Harvard Catalyst Profiles

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Jonathan Sylvan Williams, M.D.

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1994 - 1998
Calabrese Scholaraship for Academic Excellence
Alpha Omega Alpha Medical Honor Society
Scholars in Endocrinology Award
2006 - 2009
Nomination, Excellence in Mentoring Award
Early Career Mentoring Award

Available: 04/05/22, Expires: 06/01/23

I conduct human research in cardiometabolic risk by developing phenotype-genotype associations. A focus is determining how dietary salt interacts with genetic predispositions to hypertension, insulin resistance, obesity and other metabolic disorders. This includes active human research protocols and work in a large dataset which I co-direct.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U2CDK129670 (HU, FRANK B) Aug 16, 2021 - Jun 30, 2026
    Dietary Biomarkers Development Center at Harvard University
    Role: Site-PI
  2. R01DK127254 (CZEISLER, CHARLES A) Jul 29, 2021 - Apr 30, 2025
    Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
    Role: Co-Investigator
  3. 1R01HL144779-01 (WILLIAMS, GORDON H) Jan 20, 2019 - Dec 31, 2022
    Salt Sensitive Hypertension and Striatin
    Role: Co-Investigator
  4. UL1TR002541 (NADLER, LEE MARSHALL) May 1, 2018 - Apr 30, 2023
    The Harvard Clinical and Translational Science Center
    Role: CT Academy Co-Director
  5. R01HL141406 (WAINFORD, RICHARD DAVID) May 1, 2018 - Feb 28, 2022
    Central mechanisms and novel biomarkers of the salt-sensitivity of blood pressure
    Role: Site-PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner. J Endocrinol. 2023 Jan 01; 256(1). PMID: 36327153; PMCID: PMC9855026.
    Citations:    Fields:    Translation:Animals
  2. Xin Q, Yuan RK, Zitting KM, Wang W, Purcell SM, Vujovic N, Ronda JM, Quan SF, Williams JS, Buxton OM, Duffy JF, Czeisler CA. Impact of chronic sleep restriction on sleep continuity, sleep structure, and neurobehavioral performance. Sleep. 2022 07 11; 45(7). PMID: 35218665; PMCID: PMC9272266.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  3. Parksook WW, Heydarpour M, Gholami SK, Luther JM, Hopkins PN, Pojoga LH, Williams JS. Salt Sensitivity of Blood Pressure and Aldosterone: Interaction Between the Lysine-specific Demethylase 1 Gene, Sex, and Age. J Clin Endocrinol Metab. 2022 04 19; 107(5):1294-1302. PMID: 35022775; PMCID: PMC9016472.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Zitting KM, Vetrivelan R, Yuan RK, Vujovic N, Wang W, Bandaru SS, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Duffy JF, Saper CB, Czeisler CA. Chronic circadian disruption on a high-fat diet impairs glucose tolerance. Metabolism. 2022 05; 130:155158. PMID: 35150732.
    Citations:    Fields:    Translation:HumansAnimals
  5. Haas AV, En Yee L, Yuan YE, Wong YH, Hopkins PN, Jeunemaitre X, Lasky-Su J, Williams JS, Adler GK, Williams GH. Genetic Predictors of Salt Sensitivity of Blood Pressure: The Additive Impact of 2 Hits in the Same Biological Pathway. Hypertension. 2021 12; 78(6):1809-1817. PMID: 34757767; PMCID: PMC8589116.
    Citations:    Fields:    Translation:Humans
  6. Yuan RK, Zitting KM, Duffy JF, Vujovic N, Wang W, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Czeisler CA. Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance. Front Physiol. 2021; 12:764737. PMID: 34744800.
    Citations: 1     
  7. Pappa T, Heydarpour M, Williams J, Hopkins PN, Adler GK, Alexander EK, Williams G. The Role of Thyroid in Renovascular Function: Independent Association of Serum TSH With Renal Plasma Flow. J Clin Endocrinol Metab. 2021 08 18; 106(9):e3327-e3334. PMID: 34061954; PMCID: PMC8372660.
    Citations: 1     Fields:    Translation:Humans
  8. Stone IB, Green JAEM, Koefoed AW, Hornik ES, Williams JS, Adler GK, Williams GH. Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design. Pharmacogenet Genomics. 2021 06 01; 31(4):83-88. PMID: 33904521.
