Harvard Catalyst Profiles

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David M. Langenau, Ph.D.


The role of PTEN/AKT signaling in T-cell Acute Lymphoblastic Leukemia Relapse
Summer, 06/25/12 - 08/10/12

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA226926 (LANGENAU, DAVID MICHAEL) Apr 1, 2018 - Mar 31, 2023
    New models and therapeutic approaches in alveolar rhabdomyosarcoma
    Role: Principal Investigator
  2. R01CA215118 (LANGENAU, DAVID MICHAEL) Jan 10, 2018 - Dec 31, 2022
    Stem cell self-renewal programs in rhabdomyosarcoma
    Role: Principal Investigator
  3. R01CA211734 (LANGENAU, DAVID MICHAEL) Aug 1, 2017 - Jul 31, 2022
    Oncogenic pathways and therapeutic targets in T cell acute lymphoblastic leukemia
    Role: Principal Investigator
  4. R24OD016761 (LANGENAU, DAVID MICHAEL) Aug 1, 2013 - Jun 30, 2022
    Immune Compromised Zebrafish for Cell Transplantation
    Role: Principal Investigator
  5. R01CA154923 (LANGENAU, DAVID MICHAEL) Mar 1, 2011 - Feb 29, 2016
    Genetics of Rhabdomyosarcoma
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ferrero G, Gomez E, Lyer S, Rovira M, Miserocchi M, Langenau DM, Bertrand JY, Wittamer V. The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish. J Leukoc Biol. 2020 Mar; 107(3):431-443. PMID: 31909502.
  2. Yan C, Yang Q, Do D, Brunson DC, Langenau DM. Adult immune compromised zebrafish for xenograft cell transplantation studies. EBioMedicine. 2019 Sep; 47:24-26. PMID: 31416720.
  3. Yohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, Chen E, Collins N, Ehrlich A, Galindo RL, Gryder BE, Hahn H, Hammond S, Hatley ME, Hawkins DS, Hayes MN, Hayes-Jordan A, Helman LJ, Hettmer S, Ignatius MS, Keller C, Khan J, Kirsch DG, Linardic CM, Lupo PJ, Rota R, Shern JF, Shipley J, Sindiri S, Tapscott SJ, Vakoc CR, Wexler LH, Langenau DM. Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer. 2019 10; 66(10):e27869. PMID: 31222885.
  4. Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM. Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Cell. 2019 06 13; 177(7):1903-1914.e14. PMID: 31031007.
  5. Chen H, Albergante L, Hsu JY, Lareau CA, Lo Bosco G, Guan J, Zhou S, Gorban AN, Bauer DE, Aryee MJ, Langenau DM, Zinovyev A, Buenrostro JD, Yuan GC, Pinello L. Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM. Nat Commun. 2019 04 23; 10(1):1903. PMID: 31015418.
  6. Osseiran S, Austin LA, Cannon TM, Yan C, Langenau DM, Evans CL. Longitudinal monitoring of cancer cell subpopulations in monolayers, 3D spheroids, and xenografts using the photoconvertible dye DiR. Sci Rep. 2019 04 05; 9(1):5713. PMID: 30952965.
  7. Borga C, Foster CA, Iyer S, Garcia SP, Langenau DM, Frazer JK. Molecularly distinct models of zebrafish Myc-induced B cell leukemia. Leukemia. 2019 02; 33(2):559-562. PMID: 30573774.
    Citations:    Fields:    
  8. Ignatius MS, Hayes MN, Moore FE, Tang Q, Garcia SP, Blackburn PR, Baxi K, Wang L, Jin A, Ramakrishnan A, Reeder S, Chen Y, Nielsen GP, Chen EY, Hasserjian RP, Tirode F, Ekker SC, Langenau DM. tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish. Elife. 2018 09 07; 7. PMID: 30192230.
    Citations:    Fields:    Translation:AnimalsCells
  9. Mansour MR, He S, Li Z, Lobbardi R, Abraham BJ, Hug C, Rahman S, Leon TE, Kuang YY, Zimmerman MW, Blonquist T, Gjini E, Gutierrez A, Tang Q, Garcia-Perez L, Pike-Overzet K, Anders L, Berezovskaya A, Zhou Y, Zon LI, Neuberg D, Fielding AK, Staal FJT, Langenau DM, Sanda T, Young RA, Look AT. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945. PMID: 29941549.
