Harvard Catalyst Profiles

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Takao Kurt Hensch, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS080565 (JENSEN, FRANCES E) Aug 1, 2013 - Nov 30, 2018
    Early Life Seizures Disrupt Critical Period Plasticity
    Role: Principal Investigator
  2. R03NS075722 (HENSCH, TAKAO K) Apr 1, 2012 - Mar 31, 2014
    Activity-dependent modification of electrical synapse strength
    Role: Principal Investigator
  3. P50MH094271 (HENSCH, TAKAO K) Sep 5, 2011 - Mar 31, 2023
    Developmental origins of mental illness: evolution and reversibility
    Role: Principal Investigator
  4. DP1OD003699 (HENSCH, TAKAO K) Sep 30, 2007 - Jul 31, 2012
    Dissecting Non-coding RNA Function in Critical Period Brain Development and Disor
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hameed MQ, Hodgson N, Lee HHC, Pascual-Leone A, MacMullin PC, Jannati A, Dhamne SC, Hensch TK, Rotenberg A. N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model. Cereb Cortex. 2022 Sep 20. PMID: 36130098.
    Citations:    Fields:    
  2. Shonkoff JP, Boyce WT, Bush NR, Gunnar MR, Hensch TK, Levitt P, Meaney MJ, Nelson CA, Slopen N, Williams DR, Silveira PP. Translating the Biology of Adversity and Resilience Into New Measures for Pediatric Practice. Pediatrics. 2022 06 01; 149(6). PMID: 35535547.
    Citations:    Fields:    Translation:Humans
  3. Hensch T. Lifting brakes on visual cortical plasticity. J Vis. 2022 Feb 01; 22(3):49. PMID: 35120211.
    Citations:    Fields:    
  4. Sviridova N, Artoni P, Fagiolini M, Hensch TK, Aihara K. Dynamical Characteristics of Wild-Type Mouse Spontaneous Pupillary Fluctuations. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:853-856. PMID: 34891424.
    Citations:    Fields:    Translation:HumansAnimals
  5. Zhu Y, Wang MJ, Crawford KM, Ramírez-Tapia JC, Lussier AA, Davis KA, de Leeuw C, Takesian AE, Hensch TK, Smoller JW, Dunn EC. Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression. Neuropsychopharmacology. 2022 01; 47(2):497-506. PMID: 34689167; PMCID: PMC8674315.
    Citations:    Fields:    Translation:Humans
  6. Benham RS, Choi C, Hodgson NW, Hewage NB, Kastli R, Donahue RJ, Muschamp JW, Engin E, Carlezon WA, Hensch TK, Rudolph U. a2-containing ?-aminobutyric acid type A receptors promote stress resiliency in male mice. Neuropsychopharmacology. 2021 11; 46(12):2197-2206. PMID: 34408277; PMCID: PMC8505491.
    Citations:    Fields:    Translation:Animals
  7. Emoto K, Hensch TK, Yuzaki M. "Scrap & build" functional circuits: Molecular and cellular basis of neural remodeling. Neurosci Res. 2021 06; 167:1-2. PMID: 33878393.
    Citations: 1     Fields:    
  8. Matsuda YT, Miyamoto H, Joho RH, Hensch TK. Kv3.1 channels regulate the rate of critical period plasticity. Neurosci Res. 2021 Jun; 167:3-10. PMID: 33872635.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Reh RK, Hensch TK, Werker JF. Distributional learning of speech sound categories is gated by sensitive periods. Cognition. 2021 08; 213:104653. PMID: 33752869.
    Citations: 3     Fields:    Translation:Humans
  10. MacMullin P, Hodgson N, Damar U, Lee HHC, Hameed MQ, Dhamne SC, Hyde D, Conley GM, Morriss N, Qiu J, Mannix R, Hensch TK, Rotenberg A. Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio. Cereb Cortex. 2020 11 03; 30(12):6108-6120. PMID: 32676666.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Reh RK, Dias BG, Nelson CA, Kaufer D, Werker JF, Kolb B, Levine JD, Hensch TK. Critical period regulation across multiple timescales. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23242-23251. PMID: 32503914; PMCID: PMC7519216.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  12. Yamagata T, Raveau M, Kobayashi K, Miyamoto H, Tatsukawa T, Ogiwara I, Itohara S, Hensch TK, Yamakawa K. CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice. Neurobiol Dis. 2020 07; 141:104954. PMID: 32445790.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  13. Kalish BT, Barkat TR, Diel EE, Zhang EJ, Greenberg ME, Hensch TK. Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11744-11752. PMID: 32404418.