    Citations:    Fields:    Translation:HumansAnimalsCTClinical Trials
  9. Haas AV, Baudrand R, Easly RM, Murray GR, Touyz RM, Pojoga LH, Jeunemaitre X, Hopkins PN, Rosner B, Williams JS, Williams GH, Adler GK. Interplay Between Statins, Cav1 (Caveolin-1), and Aldosterone. Hypertension. 2020 09; 76(3):962-967. PMID: 32755411; PMCID: PMC7418929.
    Citations: 1     Fields:    Translation:Humans
  10. Hornik ES, Altman-Merino AE, Koefoed AW, Meyer KM, Stone IB, Green JA, Williams GH, Adler GK, Williams JS. A clinical trial to evaluate the effect of statin use on lowering aldosterone levels. BMC Endocr Disord. 2020 Jul 14; 20(1):105. PMID: 32664962.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  11. Maris SA, Meyer KM, Murray G, Williams JS. Physical Activity and the Acute Hemodynamic Response to ACE Inhibition in Hypertension. Am J Lifestyle Med. 2022 Jul-Aug; 16(4):538-545. PMID: 35860373; PMCID: PMC9290176.
  12. Maris SA, Meyer KM, Murray G, Williams JS. Physical activity and the acute hemodynamic response to ACE inhibition in hypertension. Am J Lifestyle Med. 2020; doi: 10.1177/1559827620935367.
  13. Yuan RK, Zitting KM, Wang W, Buxton OM, Williams JS, Duffy JF, Czeisler CA. Fasting blood triglycerides vary with circadian phase in both young and older people. Physiol Rep. 2020 06; 8(11):e14453. PMID: 32519460.
    Citations: 2     Fields:    Translation:Humans
  14. Bayomy O, Zaheer S, Williams JS, Curhan G, Vaidya A. Disentangling the Relationships Between the Renin-Angiotensin-Aldosterone System, Calcium Physiology, and Risk for Kidney Stones. J Clin Endocrinol Metab. 2020 06 01; 105(6). PMID: 32163150; PMCID: PMC7185954.
    Citations: 3     Fields:    Translation:Humans
  15. Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor. Hypertension. 2020 04; 75(4):1045-1053. PMID: 32160100.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Carmichael CY, Kuwabara JT, Pascale CL, Moreira JD, Mahne SE, Kapusta DR, Rosene DL, Williams JS, Cunningham JT, Wainford RD. Hypothalamic Paraventricular Nucleus Gai2 (Guanine Nucleotide-Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein-Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure. Hypertension. 2020 04; 75(4):1002-1011. PMID: 32148128.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Roumie CL, Hung AM, Russell GB, Basile J, Kreider KE, Nord J, Ramsey TM, Rastogi A, Sweeney ME, Tamariz L, Kostis WJ, Williams JS, Zias A, Cushman WC. Blood Pressure Control and the Association With Diabetes Mellitus Incidence: Results From SPRINT Randomized Trial. Hypertension. 2020 02; 75(2):331-338. PMID: 31865790; PMCID: PMC7015147.
    Citations: 4     Fields:    Translation:Humans
  18. Ranjit S, Wong JY, Tan JW, Sin Tay C, Lee JM, Yin Han Wong K, Pojoga LH, Brooks DL, Garza AE, Maris SA, Katayama IA, Williams JS, Rivera A, Adler GK, Williams GH, Romero JR. Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses. JCI Insight. 2019 11 01; 4(21). PMID: 31672933; PMCID: PMC6948756.
    Citations: 3     Fields:    Translation:HumansAnimals
  19. Chellappa SL, Vujovic N, Williams JS, Scheer FAJL. Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol Metab. 2019 10; 30(10):767-779. PMID: 31427142; PMCID: PMC6779516.
    Citations: 49     Fields:    Translation:HumansAnimals
  20. Maris SA, Williams JS, Sun B, Brown S, Mitchell GF, Conlin PR. Interactions of the DASH Diet with the Renin-Angiotensin-Aldosterone System. Curr Dev Nutr. 2019 Sep; 3(9):nzz091. PMID: 31528838; PMCID: PMC6735835.
    Citations: 7     
  21. Haas AV, Hopkins PN, Brown NJ, Pojoga LH, Williams JS, Adler GK, Williams GH. Higher urinary cortisol levels associate with increased cardiovascular risk. Endocr Connect. 2019 Jun 01; 8(6):634-640. PMID: 31018177; PMCID: PMC6528405.
