH, Clark DP, Clifton-Bligh R, Sidransky D, Ladenson PW, Sykorova V. Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA. 2013 Apr 10; 309(14):1493-501. PMID: 23571588; PMCID: PMC3791140.
  35. Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH. Human papillomavirus-related carcinomas of the sinonasal tract. Am J Surg Pathol. 2013 Feb; 37(2):185-92. PMID: 23095507; PMCID: PMC3545097.
  36. Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res. 2013 Mar 15; 73(6):1733-41. PMID: 23288508; PMCID: PMC3602406.
  37. Joseph AW, Ogawa T, Bishop JA, Lyford-Pike S, Chang X, Phelps TH, Westra WH, Pai SI. Molecular etiology of second primary tumors in contralateral tonsils of human papillomavirus-associated index tonsillar carcinomas. Oral Oncol. 2013 Mar; 49(3):244-8. PMID: 23062994; PMCID: PMC3548989.
  38. Peng S, Lyford-Pike S, Akpeng B, Wu A, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI. Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine. Cancer Immunol Immunother. 2013 Jan; 62(1):171-82. PMID: 23011589; PMCID: PMC3543472.
  39. Best SR, Niparko KJ, Pai SI. Biology of human papillomavirus infection and immune therapy for HPV-related head and neck cancers. Otolaryngol Clin North Am. 2012 Aug; 45(4):807-22. PMID: 22793854; PMCID: PMC3398423.
  40. Zaboli D, Tan M, Gogineni H, Lake S, Fan K, Zahurak ML, Messing B, Ulmer K, Zinreich ES, Levine MA, Tang M, Pai SI, Blanco RG, Saunders JR, Best SR, Califano JA, Ha PK. Hyperfractionated radiotherapy with concurrent cisplatin/5-Fluorouracil for locoregional advanced head and neck cancer: analysis of 105 consecutive patients. Int J Otolaryngol. 2012; 2012:754191. PMID: 22778748; PMCID: PMC3388433.
  41. Fan KY, Gogineni H, Zaboli D, Lake S, Zahurak ML, Best SR, Levine MA, Tang M, Zinreich ES, Saunders JR, Califano JA, Blanco RG, Pai SI, Messing B, Ha PK. Comparison of acute toxicities in two primary chemoradiation regimens in the treatment of advanced head and neck squamous cell carcinoma. Ann Surg Oncol. 2012 Jun; 19(6):1980-7. PMID: 22290566; PMCID: PMC3715048.
  42. Pai SI. HPV-associated head and neck cancers. Otolaryngol Clin North Am. 2012 Aug; 45(4):xi-xii. PMID: 22793861.
    View in: PubMed
  43. Bishop JA, Ogawa T, Chang X, Illei PB, Gabrielson E, Pai SI, Westra WH. HPV analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. Am J Surg Pathol. 2012 Jan; 36(1):142-8. PMID: 22173119; PMCID: PMC3273906.
  44. Teixeira GV, Chikota H, Teixeira T, Manfro G, Pai SI, Tufano RP. Incidence of malignancy in thyroid nodules determined to be follicular lesions of undetermined significance on fine-needle aspiration. World J Surg. 2012 Jan; 36(1):69-74. PMID: 22057754.
    View in: PubMed
  45. Wu G, Fraser S, Pai SI, Farrag TY, Ladenson PW, Tufano RP. Determining the extent of lateral neck dissection necessary to establish regional disease control and avoid reoperation after previous total thyroidectomy and radioactive iodine for papillary thyroid cancer. Head Neck. 2012 Oct; 34(10):1418-21. PMID: 22052539.
    View in: PubMed
  46. Wu G, Pai SI, Agrawal N, Richmon J, Dackiw A, Tufano RP. Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgery. Otolaryngol Head Neck Surg. 2011 Nov; 145(5):727-31. PMID: 21860058.
    View in: PubMed
  47. Bishop JA, Maleki Z, Valsamakis A, Ogawa T, Chang X, Pai SI, Westra WH. Application of the hybrid capture 2 assay to squamous cell carcinomas of the head and neck: a convenient liquid-phase approach for the reliable determination of human papillomavirus status. Cancer Cytopathol. 2012 Feb 25; 120(1):18-25. PMID: 21751428; PMCID: PMC3197962.