    Citations: 15     Fields:    Translation:AnimalsCells
  14. Maurer D, Ghloum JK, Gibson LC, Watson MR, Chen LM, Akins K, Enns JT, Hensch TK, Werker JF. Reduced perceptual narrowing in synesthesia. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):10089-10096. PMID: 32321833.
    Citations: 2     Fields:    Translation:Humans
  15. Hameed MQ, Hsieh TH, Morales-Quezada L, Lee HHC, Damar U, MacMullin PC, Hensch TK, Rotenberg A. Ceftriaxone Treatment Preserves Cortical Inhibitory Interneuron Function via Transient Salvage of GLT-1 in a Rat Traumatic Brain Injury Model. Cereb Cortex. 2019 12 17; 29(11):4506-4518. PMID: 30590449.
    Citations: 10     Fields:    Translation:AnimalsCells
  16. Roossien DH, Sadis BV, Yan Y, Webb JM, Min LY, Dizaji AS, Bogart LJ, Mazuski C, Huth RS, Stecher JS, Akula S, Shen F, Li Y, Xiao T, Vandenbrink M, Lichtman JW, Hensch TK, Herzog ED, Cai D. Multispectral tracing in densely labeled mouse brain with nTracer. Bioinformatics. 2019 09 15; 35(18):3544-3546. PMID: 30715234.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Artoni P, Piffer A, Vinci V, LeBlanc J, Nelson CA, Hensch TK, Fagiolini M. Deep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23298-23303. PMID: 31332003; PMCID: PMC7519255.
    Citations: 14     Fields:    Translation:HumansAnimals
  18. Miyamoto H, Tatsukawa T, Shimohata A, Yamagata T, Suzuki T, Amano K, Mazaki E, Raveau M, Ogiwara I, Oba-Asaka A, Hensch TK, Itohara S, Sakimura K, Kobayashi K, Kobayashi K, Yamakawa K. Impaired cortico-striatal excitatory transmission triggers epilepsy. Nat Commun. 2019 04 23; 10(1):1917. PMID: 31015467.
    Citations: 28     Fields:    Translation:AnimalsCells
  19. Batista G, Hensch TK. Critical Period Regulation by Thyroid Hormones: Potential Mechanisms and Sex-Specific Aspects. Front Mol Neurosci. 2019; 12:77. PMID: 31024251; PMCID: PMC6461013.
    Citations: 13     
  20. McNair LF, Andersen JV, Aldana BI, Hohnholt MC, Nissen JD, Sun Y, Fischer KD, Sonnewald U, Nyberg N, Webster SC, Kapur K, Rimmele TS, Barone I, Hawks-Mayer H, Lipton JO, Hodgson NW, Hensch TK, Aoki CJ, Rosenberg PA, Waagepetersen HS. Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function. J Neurosci. 2019 06 19; 39(25):4847-4863. PMID: 30926746; PMCID: PMC6670249.
    Citations: 14     Fields:    Translation:AnimalsCells
  21. Sigal YM, Bae H, Bogart LJ, Hensch TK, Zhuang X. Structural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):7071-7076. PMID: 30890637; PMCID: PMC6452715.
    Citations: 33     Fields:    Translation:AnimalsCells
  22. Picard N, Takesian AE, Fagiolini M, Hensch TK. NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity. Mol Psychiatry. 2019 06; 24(6):828-838. PMID: 30696941.
    Citations: 21     Fields:    Translation:AnimalsCells
  23. Takesian AE, Bogart LJ, Lichtman JW, Hensch TK. Publisher Correction: Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018 Oct; 21(10):1495. PMID: 29915196.