    Citations: 2     
  22. Huang Y, Ting PY, Yao TM, Homma T, Brooks D, Katayama Rangel I, Adler GK, Romero JR, Williams JS, Pojoga LH, Williams GH. Histone demethylase LSD1 deficiency and biological sex: impact on blood pressure and aldosterone production. J Endocrinol. 2019 02 01; 240(2):111-122. PMID: 30400034; PMCID: PMC6824586.
    Citations: 6     Fields:    Translation:HumansAnimals
  23. Zitting KM, Vujovic N, Yuan RK, Isherwood CM, Medina JE, Wang W, Buxton OM, Williams JS, Czeisler CA, Duffy JF. Human Resting Energy Expenditure Varies with Circadian Phase. Curr Biol. 2018 11 19; 28(22):3685-3690.e3. PMID: 30416064; PMCID: PMC6300153.
    Citations: 46     Fields:    Translation:Humans
  24. Zhang X, Frame AA, Williams JS, Wainford RD. GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study. Physiol Genomics. 2018 09 01; 50(9):724-725. PMID: 29906209; PMCID: PMC6172609.
    Citations: 8     Fields:    Translation:Humans
  25. Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR. Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II. Hypertension. 2018 06; 71(6):1083-1090. PMID: 29686001.
    Citations: 31     Fields:    Translation:HumansAnimals
  26. Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZ. Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion. TH Open. 2018 Jan; 2(1):e49-e53. PMID: 31249929; PMCID: PMC6524859.
  27. Zaheer S, Taquechel K, Brown JM, Adler GK, Williams JS, Vaidya A. A randomized intervention study to evaluate the effect of calcitriol therapy on the renin-angiotensin system in diabetes. J Renin Angiotensin Aldosterone Syst. 2018 Jan-Mar; 19(1):1470320317754178. PMID: 29562806; PMCID: PMC5896865.
    Citations: 2     Fields:    Translation:Humans
  28. Gupta T, Connors M, Tan JW, Manosroi W, Ahmed N, Ting PY, Garza AE, Romero JR, Hopkins PN, Williams JS, Williams GH. Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens. 2017 Dec 08; 31(1):124-131. PMID: 28985281; PMCID: PMC5861567.
    Citations: 3     Fields:    Translation:HumansAnimals
  29. Tan JW, Gupta T, Manosroi W, Yao TM, Hopkins PN, Williams JS, Adler GK, Romero JR, Williams GH. Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight. 2017 12 07; 2(23). PMID: 29212952; PMCID: PMC5752283.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  30. Manosroi W, Tan JW, Rariy CM, Sun B, Goodarzi MO, Saxena AR, Williams JS, Pojoga LH, Lasky-Su J, Cui J, Guo X, Taylor KD, Chen YI, Xiang AH, Hsueh WA, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Seely EW. The Association of Estrogen Receptor-ß Gene Variation With Salt-Sensitive Blood Pressure. J Clin Endocrinol Metab. 2017 11 01; 102(11):4124-4135. PMID: 28938457; PMCID: PMC5673274.
    Citations: 14     Fields:    Translation:Humans
  31. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J. Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes. N Engl J Med. 2017 08 24; 377(8):733-744. PMID: 28834483; PMCID: PMC5706112.
    Citations: 64     Fields:    Translation:Humans
  32. Bress AP, King JB, Kreider KE, Beddhu S, Simmons DL, Cheung AK, Zhang Y, Doumas M, Nord J, Sweeney ME, Taylor AA, Herring C, Kostis WJ, Powell J, Rastogi A, Roumie CL, Wiggers A, Williams JS, Yunis R, Zias A, Evans GW, Greene T, Rocco MV, Cushman WC, Reboussin DM, Feinglos MN, Papademetriou V. Effect of Intensive Versus Standard Blood Pressure Treatment According to Baseline Prediabetes Status: A Post Hoc Analysis of a Randomized Trial. Diabetes Care. 2017 Aug 09. PMID: 28793997.
    Citations: 20     Fields:    
  33. Zaheer S, Brown JM, Connors M, Williams JS, Adler GK, Vaidya A. Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion. Int J Endocrinol. 2017; 2017:4138783. PMID: 28808443; PMCID: PMC5541811.
