Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Frank Slack, Ph.D.

Other Positions

ncRNAs in Aging[login at prompt]
Available: 09/25/18, Expires: 08/31/21

The student will identify ncRNAs mis-expressed in aging animals and perform knock out experiments to identify those ncRNA with functions in aging. The model organism used here will be the nematode C. elegans, which lives about 2 weeks.

Non-coding RNAs in cancer[login at prompt]
Available: 09/24/18, Expires: 08/31/21

The student will examine cancer tissues and identify mis-expressed ncRNAs. The student will perform function assays to determine whether the ncRNAs play a role in cancer cell survival, growth or motility. The student will identify potential pathways associated with the ncRNA and begin studies to investigate mechanism of action.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA241194 (SLACK, FRANK J.) Feb 15, 2020 - Jan 31, 2025
    Targeting microRNAs in the tumor microenvironment with pHLIP conjugated next generation chemically modified PNAs
    Role: Principal Investigator
  2. R35CA232105 (SLACK, FRANK J.) Aug 22, 2019 - Jul 31, 2026
    Precision microRNA medicine in cancer
    Role: Principal Investigator
  3. R01CA235740 (DOYLE, PATRICK S) Jun 10, 2019 - May 31, 2024
    Microengineered Technologies for Quantitative, Multiplexed and Spatially Resolved Measurement of miRNA in Tissue Sections
    Role: Co-Principal Investigator
  4. R01AG058816 (SLACK, FRANK J.) Apr 1, 2018 - Mar 31, 2023
    Juvenile microRNAs promoting healthier adult aging
    Role: Principal Investigator
  5. P50CA-01 (CHEN, LIEPING) Aug 26, 2015 - Jul 31, 2020
    Yale SPORE in Lung Cancer Career Development Program
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee JD, Paulo JA, Posey RR, Mugoni V, Kong NR, Cheloni G, Lee YR, Slack FJ, Tenen DG, Clohessy JG, Gygi SP, Pandolfi PP. Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia. Nat Methods. 2021 Mar; 18(3):293-302. PMID: 33649590.
    Citations:    Fields:    
  2. Anastasiadou E, Seto AG, Beatty X, Hermreck M, Gilles ME, Stroopinsky D, Pinter-Brown LC, Pestano L, Marchese C, Avigan D, Trivedi P, Escolar DM, Jackson AL, Slack FJ. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15; 27(4):1139-1149. PMID: 33208342.
    Citations: 4     Fields:    
  3. Malik S, Lim J, Slack FJ, Braddock DT, Bahal R. Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles. J Control Release. 2020 11 10; 327:406-419. PMID: 32835710.
    Citations: 1     Fields:    
  4. Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ. TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020 Sep; 19(18):2314-2326. PMID: 32816599.
    Citations:    Fields:    
  5. Segal M, Slack FJ. Challenges identifying efficacious miRNA therapeutics for cancer. Expert Opin Drug Discov. 2020 09; 15(9):987-992. PMID: 32421364.
    Citations: 7     Fields:    
  6. Nagarajan MB, Tentori AM, Zhang WC, Slack FJ, Doyle PS. Spatially resolved and multiplexed MicroRNA quantification from tissue using nanoliter well arrays. Microsyst Nanoeng. 2020; 6:51. PMID: 32419951.
    Citations: 1     
  7. Witten L, Slack FJ. miR-155 as a novel clinical target for hematological malignancies. Carcinogenesis. 2020 03 13; 41(1):2-7. PMID: 31711135.
    Citations: 9     Fields:    Translation:HumansAnimals
  8. Ramírez-Moya J, Baker AR, Slack FJ, Santisteban P. ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Oncogene. 2020 04; 39(18):3738-3753. PMID: 32157211.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Rupaimoole R, Yoon B, Zhang WC, Adams BD, Slack FJ. A High-Throughput Small Molecule Screen Identifies Ouabain as Synergistic with miR-34a in Killing Lung Cancer Cells. iScience. 2020 Feb 21; 23(2):100878. PMID: 32062455.
  10. Segal M, Biscans A, Gilles ME, Anastasiadou E, De Luca R, Lim J, Khvorova A, Slack FJ. Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo. Mol Ther Nucleic Acids. 2020 Mar 06; 19:267-277. PMID: 31855835.
    Citations: 5     
  11. Slack FJ, Chinnaiyan AM. The Role of Non-coding RNAs in Oncology. Cell. 2019 11 14; 179(5):1033-1055. PMID: 31730848.
    Citations: 113     Fields:    Translation:Humans
  12. Mavrikaki M, Pantano L, Potter D, Rogers-Grazado MA, Anastasiadou E, Slack FJ, Amr SS, Ressler KJ, Daskalakis NP, Chartoff E. Sex-Dependent Changes in miRNA Expression in the Bed Nucleus of the Stria Terminalis Following Stress. Front Mol Neurosci. 2019; 12:236. PMID: 31636537.
