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Yoshihide Kanaoka, PH.D., M.D.

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Overview
Eicosanoids are lipid mediators derived from arachidonic acid that have been implicated in diverse inflammatory and immune responses. The cysteinyl leukotrienes (cys-LTs), leukotriene (LT) C4, LTD4, and LTE4, are a group of bioactive eicosanoids that are produced by hematopoietic cells, such as mast cells, macrophages, and dendritic cells. They constrict bronchial smooth muscle, increase vascular permeability, and promote fibrosis. LTC4 synthase, an integral membrane protein, is the critical enzyme for the cys-LT biosynthesis. There are two classical G protein-coupled receptors for the cys-LTs, termed CysLT1R and CysLT2R. We are focused on elucidating the role of cys-LTs in several models of innate and adaptive immunity and inflammation with mice null for LTC4 synthase and on clarifying the particular receptor functions in these models with mice null for CysLT1R or CysLT2R. We have recently found that there is a novel cys-LT receptor preferential for LTE4 in mice lacking both CysLT1R and CysLT2R. We have also found that an orphan G protein-coupled receptor GPR17 is a negative regulator of the CysLT1R-mediated vascular permeability in vivo. Ongoing projects include (1) the molecular identification and characterization of the LTE4 receptor and (2) the role of GPR17 in allergen-induced pulmonary inflammation.

Dectin-2 is a C-type lectin receptor that associates with the Fc receptor gamma chain to activate the signal through Syk. We have demonstrated that Dectin-2 on dendritic cells can bind to extracts from house dust mite in a mannose-dependent manner, resulting in production of cys-LTs. We are investigating the role of Dectin-2 in allergen-induced pulmonary inflammation.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI107425 (KANAOKA, YOSHIHIDE) May 21, 2013 - Apr 30, 2015
    NIH/NIAID
    Modulation of Dectin-2 as a Therapeutic Approach to Dust Mite-Elicited Asthma
    Role: Principal Investigator
  2. U19AI095219 (BOYCE, JOSHUA A) Jul 15, 2011 - Jun 30, 2021
    NIH/NIAID
    Pathophysiologic and Therapeutic Mechanisms in Aspirin Exacerbated Respiratory Disease
    Role: Co-Principal Investigator
  3. R01HL090630 (SCHMIDT-KREY, INGEBORG) Sep 20, 2008 - Apr 30, 2014
    NIH/NHLBI
    Structure and function of the membrane protein human leukotriene C4 synthase
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 Jan 21. PMID: 30664709.
    Citations:    Fields:    
  2. Duah E, Teegala LR, Kondeti V, Adapala RK, Keshamouni VG, Kanaoka Y, Austen KF, Thodeti CK, Paruchuri S. Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis. Proc Natl Acad Sci U S A. 2019 01 02; 116(1):199-204. PMID: 30559191.
    Citations:    Fields:    
  3. Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA. The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. Sci Immunol. 2018 Oct 05; 3(28). PMID: 30291131.
    Citations:    Fields:    
  4. Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Cirka H, Feng C, Boyce JA. Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. J Immunol. 2018 02 01; 200(3):915-927. PMID: 29282304.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Wang HB, Akuthota P, Kanaoka Y, Weller PF. Airway eosinophil migration into lymph nodes in mice depends on leukotriene C4. Allergy. 2017 Jun; 72(6):927-936. PMID: 27874209.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 01; 214(1):27-37. PMID: 28011865.
    Citations: 14     Fields:    Translation:AnimalsCells
  7. McGovern T, Goldberger M, Chen M, Allard B, Hamamoto Y, Kanaoka Y, Austen KF, Powell WS, Martin JG. CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma. J Immunol. 2016 07 01; 197(1):266-77. PMID: 27226094.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  8. Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA. Phosphoinositide 3-Kinase d Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. J Immunol. 2016 07 01; 197(1):278-87. PMID: 27194783; PMCID: PMC4912906.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7. PMID: 27185938; PMCID: PMC4896673.
