Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Frank Slack, Ph.D.

Other Positions

ncRNAs in Aging[login at prompt]
Available: 09/25/18, Expires: 08/31/20

The student will identify ncRNAs mis-expressed in aging animals and perform knock out experiments to identify those ncRNA with functions in aging. The model organism used here will be the nematode C. elegans, which lives about 2 weeks.

Non-coding RNAs in cancer[login at prompt]
Available: 09/24/18, Expires: 08/31/20

The student will examine cancer tissues and identify mis-expressed ncRNAs. The student will perform function assays to determine whether the ncRNAs play a role in cancer cell survival, growth or motility. The student will identify potential pathways associated with the ncRNA and begin studies to investigate mechanism of action.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA235740 (DOYLE, PATRICK S) Jun 10, 2019 - May 31, 2024
    Microengineered Technologies for Quantitative, Multiplexed and Spatially Resolved Measurement of miRNA in Tissue Sections
    Role: Co-Principal Investigator
  2. R01AG058816 (SLACK, FRANK J.) Apr 1, 2018 - Mar 31, 2023
    Juvenile microRNAs promoting healthier adult aging
    Role: Principal Investigator
  3. P50CA-01 (CHEN, LIEPING) Aug 26, 2015 - Jul 31, 2020
    Yale SPORE in Lung Cancer Career Development Program
    Role: Co-Principal Investigator
  4. P50CA196530 (HERBST, ROY S) Aug 26, 2015 - Jul 31, 2020
    Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer
    Role: Co-Principal Investigator
  5. R01CA157749 (WEIDHAAS, JOANNE B) Jul 1, 2012 - May 31, 2017
    MicroRNAs to Understand Cause and Outcome in Breast Cancer
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Non-Coding RNA Core Facility - Core services (4) and Instruments (4)

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mavrikaki M, Anastasiadou E, Ozdemir RA, Potter D, Helmholz C, Slack FJ, Chartoff EH. Overexpression of miR-9 in the Nucleus Accumbens Increases Oxycodone Self-Administration. Int J Neuropsychopharmacol. 2019 Jun 03; 22(6):383-393. PMID: 30989210.
  2. Segal M, Slack FJ. Extracellular vesicles show promise for cancer theranostics. Ann Transl Med. 2019 Apr; 7(7):158. PMID: 31157278.
  3. Nahas MR, Stroopinsky D, Rosenblatt J, Cole L, Pyzer AR, Anastasiadou E, Sergeeva A, Ephraim A, Washington A, Orr S, McMasters M, Weinstock M, Jain S, Leaf RK, Ghiasuddin H, Rahimian M, Liegel J, Molldrem JJ, Slack F, Kufe D, Avigan D. Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine. Br J Haematol. 2019 May; 185(4):679-690. PMID: 30828801.
  4. Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ. Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor. RNA. 2019 03; 25(3):352-363. PMID: 30538148.
    Citations:    Fields:    
  5. Trivedi P, Slack FJ, Anastasiadou E. Epstein-Barr virus: From kisses to cancer, an ingenious immune evader. Oncotarget. 2018 Nov 23; 9(92):36411-36412. PMID: 30559926.
    Citations:    Fields:    
  6. Witten LW, Cheng CJ, Slack FJ. miR-155 drives oncogenesis by promoting and cooperating with mutations in the c-Kit oncogene. Oncogene. 2019 03; 38(12):2151-2161. PMID: 30459357.
    Citations:    Fields:    
  7. Gilles ME, Slack FJ. Let-7 microRNA as a potential therapeutic target with implications for immunotherapy. Expert Opin Ther Targets. 2018 11; 22(11):929-939. PMID: 30328720.
    Citations:    Fields:    
  8. Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. PMID: 30232453.
    Citations:    Fields:    
  9. Nagarajan MB, Tentori AM, Zhang WC, Slack FJ, Doyle PS. Nonfouling, Encoded Hydrogel Microparticles for Multiplex MicroRNA Profiling Directly from Formalin-Fixed, Paraffin-Embedded Tissue. Anal Chem. 2018 09 04; 90(17):10279-10285. PMID: 30106558.