    Citations: 4     
  13. Gilles ME, Hao L, Brown K, Lim J, Bhatia SN, Slack FJ. Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer. Oncotarget. 2019 Sep 03; 10(51):5349-5358. PMID: 31523393.
    Citations: 3     Fields:    
  14. Mavrikaki M, Anastasiadou E, Ozdemir RA, Potter D, Helmholz C, Slack FJ, Chartoff EH. Overexpression of miR-9 in the Nucleus Accumbens Increases Oxycodone Self-Administration. Int J Neuropsychopharmacol. 2019 06 03; 22(6):383-393. PMID: 30989210.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Zhang WC, Wells JM, Chow KH, Huang H, Yuan M, Saxena T, Melnick MA, Politi K, Asara JM, Costa DB, Bult CJ, Slack FJ. miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. Nat Metab. 2019 04; 1(4):460-474. PMID: 31535082.
    Citations: 12     Translation:HumansCells
  16. Segal M, Slack FJ. Extracellular vesicles show promise for cancer theranostics. Ann Transl Med. 2019 Apr; 7(7):158. PMID: 31157278.
  17. Nahas MR, Stroopinsky D, Rosenblatt J, Cole L, Pyzer AR, Anastasiadou E, Sergeeva A, Ephraim A, Washington A, Orr S, McMasters M, Weinstock M, Jain S, Leaf RK, Ghiasuddin H, Rahimian M, Liegel J, Molldrem JJ, Slack F, Kufe D, Avigan D. Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine. Br J Haematol. 2019 05; 185(4):679-690. PMID: 30828801.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  18. Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ. Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor. RNA. 2019 03; 25(3):352-363. PMID: 30538148.
    Citations: 3     Fields:    Translation:HumansCells
  19. Trivedi P, Slack FJ, Anastasiadou E. Epstein-Barr virus: From kisses to cancer, an ingenious immune evader. Oncotarget. 2018 Nov 23; 9(92):36411-36412. PMID: 30559926.
    Citations: 3     Fields:    
  20. Witten LW, Cheng CJ, Slack FJ. miR-155 drives oncogenesis by promoting and cooperating with mutations in the c-Kit oncogene. Oncogene. 2019 03; 38(12):2151-2161. PMID: 30459357.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Gilles ME, Slack FJ. Let-7 microRNA as a potential therapeutic target with implications for immunotherapy. Expert Opin Ther Targets. 2018 11; 22(11):929-939. PMID: 30328720.
    Citations: 12     Fields:    Translation:HumansAnimals
  22. Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. PMID: 30232453.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  23. Nagarajan MB, Tentori AM, Zhang WC, Slack FJ, Doyle PS. Nonfouling, Encoded Hydrogel Microparticles for Multiplex MicroRNA Profiling Directly from Formalin-Fixed, Paraffin-Embedded Tissue. Anal Chem. 2018 09 04; 90(17):10279-10285. PMID: 30106558.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  24. Tentori AM, Nagarajan MB, Kim JJ, Zhang WC, Slack FJ, Doyle PS. Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays. Lab Chip. 2018 08 07; 18(16):2410-2424. PMID: 29998262.
    Citations: 3     Fields:    Translation:HumansCells
  25. Anastasiadou E, Faggioni A, Trivedi P, Slack FJ. The Nefarious Nexus of Noncoding RNAs in Cancer. Int J Mol Sci. 2018 Jul 17; 19(7). PMID: 30018188.
    Citations: 14     Fields:    Translation:Humans
  26. Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia. 2019 01; 33(1):132-147. PMID: 29946193.
    Citations: 31     Fields:    Translation:HumansCells
  27. Slack FJ. Tackling Tumors with Small RNAs Derived from Transfer RNA. N Engl J Med. 2018 05 10; 378(19):1842-1843. PMID: 29742367.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  28. Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ. Personalized RNA Medicine for Pancreatic Cancer. Clin Cancer Res. 2018 04 01; 24(7):1734-1747. PMID: 29330203.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  29. Jiao AL, Foster DJ, Dixon J, Slack FJ. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans. PLoS One. 2018; 13(1):e0190766. PMID: 29324872.
    Citations: 1     Fields:    Translation:AnimalsCells
  30. Anastasiadou E, Jacob LS, Slack FJ. Non-coding RNA networks in cancer. Nat Rev Cancer. 2018 Jan; 18(1):5-18. PMID: 29170536.
    Citations: 289     Fields:    Translation:HumansAnimalsCells
  31. Inukai S, Pincus Z, de Lencastre A, Slack FJ. A microRNA feedback loop regulates global microRNA abundance during aging. RNA. 2018 02; 24(2):159-172. PMID: 29114017.
    Citations: 14     Fields:    Translation:Animals
  32. Metheetrairut C, Ahuja Y, Slack FJ. acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes. . 2017 Oct 02; 16(19):1800-1809. PMID: 28933985.