    Citations:    Fields:    
  24. Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K. Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018; 1:96. PMID: 30175250.
    Citations: 33     
  25. Sun H, Takesian AE, Wang TT, Lippman-Bell JJ, Hensch TK, Jensen FE. Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity. Cell Rep. 2018 05 29; 23(9):2533-2540. PMID: 29847785.
    Citations: 16     Fields:    Translation:AnimalsCells
  26. Takesian AE, Bogart LJ, Lichtman JW, Hensch TK. Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018 02; 21(2):218-227. PMID: 29358666; PMCID: PMC5978727.
    Citations: 70     Fields:    Translation:AnimalsCells
  27. Hensch TK, Quinlan EM. Critical periods in amblyopia. Vis Neurosci. 2018 01; 35:E014. PMID: 29905116; PMCID: PMC6047524.
    Citations: 55     Fields:    Translation:Humans
  28. Hensch TK, Quinlan EM. PERSPECTIVE Critical periods in amblyopia-CORRIGENDUM. Vis Neurosci. 2018 01; 35:E024. PMID: 29905127.
    Citations:    Fields:    
  29. Hsieh TH, Lee HHC, Hameed MQ, Pascual-Leone A, Hensch TK, Rotenberg A. Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury. Cereb Cortex. 2017 12 01; 27(12):5509-5524. PMID: 27909008; PMCID: PMC6075565.
    Citations: 35     Fields:    Translation:AnimalsCells
  30. Cameron JL, Eagleson KL, Fox NA, Hensch TK, Levitt P. Social Origins of Developmental Risk for Mental and Physical Illness. J Neurosci. 2017 11 08; 37(45):10783-10791. PMID: 29118206; PMCID: PMC5678010.
    Citations: 21     Fields:    Translation:Humans
  31. Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S. Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex. Sci Rep. 2017 10 03; 7(1):12646. PMID: 28974755.
    Citations: 20     Fields:    Translation:AnimalsCells
  32. Lee HHC, Bernard C, Ye Z, Acampora D, Simeone A, Prochiantz A, Di Nardo AA, Hensch TK. Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol Psychiatry. 2017 05; 22(5):785. PMID: 28373687.
    Citations: 4     Fields:    
  33. Steullet P, Cabungcal JH, Coyle J, Didriksen M, Gill K, Grace AA, Hensch TK, LaMantia AS, Lindemann L, Maynard TM, Meyer U, Morishita H, O'Donnell P, Puhl M, Cuenod M, Do KQ. Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. Mol Psychiatry. 2017 07; 22(7):936-943. PMID: 28322275; PMCID: PMC5491690.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
  34. Lee HHC, Bernard C, Ye Z, Acampora D, Simeone A, Prochiantz A, Di Nardo AA, Hensch TK. Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol Psychiatry. 2017 05; 22(5):680-688. PMID: 28194008; PMCID: PMC5400722.
    Citations: 31     Fields:    Translation:AnimalsCells
  35. Hensch TK. THE POWER OF THE INFANT BRAIN. Sci Am. 2016 Feb; 314(2):64-9. PMID: 26930830.
    Citations: 4     Fields:    Translation:Humans
  36. Bei F, Lee HHC, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He Z. Restoration of Visual Function by Enhancing Conduction in Regenerated Axons. Cell. 2016 Jan 14; 164(1-2):219-232. PMID: 26771493.
    Citations: 94     Fields:    Translation:AnimalsCells
  37. Lennartsson A, Arner E, Fagiolini M, Saxena A, Andersson R, Takahashi H, Noro Y, Sng J, Sandelin A, Hensch TK, Carninci P. Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors. Epigenetics Chromatin. 2015; 8:55. PMID: 26673794.
    Citations: 11     Fields:    
  38. Takei Y, Kikkawa YS, Atapour N, Hensch TK, Hirokawa N. Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J Neurosci. 2015 Nov 25; 35(47):15539-54. PMID: 26609151; PMCID: PMC6705472.