    Citations: 2     
  34. Leonardi GC, Oxnard GR, Haas A, Lang JP, Williams JS, Awad MM. Diabetic Ketoacidosis as an Immune-related Adverse Event from Pembrolizumab in Non-Small Cell Lung Cancer. J Immunother. 2017 Jul/Aug; 40(6):249-251. PMID: 28557813.
    Citations: 9     Fields:    Translation:Humans
  35. Baudrand R, Gupta N, Garza AE, Vaidya A, Leopold JA, Hopkins PN, Jeunemaitre X, Ferri C, Romero JR, Williams J, Loscalzo J, Adler GK, Williams GH, Pojoga LH. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016 09 28; 5(10). PMID: 27680666; PMCID: PMC5121487.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  36. Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, Wong SY, Brownell I. A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet. 2016 07; 12(7):e1006150. PMID: 27414798.
    Citations: 16     Fields:    Translation:AnimalsCells
  37. Baudrand R, Pojoga L, Vaidya A, Garza A, Vöhringer P, Jeunemaitre X, Hopkins P, Yao T, Williams J, Adler G, Williams G. Response to Letter Regarding Article, "Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects". Circulation. 2016 Apr 19; 133(16):e606. PMID: 27142613; PMCID: PMC4862598.
    Citations:    Fields:    Translation:Humans
  38. Tamura MK, Pajewski NM, Bryan RN, Weiner DE, Diamond M, Van Buren P, Taylor A, Beddhu S, Rosendorff C, Jahanian H, Zaharchuk G. Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults. Neurology. 2016 Mar 29; 86(13):1208-16. PMID: 26920359.
    Citations: 24     Fields:    Translation:Humans
  39. Wright JT, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015 Nov 26; 373(22):2103-16. PMID: 26551272; PMCID: PMC4689591.
    Citations: 1782     Fields:    Translation:Humans
  40. Baudrand R, Pojoga LH, Vaidya A, Garza AE, Vöhringer PA, Jeunemaitre X, Hopkins PN, Yao TM, Williams J, Adler GK, Williams GH. Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects. Circulation. 2015 Nov 10; 132(19):1825-33. PMID: 26432671; PMCID: PMC4641753.
    Citations: 20     Fields:    Translation:HumansAnimals
  41. Baudrand R, Goodarzi MO, Vaidya A, Underwood PC, Williams JS, Jeunemaitre X, Hopkins PN, Brown N, Raby BA, Lasky-Su J, Adler GK, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Pojoga LH. A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics. Metabolism. 2015 Dec; 64(12):1674-81. PMID: 26475177; PMCID: PMC4641791.
    Citations: 20     Fields:    Translation:Humans
  42. Vaidya A, Brown JM, Williams JS. The renin-angiotensin-aldosterone system and calcium-regulatory hormones. J Hum Hypertens. 2015 Sep; 29(9):515-21. PMID: 25631218.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  43. Arora P, Reingold J, Baggish A, Guanaga DP, Wu C, Ghorbani A, Song Y, Chen-Tournaux A, Khan AM, Tainsh LT, Buys ES, Williams JS, Heublein DM, Burnett JC, Semigran MJ, Bloch KD, Scherrer-Crosbie M, Newton-Cheh C, Kaplan LM, Wang TJ. Weight loss, saline loading, and the natriuretic peptide system. J Am Heart Assoc. 2015 Jan 16; 4(1):e001265. PMID: 25595796.
    Citations: 14     Fields:    Translation:Humans
  44. Garza AE, Rariy CM, Sun B, Williams J, Lasky-Su J, Baudrand R, Yao T, Moize B, Hafiz WM, Romero JR, Adler GK, Ferri C, Hopkins PN, Pojoga LH, Williams GH. Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension. 2015 Jan; 65(1):211-217. PMID: 25368024.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  45. Hamnvik OP, Choueiri TK, Turchin A, McKay RR, Goyal L, Davis M, Kaymakcalan MD, Williams JS. Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway. Cancer. 2015 Jan 15; 121(2):311-9. PMID: 25236375; PMCID: PMC4293233.
    Citations: 72     Fields:    Translation:HumansCells
  46. Garg R, Sun B, Williams J. Effect of low salt diet on insulin resistance in salt-sensitive versus salt-resistant hypertension. Hypertension. 2014 Dec; 64(6):1384-7. PMID: 25185125.