    Citations:    Fields:    
  10. Tentori AM, Nagarajan MB, Kim JJ, Zhang WC, Slack FJ, Doyle PS. Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays. Lab Chip. 2018 08 07; 18(16):2410-2424. PMID: 29998262.
    Citations:    Fields:    Translation:HumansCells
  11. Anastasiadou E, Faggioni A, Trivedi P, Slack FJ. The Nefarious Nexus of Noncoding RNAs in Cancer. Int J Mol Sci. 2018 Jul 17; 19(7). PMID: 30018188.
    Citations: 1     Fields:    Translation:Humans
  12. Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia. 2019 01; 33(1):132-147. PMID: 29946193.
    Citations: 2     Fields:    
  13. Slack FJ. Tackling Tumors with Small RNAs Derived from Transfer RNA. N Engl J Med. 2018 05 10; 378(19):1842-1843. PMID: 29742367.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ. Personalized RNA Medicine for Pancreatic Cancer. Clin Cancer Res. 2018 04 01; 24(7):1734-1747. PMID: 29330203.
    Citations: 2     Fields:    
  15. Jiao AL, Foster DJ, Dixon J, Slack FJ. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans. PLoS One. 2018; 13(1):e0190766. PMID: 29324872.
    Citations:    Fields:    Translation:AnimalsCells
  16. Anastasiadou E, Jacob LS, Slack FJ. Non-coding RNA networks in cancer. Nat Rev Cancer. 2018 Jan; 18(1):5-18. PMID: 29170536.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  17. Inukai S, Pincus Z, de Lencastre A, Slack FJ. A microRNA feedback loop regulates global microRNA abundance during aging. RNA. 2018 02; 24(2):159-172. PMID: 29114017.
    Citations: 2     Fields:    Translation:Animals
  18. Metheetrairut C, Ahuja Y, Slack FJ. acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes. Cell Cycle. 2017 Oct 02; 16(19):1800-1809. PMID: 28933985.
    Citations:    Fields:    Translation:AnimalsCells
  19. Pyzer AR, Stroopinsky D, Rosenblatt J, Anastasiadou E, Rajabi H, Washington A, Tagde A, Chu JH, Coll M, Jiao AL, Tsai LT, Tenen DE, Cole L, Palmer K, Ephraim A, Leaf RK, Nahas M, Apel A, Bar-Natan M, Jain S, McMasters M, Mendez L, Arnason J, Raby BA, Slack F, Kufe D, Avigan D. MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs. Leukemia. 2017 12; 31(12):2780-2790. PMID: 28555079.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Adams BD, Parsons C, Walker L, Zhang WC, Slack FJ. Targeting noncoding RNAs in disease. J Clin Invest. 2017 Mar 01; 127(3):761-771. PMID: 28248199.
    Citations: 44     Fields:    Translation:Humans
  21. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017 Mar; 16(3):203-222. PMID: 28209991.
    Citations: 131     Fields:    Translation:HumansAnimals
  22. Smith-Vikos T, Liu Z, Parsons C, Gorospe M, Ferrucci L, Gill TM, Slack FJ. A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). Aging (Albany NY). 2016 11 07; 8(11):2971-2987. PMID: 27824314.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  23. Rupaimoole R, Slack FJ. A role for miR-34 in colon cancer stem cell homeostasis. Stem Cell Investig. 2016; 3:42. PMID: 27668249.
    Citations: 3     
  24. Zhang WC, Slack FJ. ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity. Cell Stem Cell. 2016 08 04; 19(2):141-142. PMID: 27494666.
    Citations:    Fields:    Translation:HumansCells
  25. Svoronos AA, Engelman DM, Slack FJ. OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer. Cancer Res. 2016 07 01; 76(13):3666-70. PMID: 27325641.
    Citations: 49     Fields:    Translation:HumansAnimals
  26. Pincus Z, Mazer TC, Slack FJ. Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green. Aging (Albany NY). 2016 05; 8(5):889-98. PMID: 27070172.
    Citations: 5     Fields:    Translation:Animals
  27. Kim M, Kogan N, Slack FJ. Cis-acting elements in its 3' UTR mediate post-transcriptional regulation of KRAS. Oncotarget. 2016 Mar 15; 7(11):11770-84. PMID: 26930719.