    Citations: 18     Fields:    Translation:Animals
  39. Ye Z, Mostajo-Radji MA, Brown JR, Rouaux C, Tomassy GS, Hensch TK, Arlotta P. Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons. Neuron. 2015 Nov 04; 88(3):475-83. PMID: 26539889.
    Citations: 29     Fields:    Translation:AnimalsCells
  40. Mierau SB, Patrizi A, Hensch TK, Fagiolini M. Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits. Biol Psychiatry. 2016 May 01; 79(9):746-754. PMID: 26185009.
    Citations: 28     Fields:    Translation:AnimalsCells
  41. Do KQ, Cuenod M, Hensch TK. Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia. Schizophr Bull. 2015 Jul; 41(4):835-46. PMID: 26032508.
    Citations: 60     Fields:    Translation:HumansAnimals
  42. Gurnot C, Martin-Subero I, Mah SM, Weikum W, Goodman SJ, Brain U, Werker JF, Kobor MS, Esteller M, Oberlander TF, Hensch TK. Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates. Epigenetics. 2015; 10(5):361-72. PMID: 25891251.
    Citations: 13     Fields:    Translation:HumansCells
  43. Kobayashi Y, Ye Z, Hensch TK. Clock genes control cortical critical period timing. Neuron. 2015 Apr 08; 86(1):264-75. PMID: 25801703.
    Citations: 44     Fields:    Translation:Animals
  44. Morishita H, Cabungcal JH, Chen Y, Do KQ, Hensch TK. Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons. Biol Psychiatry. 2015 Sep 15; 78(6):396-402. PMID: 25758057; PMCID: PMC4514575.
    Citations: 45     Fields:    Translation:AnimalsCells
  45. Werker JF, Hensch TK. Critical periods in speech perception: new directions. Annu Rev Psychol. 2015 Jan 03; 66:173-96. PMID: 25251488.
    Citations: 121     Fields:    Translation:HumansAnimals
  46. Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014 Aug 20; 83(4):894-905. PMID: 25088363.
    Citations: 113     Fields:    Translation:AnimalsCells
  47. Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, Holtzer R, Hyman BT, Lin FR, McKee AC, Morris JC, Petersen RC, Silbert LC, Struble RG, Trojanowski JQ, Verghese J, Wilson DA, Xu S, Zhang LI. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimers Dement. 2015 Jan; 11(1):70-98. PMID: 25022540.
    Citations: 157     Fields:    Translation:Humans
  48. Hensch TK. Bistable parvalbumin circuits pivotal for brain plasticity. Cell. 2014 Jan 16; 156(1-2):17-9. PMID: 24439367.
    Citations: 10     Fields:    Translation:AnimalsCells
  49. Gervain J, Vines BW, Chen LM, Seo RJ, Hensch TK, Werker JF, Young AH. Valproate reopens critical-period learning of absolute pitch. Front Syst Neurosci. 2013; 7:102. PMID: 24348349.
    Citations: 45     
  50. Kang E, Durand S, LeBlanc JJ, Hensch TK, Chen C, Fagiolini M. Visual acuity development and plasticity in the absence of sensory experience. J Neurosci. 2013 Nov 06; 33(45):17789-96. PMID: 24198369.
    Citations: 45     Fields:    Translation:AnimalsCells
  51. Kobayashi Y, Hensch TK. Germline recombination by conditional gene targeting with Parvalbumin-Cre lines. Front Neural Circuits. 2013; 7:168. PMID: 24137112.
    Citations: 16     Fields:    Translation:AnimalsCells
  52. Hisatsune C, Miyamoto H, Hirono M, Yamaguchi N, Sugawara T, Ogawa N, Ebisui E, Ohshima T, Yamada M, Hensch TK, Hattori M, Mikoshiba K. IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice. Front Neural Circuits. 2013; 7:156. PMID: 24109434.
    Citations: 26     Fields:    Translation:AnimalsCells
  53. Toyoizumi T, Miyamoto H, Yazaki-Sugiyama Y, Atapour N, Hensch TK, Miller KD. A theory of the transition to critical period plasticity: inhibition selectively suppresses spontaneous activity. Neuron. 2013 Oct 02; 80(1):51-63. PMID: 24094102.
