Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Young Chung, M.D.,Ph.D.

Profile Picture


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08NS112601 (CHUNG, DAVID YOUNG) Sep 15, 2019 - Aug 31, 2024
    Determinants of functional brain connectivity after subarachnoid hemorrhage
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sugimoto K, Yang J, Fischer P, Takizawa T, Mulder IA, Qin T, Erdogan TD, Yaseen MA, Sakadžic S, Chung DY, Ayata C. Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome. Stroke. 2023 Mar 06. PMID: 36876481.
    Citations:    Fields:    
  2. Aykan SA, Xie H, Zheng Y, Chung DY, Kura S, Han Lai J, Erdogan TD, Morais A, Tamim I, Yagmur D, Ishikawa H, Arai K, Abbas Yaseen M, Boas DA, Sakadzic S, Ayata C. Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions. Stroke. 2022 07; 53(7):2369-2376. PMID: 35656825; PMCID: PMC9245195.
    Citations:    Fields:    Translation:HumansAnimals
  3. Chan WP, Prescott BR, Barra ME, Chung DY, Kim IS, Saglam H, Hutch MR, Shin M, Zafar SF, Benjamin EJ, Smirnakis SM, Dupuis J, Greer DM, Ong CJ. Dexmedetomidine and Other Analgosedatives Alter Pupil Characteristics in Critically Ill Patients. Crit Care Explor. 2022 May; 4(5):e0691. PMID: 35783547; PMCID: PMC9243241.
    Citations: 1     
  4. Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RM, Nelson MT, Joutel A, Sakadzic S, Ayata C. CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. J Clin Invest. 2022 04 15; 132(8). PMID: 35202003; PMCID: PMC9012276.
    Citations:    Fields:    Translation:Animals
  5. Mosley N, Chung JY, Jin G, Franceschini MA, Whalen MJ, Chung DY. Cortical Spreading Depolarization, Blood Flow, and Cognitive Outcomes in a Closed Head Injury Mouse Model of Traumatic Brain Injury. Neurocrit Care. 2022 06; 37(Suppl 1):102-111. PMID: 35378664; PMCID: PMC9262867.
    Citations: 1     Fields:    Translation:HumansAnimals
  6. Lai JH, Qin T, Sakadžic S, Ayata C, Chung DY. Correction to: Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage. Neurocrit Care. 2022 Apr; 36(2):689. PMID: 35041114.
    Citations:    Fields:    
  7. Sivakumar S, Tsetsou S, Patel AB, Stapleton CJ, Grannan BL, Schweitzer JS, Chung DY, Rosenthal ES. Cortical Spreading Depolarizations and Clinically Measured Scalp EEG Activity After Aneurysmal Subarachnoid Hemorrhage and Traumatic Brain Injury. Neurocrit Care. 2022 06; 37(Suppl 1):49-59. PMID: 34997536; PMCID: PMC9810077.
    Citations: 1     Fields:    Translation:Humans
  8. Lai JH, Qin T, Sakadžic S, Ayata C, Chung DY. Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage. Neurocrit Care. 2022 06; 37(Suppl 1):123-132. PMID: 34981426; PMCID: PMC9250554.
    Citations:    Fields:    Translation:Animals
  9. Aykan SA, Xie H, Lai JH, Zheng Y, Chung DY, Kura S, Anzabi M, Sugimoto K, McAllister LM, Yaseen MA, Boas DA, Whalen MJ, Sakadzic S, Ayata C. Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice. Cereb Cortex. 2021 10 01; 31(11):4958-4969. PMID: 34037216; PMCID: PMC8491690.
    Citations: 1     Fields:    Translation:HumansAnimals
  10. Chung DY, Thompson BB, Kumar MA, Mahta A, Rao SS, Lai JH, Tadevosyan A, Kessler K, Locascio JJ, Patel AB, Mohamed W, Olson DM, John S, Rordorf GA. Association of External Ventricular Drain Wean Strategy with Shunt Placement and Length of Stay in Subarachnoid Hemorrhage: A Prospective Multicenter Study. Neurocrit Care. 2022 04; 36(2):536-545. PMID: 34498207; PMCID: PMC9128519.
    Citations: 2     Fields:    Translation:Humans
  11. Bernier TD, Schontz MJ, Izzy S, Chung DY, Nelson SE, Leslie-Mazwi TM, Henderson GV, Dasenbrock H, Patel N, Aziz-Sultan MA, Feske S, Du R, Abulhasan YB, Angle MR. Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal. J Neurosurg Anesthesiol. 2021 Jul 01; 33(3):195-202. PMID: 33480639; PMCID: PMC8192346.