    Citations:    Translation:AnimalsCells
  33. Pyzer AR, Stroopinsky D, Rosenblatt J, Anastasiadou E, Rajabi H, Washington A, Tagde A, Chu JH, Coll M, Jiao AL, Tsai LT, Tenen DE, Cole L, Palmer K, Ephraim A, Leaf RK, Nahas M, Apel A, Bar-Natan M, Jain S, McMasters M, Mendez L, Arnason J, Raby BA, Slack F, Kufe D, Avigan D. MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs. Leukemia. 2017 12; 31(12):2780-2790. PMID: 28555079.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  34. Adams BD, Parsons C, Walker L, Zhang WC, Slack FJ. Targeting noncoding RNAs in disease. J Clin Invest. 2017 Mar 01; 127(3):761-771. PMID: 28248199.
    Citations: 170     Fields:    Translation:Humans
  35. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017 Mar; 16(3):203-222. PMID: 28209991.
    Citations: 895     Fields:    Translation:HumansAnimals
  36. Smith-Vikos T, Liu Z, Parsons C, Gorospe M, Ferrucci L, Gill TM, Slack FJ. A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). Aging (Albany NY). 2016 11 07; 8(11):2971-2987. PMID: 27824314.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  37. Rupaimoole R, Slack FJ. A role for miR-34 in colon cancer stem cell homeostasis. Stem Cell Investig. 2016; 3:42. PMID: 27668249.
    Citations: 3     
  38. Zhang WC, Slack FJ. ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity. Cell Stem Cell. 2016 08 04; 19(2):141-142. PMID: 27494666.
    Citations: 3     Fields:    Translation:HumansCells
  39. Svoronos AA, Engelman DM, Slack FJ. OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer. Cancer Res. 2016 07 01; 76(13):3666-70. PMID: 27325641.
    Citations: 190     Fields:    Translation:HumansAnimals
  40. Pincus Z, Mazer TC, Slack FJ. Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green. Aging (Albany NY). 2016 05; 8(5):889-98. PMID: 27070172.
    Citations: 21     Fields:    Translation:Animals
  41. Kim M, Kogan N, Slack FJ. Cis-acting elements in its 3' UTR mediate post-transcriptional regulation of KRAS. Oncotarget. 2016 Mar 15; 7(11):11770-84. PMID: 26930719.
    Citations: 5     Fields:    Translation:HumansCells
  42. Adams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Gyorffy B, Santarpia L, Pusztai L, Saltzman WM, Slack FJ. miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer. Cancer Res. 2016 Feb 15; 76(4):927-39. PMID: 26676753.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  43. Adams BD, Anastasiadou E, Esteller M, He L, Slack FJ. The Inescapable Influence of Noncoding RNAs in Cancer. Cancer Res. 2015 Dec 15; 75(24):5206-10. PMID: 26567137.
    Citations: 23     Fields:    Translation:HumansAnimals
  44. Adams BD, Parsons C, Slack FJ. The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas. Expert Opin Ther Targets. 2016 Jun; 20(6):737-53. PMID: 26652031.
    Citations: 36     Fields:    Translation:HumansAnimals
  45. McVeigh TP, Jung SY, Kerin MJ, Salzman DW, Nallur S, Nemec AA, Dookwah M, Sadofsky J, Paranjape T, Kelly O, Chan E, Miller N, Sweeney KJ, Zelterman D, Sweasy J, Pilarski R, Telesca D, Slack FJ, Weidhaas JB. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant. . 2015; 14(13):2091-9. PMID: 25961464.
    Citations: 7     Translation:HumansCells
  46. Stefani G, Chen X, Zhao H, Slack FJ. A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans. RNA. 2015 May; 21(5):985-96. PMID: 25805859.
    Citations: 13     Fields:    Translation:AnimalsCells
  47. Stahlhut C, Slack FJ. Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. . 2015; 14(13):2171-80. PMID: 25714397.
    Citations: 57     Translation:HumansCells
  48. Anastasiadou E, Slack FJ. Cancer. Malicious exosomes. Science. 2014 Dec 19; 346(6216):1459-60. PMID: 25525233.
    Citations: 17     Fields:    Translation:HumansAnimals
  49. Kim M, Slack FJ. MicroRNA-mediated regulation of KRAS in cancer. J Hematol Oncol. 2014 Nov 30; 7:84. PMID: 25433809.
    Citations: 12     Fields:    Translation:HumansAnimals
  50. Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature. 2015 Feb 05; 518(7537):107-10. PMID: 25409146.
    Citations: 247     Fields:    Translation:AnimalsCells
  51. Coira IF, Rufino-Palomares EE, Romero OA, Peinado P, Metheetrairut C, Boyero-Corral L, Carretero J, Farez-Vidal E, Cuadros M, Reyes-Zurita FJ, Lupiáñez JA, Sánchez-Cespedes M, Slack FJ, Medina PP. Expression inactivation of SMARCA4 by microRNAs in lung tumors. Hum Mol Genet. 2015 Mar 01; 24(5):1400-9. PMID: 25355421.