    Citations: 7     Fields:    Translation:Humans
  47. Xiao Y, Williams JS, Brownell I. Merkel cells and touch domes: more than mechanosensory functions? Exp Dermatol. 2014 Oct; 23(10):692-5. PMID: 24862916; PMCID: PMC4180785.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  48. Coutinho P, Vega C, Pojoga LH, Rivera A, Prado GN, Yao TM, Adler G, Torres-Grajales M, Maldonado ER, Ramos-Rivera A, Williams JS, Williams G, Romero JR. Aldosterone's rapid, nongenomic effects are mediated by striatin: a modulator of aldosterone's effect on estrogen action. Endocrinology. 2014 Jun; 155(6):2233-43. PMID: 24654783; PMCID: PMC4020933.
    Citations: 19     Fields:    Translation:AnimalsCells
  49. Seth B, Williams JS. Recent AHA/ACC cholesterol guidelines: vice or virtue? Metabolism. 2014 May; 63(5):605-6. PMID: 24560624.
    Citations: 1     Fields:    Translation:Humans
  50. Brown JM, Williams JS, Luther JM, Garg R, Garza AE, Pojoga LH, Ruan DT, Williams GH, Adler GK, Vaidya A. Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension. 2014 Feb; 63(2):273-80. PMID: 24191286.
    Citations: 26     Fields:    Translation:HumansCTClinical Trials
  51. Brown JM, Secinaro K, Williams JS, Vaidya A. Evaluating hormonal mechanisms of vitamin D receptor agonist therapy in diabetic kidney disease: the VALIDATE-D study. BMC Endocr Disord. 2013 Aug 23; 13:33. PMID: 23971740.
    Citations: 11     Fields:    
  52. Williams JS. Evolving research in nongenomic actions of aldosterone. Curr Opin Endocrinol Diabetes Obes. 2013 Jun; 20(3):198-203. PMID: 23519092.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  53. Vaidya A, Underwood PC, Annes JP, Sun B, Williams GH, Forman JP, Williams JS. The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism. 2013 Apr; 62(4):539-47. PMID: 23142162.
    Citations: 3     Fields:    Translation:Humans
  54. Krug AW, Tille E, Sun B, Pojoga L, Williams J, Chamarthi B, Lichtman AH, Hopkins PN, Adler GK, Williams GH. Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake. Age (Dordr). 2013 Oct; 35(5):1809-20. PMID: 23054827.
    Citations: 9     Fields:    Translation:HumansAnimals
  55. Carey RM, Schoeffel CD, Gildea JJ, Jones JE, McGrath HE, Gordon LN, Park MJ, Sobota RS, Underwood PC, Williams J, Sun B, Raby B, Lasky-Su J, Hopkins PN, Adler GK, Williams SM, Jose PA, Felder RA. Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. Hypertension. 2012 Nov; 60(5):1359-66. PMID: 22987918.
    Citations: 51     Fields:    Translation:Humans
  56. Underwood PC, Chamarthi B, Williams JS, Vaidya A, Garg R, Adler GK, Grotzke MP, Staskus G, Wadwekar D, Hopkins PN, Ferri C, McCall A, McClain D, Williams GH. Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012 Oct; 97(10):3775-82. PMID: 22865897; PMCID: PMC3462947.
    Citations: 11     Fields:    Translation:Humans
  57. Sun B, Chamarthi B, Williams JS, Krug AW, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Ferri C, Williams GH. Different polymorphisms of the mineralocorticoid receptor gene are associated with either glucocorticoid or mineralocorticoid levels in hypertension. J Clin Endocrinol Metab. 2012 Sep; 97(9):E1825-9. PMID: 22723323; PMCID: PMC3431565.
    Citations: 2     Fields:    Translation:Humans
  58. Rao AD, Sun B, Saxena A, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams JS. Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake. J Hum Hypertens. 2013 Mar; 27(3):176-80. PMID: 22648267; PMCID: PMC3463709.
    Citations: 23     Fields:    Translation:Humans
  59. Williams JS. The early-stage patient-oriented researcher in 2012: challenges and strategies. Clin Transl Sci. 2012 Jun; 5(3):221-2. PMID: 22686197; PMCID: PMC5439880.