    Citations: 8     Fields:    Translation:AnimalsCells
  10. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029; PMCID: PMC4592820.
    Citations: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  11. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors; emerging concepts. Allergy Asthma Immunol Res. 2014 Jul; 6(4):288-95. PMID: 24991451; PMCID: PMC4077954.
    Citations: 20     
  12. Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol. 2014 Feb 15; 192(4):1361-71. PMID: 24453247; PMCID: PMC4024442.
    Citations: 13     Fields:    Translation:AnimalsCells
  13. Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JA. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013 Dec 15; 191(12):5807-10. PMID: 24244016; PMCID: PMC3869987.
    Citations: 9     Fields:    Translation:AnimalsCells
  14. Kanaoka Y, Maekawa A, Austen KF. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem. 2013 Apr 19; 288(16):10967-72. PMID: 23504326; PMCID: PMC3630866.
    Citations: 41     Fields:    Translation:Animals
  15. Ago H, Okimoto N, Kanaoka Y, Morimoto G, Ukita Y, Saino H, Taiji M, Miyano M. A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid. J Biochem. 2013 May; 153(5):421-9. PMID: 23378248; PMCID: PMC3635087.
    Citations: 3     Fields:    Translation:Cells
  16. Barrett NA, Fernandez JM, Maekawa A, Xing W, Li L, Parsons MW, Austen KF, Kanaoka Y. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J Immunol. 2012 Nov 01; 189(9):4556-65. PMID: 23002438; PMCID: PMC3478400.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Oyoshi MK, He R, Kanaoka Y, ElKhal A, Kawamoto S, Lewis CN, Austen KF, Geha RS. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4992-7. PMID: 22416124; PMCID: PMC3323994.
    Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  18. Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11. PMID: 21934409; PMCID: PMC3194098.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Kanaoka Y. [Cysteinyl reukotriene receptors]. Seikagaku. 2011 Jul; 83(7):609-14. PMID: 21866871.
    Citations:    Fields:    Translation:HumansAnimalsCells
  20. Saino H, Ukita Y, Ago H, Irikura D, Nisawa A, Ueno G, Yamamoto M, Kanaoka Y, Lam BK, Austen KF, Miyano M. The catalytic architecture of leukotriene C4 synthase with two arginine residues. J Biol Chem. 2011 May 06; 286(18):16392-401. PMID: 21454538; PMCID: PMC3091245.
    Citations: 8     Fields:    Translation:HumansCells
  21. Barrett NA, Rahman OM, Fernandez JM, Parsons MW, Xing W, Austen KF, Kanaoka Y. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med. 2011 Mar 14; 208(3):593-604. PMID: 21357742; PMCID: PMC3058587.
    Citations: 61     Fields:    Translation:AnimalsCells
  22. Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. PMID: 21307302; PMCID: PMC3711031.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  23. He P, Laidlaw T, Maekawa A, Kanaoka Y, Xu K, Lam BK. Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. J Biol Chem. 2011 Mar 11; 286(10):8277-86. PMID: 21233206; PMCID: PMC3048713.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Maekawa A, Xing W, Austen KF, Kanaoka Y. GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol. 2010 Aug 01; 185(3):1846-54. PMID: 20574000; PMCID: PMC4014011.
    Citations: 13     Fields:    Translation:AnimalsCells
  25. Queto T, Gaspar-Elsas MI, Masid-de-Brito D, Vasconcelos ZF, Ferraris FK, Penido C, Cunha FQ, Kanaoka Y, Lam BK, Xavier-Elsas P. Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow. J Leukoc Biol. 2010 May; 87(5):885-93. PMID: 20219953; PMCID: PMC2858675.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Fujitani Y, Aritake K, Kanaoka Y, Goto T, Takahashi N, Fujimori K, Kawada T. Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. FEBS J. 2010 Mar; 277(6):1410-9. PMID: 20136655.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Zhao G, Johnson MC, Schnell JR, Kanaoka Y, Haase W, Irikura D, Lam BK, Schmidt-Krey I. Two-dimensional crystallization conditions of human leukotriene C4 synthase requiring adjustment of a particularly large combination of specific parameters. J Struct Biol. 2010 Mar; 169(3):450-4. PMID: 19903529; PMCID: PMC2826519.