  48. Gomez NR, Kouniavsky G, Tsai HL, Somervell H, Pai SI, Tufano RP, Umbricht C, Kowalski J, Dackiw AP, Zeiger MA. Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer. J Surg Oncol. 2011 Nov 01; 104(6):613-6. PMID: 21744345.
    View in: PubMed
  49. Anderson KS, Wong J, D'Souza G, Riemer AB, Lorch J, Haddad R, Pai SI, Longtine J, McClean M, LaBaer J, Kelsey KT, Posner M. Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. Br J Cancer. 2011 Jun 07; 104(12):1896-905. PMID: 21654689; PMCID: PMC3111202.
  50. Cho YG, Chang X, Park IS, Yamashita K, Shao C, Ha PK, Pai SI, Sidransky D, Kim MS. Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol. 2011 Aug; 39(2):337-44. PMID: 21617854; PMCID: PMC3601031.
  51. Park IS, Chang X, Loyo M, Wu G, Chuang A, Kim MS, Chae YK, Lyford-Pike S, Westra WH, Saunders JR, Sidransky D, Pai SI. Characterization of the methylation patterns in human papillomavirus type 16 viral DNA in head and neck cancers. Cancer Prev Res (Phila). 2011 Feb; 4(2):207-17. PMID: 21292634; PMCID: PMC3079312.
  52. Best SR, Ha PK, Blanco RG, Saunders JR, Zinreich ES, Levine MA, Pai SI, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, Messing BP. Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head Neck. 2011 Dec; 33(12):1727-34. PMID: 21246640; PMCID: PMC4695991.
  53. Lyford-Pike S, Westra WH, Loyo M, Peng S, Hung CF, Wu AA, Flint PW, Tunkel DE, Saunders JR, Pai SI. Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis. Histopathology. 2010 Nov; 57(5):768-70. PMID: 21083608.
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  54. Wu A, Zeng Q, Kang TH, Peng S, Roosinovich E, Pai SI, Hung CF. Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer. Gene Ther. 2011 Mar; 18(3):304-12. PMID: 20981112; PMCID: PMC3032008.
  55. Kim D, Hoory T, Monie A, Wu A, Hsueh WT, Pai SI, Hung CF. Delivery of chemotherapeutic agents using drug-loaded irradiated tumor cells to treat murine ovarian tumors. J Biomed Sci. 2010 Jul 26; 17:61. PMID: 20659328; PMCID: PMC2918546.
  56. Kang TH, Noh KH, Kim JH, Bae HC, Lin KY, Monie A, Pai SI, Hung CF, Wu TC, Kim TW. Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. Cancer Res. 2010 Apr 15; 70(8):3062-70. PMID: 20395201; PMCID: PMC2861497.
  57. Pai SI, Tufano RP. Reoperation for recurrent/persistent well-differentiated thyroid cancer. Otolaryngol Clin North Am. 2010 Apr; 43(2):353-63, ix. PMID: 20510718.
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  58. Tufano RP, Pai SI. Thyroid and parathyroid surgery. Preface. Otolaryngol Clin North Am. 2010 Apr; 43(2):xiii-xiv. PMID: 20510709.
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  59. Peng S, Best SR, Hung CF, Loyo M, Lyford-Pike S, Flint PW, Tunkel DE, Saunders JR, Wu TC, Pai SI. Characterization of human papillomavirus type 11-specific immune responses in a preclinical model. Laryngoscope. 2010 Mar; 120(3):504-10. PMID: 20025042; PMCID: PMC2908018.
  60. Hillel AT, Fakhry C, Pai SI, Williams MF, Blanco RG, Zinreich ES, Levine MA, Westra WH, Saunders JR, Ha PK. Selective versus comprehensive neck dissection after chemoradiation for advanced oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009 Dec; 141(6):737-42. PMID: 19932847.
    View in: PubMed
  61. Kang TH, Chung JY, Monie A, Pai SI, Hung CF, Wu TC. Enhancing DNA vaccine potency by co-administration of xenogenic MHC class-I DNA. Gene Ther. 2010 Apr; 17(4):531-40. PMID: 19940864; PMCID: PMC2851845.