    Citations:    Fields:    Translation:HumansCells
  28. Adams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Gyorffy B, Santarpia L, Pusztai L, Saltzman WM, Slack FJ. miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer. Cancer Res. 2016 Feb 15; 76(4):927-39. PMID: 26676753.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  29. Adams BD, Anastasiadou E, Esteller M, He L, Slack FJ. The Inescapable Influence of Noncoding RNAs in Cancer. Cancer Res. 2015 Dec 15; 75(24):5206-10. PMID: 26567137.
    Citations: 14     Fields:    Translation:HumansAnimals
  30. Adams BD, Parsons C, Slack FJ. The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas. Expert Opin Ther Targets. 2016 Jun; 20(6):737-53. PMID: 26652031.
    Citations: 15     Fields:    Translation:HumansAnimals
  31. Stefani G, Chen X, Zhao H, Slack FJ. A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans. RNA. 2015 May; 21(5):985-96. PMID: 25805859.
    Citations: 9     Fields:    Translation:AnimalsCells
  32. Stahlhut C, Slack FJ. Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. Cell Cycle. 2015; 14(13):2171-80. PMID: 25714397.
    Citations: 30     Fields:    Translation:HumansCells
  33. Anastasiadou E, Slack FJ. Cancer. Malicious exosomes. Science. 2014 Dec 19; 346(6216):1459-60. PMID: 25525233.
    Citations: 9     Fields:    Translation:HumansAnimals
  34. Kim M, Slack FJ. MicroRNA-mediated regulation of KRAS in cancer. J Hematol Oncol. 2014 Nov 30; 7:84. PMID: 25433809.
    Citations: 8     Fields:    Translation:HumansAnimals
  35. Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature. 2015 Feb 05; 518(7537):107-10. PMID: 25409146.
    Citations: 137     Fields:    Translation:AnimalsCells
  36. Coira IF, Rufino-Palomares EE, Romero OA, Peinado P, Metheetrairut C, Boyero-Corral L, Carretero J, Farez-Vidal E, Cuadros M, Reyes-Zurita FJ, Lupiáñez JA, Sánchez-Cespedes M, Slack FJ, Medina PP. Expression inactivation of SMARCA4 by microRNAs in lung tumors. Hum Mol Genet. 2015 Mar 01; 24(5):1400-9. PMID: 25355421.
    Citations: 4     Fields:    Translation:HumansCells
  37. Smith-Vikos T, de Lencastre A, Inukai S, Shlomchik M, Holtrup B, Slack FJ. MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors. Curr Biol. 2014 Oct 06; 24(19):2238-46. PMID: 25242029.
    Citations: 10     Fields:    Translation:Animals
  38. Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB, Davis CA, Hillier L, Sisu C, Li JJ, Pei B, Harmanci AO, Duff MO, Djebali S, Alexander RP, Alver BH, Auerbach R, Bell K, Bickel PJ, Boeck ME, Boley NP, Booth BW, Cherbas L, Cherbas P, Di C, Dobin A, Drenkow J, Ewing B, Fang G, Fastuca M, Feingold EA, Frankish A, Gao G, Good PJ, Guigó R, Hammonds A, Harrow J, Hoskins RA, Howald C, Hu L, Huang H, Hubbard TJ, Huynh C, Jha S, Kasper D, Kato M, Kaufman TC, Kitchen RR, Ladewig E, Lagarde J, Lai E, Leng J, Lu Z, MacCoss M, May G, McWhirter R, Merrihew G, Miller DM, Mortazavi A, Murad R, Oliver B, Olson S, Park PJ, Pazin MJ, Perrimon N, Pervouchine D, Reinke V, Reymond A, Robinson G, Samsonova A, Saunders GI, Schlesinger F, Sethi A, Slack FJ, Spencer WC, Stoiber MH, Strasbourger P, Tanzer A, Thompson OA, Wan KH, Wang G, Wang H, Watkins KL, Wen J, Wen K, Xue C, Yang L, Yip K, Zaleski C, Zhang Y, Zheng H, Brenner SE, Graveley BR, Celniker SE, Gingeras TR, Waterston R. Comparative analysis of the transcriptome across distant species. Nature. 2014 Aug 28; 512(7515):445-8. PMID: 25164755.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  39. Adams BD, Kasinski AL, Slack FJ. Aberrant regulation and function of microRNAs in cancer. Curr Biol. 2014 Aug 18; 24(16):R762-76. PMID: 25137592.