    Citations:    Fields:    Translation:Humans
  60. Vaidya A, Sun B, Larson C, Forman JP, Williams JS. Vitamin D3 therapy corrects the tissue sensitivity to angiotensin ii akin to the action of a converting enzyme inhibitor in obese hypertensives: an interventional study. J Clin Endocrinol Metab. 2012 Jul; 97(7):2456-65. PMID: 22539586; PMCID: PMC3387405.
    Citations: 29     Fields:    Translation:HumansCTClinical Trials
  61. Williams JS, Chamarthi B, Goodarzi MO, Pojoga LH, Sun B, Garza AE, Raby BA, Adler GK, Hopkins PN, Brown NJ, Jeunemaitre X, Ferri C, Fang R, Leonor T, Cui J, Guo X, Taylor KD, Ida Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Shi Y. Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens. 2012 Jul; 25(7):812-7. PMID: 22534796.
    Citations: 23     Fields:    Translation:HumansAnimals
  62. Vaidya A, Williams JS. Vitamin D and insulin sensitivity: can gene association and pharmacogenetic studies of the vitamin D receptor provide clarity? Metabolism. 2012 Jun; 61(6):759-61. PMID: 22304841.
    Citations: 9     Fields:    Translation:Humans
  63. Larson C, Vaidya A, Sun B, Williams JS. Influence of dietary sodium modulation on electrocardiographic voltage criteria for left ventricular hypertrophy in normotensive individuals. J Investig Med. 2012 Jan; 60(1):39-43. PMID: 22089249.
    Citations:    Fields:    Translation:Humans
  64. Pojoga LH, Coutinho P, Rivera A, Yao TM, Maldonado ER, Youte R, Adler GK, Williams J, Turchin A, Williams GH, Romero JR. Activation of the mineralocorticoid receptor increases striatin levels. Am J Hypertens. 2012 Feb; 25(2):243-9. PMID: 22089104.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  65. Vaidya A, Williams JS. The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes. Metabolism. 2012 Apr; 61(4):450-8. PMID: 22075270.
    Citations: 57     Fields:    Translation:HumansAnimals
  66. Underwood PC, Chamarthi B, Williams JS, Sun B, Vaidya A, Raby BA, Lasky-Su J, Hopkins PN, Adler GK, Williams GH. Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance. Metabolism. 2012 May; 61(5):667-71. PMID: 22075267.
    Citations: 6     Fields:    Translation:HumansCells
  67. Williams JS, Hopkins PN, Jeunemaitre X, Brown NJ. CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow. J Hypertens. 2011 Oct; 29(10):1913-8. PMID: 21873888.
    Citations: 18     Fields:    Translation:Humans
  68. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71. PMID: 21873498.
    Citations: 35     Fields:    Translation:AnimalsCells
  69. Vaidya A, Williams JS, Forman JP. The independent association between 25-hydroxyvitamin D and adiponectin and its relation with BMI in two large cohorts: the NHS and the HPFS. Obesity (Silver Spring). 2012 Jan; 20(1):186-91. PMID: 21760630.
    Citations: 36     Fields:    Translation:Humans
  70. Vaidya A, Sun B, Forman JP, Hopkins PN, Brown NJ, Kolatkar NS, Williams GH, Williams JS. The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians. Clin Endocrinol (Oxf). 2011 Jun; 74(6):783-90. PMID: 21521263; PMCID: PMC3089671.
    Citations: 30     Fields:    Translation:HumansCTClinical Trials
  71. Pojoga LH, Underwood PC, Goodarzi MO, Williams JS, Adler GK, Jeunemaitre X, Hopkins PN, Raby BA, Lasky-Su J, Sun B, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH. Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. J Clin Endocrinol Metab. 2011 Aug; 96(8):E1288-92. PMID: 21613355; PMCID: PMC3146791.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  72. Sun B, Williams JS, Pojoga L, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Ferri C, Williams GH. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses. J Renin Angiotensin Aldosterone Syst. 2011 Dec; 12(4):564-71. PMID: 21490026.
    Citations: 12     Fields:    Translation:Humans
  73. Vaidya A, Forman JP, Underwood PC, Hopkins PN, Williams GH, Pojoga LH, Williams JS. The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men. Eur J Endocrinol. 2011 Jun; 164(6):995-1002. PMID: 21402748; PMCID: PMC3104074.
    Citations: 21     Fields:    Translation:Humans
  74. Vaidya A, Pojoga L, Underwood PC, Forman JP, Hopkins PN, Williams GH, Williams JS. The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension. Clin Endocrinol (Oxf). 2011 Mar; 74(3):294-9. PMID: 21050256.