    Citations: 62     Fields:    Translation:Animals
  54. Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller M. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain. 2013 Oct; 136(Pt 10):3018-27. PMID: 24030951; PMCID: PMC3784285.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  55. Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa K. Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Hum Mol Genet. 2013 Dec 01; 22(23):4784-804. PMID: 23922229.
    Citations: 79     Fields:    Translation:AnimalsCells
  56. Spatazza J, Lee HH, Di Nardo AA, Tibaldi L, Joliot A, Hensch TK, Prochiantz A. Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. Cell Rep. 2013 Jun 27; 3(6):1815-23. PMID: 23770240.
    Citations: 88     Fields:    Translation:HumansAnimals
  57. Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQ. Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9130-5. PMID: 23671099.
    Citations: 210     Fields:    Translation:AnimalsCells
  58. Takesian AE, Hensch TK. Balancing plasticity/stability across brain development. Prog Brain Res. 2013; 207:3-34. PMID: 24309249.
    Citations: 189     Fields:    Translation:HumansAnimals
  59. Durand S, Patrizi A, Quast KB, Hachigian L, Pavlyuk R, Saxena A, Carninci P, Hensch TK, Fagiolini M. NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2. Neuron. 2012 Dec 20; 76(6):1078-90. PMID: 23259945.
    Citations: 98     Fields:    Translation:AnimalsCells
  60. Miyamoto H, Nakamaru-Ogiso E, Hamada K, Hensch TK. Serotonergic integration of circadian clock and ultradian sleep-wake cycles. J Neurosci. 2012 Oct 17; 32(42):14794-803. PMID: 23077063.
    Citations: 21     Fields:    Translation:Animals
  61. Weikum WM, Oberlander TF, Hensch TK, Werker JF. Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception. Proc Natl Acad Sci U S A. 2012 Oct 16; 109 Suppl 2:17221-7. PMID: 23045665.
    Citations: 44     Fields:    Translation:Humans
  62. Yang EJ, Lin EW, Hensch TK. Critical period for acoustic preference in mice. Proc Natl Acad Sci U S A. 2012 Oct 16; 109 Suppl 2:17213-20. PMID: 23045690.
    Citations: 43     Fields:    Translation:Animals
  63. Bilimoria PM, Hensch TK, Bavelier D. A mouse model for too much TV? Trends Cogn Sci. 2012 Nov; 16(11):529-31. PMID: 22999015.
    Citations: 2     Fields:    Translation:HumansAnimals
  64. Hensch TK, Bilimoria PM. Re-opening Windows: Manipulating Critical Periods for Brain Development. Cerebrum. 2012 Jul; 2012:11. PMID: 23447797.
    Citations: 68     
  65. Ito S, Ogiwara I, Yamada K, Miyamoto H, Hensch TK, Osawa M, Yamakawa K. Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment. Neurobiol Dis. 2013 Jan; 49:29-40. PMID: 22986304.
    Citations: 37     Fields:    Translation:Animals
  66. Beurdeley M, Spatazza J, Lee HH, Sugiyama S, Bernard C, Di Nardo AA, Hensch TK, Prochiantz A. Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex. J Neurosci. 2012 Jul 04; 32(27):9429-37. PMID: 22764251.
    Citations: 166     Fields:    Translation:AnimalsCells
  67. Saxena A, Wagatsuma A, Noro Y, Kuji T, Asaka-Oba A, Watahiki A, Gurnot C, Fagiolini M, Hensch TK, Carninci P. Trehalose-enhanced isolation of neuronal sub-types from adult mouse brain. Biotechniques. 2012 Jun; 52(6):381-5. PMID: 22668417.
    Citations: 40     Fields:    Translation:AnimalsCells
  68. Maurer D, Hensch TK. Amblyopia: background to the special issue on stroke recovery. Dev Psychobiol. 2012 Apr; 54(3):224-38. PMID: 22415912.
    Citations: 12     Fields:    Translation:HumansAnimals
  69. Barkat TR, Polley DB, Hensch TK. A critical period for auditory thalamocortical connectivity. Nat Neurosci. 2011 Jul 31; 14(9):1189-94. PMID: 21804538.