    Citations: 106     Fields:    
  40. Chu YD, Wang WC, Chen SA, Hsu YT, Yeh MW, Slack FJ, Chan SP. RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans. Cell Cycle. 2014; 13(12):1995-2009. PMID: 24776851.
    Citations: 6     Fields:    Translation:Animals
  41. Kim M, Chen X, Chin LJ, Paranjape T, Speed WC, Kidd KK, Zhao H, Weidhaas JB, Slack FJ. Extensive sequence variation in the 3' untranslated region of the KRAS gene in lung and ovarian cancer cases. Cell Cycle. 2014; 13(6):1030-40. PMID: 24552817.
    Citations: 18     Fields:    Translation:Humans
  42. Turner MJ, Jiao AL, Slack FJ. Autoregulation of lin-4 microRNA transcription by RNA activation (RNAa) in C. elegans. Cell Cycle. 2014; 13(5):772-81. PMID: 24398561.
    Citations: 15     Fields:    Translation:AnimalsCells
  43. Jiao AL, Slack FJ. RNA-mediated gene activation. Epigenetics. 2014 Jan; 9(1):27-36. PMID: 24185374.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  44. Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D. Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol. 2013 Jul; 11(7):e1001613. PMID: 23935448.
    Citations: 25     Fields:    Translation:Animals
  45. Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT. Noncoding RNAs and cancer. Cell. 2013 Mar 28; 153(1):9-10. PMID: 23781554.
    Citations: 18     Fields:    Translation:HumansAnimals
  46. Cheng CJ, Saltzman WM, Slack FJ. Canonical and non-canonical barriers facing antimiR cancer therapeutics. Curr Med Chem. 2013; 20(29):3582-93. PMID: 23745563.
    Citations: 18     Fields:    Translation:HumansAnimals
  47. Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF regulates TGF-ß signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012 Dec 27; 2(6):1684-96. PMID: 23200853.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  48. Jiao A, Slack FJ. MicroRNAs micromanage themselves. Circ Res. 2012 Nov 09; 111(11):1395-7. PMID: 23139285.
    Citations:    Fields:    
  49. Kasinski AL, Slack FJ. miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res. 2012 Nov 01; 72(21):5576-87. PMID: 22964582.
    Citations: 80     Fields:    Translation:AnimalsCells
  50. Babar IA, Cheng CJ, Booth CJ, Liang X, Weidhaas JB, Saltzman WM, Slack FJ. Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):E1695-704. PMID: 22685206.
    Citations: 122     Fields:    Translation:AnimalsCells
  51. Cheng CJ, Slack FJ. The duality of oncomiR addiction in the maintenance and treatment of cancer. Cancer J. 2012 May-Jun; 18(3):232-7. PMID: 22647359.
    Citations: 21     Fields:    Translation:Humans
  52. Slack FJ. MicroRNAs regulate expression of oncogenes. Clin Chem. 2013 Jan; 59(1):325-6. PMID: 22529108.
  53. Inukai S, Slack FJ. MiR-33 connects cholesterol to the cell cycle. Cell Cycle. 2012 Mar 15; 11(6):1060-1. PMID: 22391211.
    Citations: 2     Fields:    Translation:Animals
  54. Kundu ST, Nallur S, Paranjape T, Boeke M, Weidhaas JB, Slack FJ. KRAS alleles: the LCS6 3'UTR variant and KRAS coding sequence mutations in the NCI-60 panel. Cell Cycle. 2012 Jan 15; 11(2):361-6. PMID: 22189714.
    Citations: 12     Fields:    Translation:HumansCells
  55. Smith-Vikos T, Slack FJ. MicroRNAs and their roles in aging. J Cell Sci. 2012 Jan 01; 125(Pt 1):7-17. PMID: 22294612.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  56. Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer. 2011 Nov 24; 11(12):849-64. PMID: 22113163.
    Citations: 330     Fields:    Translation:HumansAnimals
  57. Babar IA, Czochor J, Steinmetz A, Weidhaas JB, Glazer PM, Slack FJ. Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. Cancer Biol Ther. 2011 Nov 15; 12(10):908-14. PMID: 22027557.