    Citations: 8     Fields:    Translation:HumansCells
  52. Smith-Vikos T, de Lencastre A, Inukai S, Shlomchik M, Holtrup B, Slack FJ. MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors. Curr Biol. 2014 Oct 06; 24(19):2238-46. PMID: 25242029.
    Citations: 23     Fields:    Translation:Animals
  53. Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB, Davis CA, Hillier L, Sisu C, Li JJ, Pei B, Harmanci AO, Duff MO, Djebali S, Alexander RP, Alver BH, Auerbach R, Bell K, Bickel PJ, Boeck ME, Boley NP, Booth BW, Cherbas L, Cherbas P, Di C, Dobin A, Drenkow J, Ewing B, Fang G, Fastuca M, Feingold EA, Frankish A, Gao G, Good PJ, Guigó R, Hammonds A, Harrow J, Hoskins RA, Howald C, Hu L, Huang H, Hubbard TJ, Huynh C, Jha S, Kasper D, Kato M, Kaufman TC, Kitchen RR, Ladewig E, Lagarde J, Lai E, Leng J, Lu Z, MacCoss M, May G, McWhirter R, Merrihew G, Miller DM, Mortazavi A, Murad R, Oliver B, Olson S, Park PJ, Pazin MJ, Perrimon N, Pervouchine D, Reinke V, Reymond A, Robinson G, Samsonova A, Saunders GI, Schlesinger F, Sethi A, Slack FJ, Spencer WC, Stoiber MH, Strasbourger P, Tanzer A, Thompson OA, Wan KH, Wang G, Wang H, Watkins KL, Wen J, Wen K, Xue C, Yang L, Yip K, Zaleski C, Zhang Y, Zheng H, Brenner SE, Graveley BR, Celniker SE, Gingeras TR, Waterston R. Comparative analysis of the transcriptome across distant species. Nature. 2014 Aug 28; 512(7515):445-8. PMID: 25164755.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  54. Adams BD, Kasinski AL, Slack FJ. Aberrant regulation and function of microRNAs in cancer. Curr Biol. 2014 Aug 18; 24(16):R762-76. PMID: 25137592.
    Citations: 179     Fields:    
  55. Chu YD, Wang WC, Chen SA, Hsu YT, Yeh MW, Slack FJ, Chan SP. RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans. . 2014; 13(12):1995-2009. PMID: 24776851.
    Citations: 9     Translation:Animals
  56. Kim M, Chen X, Chin LJ, Paranjape T, Speed WC, Kidd KK, Zhao H, Weidhaas JB, Slack FJ. Extensive sequence variation in the 3' untranslated region of the KRAS gene in lung and ovarian cancer cases. . 2014; 13(6):1030-40. PMID: 24552817.
    Citations: 22     Translation:Humans
  57. Turner MJ, Jiao AL, Slack FJ. Autoregulation of lin-4 microRNA transcription by RNA activation (RNAa) in C. elegans. . 2014; 13(5):772-81. PMID: 24398561.
    Citations: 18     Translation:AnimalsCells
  58. Slack FJ. In this issue of Epigenetics: special focus on non-coding RNAs in epigenetic regulation. Epigenetics. 2014 Jan; 9(1):1-2. PMID: 24739672.
    Citations:    Fields:    Translation:HumansAnimals
  59. Jiao AL, Slack FJ. RNA-mediated gene activation. Epigenetics. 2014 Jan; 9(1):27-36. PMID: 24185374.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  60. Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D. Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol. 2013 Jul; 11(7):e1001613. PMID: 23935448.
    Citations: 43     Fields:    Translation:Animals
  61. Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT. Noncoding RNAs and cancer. Cell. 2013 Mar 28; 153(1):9-10. PMID: 23781554.
    Citations: 21     Fields:    Translation:HumansAnimals
  62. Metheetrairut C, Slack FJ. MicroRNAs in the ionizing radiation response and in radiotherapy. Curr Opin Genet Dev. 2013 Feb; 23(1):12-9. PMID: 23453900.
    Citations: 72     Fields:    Translation:HumansCells
  63. Cheng CJ, Saltzman WM, Slack FJ. Canonical and non-canonical barriers facing antimiR cancer therapeutics. Curr Med Chem. 2013; 20(29):3582-93. PMID: 23745563.
    Citations: 22     Fields:    Translation:HumansAnimals
  64. Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF regulates TGF-ß signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012 Dec 27; 2(6):1684-96. PMID: 23200853.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  65. Jiao A, Slack FJ. MicroRNAs micromanage themselves. Circ Res. 2012 Nov 09; 111(11):1395-7. PMID: 23139285.
    Citations: 1     Fields:    
  66. Kasinski AL, Slack FJ. miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res. 2012 Nov 01; 72(21):5576-87. PMID: 22964582.
    Citations: 104     Fields:    Translation:AnimalsCells
  67. Babar IA, Cheng CJ, Booth CJ, Liang X, Weidhaas JB, Saltzman WM, Slack FJ. Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):E1695-704. PMID: 22685206.