    Citations: 117     Fields:    Translation:Animals
  70. Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, Arlotta P. Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Neuron. 2011 Feb 24; 69(4):763-79. PMID: 21338885.
    Citations: 100     Fields:    Translation:AnimalsCells
  71. Hackett TA, Barkat TR, O'Brien BM, Hensch TK, Polley DB. Linking topography to tonotopy in the mouse auditory thalamocortical circuit. J Neurosci. 2011 Feb 23; 31(8):2983-95. PMID: 21414920.
    Citations: 99     Fields:    Translation:AnimalsCells
  72. Morishita H, Miwa JM, Heintz N, Hensch TK. Lynx1, a cholinergic brake, limits plasticity in adult visual cortex. Science. 2010 Nov 26; 330(6008):1238-40. PMID: 21071629.
    Citations: 187     Fields:    Translation:AnimalsCells
  73. Bavelier D, Levi DM, Li RW, Dan Y, Hensch TK. Removing brakes on adult brain plasticity: from molecular to behavioral interventions. J Neurosci. 2010 Nov 10; 30(45):14964-71. PMID: 21068299.
    Citations: 227     Fields:    Translation:HumansAnimalsCells
  74. Yazaki-Sugiyama Y, Kang S, Câteau H, Fukai T, Hensch TK. Bidirectional plasticity in fast-spiking GABA circuits by visual experience. Nature. 2009 Nov 12; 462(7270):218-21. PMID: 19907494.
    Citations: 102     Fields:    Translation:AnimalsCells
  75. Hensch TK, Brand AH. Development. Editorial overview. Curr Opin Neurobiol. 2009 Apr; 19(2):109-11. PMID: 19604684.
    Citations:    Fields:    Translation:HumansAnimalsCells
  76. Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord. 2009 Jun; 1(2):172-81. PMID: 20664807.
    Citations: 299     Fields:    
  77. Sugiyama S, Prochiantz A, Hensch TK. From brain formation to plasticity: insights on Otx2 homeoprotein. Dev Growth Differ. 2009 Apr; 51(3):369-77. PMID: 19298552.
    Citations: 26     Fields:    Translation:Animals
  78. Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y, Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV, Yamakawa K. Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Hum Mol Genet. 2009 Mar 15; 18(6):1099-109. PMID: 19147686.
    Citations: 33     Fields:    Translation:AnimalsCells
  79. Plessy C, Fagiolini M, Wagatsuma A, Harasawa N, Kuji T, Asaka-Oba A, Kanzaki Y, Fujishima S, Waki K, Nakahara H, Hensch TK, Carninci P. A resource for transcriptomic analysis in the mouse brain. PLoS One. 2008 Aug 20; 3(8):e3012. PMID: 18714383.
    Citations: 9     Fields:    Translation:AnimalsCells
  80. Sugiyama S, Di Nardo AA, Aizawa S, Matsuo I, Volovitch M, Prochiantz A, Hensch TK. Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity. Cell. 2008 Aug 08; 134(3):508-20. PMID: 18692473.
    Citations: 230     Fields:    Translation:HumansAnimalsCells
  81. Morishita H, Hensch TK. Critical period revisited: impact on vision. Curr Opin Neurobiol. 2008 Feb; 18(1):101-7. PMID: 18534841.
    Citations: 141     Fields:    Translation:HumansAnimals
  82. Hensch T, Herold U, Diers K, Armbruster D, Brocke B. Reliability of intensity dependence of auditory-evoked potentials. Clin Neurophysiol. 2008 Jan; 119(1):224-36. PMID: 18039590.
    Citations: 17     Fields:    Translation:Humans
  83. Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K. Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci. 2007 May 30; 27(22):5903-14. PMID: 17537961; PMCID: PMC6672241.
    Citations: 339     Fields:    Translation:HumansAnimalsCells
  84. Katagiri H, Fagiolini M, Hensch TK. Optimization of somatic inhibition at critical period onset in mouse visual cortex. Neuron. 2007 Mar 15; 53(6):805-12. PMID: 17359916.