    Citations:    Fields:    
  10. Garcia EG, Iyer S, Garcia SP, Loontiens S, Sadreyev RI, Speleman F, Langenau DM. Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia. Leukemia. 2018 08; 32(8):1860-1865. PMID: 29749398.
    Citations: 1     Fields:    
  11. Hayes MN, McCarthy K, Jin A, Oliveira ML, Iyer S, Garcia SP, Sindiri S, Gryder B, Motala Z, Nielsen GP, Borg JP, van de Rijn M, Malkin D, Khan J, Ignatius MS, Langenau DM. Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma. Cell Stem Cell. 2018 03 01; 22(3):414-427.e6. PMID: 29499154.
    Citations:    Fields:    
  12. Kasheta M, Painter CA, Moore FE, Lobbardi R, Bryll A, Freiman E, Stachura D, Rogers AB, Houvras Y, Langenau DM, Ceol CJ. Identification and characterization of T reg-like cells in zebrafish. J Exp Med. 2017 Dec 04; 214(12):3519-3530. PMID: 29066577.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM. TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 11; 7(11):1336-1353. PMID: 28974511.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Tang Q, Iyer S, Lobbardi R, Moore JC, Chen H, Lareau C, Hebert C, Shaw ML, Neftel C, Suva ML, Ceol CJ, Bernards A, Aryee M, Pinello L, Drummond IA, Langenau DM. Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. J Exp Med. 2017 Oct 02; 214(10):2875-2887. PMID: 28878000.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Bharathy N, Svalina MN, Settelmeyer TP, Cleary MM, Berlow NE, Airhart SD, Xiang S, Keck J, Hayden JB, Shern JF, Mansoor A, Lathara M, Srinivasa G, Langenau DM, Keller C. Preclinical testing of the glycogen synthase kinase-3ß inhibitor tideglusib for rhabdomyosarcoma. Oncotarget. 2017 Sep 08; 8(38):62976-62983. PMID: 28968964.
    Citations: 1     Fields:    
  16. Bharathy N, Svalina MN, Settelmeyer TP, Cleary MM, Berlow NE, Airhart SD, Xiang S, Keck J, Hayden JB, Shern JF, Mansoor A, Lathara M, Srinivasa G, Langenau DM, Keller C. Preclinical testing of the glycogen synthase kinase-3ß inhibitor tideglusib for rhabdomyosarcoma. Oncotarget. 2017 Jun 16. PMID: 28679860.
  17. Ignatius MS, Hayes MN, Lobbardi R, Chen EY, McCarthy KM, Sreenivas P, Motala Z, Durbin AD, Molodtsov A, Reeder S, Jin A, Sindiri S, Beleyea BC, Bhere D, Alexander MS, Shah K, Keller C, Linardic CM, Nielsen PG, Malkin D, Khan J, Langenau DM. The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep. 2017 06 13; 19(11):2304-2318. PMID: 28614716.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Fazio M, Avagyan S, van Rooijen E, Mannherz W, Kaufman CK, Lobbardi R, Langenau DM, Zon LI. Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors. Zebrafish. 2017 08; 14(4):379-382. PMID: 28557653.
    Citations:    Fields:    Translation:AnimalsCells
  19. Berberoglu MA, Gallagher TL, Morrow ZT, Talbot JC, Hromowyk KJ, Tenente IM, Langenau DM, Amacher SL. Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Dev Biol. 2017 04 15; 424(2):162-180. PMID: 28279710.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Tenente IM, Hayes MN, Ignatius MS, McCarthy K, Yohe M, Sindiri S, Gryder B, Oliveira ML, Ramakrishnan A, Tang Q, Chen EY, Petur Nielsen G, Khan J, Langenau DM. Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma. Elife. 2017 01 12; 6. PMID: 28080960.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Hayes MN, Langenau DM. Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma. Methods Cell Biol. 2017; 138:525-561. PMID: 28129857.
    Citations:    Fields:    Translation:HumansAnimals
  22. Moore JC, Mulligan TS, Yordán NT, Castranova D, Pham VN, Tang Q, Lobbardi R, Anselmo A, Liwski RS, Berman JN, Sadreyev RI, Weinstein BM, Langenau DM. T Cell Immune Deficiency in zap70 Mutant Zebrafish. Mol Cell Biol. 2016 Dec 01; 36(23):2868-2876. PMID: 27601584.
