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Nilay Singh Sethi, M.D., Ph.D.

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The College of New Jersey, Ewing, NJB.S.05/2004Biology
Princeton University, Princeton, NJPh.D.06/2010Molecular Biology
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJM.D.05/2012
University of California, San Francisco, San Francisco, CA06/2014Internal medicine
Dana-Farber Cancer Institute, Boston, MA6/2018Hematology/Oncology
Joseph Vina Junior Award (TCNJ)
Bristol Myers Squibb Senior Award (TCNJ)
MD/PhD Conference Award (MGH-Karolinska-Cell Press Days of Molecular Medicine Conference)
AACR Scholar-in-Training Award (Joint MRS Conference)
Gallo Award for Scientific Excellence (NJCCR)
New Jersey Cancer Research Award for Scientific (NJCCR) Excellece
Outstanding Achievement in the MD-PhD Program
Dean's Research Award (RWJMS)
Favorite Doctor | Staff Holiday Awards (UCSF)
AACR Scholar-in-Training Award ( Environmental Carcinogenesis Conference)
ASCI Young Physician Scientist Award

My passion for investigative research is fundamentally dependent on its power to impact our understanding of human disease and ultimately improve patient care. I engage basic and translational research efforts to generate opportunities for advances in medical oncology. In particular, I am committed to understanding the specific genomic alterations and fundamental molecular mechanisms that promote gastrointestinal malignancies with the hope that novel insights will translate into clinical advances.

Available: 10/15/20, Expires: 10/15/24

Project description and duties: The overall goal of the Sethi laboratory (http://sethilab.dana-farber.org/) is to combine clinical observations and patient-derived data with rigorous basic research to yield opportunities for translational advances. In particular, we are focused on better understanding gastrointestinal cancers with the hope that this knowledge will stimulate new ideas for prevention, diagnosis, and treatment of these deadly cancers. Currently, the research projects in the lab fall under two categories: (1) investigate the therapeutic efficacy of DNA damage response inhibitors in gastric and esophageal adenocarcinomas and (2) define the mechanism underlying differentiation blocks in colorectal cancer. Each of these research themes is broken down into smaller projects led by postdoctoral fellows and/or graduate students. The goal is to assemble a team composed of trainees of different levels to maximize collaborative science. Depending on the student’s passion and needs of the laboratory, a project of mutual interest will be assigned.

Skills required: For the remote research opportunity, students should be familiar with basic concepts in cell and molecular biology. To maximize the ability of the student to learn from the remote experience, a basic knowledge of programming in R is preferred. The student will work with members of the laboratory to build on basic biology and computational skillsets. When students return to campus, hands-on wet lab research experience will be the goal. Student’s with experience in techniques in cell and molecular biology will be preferred, but all students will be considered regardless of experience. The most important factor is motivation to learn and commitment to the team.

Learning outcomes: Students will benefit in many ways when engaging the lab: (1) they will learn how to thinking critically and understanding how hypotheses are generated; (2) they will learn how to design careful and well-controlled experiments to test emergent hypotheses; (3) for remote work, students will learn how to apply computational tools to interrogate molecular data sets such as those generated from whole exome (DNA) sequencing, RNA-seq, single-cell RNA-seq, CHIP-seq, and ATAC-seq to answer specific questions and generate new relationships; (4) when students return to campus, they will learn laboratory techniques in cell and molecular biology; (5) career mentorship for residency and fellowship placement will also be part of the experience.

Nilay Seth is the primary mentor. Please visit http://sethilab.dana-farber.org/ to learn more about the laboratory. Please send a statement of interest and resume (nilay_sethi@dfci.harvard.edu)

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08DK120930 (SETHI, NILAY) Apr 1, 2019 - Jan 31, 2024
    Integration of early genetic alterations and inflammation in gastroesophageal premalignancy
    Role: Principal Investigator
  2. (Sethi) Jul 1, 2018 - Jun 30, 2020
    Claudia Adams Barr Program in Cancer Research
    Elucidating the Molecular Mechanisms of Mutant SOX9 in Colorectal Cancer

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.