  62. Sedaghat AR, Zhang Z, Begum S, Palermo R, Best S, Ulmer KM, Levine M, Zinreich E, Messing BP, Gold D, Wu AA, Niparko KJ, Kowalski J, Hirata RM, Saunders JR, Westra WH, Pai SI. Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas. Laryngoscope. 2009 Aug; 119(8):1542-9. PMID: 19522004.
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  63. Best SR, Peng S, Juang CM, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI. Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery. Vaccine. 2009 Sep 04; 27(40):5450-9. PMID: 19622402; PMCID: PMC2745985.
  64. Chuang CM, Monie A, Wu A, Pai SI, Hung CF. Combination of viral oncolysis and tumor-specific immunity to control established tumors. Clin Cancer Res. 2009 Jul 15; 15(14):4581-8. PMID: 19584165; PMCID: PMC3076709.
  65. Tsen SW, Wu CY, Meneshian A, Pai SI, Hung CF, Wu TC. Femtosecond laser treatment enhances DNA transfection efficiency in vivo. J Biomed Sci. 2009 Apr 01; 16:36. PMID: 19338665; PMCID: PMC2669473.
  66. Pai SI, Westra WH. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol. 2009; 4:49-70. PMID: 18729723; PMCID: PMC3703474.
  67. Noh KH, Kang TH, Kim JH, Pai SI, Lin KY, Hung CF, Wu TC, Kim TW. Activation of Akt as a mechanism for tumor immune evasion. Mol Ther. 2009 Mar; 17(3):439-47. PMID: 19107122; PMCID: PMC2835083.
  68. Pai SI, Tufano RP. Central compartment neck dissection for thyroid cancer. Technical considerations. ORL J Otorhinolaryngol Relat Spec. 2008; 70(5):292-7. PMID: 18971593.
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  69. Loyo M, Pai SI. The molecular genetics of laryngeal cancer. Otolaryngol Clin North Am. 2008 Aug; 41(4):657-72, v. PMID: 18570952.
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  70. Goldenberg D, Begum S, Westra WH, Khan Z, Sciubba J, Pai SI, Califano JA, Tufano RP, Koch WM. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008 Jul; 30(7):898-903. PMID: 18383529.
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  71. Loyo M, Pai SI, Netto GJ, Tunkel DE. Aggressive recurrent respiratory papillomatosis in a neonate. Int J Pediatr Otorhinolaryngol. 2008 Jun; 72(6):917-20. PMID: 18423627.
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  72. Wu AA, Niparko KJ, Pai SI. Immunotherapy for head and neck cancer. J Biomed Sci. 2008 May; 15(3):275-89. PMID: 18392689.
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  73. Lin LM, Pai SI, Flint PW. A retropharyngeal pseudoabscess in a patient with paroxysmal nocturnal hemoglobinuria. Otolaryngol Head Neck Surg. 2007 Oct; 137(4):684-6. PMID: 17903595.
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  74. Kang TH, Lee JH, Song CK, Han HD, Shin BC, Pai SI, Hung CF, Trimble C, Lim JS, Kim TW, Wu TC. Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Res. 2007 Jan 15; 67(2):802-11. PMID: 17234792; PMCID: PMC3181129.
  75. Pai SI, Goldstein BJ, Studeman KD, Westra WH, Tufano RP. Concurrent sporadic parathyroid adenoma and carcinoma. Am J Otolaryngol. 2006 Sep-Oct; 27(5):346-8. PMID: 16935182.
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  76. Pai SI, Lin YY, Macaes B, Meneshian A, Hung CF, Wu TC. Prospects of RNA interference therapy for cancer. Gene Ther. 2006 Mar; 13(6):464-77. PMID: 16341059.
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  77. Flint PW, Li ZB, Lehar M, Saito K, Pai SI. Laryngeal muscle surface receptors identified using random phage library. Laryngoscope. 2005 Nov; 115(11):1930-7. PMID: 16319601.
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  78. Kim TW, Hung CF, Zheng M, Boyd DA, He L, Pai SI, Wu TC. A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response. J Biomed Sci. 2004 Jul-Aug; 11(4):493-9. PMID: 15153784.