    Citations: 5     Fields:    
  23. Moore JC, Tang Q, Yordán NT, Moore FE, Garcia EG, Lobbardi R, Ramakrishnan A, Marvin DL, Anselmo A, Sadreyev RI, Langenau DM. Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish. J Exp Med. 2016 11 14; 213(12):2575-2589. PMID: 27810924.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  24. Moore FE, Garcia EG, Lobbardi R, Jain E, Tang Q, Moore JC, Cortes M, Molodtsov A, Kasheta M, Luo CC, Garcia AJ, Mylvaganam R, Yoder JA, Blackburn JS, Sadreyev RI, Ceol CJ, North TE, Langenau DM. Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. J Exp Med. 2016 05 30; 213(6):979-92. PMID: 27139488.
    Citations: 13     Fields:    Translation:AnimalsCells
  25. Au SH, Storey BD, Moore JC, Tang Q, Chen YL, Javaid S, Sarioglu AF, Sullivan R, Madden MW, O'Keefe R, Haber DA, Maheswaran S, Langenau DM, Stott SL, Toner M. Clusters of circulating tumor cells traverse capillary-sized vessels. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4947-52. PMID: 27091969.
    Citations: 27     Fields:    Translation:HumansCells
  26. Tang Q, Moore JC, Ignatius MS, Tenente IM, Hayes MN, Garcia EG, Torres Yordán N, Bourque C, He S, Blackburn JS, Look AT, Houvras Y, Langenau DM. Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish. Nat Commun. 2016 Jan 21; 7:10358. PMID: 26790525.
    Citations: 15     Fields:    Translation:HumansAnimals
  27. Moore JC, Langenau DM. Allograft Cancer Cell Transplantation in Zebrafish. Adv Exp Med Biol. 2016; 916:265-87. PMID: 27165358.
    Citations: 5     Fields:    Translation:Animals
  28. Ignatius MS, Hayes M, Langenau DM. In Vivo Imaging of Cancer in Zebrafish. Adv Exp Med Biol. 2016; 916:219-37. PMID: 27165356.
    Citations: 2     Fields:    Translation:AnimalsCells
  29. Langenau DM, Sweet-Cordero A, Wechsler-Reya R, Dyer MA. Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. Cancer Res. 2015 Dec 15; 75(24):5176-5186. PMID: 26627009.
    Citations: 2     Fields:    Translation:HumansAnimals
  30. Tenente IM, Tang Q, Moore JC, Langenau DM. Normal and malignant muscle cell transplantation into immune compromised adult zebrafish. J Vis Exp. 2014 Dec 26; (94). PMID: 25591079.
    Citations: 5     Fields:    Translation:Animals
  31. Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C. Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med. 2014 Nov 03; 4(11):a025650. PMID: 25368019.
    Citations: 15     Fields:    Translation:Humans
  32. Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN, Liwski RS, Houvras Y, Langenau DM. Optimized cell transplantation using adult rag2 mutant zebrafish. Nat Methods. 2014 Aug; 11(8):821-4. PMID: 25042784.
    Citations: 28     Fields:    Translation:HumansAnimals
  33. Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014 Jul 15; 28(14):1578-91. PMID: 25030697.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  34. Blackburn JS, Langenau DM. Zebrafish as a model to assess cancer heterogeneity, progression and relapse. Dis Model Mech. 2014 Jul; 7(7):755-62. PMID: 24973745.
    Citations: 13     Fields:    Translation:HumansAnimals
  35. Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT. Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol. 2014 Jul; 166(1):84-90. PMID: 24690081.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  36. Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM. Glycogen synthase kinase 3 inhibitors induce the canonical WNT/ß-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5349-54. PMID: 24706870.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  37. Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, Martinez SA, Chen EY, Lee C, Langenau DM. Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell. 2014 Mar 17; 25(3):366-78. PMID: 24613413.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  38. Langenau DM. Pten regulates zebrafish hematopoiesis. Blood. 2014 Jan 09; 123(2):149-50. PMID: 24408201.
    Citations: 1     Fields:    Translation:AnimalsCells
  39. Chen EY, Dobrinski KP, Brown KH, Clagg R, Edelman E, Ignatius MS, Chen JY, Brockmann J, Nielsen GP, Ramaswamy S, Keller C, Lee C, Langenau DM. Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma. PLoS Genet. 2013 Aug; 9(8):e1003727. PMID: 24009521.
