Harvard Catalyst Profiles

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Nilay Singh Sethi, M.D., Ph.D.

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The College of New Jersey, Ewing, NJB.S.05/2004Biology
Princeton University, Princeton, NJPh.D.06/2010Molecular Biology
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJM.D.05/2012
University of California, San Francisco, San Francisco, CA06/2014Internal medicine
Dana-Farber Cancer Institute, Boston, MA6/2018Hematology/Oncology
Joseph Vina Junior Award
Bristol Myers Squibb Senior Award
MD/PhD Scholarship (conference award)
AACR Scholar-in-Training Award
Gallo Award for Scientific Excellence
New Jersey Cancer Research Award for Scientific Excellece
Outstanding Achievement in the MD-PhD Program
Dean's Research Award (RWJMS)
Favorite Doctor | Staff Holiday Awards (UCSF)
2017 - 2019
KL2/CMeRIT Award
2017 - 2020
ACS Postdoctoral Fellowship
AACR Scholar-in-Training Award
Young Physician Scientist Award

My passion for investigative research is fundamentally dependent on its power to impact our understanding of human disease and ultimately improve patient care. I engage basic and translational research efforts to generate opportunities for advances in medical oncology. In particular, I am committed to understanding the specific genomic alterations and fundamental molecular mechanisms that promote gastrointestinal malignancies with the hope that novel insights will translate into clinical advances.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08DK120930 (SETHI, NILAY) Apr 1, 2019 - Jan 31, 2024
    Integration of early genetic alterations and inflammation in gastroesophageal premalignancy
    Role: Principal Investigator
  2. (Sethi) Jul 1, 2018 - Jun 30, 2020
    Claudia Adams Barr Program in Cancer Research
    Elucidating the Molecular Mechanisms of Mutant SOX9 in Colorectal Cancer

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sethi NS, Kikuchi O, Duronio GN, Stachler MD, McFarland JM, Ferrer-Luna R, Zhang Y, Bao C, Bronson R, Patil D, Sanchez-Vega F, Liu JB, Sicinska E, Lazaro JB, Ligon KL, Beroukhim R, Bass AJ. Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nat Genet. 2020 Feb; 52(2):219-230. PMID: 32025000.
  2. Sethi N, Kikuchi O, McFarland J, Zhang Y, Chung M, Kafker N, Islam M, Lampson B, Chakraborty A, Kaelin WG, Bass AJ. Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma. JCI Insight. 2019 08 08; 4(15). PMID: 31391338.
  3. Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R, Thorsson V, Bass AJ, Laird PW. Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell. 2018 04 09; 33(4):721-735.e8. PMID: 29622466.
    Citations: 6     Fields:    
  4. Sethi N, Sedighi Manesh R, Sperling A, Bresler SC, Connell NT, Tierney LM. Factoring in the missing link. Am J Hematol. 2017 Jan; 92(1):110-113. PMID: 27486087.
    Citations:    Fields:    Translation:Humans
  5. Hayakawa Y, Sethi N, Sepulveda AR, Bass AJ, Wang TC. Oesophageal adenocarcinoma and gastric cancer: should we mind the gap? Nat Rev Cancer. 2016 04 26; 16(5):305-18. PMID: 27112208.
    Citations: 20     Fields:    Translation:HumansAnimals
  6. Marmarelis ME, Davis MR, Sethi NS, Krajewksi KM, McKay RR, Choueiri TK, Ott PA. Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma. J Immunother Cancer. 2016; 4:26. PMID: 27099755.
    Citations:    Fields:    
  7. Sethi N, Kang Y. Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Rep. 2012; 1:3. PMID: 23951415.
    Citations: 7     
  8. Sethi N, Kang Y. Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer. 2011 Sep 23; 11(10):735-48. PMID: 21941285.
    Citations: 115     Fields:    Translation:HumansAnimals
  9. Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell. 2011 Feb 15; 19(2):192-205. PMID: 21295524.
    Citations: 155     Fields:    Translation:AnimalsCells
  10. Gandhi G, Londoño D, Whetstine CR, Sethi N, Kim KS, Zückert WR, Cadavid D. Interaction of variable bacterial outer membrane lipoproteins with brain endothelium. PLoS One. 2010 Oct 22; 5(10):e13257. PMID: 21063459.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Sethi N, Yan Y, Quek D, Schupbach T, Kang Y. Rabconnectin-3 is a functional regulator of mammalian Notch signaling. J Biol Chem. 2010 Nov 05; 285(45):34757-64. PMID: 20810660.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  12. Sethi N, Kang Y. Dysregulation of developmental pathways in bone metastasis. Bone. 2011 Jan; 48(1):16-22. PMID: 20630490.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  13. Deshpande G, Sethi N, Schedl P. toutvelu, a regulator of heparan sulfate proteoglycan biosynthesis, controls guidance cues for germ-cell migration. Genetics. 2007 Jun; 176(2):905-12. PMID: 17409068.
    Citations: 6     Fields:    Translation:AnimalsCells
  14. Sethi N, Sondey M, Bai Y, Kim KS, Cadavid D. Interaction of a neurotropic strain of Borrelia turicatae with the cerebral microcirculation system. Infect Immun. 2006 Nov; 74(11):6408-18. PMID: 16940140.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Wolansky LJ, Haghighi MH, Sevdalis E, Cook SD, Sethi N, Liu J, Joseph G, Tulloch K, Cadavid D. Safety of serial monthly administration of triple-dose gadopentetate dimeglumine in multiple sclerosis patients: preliminary results of the BECOME trial. J Neuroimaging. 2005 Jul; 15(3):289-90. PMID: 15951416.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.