    Citations: 4     Fields:    Translation:HumansCells
  28. Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, Kanaoka Y, Conley P, Boyce JA. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med. 2009 Oct 26; 206(11):2543-55. PMID: 19822647; PMCID: PMC2768854.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  29. Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol. 2009 Sep; 124(3):406-14; quiz 415-6. PMID: 19647860; PMCID: PMC2739263.
    Citations: 26     Fields:    Translation:HumansAnimals
  30. Maekawa A, Balestrieri B, Austen KF, Kanaoka Y. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11685-90. PMID: 19561298; PMCID: PMC2710631.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  31. Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol. 2009 Jan 15; 182(2):1129-37. PMID: 19124756; PMCID: PMC2615395.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  32. Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol. 2009 Jan 15; 182(2):1119-28. PMID: 19124755; PMCID: PMC3682801.
    Citations: 83     Fields:    Translation:AnimalsCells
  33. Maekawa A, Kanaoka Y, Xing W, Austen KF. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16695-700. PMID: 18931305; PMCID: PMC2575482.
    Citations: 43     Fields:    Translation:Animals
  34. Elsas PX, Queto T, Mendonça-Sales SC, Elsas MI, Kanaoka Y, Lam BK. Cysteinyl leukotrienes mediate the enhancing effects of indomethacin and aspirin on eosinophil production in murine bone marrow cultures. Br J Pharmacol. 2008 Feb; 153(3):528-35. PMID: 18037915; PMCID: PMC2241793.
    Citations: 9     Fields:    Translation:AnimalsCells
  35. Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JA. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 2007 Nov 01; 110(9):3263-70. PMID: 17693579; PMCID: PMC2200919.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  36. Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007 Aug 02; 448(7153):609-12. PMID: 17632548.
    Citations: 49     Fields:    Translation:HumansCells
  37. Park JM, Kanaoka Y, Eguchi N, Aritake K, Grujic S, Materi AM, Buslon VS, Tippin BL, Kwong AM, Salido E, French SW, Urade Y, Lin HJ. Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Cancer Res. 2007 Feb 01; 67(3):881-9. PMID: 17283118.
    Citations: 20     Fields:    Translation:Animals
  38. Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce JA. Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J Immunol. 2006 Sep 01; 177(5):2755-9. PMID: 16920908.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  39. Mohri I, Taniike M, Taniguchi H, Kanekiyo T, Aritake K, Inui T, Fukumoto N, Eguchi N, Kushi A, Sasai H, Kanaoka Y, Ozono K, Narumiya S, Suzuki K, Urade Y. Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J Neurosci. 2006 Apr 19; 26(16):4383-93. PMID: 16624958.
    Citations: 52     Fields:    Translation:AnimalsCells
  40. Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol. 2006 Apr 01; 176(7):4440-8. PMID: 16547282.
    Citations: 52     Fields:    Translation:AnimalsCells
  41. Chen M, Lam BK, Kanaoka Y, Nigrovic PA, Audoly LP, Austen KF, Lee DM. Neutrophil-derived leukotriene B4 is required for inflammatory arthritis. J Exp Med. 2006 Apr 17; 203(4):837-42. PMID: 16567388; PMCID: PMC2118292.
    Citations: 94     Fields:    Translation:AnimalsCells
  42. Trivedi SG, Newson J, Rajakariar R, Jacques TS, Hannon R, Kanaoka Y, Eguchi N, Colville-Nash P, Gilroy DW. Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5179-84. PMID: 16547141; PMCID: PMC1458814.