    Citations: 15     Fields:    Translation:HumansAnimals
  40. Storer NY, White RM, Uong A, Price E, Nielsen GP, Langenau DM, Zon LI. Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. Development. 2013 Jul; 140(14):3040-50. PMID: 23821038.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  41. Albacker CE, Storer NY, Langdon EM, Dibiase A, Zhou Y, Langenau DM, Zon LI. The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PLoS One. 2013; 8(5):e64969. PMID: 23705022.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  42. Sokolowski E, Turina CB, Kikuchi K, Langenau DM, Keller C. Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma. Oncogene. 2014 Apr 10; 33(15):1877-89. PMID: 23665679.
    Citations: 10     Fields:    Translation:Humans
  43. Le X, Pugach EK, Hettmer S, Storer NY, Liu J, Wills AA, DiBiase A, Chen EY, Ignatius MS, Poss KD, Wagers AJ, Langenau DM, Zon LI. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development. 2013 Jun; 140(11):2354-64. PMID: 23615277.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  44. Moore FE, Langenau DM. Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish. Adv Hematol. 2012; 2012:478164. PMID: 22829834.
    Citations: 6     
  45. Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM. Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs). PLoS One. 2012; 7(5):e37877. PMID: 22655075.
    Citations: 54     Fields:    Translation:AnimalsCells
  46. Ignatius MS, Chen E, Elpek NM, Fuller AZ, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg AE, Nielsen PG, Mempel TR, Langenau DM. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012 May 15; 21(5):680-93. PMID: 22624717.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  47. Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM. Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 2012 Sep; 26(9):2069-78. PMID: 22538478.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  48. Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20002-7. PMID: 22135462.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  49. Blackburn JS, Liu S, Langenau DM. Quantifying the frequency of tumor-propagating cells using limiting dilution cell transplantation in syngeneic zebrafish. J Vis Exp. 2011 Jul 14; (53):e2790. PMID: 21775966.
    Citations: 9     Fields:    Translation:AnimalsCells
  50. Hettmer S, Liu J, Miller CM, Bronson RT, Langenau DM, Wagers AJ. Use of cellular context to determine sarcoma phenotype in a new mouse sarcoma model. J Clin Oncol. 2011 May 20; 29(15_suppl):10029. PMID: 28021101.
  51. Blackburn JS, Liu S, Raimondi AR, Ignatius MS, Salthouse CD, Langenau DM. High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope. Nat Protoc. 2011 Feb; 6(2):229-41. PMID: 21293462.
    Citations: 12     Fields:    Translation:Animals
  52. Chen EY, Langenau DM. Zebrafish models of rhabdomyosarcoma. Methods Cell Biol. 2011; 105:383-402. PMID: 21951539.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  53. Ignatius MS, Langenau DM. Fluorescent imaging of cancer in zebrafish. Methods Cell Biol. 2011; 105:437-59. PMID: 21951542.
    Citations: 8     Fields:    Translation:Animals
  54. Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods. 2011 Jan; 8(1):67-9. PMID: 21151135.
    Citations: 175     Fields:    Translation:AnimalsCells
  55. Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66. PMID: 20951945.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  56. Blackburn JS, Langenau DM. aMAZe-ing tools for mosaic analysis in zebrafish. Nat Methods. 2010 Mar; 7(3):188-90. PMID: 20195251.
    Citations: 3     Fields:    Translation:Animals
  57. Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, Storer NY, de Jong JL, Chen AT, Zhou Y, Revskoy S, Zon LI, Langenau DM. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 22; 115(16):3296-303. PMID: 20056790.
    Citations: 46     Fields:    Translation:AnimalsCells
  58. Ignatius MS, Langenau DM. Zebrafish as a model for cancer self-renewal. Zebrafish. 2009 Dec; 6(4):377-87. PMID: 19954344.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  59. Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C. Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb; 48(2):155-70. PMID: 18973135.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  60. Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, Stewart RA, Langenau DM, Look AT, Letai A. BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals. Cell Death Differ. 2008 Jun; 15(6):1063-72. PMID: 18404156.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  61. Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI. Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 2008 Jul 10; 27(30):4242-8. PMID: 18345029.
    Citations: 37     Fields:    Translation:Animals
  62. Burket CT, Montgomery JE, Thummel R, Kassen SC, LaFave MC, Langenau DM, Zon LI, Hyde DR. Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic Res. 2008 Apr; 17(2):265-79. PMID: 17968670.