  58. Weidhaas JB, Slack FJ. KRAS rs61764370 in Epithelial Ovarian Cancer-Letter. Clin Cancer Res. 2011 Oct 15; 17(20):6600; author reply 6601. PMID: 22003074.
    Citations: 2     Fields:    Translation:Humans
  59. Pincus Z, Smith-Vikos T, Slack FJ. MicroRNA predictors of longevity in Caenorhabditis elegans. PLoS Genet. 2011 Sep; 7(9):e1002306. PMID: 21980307.
    Citations: 52     Fields:    Translation:AnimalsCells
  60. Kato M, Chen X, Inukai S, Zhao H, Slack FJ. Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA. 2011 Oct; 17(10):1804-20. PMID: 21810936.
    Citations: 50     Fields:    Translation:AnimalsCells
  61. Zhou KI, Pincus Z, Slack FJ. Longevity and stress in Caenorhabditis elegans. Aging (Albany NY). 2011 Aug; 3(8):733-53. PMID: 21937765.
    Citations: 37     Fields:    Translation:Animals
  62. Olsson-Carter K, Slack FJ. The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth. Dev Dyn. 2011 Jul; 240(7):1815-25. PMID: 21656875.
    Citations: 4     Fields:    Translation:AnimalsCells
  63. Chan E, Patel R, Nallur S, Ratner E, Bacchiocchi A, Hoyt K, Szpakowski S, Godshalk S, Ariyan S, Sznol M, Halaban R, Krauthammer M, Tuck D, Slack FJ, Weidhaas JB. MicroRNA signatures differentiate melanoma subtypes. Cell Cycle. 2011 Jun 01; 10(11):1845-52. PMID: 21543894.
    Citations: 39     Fields:    Translation:HumansCells
  64. Kim M, Kasinski AL, Slack FJ. MicroRNA therapeutics in preclinical cancer models. Lancet Oncol. 2011 Apr; 12(4):319-21. PMID: 21463831.
    Citations: 17     Fields:    Translation:Humans
  65. Trang P, Wiggins JF, Daige CL, Cho C, Omotola M, Brown D, Weidhaas JB, Bader AG, Slack FJ. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther. 2011 Jun; 19(6):1116-22. PMID: 21427705.
  66. Van Wynsberghe PM, Chan SP, Slack FJ, Pasquinelli AE. Analysis of microRNA expression and function. Methods Cell Biol. 2011; 106:219-252. PMID: 22118279.
    Citations: 26     Fields:    Translation:Animals
  67. Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T, Yip KY, Robilotto R, Rechtsteiner A, Ikegami K, Alves P, Chateigner A, Perry M, Morris M, Auerbach RK, Feng X, Leng J, Vielle A, Niu W, Rhrissorrakrai K, Agarwal A, Alexander RP, Barber G, Brdlik CM, Brennan J, Brouillet JJ, Carr A, Cheung MS, Clawson H, Contrino S, Dannenberg LO, Dernburg AF, Desai A, Dick L, Dosé AC, Du J, Egelhofer T, Ercan S, Euskirchen G, Ewing B, Feingold EA, Gassmann R, Good PJ, Green P, Gullier F, Gutwein M, Guyer MS, Habegger L, Han T, Henikoff JG, Henz SR, Hinrichs A, Holster H, Hyman T, Iniguez AL, Janette J, Jensen M, Kato M, Kent WJ, Kephart E, Khivansara V, Khurana E, Kim JK, Kolasinska-Zwierz P, Lai EC, Latorre I, Leahey A, Lewis S, Lloyd P, Lochovsky L, Lowdon RF, Lubling Y, Lyne R, MacCoss M, Mackowiak SD, Mangone M, McKay S, Mecenas D, Merrihew G, Miller DM, Muroyama A, Murray JI, Ooi SL, Pham H, Phippen T, Preston EA, Rajewsky N, Rätsch G, Rosenbaum H, Rozowsky J, Rutherford K, Ruzanov P, Sarov M, Sasidharan R, Sboner A, Scheid P, Segal E, Shin H, Shou C, Slack FJ, Slightam C, Smith R, Spencer WC, Stinson EO, Taing S, Takasaki T, Vafeados D, Voronina K, Wang G, Washington NL, Whittle CM, Wu B, Yan KK, Zeller G, Zha Z, Zhong M, Zhou X, Ahringer J, Strome S, Gunsalus KC, Micklem G, Liu XS, Reinke V, Kim SK, Hillier LW, Henikoff S, Piano F, Snyder M, Stein L, Lieb JD, Waterston RH. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science. 2010 Dec 24; 330(6012):1775-87. PMID: 21177976.
