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David M. Langenau, Ph.D.

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Available: 01/02/23, Expires: 12/31/26

Rhabdomyosarcoma (RMS) accounts for 50% of all soft-tissue childhood sarcomas and is characterized by tumor cells that molecularly and morphologically resemble undifferentiated skeletal muscle. Work from our group has recently identified a cancer stem cell in a subtype of RMS that drives therapy resistance (Wei et al., Nature Cancer 2022), yet mechanisms governing retention of the cancer stem cell state or pathways regulating therapy resistance within this subpopulation of cells are currently unknown. The goal for this project is to identify genetic modifiers that drive RMS growth, aggression, and stem cell self-renewal and to use this knowledge to uncover new therapeutic vulnerabilities to prevent tumor progression and relapse. Work will use loss-of-function and gain-of-function in human RMS cells to identify new cancer stem cell genes, 2) dynamically visualize effects on modulating human RMS CSC self-renewal, and 3) directly visualize the effects of therapy on RMS CSC self-renewal. This work will capitalize on the transgenic, photoconveratable cell lineage reporters that label and track human RMS CSCs.

The role of PTEN/AKT signaling in T-cell Acute Lymphoblastic Leukemia Relapse
Summer, 06/25/12 - 08/10/12

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA269213 (LANGENAU, DAVID MICHAEL) May 1, 2023 - Apr 30, 2028
    NIH
    Oncogenic Drivers of Rhabdomyosarcoma Cell State, Cancer Stem Cells and Metastasis
    Role: Principal Investigator
  2. R01CA276116 (LANGENAU, DAVID MICHAEL) Mar 1, 2023 - Feb 29, 2028
    NIH
    Mechanisms of aggressive Rhabdomyosarcoma.
    Role: Principal Investigator
  3. R24OD031955 (LANGENAU, DAVID MICHAEL) Mar 1, 2022 - Feb 28, 2026
    NIH
    Developing preclinical xenograft models in zebrafish.
    Role: Principal Investigator
  4. R01CA226926 (LANGENAU, DAVID MICHAEL) Apr 1, 2018 - Mar 31, 2024
    NIH
    New models and therapeutic approaches in alveolar rhabdomyosarcoma
    Role: Principal Investigator
  5. R01CA215118 (LANGENAU, DAVID MICHAEL) Jan 10, 2018 - Dec 31, 2022
    NIH
    Stem cell self-renewal programs in rhabdomyosarcoma
    Role: Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.