    Citations: 5     Fields:    Translation:Humans
  12. Tamim I, Chung DY, de Morais AL, Loonen ICM, Qin T, Misra A, Schlunk F, Endres M, Schiff SJ, Ayata C. Spreading depression as an innate antiseizure mechanism. Nat Commun. 2021 04 13; 12(1):2206. PMID: 33850125; PMCID: PMC8044138.
    Citations: 11     Fields:    Translation:Animals
  13. Takahashi CE, Virmani D, Chung DY, Ong C, Cervantes-Arslanian AM. Blunt and Penetrating Severe Traumatic Brain Injury. Neurol Clin. 2021 05; 39(2):443-469. PMID: 33896528.
    Citations: 2     Fields:    Translation:Humans
  14. Chung DY, Abdalkader M, Nguyen TN. Aneurysmal Subarachnoid Hemorrhage. Neurol Clin. 2021 05; 39(2):419-442. PMID: 33896527; PMCID: PMC8147706.
    Citations: 4     Fields:    Translation:Humans
  15. Nguyen TN, Haussen DC, Qureshi MM, Yamagami H, Fujinaka T, Mansour OY, Abdalkader M, Frankel M, Qiu Z, Taylor A, Lylyk P, Eker OF, Mechtouff L, Piotin M, Lima FO, Mont'Alverne F, Izzath W, Sakai N, Mohammaden M, Al-Bayati AR, Renieri L, Mangiafico S, Ozretic D, Chalumeau V, Ahmad S, Rashid U, Hussain SI, John S, Griffin E, Thornton J, Fiorot JA, Rivera R, Hammami N, Cervantes-Arslanian AM, Dasenbrock HH, Vu HL, Nguyen VQ, Hetts S, Bourcier R, Guile R, Walker M, Sharma M, Frei D, Jabbour P, Herial N, Al-Mufti F, Ozdemir AO, Aykac O, Gandhi D, Chugh C, Matouk C, Lavoie P, Edgell R, Beer-Furlan A, Chen M, Killer-Oberpfalzer M, Pereira VM, Nicholson P, Huded V, Ohara N, Watanabe D, Shin DH, Magalhaes PS, Kikano R, Ortega-Gutierrez S, Farooqui M, Abou-Hamden A, Amano T, Yamamoto R, Weeks A, Cora EA, Sivan-Hoffmann R, Crosa R, Möhlenbruch M, Nagel S, Al-Jehani H, Sheth SA, Lopez Rivera VS, Siegler JE, Sani AF, Puri AS, Kuhn AL, Bernava G, Machi P, Abud DG, Pontes-Neto OM, Wakhloo AK, Voetsch B, Raz E, Yaghi S, Mehta BP, Kimura N, Murakami M, Lee JS, Hong JM, Fahed R, Walker G, Hagashi E, Cordina SM, Roh HG, Wong K, Arenillas JF, Martinez-Galdamez M, Blasco J, Rodriguez Vasquez A, Fonseca L, Silva ML, Wu TY, John S, Brehm A, Psychogios M, Mack WJ, Tenser M, Todaka T, Fujimura M, Novakovic R, Deguchi J, Sugiura Y, Tokimura H, Khatri R, Kelly M, Peeling L, Murayama Y, Winters HS, Wong J, Teleb M, Payne J, Fukuda H, Miyake K, Shimbo J, Sugimura Y, Uno M, Takenobu Y, Matsumaru Y, Yamada S, Kono R, Kanamaru T, Morimoto M, Iida J, Saini V, Yavagal D, Bushnaq S, Huang W, Linfante I, Kirmani J, Liebeskind DS, Szeder V, Shah R, Devlin TG, Birnbaum L, Luo J, Churojana A, Masoud HE, Lopez CY, Steinfort B, Ma A, Hassan AE, Al Hashmi A, McDermott M, Mokin M, Chebl A, Kargiotis O, Tsivgoulis G, Morris JG, Eskey CJ, Thon J, Rebello L, Altschul D, Cornett O, Singh V, Pandian J, Kulkarni A, Lavados PM, Olavarria VV, Todo K, Yamamoto Y, Silva GS, Geyik S, Johann J, Multani S, Kaliaev A, Sonoda K, Hashimoto H, Alhazzani A, Chung DY, Mayer SA, Fifi JT, Hill MD, Zhang H, Yuan Z, Shang X, Castonguay AC, Gupta R, Jovin TG, Raymond J, Zaidat OO, Nogueira RG. Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic. Stroke Vasc Neurol. 2021 12; 6(4):542-552. PMID: 33771936.
    Citations: 18     Fields:    Translation:HumansCellsPHPublic Health
  16. Abdalkader M, Sathya A, Ma A, Cervantes-Arslanian AM, Chung DY, Barest G, Nguyen TN. Hydrophilic polymer embolization following flow diversion of cerebral aneurysms. Neuroradiol J. 2021 Aug; 34(4):363-369. PMID: 33765885; PMCID: PMC8447820.