    Citations: 412     Fields:    Translation:AnimalsCells
  68. de Lencastre A, Pincus Z, Zhou K, Kato M, Lee SS, Slack FJ. MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol. 2010 Dec 21; 20(24):2159-68. PMID: 21129974.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  69. Banerjee D, Chen X, Lin SY, Slack FJ. kin-19/casein kinase Ia has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells. Cell Cycle. 2010 Dec 01; 9(23):4748-65. PMID: 21127398.
    Citations: 9     Fields:    Translation:AnimalsCells
  70. Medina PP, Nolde M, Slack FJ. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature. 2010 Sep 02; 467(7311):86-90. PMID: 20693987.
    Citations: 331     Fields:    Translation:AnimalsCells
  71. Olsson-Carter K, Slack FJ. A developmental timing switch promotes axon outgrowth independent of known guidance receptors. PLoS Genet. 2010 Aug 05; 6(8). PMID: 20700435.
    Citations: 21     Fields:    Translation:AnimalsCells
  72. Hada K, Asahina M, Hasegawa H, Kanaho Y, Slack FJ, Niwa R. The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition. Dev Biol. 2010 Aug 15; 344(2):1100-9. PMID: 20678979.
    Citations: 15     Fields:    Translation:Animals
  73. Pincus Z, Slack FJ. Developmental biomarkers of aging in Caenorhabditis elegans. Dev Dyn. 2010 May; 239(5):1306-14. PMID: 20151474.
    Citations: 14     Fields:    Translation:Animals
  74. Kundu ST, Slack FJ. Robust and specific inhibition of microRNAs in Caenorhabditis elegans. J Biol. 2010; 9(3):20. PMID: 20359318.
    Citations:    Fields:    Translation:AnimalsCells
  75. Kasinski AL, Slack FJ. Potential microRNA therapies targeting Ras, NFkappaB and p53 signaling. Curr Opin Mol Ther. 2010 Apr; 12(2):147-57. PMID: 20373258.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  76. Godshalk SE, Melnik-Martinez KV, Pasquinelli AE, Slack FJ. MicroRNAs and cancer: a meeting summary of the eponymous Keystone Conference. Epigenetics. 2010 Feb 16; 5(2):164-8. PMID: 20168081.
    Citations: 2     Fields:    Translation:HumansAnimals
  77. Slack FJ. Stem cells: Big roles for small RNAs. Nature. 2010 Feb 04; 463(7281):616. PMID: 20130638.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  78. Niwa R, Hada K, Moliyama K, Ohniwa RL, Tan YM, Olsson-Carter K, Chi W, Reinke V, Slack FJ. C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor. Cell Cycle. 2009 Dec 15; 8(24):4147-54. PMID: 19923914.
    Citations: 2     Fields:    Translation:AnimalsCells
  79. Roush SF, Slack FJ. Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1. Dev Biol. 2009 Oct 15; 334(2):523-34. PMID: 19627983.
    Citations: 22     Fields:    Translation:AnimalsCells
  80. Chan SP, Slack FJ. Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans. Dev Biol. 2009 Oct 01; 334(1):152-60. PMID: 19627982.
    Citations: 9     Fields:    Translation:Animals
  81. Kato M, de Lencastre A, Pincus Z, Slack FJ. Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol. 2009; 10(5):R54. PMID: 19460142.
    Citations: 75     Fields:    Translation:Animals
  82. Nimmo RA, Slack FJ. An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma. 2009 Aug; 118(4):405-18. PMID: 19340450.
    Citations: 66     Fields:    Translation:AnimalsCells
  83. Turner MJ, Slack FJ. Transcriptional control of microRNA expression in C. elegans: promoting better understanding. RNA Biol. 2009 Jan-Mar; 6(1):49-53. PMID: 19106630.