    Citations: 41     Fields:    Translation:AnimalsCells
  43. Abonia JP, Friend DS, Austen WG, Moore FD, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol. 2005 Jun 01; 174(11):7285-91. PMID: 15905575; PMCID: PMC2951006.
    Citations: 29     Fields:    Translation:AnimalsCells
  44. Schmidt-Krey I, Kanaoka Y, Mills DJ, Irikura D, Haase W, Lam BK, Austen KF, Kühlbrandt W. Human leukotriene C(4) synthase at 4.5 A resolution in projection. Structure. 2004 Nov; 12(11):2009-14. PMID: 15530365.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  45. Beller TC, Maekawa A, Friend DS, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem. 2004 Oct 29; 279(44):46129-34. PMID: 15328359.
    Citations: 40     Fields:    Translation:AnimalsCells
  46. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol. 2004 Aug 01; 173(3):1503-10. PMID: 15265876.
    Citations: 74     Fields:    Translation:HumansAnimals
  47. Beller TC, Friend DS, Maekawa A, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3047-52. PMID: 14970333; PMCID: PMC365742.
    Citations: 36     Fields:    Translation:AnimalsCells
  48. Satake Y, Diaz BL, Balestrieri B, Lam BK, Kanaoka Y, Grusby MJ, Arm JP. Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J Biol Chem. 2004 Apr 16; 279(16):16488-94. PMID: 14761945; PMCID: PMC1201398.
    Citations: 58     Fields:    Translation:Animals
  49. Kanaoka Y, Urade Y. Hematopoietic prostaglandin D synthase. Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep; 69(2-3):163-7. PMID: 12895599.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  50. Feldweg AM, Friend DS, Zhou JS, Kanaoka Y, Daheshia M, Li L, Austen KF, Katz HR. gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo. Eur J Immunol. 2003 Aug; 33(8):2262-8. PMID: 12884301.
    Citations: 9     Fields:    Translation:AnimalsCells
  51. Kanaoka Y, Yagi T, Sadamori H, Matsukawa H, Matsuda H, Inagaki M, Ishikawa T, Saito S, Iwagaki H, Tanaka N. Analysis of host response to hepatectomy by simultaneous measurement of cytokines in the portal vein, caval vein and radial artery. J Int Med Res. 2002 Sep-Oct; 30(5):496-505. PMID: 12449519.
    Citations: 3     Fields:    Translation:Humans
  52. Maekawa A, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J Biol Chem. 2002 Jun 07; 277(23):20820-4. PMID: 11932261.
    Citations: 37     Fields:    Translation:AnimalsCells
  53. Diaz BL, Fujishima H, Kanaoka Y, Urade Y, Arm JP. Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. J Immunol. 2002 Feb 01; 168(3):1397-404. PMID: 11801681.
    Citations: 9     Fields:    Translation:AnimalsCells
  54. Fujitani Y, Kanaoka Y, Aritake K, Uodome N, Okazaki-Hatake K, Urade Y. Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J Immunol. 2002 Jan 01; 168(1):443-9. PMID: 11751991.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  55. Seymour ML, Rak S, Aberg D, Riise GC, Penrose JF, Kanaoka Y, Austen KF, Holgate ST, Sampson AP. Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics. Am J Respir Crit Care Med. 2001 Dec 01; 164(11):2051-6. PMID: 11739134.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  56. Kanaoka Y, Maekawa A, Penrose JF, Austen KF, Lam BK. Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. J Biol Chem. 2001 Jun 22; 276(25):22608-13. PMID: 11319240.
    Citations: 51     Fields:    Translation:AnimalsCells
  57. Maekawa A, Kanaoka Y, Lam BK, Austen KF. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2256-61. PMID: 11226226; PMCID: PMC30125.