    Citations: 170     Fields:    Translation:AnimalsCells
  68. Cheng CJ, Slack FJ. The duality of oncomiR addiction in the maintenance and treatment of cancer. Cancer J. 2012 May-Jun; 18(3):232-7. PMID: 22647359.
    Citations: 27     Fields:    Translation:Humans
  69. Slack FJ. MicroRNAs regulate expression of oncogenes. Clin Chem. 2013 Jan; 59(1):325-6. PMID: 22529108.
    Citations: 6     Fields:    
  70. Kasinski AL, Slack FJ. Arresting the Culprit: Targeted Antagomir Delivery to Sequester Oncogenic miR-221 in HCC. Mol Ther Nucleic Acids. 2012 Mar 20; 1:e12. PMID: 23343881.
    Citations: 4     
  71. Inukai S, Slack FJ. MiR-33 connects cholesterol to the cell cycle. . 2012 Mar 15; 11(6):1060-1. PMID: 22391211.
    Citations: 2     Translation:Animals
  72. Kundu ST, Nallur S, Paranjape T, Boeke M, Weidhaas JB, Slack FJ. KRAS alleles: the LCS6 3'UTR variant and KRAS coding sequence mutations in the NCI-60 panel. . 2012 Jan 15; 11(2):361-6. PMID: 22189714.
    Citations: 12     Translation:HumansCells
  73. Smith-Vikos T, Slack FJ. MicroRNAs and their roles in aging. J Cell Sci. 2012 Jan 01; 125(Pt 1):7-17. PMID: 22294612.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  74. Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer. 2011 Nov 24; 11(12):849-64. PMID: 22113163.
    Citations: 411     Fields:    Translation:HumansAnimals
  75. Babar IA, Czochor J, Steinmetz A, Weidhaas JB, Glazer PM, Slack FJ. Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. . 2011 Nov 15; 12(10):908-14. PMID: 22027557.
    Citations: 63     Translation:HumansCells
  76. Weidhaas JB, Slack FJ. KRAS rs61764370 in Epithelial Ovarian Cancer-Letter. Clin Cancer Res. 2011 Oct 15; 17(20):6600; author reply 6601. PMID: 22003074.
    Citations: 2     Fields:    Translation:Humans
  77. Pincus Z, Smith-Vikos T, Slack FJ. MicroRNA predictors of longevity in Caenorhabditis elegans. PLoS Genet. 2011 Sep; 7(9):e1002306. PMID: 21980307.
    Citations: 75     Fields:    Translation:AnimalsCells
  78. Kato M, Chen X, Inukai S, Zhao H, Slack FJ. Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA. 2011 Oct; 17(10):1804-20. PMID: 21810936.
    Citations: 66     Fields:    Translation:AnimalsCells
  79. Zhou KI, Pincus Z, Slack FJ. Longevity and stress in Caenorhabditis elegans. Aging (Albany NY). 2011 Aug; 3(8):733-53. PMID: 21937765.
    Citations: 50     Fields:    Translation:Animals
  80. Olsson-Carter K, Slack FJ. The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth. Dev Dyn. 2011 Jul; 240(7):1815-25. PMID: 21656875.
    Citations: 5     Fields:    Translation:AnimalsCells
  81. Chan E, Patel R, Nallur S, Ratner E, Bacchiocchi A, Hoyt K, Szpakowski S, Godshalk S, Ariyan S, Sznol M, Halaban R, Krauthammer M, Tuck D, Slack FJ, Weidhaas JB. MicroRNA signatures differentiate melanoma subtypes. . 2011 Jun 01; 10(11):1845-52. PMID: 21543894.
    Citations: 43     Translation:HumansCells
  82. Kim M, Kasinski AL, Slack FJ. MicroRNA therapeutics in preclinical cancer models. Lancet Oncol. 2011 Apr; 12(4):319-21. PMID: 21463831.
    Citations: 22     Fields:    Translation:Humans
  83. Trang P, Wiggins JF, Daige CL, Cho C, Omotola M, Brown D, Weidhaas JB, Bader AG, Slack FJ. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther. 2011 Jun; 19(6):1116-22. PMID: 21427705.
    Citations: 242     Fields:    Translation:HumansAnimalsCells
  84. Pelletier C, Speed WC, Paranjape T, Keane K, Blitzblau R, Hollestelle A, Safavi K, van den Ouweland A, Zelterman D, Slack FJ, Kidd KK, Weidhaas JB. Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk. . 2011 Jan 01; 10(1):90-9. PMID: 21191178.
    Citations: 18     Translation:Humans
  85. Van Wynsberghe PM, Chan SP, Slack FJ, Pasquinelli AE. Analysis of microRNA expression and function. Methods Cell Biol. 2011; 106:219-252. PMID: 22118279.