    Citations: 9     Fields:    Translation:AnimalsCells
  84. Slack FJ, Weidhaas JB. MicroRNA in cancer prognosis. N Engl J Med. 2008 Dec 18; 359(25):2720-2. PMID: 19092157.
    Citations: 69     Fields:    Translation:Humans
  85. Maller Schulman BR, Liang X, Stahlhut C, DelConte C, Stefani G, Slack FJ. The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle. 2008 Dec 15; 7(24):3935-42. PMID: 19098426.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  86. Godshalk SE, Bhaduri-McIntosh S, Slack FJ. Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle. 2008 Nov 15; 7(22):3595-600. PMID: 19001862.
    Citations: 28     Fields:    Translation:HumansCells
  87. Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008 Oct 15; 68(20):8535-40. PMID: 18922928.
    Citations: 247     Fields:    Translation:Humans
  88. Ding XC, Slack FJ, Grosshans H. The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. Cell Cycle. 2008 Oct; 7(19):3083-90. PMID: 18818519.
    Citations: 15     Fields:    Translation:AnimalsCells
  89. Pincus Z, Slack FJ. Transcriptional (dys)regulation and aging in Caenorhabditis elegans. Genome Biol. 2008; 9(9):233. PMID: 18828877.
    Citations: 4     Fields:    Translation:AnimalsCells
  90. Roush S, Slack FJ. The let-7 family of microRNAs. Trends Cell Biol. 2008 Oct; 18(10):505-16. PMID: 18774294.
    Citations: 376     Fields:    Translation:HumansAnimalsCells
  91. Chan SP, Ramaswamy G, Choi EY, Slack FJ. Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans. RNA. 2008 Oct; 14(10):2104-14. PMID: 18719242.
    Citations: 12     Fields:    Translation:Animals
  92. Büssing I, Slack FJ, Grosshans H. let-7 microRNAs in development, stem cells and cancer. Trends Mol Med. 2008 Sep; 14(9):400-9. PMID: 18674967.
    Citations: 189     Fields:    Translation:HumansAnimalsCells
  93. Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L, Weidhaas JB, Brown D, Bader AG, Slack FJ. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle. 2008 Mar 15; 7(6):759-64. PMID: 18344688.
    Citations: 216     Fields:    Translation:HumansAnimalsCells
  94. Kato M, Slack FJ. microRNAs: small molecules with big roles - C. elegans to human cancer. Biol Cell. 2008 Feb; 100(2):71-81. PMID: 18199046.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  95. Niwa R, Zhou F, Li C, Slack FJ. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev Biol. 2008 Mar 15; 315(2):418-25. PMID: 18262516.
    Citations: 37     Fields:    Translation:HumansAnimals
  96. Weidhaas JB, Babar I, Nallur SM, Trang P, Roush S, Boehm M, Gillespie E, Slack FJ. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res. 2007 Dec 01; 67(23):11111-6. PMID: 18056433.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  97. Chan SP, Slack FJ. And now introducing mammalian mirtrons. Dev Cell. 2007 Nov; 13(5):605-7. PMID: 17981129.
  98. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D, Slack FJ. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007 Aug 15; 67(16):7713-22. PMID: 17699775.
    Citations: 437     Fields:    Translation:HumansCells
  99. Nolde MJ, Saka N, Reinert KL, Slack FJ. The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1. Dev Biol. 2007 May 15; 305(2):551-63. PMID: 17412319.
    Citations: 36     Fields:    Translation:AnimalsCells
  100. Niwa R, Slack FJ. The evolution of animal microRNA function. Curr Opin Genet Dev. 2007 Apr; 17(2):145-50. PMID: 17317150.
    Citations: 80     Fields:    Translation:AnimalsCells
  101. Stahlhut Espinosa CE, Slack FJ. The role of microRNAs in cancer. Yale J Biol Med. 2006 Dec; 79(3-4):131-40. PMID: 17940623.
    Citations: 52     Fields:    Translation:HumansAnimals
  102. Roush SF, Slack FJ. Micromanagement: a role for microRNAs in mRNA stability. ACS Chem Biol. 2006 Apr 25; 1(3):132-4. PMID: 17163657.