    Citations: 16     Fields:    Translation:Humans
  75. Vaidya A, Forman JP, Hopkins PN, Seely EW, Williams JS. 25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians. J Renin Angiotensin Aldosterone Syst. 2011 Sep; 12(3):311-9. PMID: 21330422; PMCID: PMC3146958.
    Citations: 46     Fields:    Translation:HumansCTClinical Trials
  76. Underwood PC, Sun B, Williams JS, Pojoga LH, Raby B, Lasky-Su J, Hunt S, Hopkins PN, Jeunemaitre X, Adler GK, Williams GH. The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach. Metabolism. 2011 Aug; 60(8):1150-7. PMID: 21306748.
    Citations: 10     Fields:    Translation:Humans
  77. Vaidya A, Forman JP, Williams JS. Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension. J Hum Hypertens. 2011 Nov; 25(11):672-8. PMID: 21124341; PMCID: PMC3146961.
    Citations: 24     Fields:    Translation:Humans
  78. Underwood PC, Sun B, Williams JS, Pojoga LH, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams GH. The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study. J Clin Endocrinol Metab. 2010 Sep; 95(9):E75-9. PMID: 20631015; PMCID: PMC2936061.
    Citations: 6     Fields:    Translation:Humans
  79. Sun B, Williams JS, Svetkey LP, Kolatkar NS, Conlin PR. Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. Am J Clin Nutr. 2010 Aug; 92(2):444-9. PMID: 20519561; PMCID: PMC2904038.
    Citations: 14     Fields:    Translation:Humans
  80. Williams JS. Hypertension: spironolactone and resistant hypertension. Nat Rev Endocrinol. 2010 May; 6(5):248-50. PMID: 20414316.
    Citations: 1     Fields:    Translation:Humans
  81. Chamarthi B, Williams JS, Williams GH. A mechanism for salt-sensitive hypertension: abnormal dietary sodium-mediated vascular response to angiotensin-II. J Hypertens. 2010 May; 28(5):1020-6. PMID: 20216091; PMCID: PMC2945810.
    Citations: 24     Fields:    Translation:Humans
  82. Forman JP, Williams JS, Fisher ND. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension. 2010 May; 55(5):1283-8. PMID: 20351344; PMCID: PMC3023301.
    Citations: 120     Fields:    Translation:Humans
  83. Vaidya A, Bentley-Lewis R, Jeunemaitre X, Adler GK, Williams JS. Dietary sodium alters the prevalence of electrocardiogram determined left ventricular hypertrophy in hypertension. Am J Hypertens. 2009 Jun; 22(6):669-73. PMID: 19265788.
    Citations: 4     Fields:    Translation:Humans
  84. Williams JS, Brown SM, Conlin PR. Videos in clinical medicine. Blood-pressure measurement. N Engl J Med. 2009 Jan 29; 360(5):e6. PMID: 19179309; PMCID: PMC2825670.
    Citations: 18     Fields:    Translation:Humans
  85. Chamarthi B, Kolatkar NS, Hunt SC, Williams JS, Seely EW, Brown NJ, Murphey LJ, Jeunemaitre X, Williams GH. Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. J Clin Endocrinol Metab. 2007 Apr; 92(4):1340-6. PMID: 17264181.
    Citations: 11     Fields:    Translation:Humans
  86. Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension. 2007 Mar; 49(3):461-6. PMID: 17224473.
    Citations: 33     Fields:    Translation:Humans
  87. Williams JS, Williams GH, Ricchuiti V. Low-renin hypertension is associated with elevated NT-proBNP concentrations on a high sodium diet. Proceedings of the 22nd Annual Scientific Meeting of the American Society of Hypertension. 2007.
  88. Raji A, Williams JS, Hopkins PN, Simonson DC, Williams GH. Familial aggregation of insulin resistance and cardiovascular risk factors in hypertension. J Clin Hypertens (Greenwich). 2006 Nov; 8(11):791-6. PMID: 17086019.
    Citations: 3     Fields:    Translation:Humans
  89. Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown NJ, Hopkins PN, Raby BA, Williams GH. Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension. 2006 Nov; 48(5):892-900. PMID: 17015767.