    Citations: 11     Fields:    Translation:AnimalsCells
  63. Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT. Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol. 2007 Jul; 138(2):169-75. PMID: 17593023.
    Citations: 40     Fields:    Translation:AnimalsCells
  64. Le X, Langenau DM, Keefe MD, Kutok JL, Neuberg DS, Zon LI. Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9410-5. PMID: 17517602.
    Citations: 59     Fields:    Translation:Animals
  65. Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le X, Goessling W, Neuberg DS, Kunkel LM, Zon LI. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 2007 Jun 01; 21(11):1382-95. PMID: 17510286.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  66. Berghmans S, Jette C, Langenau D, Hsu K, Stewart R, Look T, Kanki JP. Making waves in cancer research: new models in the zebrafish. Biotechniques. 2005 Aug; 39(2):227-37. PMID: 16116796.
    Citations: 32     Fields:    Translation:Animals
  67. Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6068-73. PMID: 15827121.
    Citations: 73     Fields:    Translation:HumansAnimals
  68. Langenau DM, Zon LI. The zebrafish: a new model of T-cell and thymic development. Nat Rev Immunol. 2005 Apr; 5(4):307-17. PMID: 15803150.
    Citations: 23     Fields:    Translation:AnimalsCells
  69. Langenau DM, Jette C, Berghmans S, Palomero T, Kanki JP, Kutok JL, Look AT. Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Blood. 2005 Apr 15; 105(8):3278-85. PMID: 15618471.
    Citations: 32     Fields:    Translation:AnimalsCells
  70. Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI. Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood. 2004 Sep 01; 104(5):1298-305. PMID: 15142873.
    Citations: 52     Fields:    Translation:Animals
  71. Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7369-74. PMID: 15123839.
    Citations: 88     Fields:    Translation:AnimalsCells
  72. Trede NS, Langenau DM, Traver D, Look AT, Zon LI. The use of zebrafish to understand immunity. Immunity. 2004 Apr; 20(4):367-79. PMID: 15084267.
    Citations: 117     Fields:    Translation:Animals
  73. Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell. 2003 Dec; 5(6):903-14. PMID: 14667412.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  74. Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT. Myc-induced T cell leukemia in transgenic zebrafish. Science. 2003 Feb 07; 299(5608):887-90. PMID: 12574629.
    Citations: 138     Fields:    Translation:AnimalsCells
  75. Langenau DM, Palomero T, Kanki JP, Ferrando AA, Zhou Y, Zon LI, Look AT. Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio). Mech Dev. 2002 Sep; 117(1-2):243-8. PMID: 12204264.
    Citations: 9     Fields:    Translation:AnimalsCells
  76. Bennett CM, Kanki JP, Rhodes J, Liu TX, Paw BH, Kieran MW, Langenau DM, Delahaye-Brown A, Zon LI, Fleming MD, Look AT. Myelopoiesis in the zebrafish, Danio rerio. Blood. 2001 Aug 01; 98(3):643-51. PMID: 11468162.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  77. Bauer MP, Bridgham JT, Langenau DM, Johnson AL, Goetz FW. Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates. Mol Cell Endocrinol. 2000 Oct 25; 168(1-2):119-25. PMID: 11064158.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  78. Xia Z, Gale WL, Chang X, Langenau D, Patiño R, Maule AG, Densmore LD. Phylogenetic sequence analysis, recombinant expression, and tissue distribution of a channel catfish estrogen receptor beta. Gen Comp Endocrinol. 2000 Apr; 118(1):139-49. PMID: 10753576.
    Citations: 1     Fields:    Translation:AnimalsCells
  79. Roberts SB, Langenau DM, Goetz FW. Cloning and characterization of prostaglandin endoperoxide synthase-1 and -2 from the brook trout ovary. Mol Cell Endocrinol. 2000 Feb 25; 160(1-2):89-97. PMID: 10715542.
    Citations: 4     Fields:    Translation:AnimalsCells
  80. Langenau DM, Goetz FW, Roberts SB. The upregulation of messenger ribonucleic acids during 17alpha, 20beta-dihydroxy-4-pregnen-3-one-induced ovulation in the perch ovary. J Mol Endocrinol. 1999 Oct; 23(2):137-52. PMID: 10514552.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.