    Citations: 8     Fields:    Translation:AnimalsCells
  103. Boehm M, Slack FJ. MicroRNA control of lifespan and metabolism. Cell Cycle. 2006 Apr; 5(8):837-40. PMID: 16627994.
    Citations: 34     Fields:    Translation:HumansAnimals
  104. Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 2006 Apr; 6(4):259-69. PMID: 16557279.
    Citations: 2378     Fields:    Translation:HumansAnimals
  105. Slack FJ, Weidhaas JB. MicroRNAs as a potential magic bullet in cancer. Future Oncol. 2006 Feb; 2(1):73-82. PMID: 16556074.
    Citations: 27     Fields:    Translation:HumansAnimals
  106. Slack FJ. Regulatory RNAs and the demise of 'junk' DNA. Genome Biol. 2006; 7(9):328. PMID: 17020591.
  107. Schulman BR, Esquela-Kerscher A, Slack FJ. Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev Dyn. 2005 Dec; 234(4):1046-54. PMID: 16247770.
    Citations: 47     Fields:    Translation:AnimalsCells
  108. Vella MC, Slack FJ. C. elegans microRNAs. WormBook. 2005 Sep 21; 1-9. PMID: 18050425.
    Citations: 10     Fields:    Translation:HumansAnimals
  109. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ. RAS is regulated by the let-7 microRNA family. Cell. 2005 Mar 11; 120(5):635-47. PMID: 15766527.
    Citations: 1221     Fields:    Translation:HumansAnimalsCells
  110. Grosshans H, Johnson T, Reinert KL, Gerstein M, Slack FJ. The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev Cell. 2005 Mar; 8(3):321-30. PMID: 15737928.
    Citations: 87     Fields:    Translation:Animals
  111. Banerjee D, Kwok A, Lin SY, Slack FJ. Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev Cell. 2005 Feb; 8(2):287-95. PMID: 15691769.
    Citations: 23     Fields:    Translation:Animals
  112. Banerjee D, Slack FJ. Temporal and spatial patterning of an organ by a single transcription factor. Genome Biol. 2005; 6(2):205. PMID: 15693952.
    Citations: 2     Fields:    Translation:AnimalsCells
  113. Vella MC, Reinert K, Slack FJ. Architecture of a validated microRNA::target interaction. Chem Biol. 2004 Dec; 11(12):1619-23. PMID: 15610845.
    Citations: 66     Fields:    Translation:AnimalsCells
  114. Vella MC, Choi EY, Lin SY, Reinert K, Slack FJ. The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev. 2004 Jan 15; 18(2):132-7. PMID: 14729570.
    Citations: 178     Fields:    Translation:AnimalsCells
  115. Johnson SM, Lin SY, Slack FJ. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev Biol. 2003 Jul 15; 259(2):364-79. PMID: 12871707.
    Citations: 72     Fields:    Translation:AnimalsCells
  116. Lin SY, Johnson SM, Abraham M, Vella MC, Pasquinelli A, Gamberi C, Gottlieb E, Slack FJ. The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell. 2003 May; 4(5):639-50. PMID: 12737800.
    Citations: 123     Fields:    Translation:AnimalsCells
  117. Grosshans H, Slack FJ. Micro-RNAs: small is plentiful. J Cell Biol. 2002 Jan 07; 156(1):17-21. PMID: 11781331.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  118. Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000 Nov 02; 408(6808):86-9. PMID: 11081512.
    Citations: 620     Fields:    Translation:HumansAnimalsCells
  119. Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000 Apr; 5(4):659-69. PMID: 10882102.
    Citations: 209     Fields:    Translation:AnimalsCells
  120. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24; 403(6772):901-6. PMID: 10706289.
    Citations: 1329     Fields:    Translation:AnimalsCells
  121. Slack F, Ruvkun G. Heterochronic genes in development and evolution. Biol Bull. 1998 Dec; 195(3):375-6. PMID: 9924779.
    Citations: 3     Fields:    Translation:Animals
  122. Slack FJ, Ruvkun G. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci. 1998 Dec; 23(12):474-5. PMID: 9868369.
    Citations: 51     Fields:    Translation:Cells
  123. Slack F, Ruvkun G. Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1997; 31:611-34. PMID: 9442909.
    Citations: 26     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.