    Citations: 66     Fields:    Translation:AnimalsCells
  85. Brocke B, Armbruster D, Muller J, Hensch T, Jacob CP, Lesch KP, Kirschbaum C, Strobel A. Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle. Mol Psychiatry. 2006 Dec; 11(12):1106-12. PMID: 17033630.
    Citations: 31     Fields:    Translation:HumansCellsCTClinical Trials
  86. Illes J, Blakemore C, Hansson MG, Hensch TK, Leshner A, Maestre G, Magistretti P, Quirion R, Strata P. International perspectives on engaging the public in neuroethics. Nat Rev Neurosci. 2005 Dec; 6(12):977-82. PMID: 16340957; PMCID: PMC1794674.
    Citations: 5     Fields:    Translation:Humans
  87. Hensch TK. Critical period plasticity in local cortical circuits. Nat Rev Neurosci. 2005 Nov; 6(11):877-88. PMID: 16261181.
    Citations: 924     Fields:    Translation:HumansAnimalsCells
  88. Hensch TK. Recovery in the blink of an eye. Neuron. 2005 Oct 20; 48(2):166-8. PMID: 16242396.
    Citations: 3     Fields:    Translation:Animals
  89. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y. The transcriptional landscape of the mammalian genome. Science. 2005 Sep 02; 309(5740):1559-63. PMID: 16141072.
    Citations: 1660     Fields:    Translation:HumansAnimalsCells
  90. Bellinger FP, Hensch TK. Differential Distribution of NMDA and AMPA Receptor Activity in Layer II/III in Mouse Primary Visual Cortex. Microsc Microanal. 2005 Aug; 11 Suppl 2:1124-5. PMID: 24017432.
  91. Hensch TK, Fagiolini M. Excitatory-inhibitory balance and critical period plasticity in developing visual cortex. Prog Brain Res. 2005; 147:115-24. PMID: 15581701.
    Citations: 112     Fields:    Translation:Animals
  92. Hensch TK. Critical period mechanisms in developing visual cortex. Curr Top Dev Biol. 2005; 69:215-37. PMID: 16243601.
    Citations: 95     Fields:    Translation:Animals
  93. Mataga N, Mizuguchi Y, Hensch TK. Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator. Neuron. 2004 Dec 16; 44(6):1031-41. PMID: 15603745.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  94. Möhler H, Fritschy JM, Crestani F, Hensch T, Rudolph U. Specific GABA(A) circuits in brain development and therapy. Biochem Pharmacol. 2004 Oct 15; 68(8):1685-90. PMID: 15451412.
    Citations: 25     Fields:    Translation:HumansAnimals
  95. Hensch TK, Stryker MP. Columnar architecture sculpted by GABA circuits in developing cat visual cortex. Science. 2004 Mar 12; 303(5664):1678-81. PMID: 15017001.
    Citations: 65     Fields:    Translation:AnimalsCells
  96. Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK. Specific GABAA circuits for visual cortical plasticity. Science. 2004 Mar 12; 303(5664):1681-3. PMID: 15017002.
    Citations: 207     Fields:    Translation:AnimalsCells
  97. Hensch TK. Critical period regulation. Annu Rev Neurosci. 2004; 27:549-79. PMID: 15217343.
    Citations: 452     Fields:    Translation:HumansAnimalsCells
  98. Miyamoto H, Hensch TK. Reciprocal interaction of sleep and synaptic plasticity. Mol Interv. 2003 Oct; 3(7):404-17. PMID: 14993461.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  99. Hirozane-Kishikawa T, Shiraki T, Waki K, Nakamura M, Arakawa T, Kawai J, Fagiolini M, Hensch TK, Hayashizaki Y, Carninci P. Subtraction of cap-trapped full-length cDNA libraries to select rare transcripts. Biotechniques. 2003 Sep; 35(3):510-6, 518. PMID: 14513556.
