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Lauren L Orefice, Ph.D.

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Georgetown University, Washington, D.C.Ph.D.05/2013Neuroscience

Our lab studies the development, function and dysfunction of the somatosensory system.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS122788 (OREFICE, LAUREN LYNN) Jul 15, 2021 - Jun 30, 2026
    The effects of somatosensory experience on brain development and function in autism spectrum disorders
    Role: Principal Investigator
  2. R00NS101057 (OREFICE, LAUREN LYNN) Sep 1, 2017 - Jan 31, 2022
    Understanding Somatosensory Deficits in Autism Spectrum Disorders
    Role: Principal Investigator
  3. K99NS101057 (OREFICE, LAUREN LYNN) Sep 1, 2017 - Aug 31, 2019
    Understanding Somatosensory Deficits in Autism Spectrum Disorders
    Role: Principal Investigator
  4. F31NS074840 (OREFICE, LAUREN LYNN) Sep 30, 2011 - Sep 29, 2014
    The Role of Local BDNF Synthesis in Spine Morphogenesis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bohnslav JP, Wimalasena NK, Clausing KJ, Dai YY, Yarmolinsky DA, Cruz T, Kashlan AD, Chiappe ME, Orefice LL, Woolf CJ, Harvey CD. DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels. Elife. 2021 09 02; 10. PMID: 34473051.
    Citations:    Fields:    
  2. Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD. Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception. Science. 2020 06 19; 368(6497). PMID: 32554568.
    Citations: 10     Fields:    Translation:AnimalsCells
  3. Orefice LL. Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders. Neuroscience. 2020 10 01; 445:120-129. PMID: 32035119.
    Citations: 4     Fields:    Translation:AnimalsCells
  4. Orefice LL. Outside-in: Rethinking the etiology of autism spectrum disorders Science. 2019 10 04; 366(6461):45-46. PMID: 31604296.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  5. Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Cell. 2019 08 08; 178(4):867-886.e24. PMID: 31398341.
    Citations: 27     Fields:    Translation:AnimalsCells
  6. Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019 05 30; 177(6):1507-1521.e16. PMID: 31031004.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  7. Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E619-E628. PMID: 28069946.
    Citations: 18     Fields:    Translation:AnimalsCells
  8. Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12; 168(1-2):295-310.e19. PMID: 28041852.
    Citations: 89     Fields:    Translation:AnimalsCells
  9. Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. Cell. 2016 Jul 14; 166(2):299-313. PMID: 27293187.
    Citations: 86     Fields:    Translation:AnimalsCells
  10. Orefice LL, Shih CC, Xu H, Waterhouse EG, Xu B. Control of spine maturation and pruning through proBDNF synthesized and released in dendrites. Mol Cell Neurosci. 2016 Mar; 71:66-79. PMID: 26705735.
    Citations: 20     Fields:    Translation:AnimalsCells
  11. Orefice LL, Waterhouse EG, Partridge JG, Lalchandani RR, Vicini S, Xu B. Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines. J Neurosci. 2013 Jul 10; 33(28):11618-32. PMID: 23843530.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  12. Waterhouse EG, An JJ, Orefice LL, Baydyuk M, Liao GY, Zheng K, Lu B, Xu B. BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. J Neurosci. 2012 Oct 10; 32(41):14318-30. PMID: 23055503.
    Citations: 89     Fields:    Translation:AnimalsCells
  13. Orefice LL, Heinrichs SC. Paternal care paradoxically increases offspring seizure susceptibility in the El mouse model of epilepsy. Epilepsy Behav. 2008 Feb; 12(2):234-41. PMID: 17964859.
    Citations: 1     Fields:    Translation:HumansAnimals
  14. Forcelli PA, Orefice LL, Heinrichs SC. Neural, endocrine and electroencephalographic hyperreactivity to human contact: a diathesis-stress model of seizure susceptibility in El mice. Brain Res. 2007 May 04; 1144:248-56. PMID: 17320061.
    Citations: 3     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.