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Amanda Lyall, Ph.D.

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Biography
University of North Carolina - Chapel HillPh.D.05/2014Neurobiology
Wake Forest UniversityB.A.05/2008Psychology/Neuroscience

Mentoring
Available: 01/10/23, Expires: 02/01/24

Scientific Project: The over-arching goal of this study is to comprehensively characterize the impact of restrictive eating disorders on white matter development. This study will leverage unique access to extant neuroimaging, clinical, blood, and dietary intake data collected under 4 parent NIMH grant mechanisms at the Eating Disorders Clinical Research Program at Massachusetts General Hospital, Harvard Medical School. We will use our well-validated diffusion magnetic resonance imaging (dMRI) harmonization framework to combine these data with 2 publicly available dMRI datasets of healthy controls, yielding a cohort of harmonized imaging data spanning the period of white matter development from ages 9 to 40 years. With these data, we will examine the trajectories of global and region-specific white matter development using advanced dMRI analysis tools between healthy controls and individuals with restrictive eating disorders (Aim 1). Next, we will determine the extent to which age or pubertal stage modifies the relationship between potential white matter alterations in individuals with restrictive eating disorders and the duration of dietary restriction (Aim 2). Finally, we will evaluate the extent to which total caloric and/or specific nutritional deficiencies that arise because of severe dietary restriction impact white matter development (Aim 3). We believe that the information generated within this proposal will provide a critical first step in developing a knowledge base about the impact of severe dietary restriction on brain development. Mentorship Opportunities and Training: Students will work directly with Dr. Lyall and other faculty members within the Psychiatry Neuroimaging Laboratory, the Eating Disorder Clinical Research Program, and the Neuroendocrine Unit at MGH. Students will have the opportunity to lead specific facets of the aforementioned project. Students will learn to communicate science effectively in both written and oral format, as well as become well-trained in the best practices for executing rigorous and reproducible scientific studies. Senior thesis projects are welcome and authorship opportunities are open for discussion, dependent on the work carried out by the student. Additional responsibilities/training opportunities may include: -Work closely with others in a collaborative research environment which includes research assistants, physicians, computer scientists, psychologists, neuroscientists, and other Principal Investigators on ongoing research studies involving investigating brain abnormalities in schizophrenia, traumatic brain injury, and other populations. - Assist in managing and coordinating research studies by entering data, assisting with data analysis - Learn to use image processing tools for the pre-processing and analysis of structural, functional, and diffusion Magnetic Resonance Images (MRI). - Learn to use statistical programs such as R to manage participant data and run statistical analyses. - Learn to troubleshoot and modify image processing pipelines. - Collect, describe, and help analyze library research materials. Help to prepare and proofread scientific manuscripts and grant applications.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (LYALL, AMANDA ELLIS) Nov 1, 2022 - Dec 1, 2023
    Brigham Research Institute Pilot Grant Program
    Characterizing Amygdala Circuitry in Women with Anorexia Nervosa using High-Resolution Neuroimaging
    Role Description: This BRI Pilot Funding Award will test the overarching hypothesis that anorexia nervosa is associated with structural abnormalities and dysfunction within discrete amygdala nuclei which govern appetitive drive and food avoidance behaviors.
    Role: Principal Investigator
  2. 1R01MH130781-01 (LYALL, AMANDA ELLIS) Sep 1, 2022 - Aug 31, 2027
    NIMH
    Evaluating the Impact of Restrictive Eating Disorders on White Matter Development
    Role: Principal Investigator
  3. 2019 Young Investigator Award (LYALL, AMANDA ELLIS) Jan 1, 2020 - Dec 31, 2024
    Brain and Behavior Research Foundation
    Multimodal Imaging of Glutamate in Bipolar Disorder: A Joint GluCEST/MR-PET Study
    Role: Principal Investigator
  4. K01MH115247 (LYALL, AMANDA ELLIS) Aug 1, 2018 - Jul 31, 2023
    NIH
    Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET Study
    Role: Principal Investigator
  5. R03MH110745 (LYALL, AMANDA ELLIS) Aug 15, 2016 - Jul 31, 2019
    NIH
    Imaging White Matter Maturation and Genetic High Risk for Schizophrenia
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.