    Citations: 11     Fields:    Translation:AnimalsCells
  58. Fujimori K, Kanaoka Y, Sakaguchi Y, Urade Y. Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1. J Biol Chem. 2000 Dec 22; 275(51):40511-6. PMID: 10998423.
    Citations: 9     Fields:    Translation:HumansCells
  59. Pinzar E, Miyano M, Kanaoka Y, Urade Y, Hayaishi O. Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis. J Biol Chem. 2000 Oct 06; 275(40):31239-44. PMID: 10871602.
    Citations: 7     Fields:    Translation:AnimalsCells
  60. Kanaoka Y, Fujimori K, Kikuno R, Sakaguchi Y, Urade Y, Hayaishi O. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. Eur J Biochem. 2000 Jun; 267(11):3315-22. PMID: 10824118.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  61. Pinzar E, Kanaoka Y, Inui T, Eguchi N, Urade Y, Hayaishi O. Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4903-7. PMID: 10781097; PMCID: PMC18330.
    Citations: 24     Fields:    Translation:HumansAnimals
  62. Yamamoto H, Tsukahara K, Kanaoka Y, Jinno S, Okayama H. Isolation of a mammalian homologue of a fission yeast differentiation regulator. Mol Cell Biol. 1999 May; 19(5):3829-41. PMID: 10207106; PMCID: PMC84229.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  63. Eguchi N, Minami T, Shirafuji N, Kanaoka Y, Tanaka T, Nagata A, Yoshida N, Urade Y, Ito S, Hayaishi O. Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):726-30. PMID: 9892701; PMCID: PMC15204.
    Citations: 42     Fields:    Translation:Animals
  64. Gerashchenko D, Beuckmann CT, Kanaoka Y, Eguchi N, Gordon WC, Urade Y, Bazan NG, Hayaishi O. Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes. J Neurochem. 1998 Sep; 71(3):937-45. PMID: 9721719.
    Citations: 8     Fields:    Translation:AnimalsCells
  65. Gerashchenko DY, Beuckmann CT, Marcheselli VL, Gordon WC, Kanaoka Y, Eguchi N, Urade Y, Hayaishi O, Bazan NG. Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids. Invest Ophthalmol Vis Sci. 1998 Jan; 39(1):198-203. PMID: 9430563.
    Citations: 8     Fields:    Translation:Animals
  66. Suzuki T, Watanabe K, Kanaoka Y, Sato T, Hayaishi O. Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. Biochem Biophys Res Commun. 1997 Dec 18; 241(2):288-93. PMID: 9425264.
    Citations: 1     Fields:    Translation:HumansCells
  67. Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O. Prostaglandin D synthase in human megakaryoblastic cells. J Biol Chem. 1997 Nov 07; 272(45):28263-6. PMID: 9353279.
    Citations: 10     Fields:    Translation:HumansCells
  68. Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell. 1997 Sep 19; 90(6):1085-95. PMID: 9323136.
    Citations: 47     Fields:    Translation:AnimalsCells
  69. Yamashima T, Sakuda K, Tohma Y, Yamashita J, Oda H, Irikura D, Eguchi N, Beuckmann CT, Kanaoka Y, Urade Y, Hayaishi O. Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. J Neurosci. 1997 Apr 01; 17(7):2376-82. PMID: 9065498.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  70. Kanaoka Y, Kimura SH, Okazaki I, Ikeda M, Nojima H. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. FEBS Lett. 1997 Jan 27; 402(1):73-80. PMID: 9013862.
    Citations: 31     Fields:    Translation:Cells
  71. Beuckmann CT, Gordon WC, Kanaoka Y, Eguchi N, Marcheselli VL, Gerashchenko DY, Urade Y, Hayaishi O, Bazan NG. Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix. J Neurosci. 1996 Oct 01; 16(19):6119-24. PMID: 8815894.