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  79. Kim JW, Hung CF, Juang J, He L, Kim TW, Armstrong DK, Pai SI, Chen PJ, Lin CT, Boyd DA, Wu TC. Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther. 2004 Jun; 11(12):1011-8. PMID: 14985791.
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  80. Trimble C, Lin CT, Hung CF, Pai S, Juang J, He L, Gillison M, Pardoll D, Wu L, Wu TC. Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine. 2003 Sep 08; 21(25-26):4036-42. PMID: 12922140.
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  81. Pai SI, Limb CJ, Nicol T, Williams MF. Leiomyosarcoma of the auricle. Otolaryngol Head Neck Surg. 2003 Mar; 128(3):442-4. PMID: 12646855.
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  82. Cheng WF, Hung CF, Pai SI, Hsu KF, He L, Ling M, Wu TC. Repeated DNA vaccinations elicited qualitatively different cytotoxic T lymphocytes and improved protective antitumor effects. J Biomed Sci. 2002 Nov-Dec; 9(6 Pt 2):675-87. PMID: 12432234.
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  83. Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA. Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002 May; 8(5):1203-9. PMID: 12006539.
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  84. Dong SM, Pai SI, Rha SH, Hildesheim A, Kurman RJ, Schwartz PE, Mortel R, McGowan L, Greenberg MD, Barnes WA, Sidransky D. Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma. Cancer Epidemiol Biomarkers Prev. 2002 Jan; 11(1):3-6. PMID: 11815394.
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  85. Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med. 2001 Apr 02; 193(7):839-46. PMID: 11283156; PMCID: PMC2193370.
  86. Capone RB, Pai SI, Koch WM, Gillison ML, Danish HN, Westra WH, Daniel R, Shah KV, Sidransky D. Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma. Clin Cancer Res. 2000 Nov; 6(11):4171-5. PMID: 11106228.
    View in: PubMed
  87. Wang TL, Ling M, Shih IM, Pham T, Pai SI, Lu Z, Kurman RJ, Pardoll DM, Wu TC. Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gene Ther. 2000 May; 7(9):726-33. PMID: 10822298.
    View in: PubMed
  88. Ji H, Wang TL, Chen CH, Pai SI, Hung CF, Lin KY, Kurman RJ, Pardoll DM, Wu TC. Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors. Hum Gene Ther. 1999 Nov 20; 10(17):2727-40. PMID: 10584920.
    View in: PubMed
  89. Pai SI, Wu GS, Ozören N, Wu L, Jen J, Sidransky D, El-Deiry WS. Rare loss-of-function mutation of a death receptor gene in head and neck cancer. Cancer Res. 1998 Aug 15; 58(16):3513-8. PMID: 9721851.
    View in: PubMed
  90. Trink B, Pai SI, Spunt SL, Raman V, Cairns P, Jen J, Gabrielson E, Sukumar S, Sidransky D. Absence of TSG101 transcript abnormalities in human cancers. Oncogene. 1998 May 28; 16(21):2815-8. PMID: 9652749.
    View in: PubMed
  91. Nichols RC, Blinder J, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P. Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. Genomics. 1996 Aug 15; 36(1):210-3. PMID: 8812440.
    View in: PubMed
  92. Nichols RC, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P. Localization of two human autoantigen genes by PCR screening and in situ hybridization--glycyl-tRNA synthetase locates to 7p15 and alanyl-tRNA synthetase locates to 16q22. Genomics. 1995 Nov 01; 30(1):131-2. PMID: 8595897.
    View in: PubMed
  93. North WG, Pai S, Friedmann A, Yu X, Fay M, Memoli V. Vasopressin gene related products are markers of human breast cancer. Breast Cancer Res Treat. 1995 Jun; 34(3):229-35. PMID: 7579487.
    View in: PubMed
  94. Friedmann AS, Malott KA, Memoli VA, Pai SI, Yu XM, North WG. Products of vasopressin gene expression in small-cell carcinoma of the lung. Br J Cancer. 1994 Feb; 69(2):260-3. PMID: 8297723; PMCID: PMC1968694.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.