    Citations: 31     Fields:    Translation:Animals
  86. Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T, Yip KY, Robilotto R, Rechtsteiner A, Ikegami K, Alves P, Chateigner A, Perry M, Morris M, Auerbach RK, Feng X, Leng J, Vielle A, Niu W, Rhrissorrakrai K, Agarwal A, Alexander RP, Barber G, Brdlik CM, Brennan J, Brouillet JJ, Carr A, Cheung MS, Clawson H, Contrino S, Dannenberg LO, Dernburg AF, Desai A, Dick L, Dosé AC, Du J, Egelhofer T, Ercan S, Euskirchen G, Ewing B, Feingold EA, Gassmann R, Good PJ, Green P, Gullier F, Gutwein M, Guyer MS, Habegger L, Han T, Henikoff JG, Henz SR, Hinrichs A, Holster H, Hyman T, Iniguez AL, Janette J, Jensen M, Kato M, Kent WJ, Kephart E, Khivansara V, Khurana E, Kim JK, Kolasinska-Zwierz P, Lai EC, Latorre I, Leahey A, Lewis S, Lloyd P, Lochovsky L, Lowdon RF, Lubling Y, Lyne R, MacCoss M, Mackowiak SD, Mangone M, McKay S, Mecenas D, Merrihew G, Miller DM, Muroyama A, Murray JI, Ooi SL, Pham H, Phippen T, Preston EA, Rajewsky N, Rätsch G, Rosenbaum H, Rozowsky J, Rutherford K, Ruzanov P, Sarov M, Sasidharan R, Sboner A, Scheid P, Segal E, Shin H, Shou C, Slack FJ, Slightam C, Smith R, Spencer WC, Stinson EO, Taing S, Takasaki T, Vafeados D, Voronina K, Wang G, Washington NL, Whittle CM, Wu B, Yan KK, Zeller G, Zha Z, Zhong M, Zhou X, Ahringer J, Strome S, Gunsalus KC, Micklem G, Liu XS, Reinke V, Kim SK, Hillier LW, Henikoff S, Piano F, Snyder M, Stein L, Lieb JD, Waterston RH. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science. 2010 Dec 24; 330(6012):1775-87. PMID: 21177976.
    Citations: 499     Fields:    Translation:AnimalsCells
  87. de Lencastre A, Pincus Z, Zhou K, Kato M, Lee SS, Slack FJ. MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol. 2010 Dec 21; 20(24):2159-68. PMID: 21129974.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  88. Banerjee D, Chen X, Lin SY, Slack FJ. kin-19/casein kinase Ia has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells. . 2010 Dec 01; 9(23):4748-65. PMID: 21127398.
    Citations: 12     Translation:AnimalsCells
  89. Medina PP, Nolde M, Slack FJ. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature. 2010 Sep 02; 467(7311):86-90. PMID: 20693987.
    Citations: 399     Fields:    Translation:AnimalsCells
  90. Olsson-Carter K, Slack FJ. A developmental timing switch promotes axon outgrowth independent of known guidance receptors. PLoS Genet. 2010 Aug 05; 6(8). PMID: 20700435.
    Citations: 24     Fields:    Translation:AnimalsCells
  91. Hada K, Asahina M, Hasegawa H, Kanaho Y, Slack FJ, Niwa R. The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition. Dev Biol. 2010 Aug 15; 344(2):1100-9. PMID: 20678979.
    Citations: 18     Fields:    Translation:Animals
  92. Pincus Z, Slack FJ. Developmental biomarkers of aging in Caenorhabditis elegans. Dev Dyn. 2010 May; 239(5):1306-14. PMID: 20151474.
    Citations: 23     Fields:    Translation:Animals
  93. Kundu ST, Slack FJ. Robust and specific inhibition of microRNAs in Caenorhabditis elegans. J Biol. 2010; 9(3):20. PMID: 20359318.
    Citations:    Fields:    Translation:AnimalsCells
  94. Kasinski AL, Slack FJ. Potential microRNA therapies targeting Ras, NFkappaB and p53 signaling. Curr Opin Mol Ther. 2010 Apr; 12(2):147-57. PMID: 20373258.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  95. Godshalk SE, Melnik-Martinez KV, Pasquinelli AE, Slack FJ. MicroRNAs and cancer: a meeting summary of the eponymous Keystone Conference. Epigenetics. 2010 Feb 16; 5(2):164-8. PMID: 20168081.
    Citations: 2     Fields:    Translation:HumansAnimals
  96. Slack FJ. Stem cells: Big roles for small RNAs. Nature. 2010 Feb 04; 463(7281):616. PMID: 20130638.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  97. Niwa R, Hada K, Moliyama K, Ohniwa RL, Tan YM, Olsson-Carter K, Chi W, Reinke V, Slack FJ. C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor. . 2009 Dec 15; 8(24):4147-54. PMID: 19923914.
    Citations: 6     Translation:AnimalsCells
  98. Roush SF, Slack FJ. Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1. Dev Biol. 2009 Oct 15; 334(2):523-34. PMID: 19627983.
    Citations: 25     Fields:    Translation:AnimalsCells
  99. Chan SP, Slack FJ. Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans. Dev Biol. 2009 Oct 01; 334(1):152-60. PMID: 19627982.
