Harvard Catalyst Profiles

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Patrick Donnelly Tyler, M.D.

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Beth Israel Deaconess Medical Center, Boston, MA06/2020Residency, Emergency Medicine
Beth Israel Deaconess Medical Center, Boston, MA06/2017Residency, Internal Medicine
Northwestern University, Chicago, ILMD06/2014Medicine
University of Virginia, Charlottesville, VABA06/2009Biomedical ethics

I am a clinician and researcher in the fields of Internal and Emergency Medicine. From a clinical perspective, I focus on treating patients with all forms minor to life-threatening injuries who present acutely for care. From a research perspective, my primary interest is in the pathobiology of sepsis, a condition in which the inflammation caused by infection leads to organ dysfunction and death. Despite decades of efforts, relatively little headway has been made in terms of better understanding sepsis and developing new treatments. My area of interest is in how inflammation leads to (a) dysregulation of the blood clotting system (which can lead to either too much or too little clotting); and (b) damage to the internal structure of blood vessel walls (glycocalyx), which affects the normal function of the blood vessels and could be a mechanism for organ injury in sepsis. I am also interested in how data science and machine learning can help us examine the vast quantities of data we generate about our patients to gain new insights into how to better care for them.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. EMF18_EMRA_RESR_0007 (Patrick D Tyler) Jul 1, 2019 - Jun 30, 2020
    Thromboelastography to Assess Coagulopathy and Glycocalyx Degradation in Sepsis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tyler PD, Yang LM, Snider SB, Lerner AB, Aird WC, Shapiro NI. New Uses for Thromboelastography and Other Forms of Viscoelastic Monitoring in the Emergency Department: A Narrative Review. Ann Emerg Med. 2021 03; 77(3):357-366. PMID: 32988649.
    Citations:    Fields:    Translation:Humans
  2. Shahn Z, Shapiro NI, Tyler PD, Talmor D, Lehman LH. Fluid-limiting treatment strategies among sepsis patients in the ICU: a retrospective causal analysis. Crit Care. 2020 Feb 22; 24(1):62. PMID: 32087760.
    Citations:    Fields:    Translation:Humans
  3. Tyler PD, Fossa A, Joseph JW, Sanchez LD. Later emergency provider shift hour is associated with increased risk of admission: a retrospective cohort study. BMJ Qual Saf. 2020 06; 29(6):465-471. PMID: 31723019.
    Citations:    Fields:    
  4. Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 07 23; 23(1):259. PMID: 31337421.
    Citations: 18     Fields:    Translation:HumansCells
  5. Tyler PD, Carey J, Stashko E, Levenson RB, Shapiro NI, Rosen CL. The Potential Role of Ultrasound in the Work-up of Appendicitis in the Emergency Department. J Emerg Med. 2019 Feb; 56(2):191-196. PMID: 30594351.
    Citations:    Fields:    Translation:Humans
  6. Tyler PD, Du H, Feng M, Bai R, Xu Z, Horowitz GL, Stone DJ, Celi LA. Assessment of Intensive Care Unit Laboratory Values That Differ From Reference Ranges and Association With Patient Mortality and Length of Stay. JAMA Netw Open. 2018 11 02; 1(7):e184521. PMID: 30646358.
    Citations: 3     Fields:    Translation:Humans
  7. Tyler PD, Rush B, Celi LA. The authors reply. Crit Care Med. 2018 09; 46(9):e963-e964. PMID: 30113385.
    Citations:    Fields:    Translation:Humans
  8. Tyler PD, Rush B, Celi LA. The authors reply. Crit Care Med. 2018 07; 46(7):e730-e731. PMID: 29912132.
    Citations:    Fields:    Translation:Humans
  9. Gehrmann S, Dernoncourt F, Li Y, Carlson ET, Wu JT, Welt J, Foote J, Moseley ET, Grant DW, Tyler PD, Celi LA. Comparing deep learning and concept extraction based methods for patient phenotyping from clinical narratives. PLoS One. 2018; 13(2):e0192360. PMID: 29447188.
    Citations: 26     Fields:    Translation:Humans
  10. Brisson GE, Barnard C, Tyler PD, Liebovitz DM, Neely KJ. A Framework for Tracking Former Patients in the Electronic Health Record Using an Educational Registry. J Gen Intern Med. 2018 04; 33(4):563-566. PMID: 29302880.