    Citations: 12     Fields:    Translation:AnimalsCells
  72. Nojima H, Leem SH, Araki H, Sakai A, Nakashima N, Kanaoka Y, Ono Y. Hac1: a novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdc10 mutant of Schizosaccharomyces pombe. Nucleic Acids Res. 1994 Dec 11; 22(24):5279-88. PMID: 7816617; PMCID: PMC332072.
    Citations: 19     Fields:    Translation:AnimalsCells
  73. Kanaoka Y, Nojima H. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. Nucleic Acids Res. 1994 Jul 11; 22(13):2687-93. PMID: 8041632; PMCID: PMC308228.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  74. Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, Okayama H. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 1994 Apr 01; 13(7):1549-56. PMID: 8156993; PMCID: PMC394984.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  75. Tamura K, Kanaoka Y, Jinno S, Nagata A, Ogiso Y, Shimizu K, Hayakawa T, Nojima H, Okayama H. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Oncogene. 1993 Aug; 8(8):2113-8. PMID: 8336937.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  76. Kuniyasu A, Oka K, Ide-Yamada T, Hatanaka Y, Abe T, Nakayama H, Kanaoka Y. Structural characterization of the dihydropyridine receptor-linked calcium channel from porcine heart. J Biochem. 1992 Aug; 112(2):235-42. PMID: 1328169.
    Citations: 3     Fields:    Translation:AnimalsCells
  77. Kajiwara K, Kumazaki T, Sato E, Kanaoka Y, Ishii S. Application of bimane-peptide substrates to spectrofluorometric assays of metalloendopeptidases. J Biochem. 1991 Sep; 110(3):345-9. PMID: 1769960.
    Citations:    Fields:    Translation:Cells
  78. Tanizawa K, Kanaoka Y. Oxygen and sulfur esters of "inverse substrates": different responses of amidinophenol and amidinothiophenol in the activation of the rate of tryptic hydrolysis of the inverse esters. J Biochem. 1985 Jan; 97(1):275-80. PMID: 3997793.
    Citations:    Fields:    Translation:Cells
  79. Tanizawa K, Nakano M, Lawson WB, Kanaoka Y. Essential roles of alkylammonium and alkylguanidinium ions in trypsin-catalyzed hydrolysis of acetylglycine esters: enhancement of catalytic efficiency analyzed by the use of "inverse substrates". J Biochem. 1982 Sep; 92(3):945-51. PMID: 7142128.
    Citations:    Fields:    Translation:Cells
  80. Nozawa M, Tanizawa K, Kanaoka Y. Comparative studies on the structure of active sites. Behavior of "inverse substrates" toward trypsin and related enzymes. J Biochem. 1982 Jun; 91(6):1837-43. PMID: 6811567.
    Citations:    Fields:    Translation:HumansAnimalsCells
  81. Fujioka T, Tanizawa K, Kanaoka Y. Analysis of latent properties of trypsin. Acyl trypsins derived from enantiomeric pairs of "inverse substrates". J Biochem. 1981 Feb; 89(2):637-43. PMID: 7240132.
    Citations:    Fields:    Translation:Cells
  82. Fujioka T, Satoh T, Tanizawa K, Kanaoka Y. Tryptic hydrolysis of omega-amidino alpha-amino acid (indospecine) esters. J Biochem. 1980 Apr; 87(4):1229-34. PMID: 7390986.
    Citations:    Fields:    
  83. Tanizawa K, Kasaba Y, Kanaoka Y. Induced activation in the deacylation step of tryptic hydrolysis. An application of "inverse substrates" to mechanistic studies of the enzyme. J Biochem. 1980 Feb; 87(2):417-27. PMID: 7358646.
    Citations: 1     Fields:    Translation:Cells
  84. Tanizawa K, Ishii S, Hamaguchi K, Kanaoka Y. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May; 69(5):893-9. PMID: 5577153.
    Citations: 1     Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.