    Citations: 28     Fields:    Translation:HumansAnimals
  90. Williams JS, Solomon SD, Crivaro M, Conlin PR. Dietary sodium intake modulates myocardial relaxation responsiveness to angiotensin II. Transl Res. 2006 Aug; 148(2):49-54. PMID: 16890144.
    Citations: 5     Fields:    Translation:Humans
  91. Szmuilowicz ED, Adler GK, Williams JS, Green DE, Yao TM, Hopkins PN, Seely EW. Relationship between aldosterone and progesterone in the human menstrual cycle. J Clin Endocrinol Metab. 2006 Oct; 91(10):3981-7. PMID: 16868049.
    Citations: 23     Fields:    Translation:Humans
  92. Raji A, Gerhard-Herman MD, Williams JS, O'connor ME, Simonson DC. Effect of pioglitazone on insulin sensitivity, vascular function and cardiovascular inflammatory markers in insulin-resistant non-diabetic Asian Indians. Diabet Med. 2006 May; 23(5):537-43. PMID: 16681563.
    Citations: 3     Fields:    Translation:Humans
  93. Williams JS, Williams GH, Raji A, Jeunemaitre X, Brown NJ, Hopkins PN, Conlin PR. Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia. J Hum Hypertens. 2006 Feb; 20(2):129-36. PMID: 16292348.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
  94. *Raji A, *Williams JS, Hopkins PN, Simonson DC, Williams GH. Familial aggregation of insulin resistance in hypertension. Proceedings of the American Diabetes Association. 2006.
  95. Williams JS, Raji A, Conlin PR, Hopkins PN, Jeunemaitre X, Williams GH. Non-modulating hypertension is associated with insulin resistance and the Lys528Arg variant of human adipocyte derived leucine aminopeptidase. Proceedings of the 60th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. 2006.
  96. Williams JS, Williams GH, Jeunemaitre X, Hopkins PN, Conlin PR. Influence of dietary sodium on the renin-angiotensin-aldosterone system and prevalence of left ventricular hypertrophy by EKG criteria. J Hum Hypertens. 2005 Feb; 19(2):133-8. PMID: 15361890.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  97. Williams JS, Williams GH, Raji A, Jeuenemaitre X, Brown NJ, Hopkins PN, Conlin PR. Low prevalence of primary hyperaldosteronism in general hypertension. Proceedings of the 20th Annual Scientific Meeting of the American Society of Hypertension. 2005.
  98. Williams JR. Depression as a mediator between spousal bereavement and mortality from cardiovascular disease: appreciating and managing the adverse health consequences of depression in an elderly surviving spouse. South Med J. 2005 Jan; 98(1):90-5. PMID: 15678641.
    Citations: 6     Fields:    Translation:Humans
  99. Williams JS, Solomon SD, Crivaro M, Gerhard-Herman, M, Conlin PR. Dietary sodium intake modulates myocardial relaxation velocity in normal healthy individuals. Proceedings of Clinical Research 2004. 2004.
  100. Williams JS, Williams GH, Jeunemaitre X, Hopkins PN, Brown NJ, Conlin PR. Loss of normal dietary sodium blood pressure response to angiotensin II infusion in essential hypertension. Proceedings of the American Society of Hypertension. 2004.
  101. Williams JS, Williams GH. 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun; 88(6):2364-72. PMID: 12788829.
    Citations: 36     Fields:    Translation:HumansAnimals
  102. Williams JS, Williams GH, Jeunemaitre X, Hopkins PN, Hurwitz S, Conlin PR. Prevalence of left ventricular hypertrophy by EKG criteria in low-renin hypertension. Proceedings of the 57th Annual Fall Conference and Scientific Sessions of the Council on High Blood Pressure Research. 2003.
  103. Conlin, PR, Bryan McIver, Williams JS. A diagnostic approach for evaluating the adrenal mass. Hospital Physician Board Review Manual, Endocrinology. 2002; 1-12.
  104. Williams JS, Baker J, Nelson LM, Ward K, Smotkin D. No Evidence for somatic deletion of the COL4A5 and COL4A6 collagen gene of the X chromosome in benign uterine leiomyomata. Proceedings of the Annual Program of the Society for Gynecologic Investigations. 1993.
  105. Williams JS, Baker J, Dildy G, Ward K. Rhesus D typing of the fetus at risk for isoimmunization using DNA from amniotic fluid. Proceedings of the Annual Program of the Society for Gynecologic Investigations. 1993.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.