    Citations: 13     Fields:    Translation:Animals
  100. Kato M, de Lencastre A, Pincus Z, Slack FJ. Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol. 2009; 10(5):R54. PMID: 19460142.
    Citations: 82     Fields:    Translation:Animals
  101. Nimmo RA, Slack FJ. An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma. 2009 Aug; 118(4):405-18. PMID: 19340450.
    Citations: 73     Fields:    Translation:AnimalsCells
  102. Turner MJ, Slack FJ. Transcriptional control of microRNA expression in C. elegans: promoting better understanding. RNA Biol. 2009 Jan-Mar; 6(1):49-53. PMID: 19106630.
    Citations: 12     Fields:    Translation:AnimalsCells
  103. Medina PP, Slack FJ. Inhibiting microRNA function in vivo. Nat Methods. 2009 Jan; 6(1):37-8. PMID: 19116612.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  104. Slack FJ, Weidhaas JB. MicroRNA in cancer prognosis. N Engl J Med. 2008 Dec 18; 359(25):2720-2. PMID: 19092157.
    Citations: 75     Fields:    Translation:Humans
  105. Maller Schulman BR, Liang X, Stahlhut C, DelConte C, Stefani G, Slack FJ. The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. . 2008 Dec 15; 7(24):3935-42. PMID: 19098426.
    Citations: 55     Translation:HumansAnimalsCells
  106. Godshalk SE, Bhaduri-McIntosh S, Slack FJ. Epstein-Barr virus-mediated dysregulation of human microRNA expression. . 2008 Nov 15; 7(22):3595-600. PMID: 19001862.
    Citations: 34     Translation:HumansCells
  107. Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008 Oct 15; 68(20):8535-40. PMID: 18922928.
    Citations: 279     Fields:    Translation:Humans
  108. Ding XC, Slack FJ, Grosshans H. The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. . 2008 Oct; 7(19):3083-90. PMID: 18818519.
    Citations: 18     Translation:AnimalsCells
  109. Pincus Z, Slack FJ. Transcriptional (dys)regulation and aging in Caenorhabditis elegans. Genome Biol. 2008; 9(9):233. PMID: 18828877.
    Citations: 4     Fields:    Translation:AnimalsCells
  110. Roush S, Slack FJ. The let-7 family of microRNAs. Trends Cell Biol. 2008 Oct; 18(10):505-16. PMID: 18774294.
    Citations: 472     Fields:    Translation:HumansAnimalsCells
  111. Chan SP, Ramaswamy G, Choi EY, Slack FJ. Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans. RNA. 2008 Oct; 14(10):2104-14. PMID: 18719242.
    Citations: 13     Fields:    Translation:Animals
  112. Medina PP, Slack FJ. microRNAs and cancer: an overview. . 2008 Aug 15; 7(16):2485-92. PMID: 18719380.
    Citations: 130     Translation:HumansAnimals
  113. Büssing I, Slack FJ, Grosshans H. let-7 microRNAs in development, stem cells and cancer. Trends Mol Med. 2008 Sep; 14(9):400-9. PMID: 18674967.
    Citations: 233     Fields:    Translation:HumansAnimalsCells
  114. Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L, Weidhaas JB, Brown D, Bader AG, Slack FJ. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. . 2008 Mar 15; 7(6):759-64. PMID: 18344688.
    Citations: 245     Translation:HumansAnimalsCells
  115. Stefani G, Slack FJ. Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol. 2008 Mar; 9(3):219-30. PMID: 18270516.
    Citations: 593     Fields:    Translation:HumansAnimalsCells
  116. Kato M, Slack FJ. microRNAs: small molecules with big roles - C. elegans to human cancer. Biol Cell. 2008 Feb; 100(2):71-81. PMID: 18199046.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  117. Niwa R, Zhou F, Li C, Slack FJ. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev Biol. 2008 Mar 15; 315(2):418-25. PMID: 18262516.
    Citations: 43     Fields:    Translation:HumansAnimals
  118. Weidhaas JB, Babar I, Nallur SM, Trang P, Roush S, Boehm M, Gillespie E, Slack FJ. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res. 2007 Dec 01; 67(23):11111-6. PMID: 18056433.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  119. Chan SP, Slack FJ. And now introducing mammalian mirtrons. Dev Cell. 2007 Nov; 13(5):605-7. PMID: 17981129.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  120. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D, Slack FJ. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007 Aug 15; 67(16):7713-22. PMID: 17699775.
    Citations: 509     Fields:    Translation:HumansCells
  121. Nolde MJ, Saka N, Reinert KL, Slack FJ. The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1. Dev Biol. 2007 May 15; 305(2):551-63. PMID: 17412319.
    Citations: 43     Fields:    Translation:AnimalsCells
  122. Niwa R, Slack FJ. The evolution of animal microRNA function. Curr Opin Genet Dev. 2007 Apr; 17(2):145-50. PMID: 17317150.