    Citations: 7     Fields:    Translation:Cells
  100. Hensch TK. Controlling the critical period. Neurosci Res. 2003 Sep; 47(1):17-22. PMID: 12941442.
    Citations: 18     Fields:    Translation:HumansAnimals
  101. Iwai Y, Fagiolini M, Obata K, Hensch TK. Rapid critical period induction by tonic inhibition in visual cortex. J Neurosci. 2003 Jul 30; 23(17):6695-702. PMID: 12890762; PMCID: PMC6740711.
    Citations: 75     Fields:    Translation:AnimalsCells
  102. Miyamoto H, Katagiri H, Hensch T. Experience-dependent slow-wave sleep development. Nat Neurosci. 2003 Jun; 6(6):553-4. PMID: 12754515.
    Citations: 30     Fields:    Translation:AnimalsCells
  103. Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res. 2003 Jun; 13(6B):1273-89. PMID: 12819125; PMCID: PMC403712.
    Citations: 79     Fields:    Translation:AnimalsCells
  104. Fagiolini M, Katagiri H, Miyamoto H, Mori H, Grant SG, Mishina M, Hensch TK. Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2854-9. PMID: 12591944; PMCID: PMC151430.
    Citations: 81     Fields:    Translation:AnimalsCells
  105. Mataga N, Nagai N, Hensch TK. Permissive proteolytic activity for visual cortical plasticity. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7717-21. PMID: 12032349; PMCID: PMC124331.
    Citations: 63     Fields:    Translation:AnimalsCells
  106. Renger JJ, Hartman KN, Tsuchimoto Y, Yokoi M, Nakanishi S, Hensch TK. Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):1041-6. PMID: 11805343; PMCID: PMC117426.
    Citations: 21     Fields:    Translation:AnimalsCells
  107. Mataga N, Fujishima S, Condie BG, Hensch TK. Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J Neurosci. 2001 Dec 15; 21(24):9724-32. PMID: 11739581; PMCID: PMC6763037.
    Citations: 23     Fields:    Translation:AnimalsCells
  108. Fagiolini M, Hensch TK. Inhibitory threshold for critical-period activation in primary visual cortex. Nature. 2000 Mar 09; 404(6774):183-6. PMID: 10724170.
    Citations: 276     Fields:    Translation:Animals
  109. Hensch TK. Whisking away space in the brain. Neuron. 1999 Nov; 24(3):492-3. PMID: 10595498.
    Citations:    Fields:    Translation:Animals
  110. Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF. Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science. 1998 Nov 20; 282(5393):1504-8. PMID: 9822384.
    Citations: 376     Fields:    Translation:AnimalsCells
  111. Hensch TK, Gordon JA, Brandon EP, McKnight GS, Idzerda RL, Stryker MP. Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice. J Neurosci. 1998 Mar 15; 18(6):2108-17. PMID: 9482797.
    Citations: 32     Fields:    Translation:AnimalsCells
  112. Artola A, Hensch T, Singer W. Calcium-induced long-term depression in the visual cortex of the rat in vitro. J Neurophysiol. 1996 Aug; 76(2):984-94. PMID: 8871213.
    Citations: 6     Fields:    Translation:AnimalsCells
  113. Hensch TK, Stryker MP. Ocular dominance plasticity under metabotropic glutamate receptor blockade. Science. 1996 Apr 26; 272(5261):554-7. PMID: 8614806.
    Citations: 18     Fields:    Translation:Animals
  114. Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature. 1996 Feb 29; 379(6568):837-40. PMID: 8587609.
    Citations: 148     Fields:    Translation:HumansAnimalsCells
  115. Ajima A, Hensch T, Kado RT, Ito M. Differential blocking action of Joro spider toxin analog on parallel fiber and climbing fiber synapses in cerebellar Purkinje cells. Neurosci Res. 1991 Oct; 12(1):281-6. PMID: 1684239.
    Citations: 5     Fields:    Translation:AnimalsCells
  116. Nagao S, Yoshioka N, Hensch T, Hasegawa I, Nakamura N, Nagao Y, Ito M. The role of cerebellar flocculus in adaptive gain control of ocular reflexes. Acta Otolaryngol Suppl. 1991; 481:234-6. PMID: 1927383.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.