    Citations: 4     Fields:    Translation:Humans
  11. Tyler PD, Stone DJ, Geisler BP, McLennan S, Celi LA, Rush B. Racial and Geographic Disparities in Interhospital ICU Transfers. Crit Care Med. 2018 01; 46(1):e76-e80. PMID: 29068859.
    Citations: 5     Fields:    Translation:Humans
  12. Rush B, Tyler PD, Stone DJ, Geisler BP, Walley KR, Celi LA. Outcomes of Ventilated Patients With Sepsis Who Undergo Interhospital Transfer: A Nationwide Linked Analysis. Crit Care Med. 2018 01; 46(1):e81-e86. PMID: 29068858.
    Citations: 3     Fields:    Translation:Humans
  13. Wu JT, Dernoncourt F, Gehrmann S, Tyler PD, Moseley ET, Carlson ET, Grant DW, Li Y, Welt J, Celi LA. Behind the scenes: A medical natural language processing project. Int J Med Inform. 2018 04; 112:68-73. PMID: 29500024.
    Citations: 1     Fields:    Translation:Humans
  14. Tyler PD, Celi LA. Tele-ICU Increases Interhospital Transfers: Does Big Brother Know Better? Crit Care Med. 2017 08; 45(8):1417-1419. PMID: 28708685.
    Citations: 3     Fields:    Translation:Humans
  15. Tyler PD, Larochelle MR, Mafi JN. Access to Prescription Opioids-Primum Non Nocere: A Teachable Moment. JAMA Intern Med. 2016 09 01; 176(9):1251-2. PMID: 27428930.
    Citations: 2     Fields:    Translation:Humans
  16. Brisson GE, Tyler PD. Medical Student Use of Electronic Health Records to Track Former Patients. JAMA Intern Med. 2016 09 01; 176(9):1395-7. PMID: 27454543.
    Citations: 3     Fields:    Translation:Humans
  17. White SB, Procissi D, Chen J, Gogineni VR, Tyler P, Yang Y, Omary RA, Larson AC. Characterization of CC-531 as a Rat Model of Colorectal Liver Metastases. PLoS One. 2016; 11(5):e0155334. PMID: 27171151.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Brisson GE, Neely KJ, Tyler PD, Barnard C. Should medical students track former patients in the electronic health record? An emerging ethical conflict. Acad Med. 2015 Aug; 90(8):1020-4. PMID: 25565261.
    Citations: 6     Fields:    Translation:Humans
  19. Brisson GE, Neely KJ, Tyler PD, Barnard C. Privacy versus confidentiality: more on the use of the electronic health record for learning. Acad Med. 2015 Aug; 90(8):1001. PMID: 26218355.
    Citations: 3     Fields:    Translation:Humans
  20. Tyler PD, Kang PM. Diagnostic and Therapeutic Nanoparticles in Cardiovascular Diseases. Curr Pharm Des. 2015; 21(42):6070-80. PMID: 26503151.
    Citations: 1     Fields:    Translation:HumansAnimals
  21. McDevitt JL, Mouli SK, Tyler PD, Li W, Nicolai J, Procissi D, Ragin AB, Wang YA, Lewandowski RJ, Salem R, Larson AC, Omary RA. MR imaging enables measurement of therapeutic nanoparticle uptake in rat N1-S1 liver tumors after nanoablation. J Vasc Interv Radiol. 2014 Aug; 25(8):1288-94. PMID: 24854392.
    Citations: 1     Fields:    Translation:Animals
  22. Tyler PD, McDevitt JL, Sheu AY, Nicolai J, Procissi D, Ragin AB, Lewandowski RJ, Salem R, Larson AC, Omary RA. Seven-tesla magnetic resonance imaging accurately quantifies intratumoral uptake of therapeutic nanoparticles in the McA rat model of hepatocellular carcinoma: preclinical study in a rodent model. Invest Radiol. 2014 Feb; 49(2):87-92. PMID: 24089022.
    Citations: 2     Fields:    Translation:HumansAnimals
  23. Zhang Z, Li W, Procissi D, Tyler P, Omary RA, Larson AC. Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation. Nanomedicine (Lond). 2014; 9(8):1181-92. PMID: 24024571.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  24. Mouli SK, Tyler P, McDevitt JL, Eifler AC, Guo Y, Nicolai J, Lewandowski RJ, Li W, Procissi D, Ryu RK, Wang YA, Salem R, Larson AC, Omary RA. Image-guided local delivery strategies enhance therapeutic nanoparticle uptake in solid tumors. ACS Nano. 2013 Sep 24; 7(9):7724-33. PMID: 23952712.
    Citations: 19     Fields:    Translation:AnimalsCells
  25. Walvekar RR, Tyler PD, Tammareddi N, Peters G. Robotic-assisted transoral removal of a submandibular megalith. Laryngoscope. 2011 Mar; 121(3):534-7. PMID: 21344429.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.