    Citations: 85     Fields:    Translation:AnimalsCells
  123. Stahlhut Espinosa CE, Slack FJ. The role of microRNAs in cancer. Yale J Biol Med. 2006 Dec; 79(3-4):131-40. PMID: 17940623.
    Citations: 62     Fields:    Translation:HumansAnimals
  124. Roush SF, Slack FJ. Micromanagement: a role for microRNAs in mRNA stability. ACS Chem Biol. 2006 Apr 25; 1(3):132-4. PMID: 17163657.
    Citations: 8     Fields:    Translation:AnimalsCells
  125. Boehm M, Slack FJ. MicroRNA control of lifespan and metabolism. . 2006 Apr; 5(8):837-40. PMID: 16627994.
    Citations: 46     Translation:HumansAnimals
  126. Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 2006 Apr; 6(4):259-69. PMID: 16557279.
    Citations: 2801     Fields:    Translation:HumansAnimals
  127. Slack FJ, Weidhaas JB. MicroRNAs as a potential magic bullet in cancer. Future Oncol. 2006 Feb; 2(1):73-82. PMID: 16556074.
    Citations: 28     Fields:    Translation:HumansAnimals
  128. Slack FJ. Regulatory RNAs and the demise of 'junk' DNA. Genome Biol. 2006; 7(9):328. PMID: 17020591.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  129. Schulman BR, Esquela-Kerscher A, Slack FJ. Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev Dyn. 2005 Dec; 234(4):1046-54. PMID: 16247770.
    Citations: 60     Fields:    Translation:AnimalsCells
  130. Vella MC, Slack FJ. C. elegans microRNAs. WormBook. 2005 Sep 21; 1-9. PMID: 18050425.
    Citations: 13     Fields:    Translation:HumansAnimals
  131. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ. RAS is regulated by the let-7 microRNA family. Cell. 2005 Mar 11; 120(5):635-47. PMID: 15766527.
    Citations: 1366     Fields:    Translation:HumansAnimalsCells
  132. Grosshans H, Johnson T, Reinert KL, Gerstein M, Slack FJ. The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev Cell. 2005 Mar; 8(3):321-30. PMID: 15737928.
    Citations: 95     Fields:    Translation:Animals
  133. Banerjee D, Kwok A, Lin SY, Slack FJ. Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev Cell. 2005 Feb; 8(2):287-95. PMID: 15691769.
    Citations: 27     Fields:    Translation:Animals
  134. Banerjee D, Slack FJ. Temporal and spatial patterning of an organ by a single transcription factor. Genome Biol. 2005; 6(2):205. PMID: 15693952.
    Citations: 2     Fields:    Translation:AnimalsCells
  135. Vella MC, Reinert K, Slack FJ. Architecture of a validated microRNA::target interaction. Chem Biol. 2004 Dec; 11(12):1619-23. PMID: 15610845.
    Citations: 70     Fields:    Translation:AnimalsCells
  136. Esquela-Kerscher A, Slack FJ. The age of high-throughput microRNA profiling. Nat Methods. 2004 Nov; 1(2):106-7. PMID: 15782171.
    Citations: 5     Fields:    Translation:HumansAnimals
  137. Vella MC, Choi EY, Lin SY, Reinert K, Slack FJ. The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev. 2004 Jan 15; 18(2):132-7. PMID: 14729570.
    Citations: 194     Fields:    Translation:AnimalsCells
  138. Johnson SM, Lin SY, Slack FJ. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev Biol. 2003 Jul 15; 259(2):364-79. PMID: 12871707.
    Citations: 78     Fields:    Translation:AnimalsCells
  139. Lin SY, Johnson SM, Abraham M, Vella MC, Pasquinelli A, Gamberi C, Gottlieb E, Slack FJ. The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell. 2003 May; 4(5):639-50. PMID: 12737800.
    Citations: 136     Fields:    Translation:AnimalsCells
  140. Grosshans H, Slack FJ. Micro-RNAs: small is plentiful. J Cell Biol. 2002 Jan 07; 156(1):17-21. PMID: 11781331.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  141. Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000 Nov 02; 408(6808):86-9. PMID: 11081512.
    Citations: 723     Fields:    Translation:HumansAnimalsCells
  142. Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000 Apr; 5(4):659-69. PMID: 10882102.
    Citations: 242     Fields:    Translation:AnimalsCells
  143. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24; 403(6772):901-6. PMID: 10706289.
    Citations: 1558     Fields:    Translation:AnimalsCells
  144. Slack F, Ruvkun G. Heterochronic genes in development and evolution. Biol Bull. 1998 Dec; 195(3):375-6. PMID: 9924779.
    Citations: 3     Fields:    Translation:Animals
  145. Slack FJ, Ruvkun G. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci. 1998 Dec; 23(12):474-5. PMID: 9868369.
    Citations: 60     Fields:    Translation:Cells
  146. Slack F, Ruvkun G. Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1997; 31:611-34. PMID: 9442909.
    Citations: 29     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.