    Citations:    Fields:    Translation:Humans
  17. Sugimoto K, Morais A, Sadeghian H, Qin T, Chung DY, Ashina M, Hougaard A, Ayata C. Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations. J Headache Pain. 2020 Oct 27; 21(1):127. PMID: 33109086.
    Citations:    Fields:    Translation:HumansAnimals
  18. Harriott AM, Chung DY, Uner A, Bozdayi RO, Morais A, Takizawa T, Qin T, Ayata C. Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior. Ann Neurol. 2021 01; 89(1):99-110. PMID: 33016466.
    Citations: 17     Fields:    Translation:Animals
  19. Fischer P, Sugimoto K, Chung DY, Tamim I, Morais A, Takizawa T, Qin T, Gomez CA, Schlunk F, Endres M, Yaseen MA, Sakadzic S, Ayata C. Rapid hematoma growth triggers spreading depolarizations in experimental intracortical hemorrhage. J Cereb Blood Flow Metab. 2021 06; 41(6):1264-1276. PMID: 32936730; PMCID: PMC8142136.
    Citations: 3     Fields:    Translation:Animals
  20. Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan SA, Qin T, Edmiston WJ, Lee H, Yaseen MA, Sakadžic S, Boas DA, Whalen MJ, Ayata C. Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. J Cereb Blood Flow Metab. 2021 05; 41(5):975-985. PMID: 32936728.
    Citations: 11     Fields:    Translation:Animals
  21. Yanagisawa T, Zhang H, Suzuki T, Kamio Y, Takizawa T, Morais A, Chung DY, Qin T, Murayama Y, Faber JE, Patel AB, Ayata C. Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms. Stroke. 2020 10; 51(10):3083-3094. PMID: 32912097.
    Citations: 5     Fields:    Translation:Animals
  22. Barra ME, Phillips KM, Chung DY, Rosenthal ES. A Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients. Ther Drug Monit. 2020 08; 42(4):617-625. PMID: 32049893; PMCID: PMC7377971.
    Citations: 3     Fields:    Translation:Humans
  23. Anand P, Lau KHV, Chung DY, Virmani D, Cervantes-Arslanian AM, Mian AZ, Takahashi CE. Posterior Reversible Encephalopathy Syndrome in Patients with Coronavirus Disease 2019: Two Cases and A Review of The Literature. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105212. PMID: 33066908.
    Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
  24. Sugimoto K, Chung DY, Böhm M, Fischer P, Takizawa T, Aykan SA, Qin T, Yanagisawa T, Harriott A, Oka F, Yaseen MA, Sakadžic S, Ayata C. Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations. Stroke. 2020 08; 51(8):2526-2535. PMID: 32640946.
    Citations: 4     Fields:    Translation:Animals
  25. Morais A, Liu TT, Qin T, Sadhegian H, Ay I, Yagmur D, Mendes da Silva R, Chung D, Simon B, Guedes R, Chen SP, Wang SJ, Yen JC, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression exclusively through central mechanisms. Pain. 2020 07; 161(7):1661-1669. PMID: 32142015; PMCID: PMC7305968.
    Citations: 12     Fields:    Translation:Animals
  26. Sugimoto K, Chung DY. Spreading Depolarizations and Subarachnoid Hemorrhage. Neurotherapeutics. 2020 04; 17(2):497-510. PMID: 32323204.
    Citations: 8     Fields:    Translation:HumansAnimals
  27. Oka F, Chung DY, Suzuki M, Ayata C. Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental-Clinical Disconnect and the Unmet Need. Neurocrit Care. 2020 02; 32(1):238-251. PMID: 30671784; PMCID: PMC7387950.
    Citations: 14     Fields:    Translation:Animals
  28. Chung DY, Olson DM, John S, Mohamed W, Kumar MA, Thompson BB, Rordorf GA. Evidence-Based Management of External Ventricular Drains. Curr Neurol Neurosci Rep. 2019 11 26; 19(12):94. PMID: 31773310.
    Citations: 11     Fields:    Translation:Humans
  29. Balkaya M, Seidel JL, Sadeghian H, Qin T, Chung DY, Eikermann-Haerter K, van den Maagdenberg AMJM, Ferrari MD, Ayata C. Relief Following Chronic Stress Augments Spreading Depolarization Susceptibility in Familial Hemiplegic Migraine Mice. Neuroscience. 2019 09 01; 415:1-9. PMID: 31299346.
    Citations: 4     Fields:    Translation:Animals
  30. Takizawa T, Qin T, Lopes de Morais A, Sugimoto K, Chung JY, Morsett L, Mulder I, Fischer P, Suzuki T, Anzabi M, Böhm M, Qu WS, Yanagisawa T, Hickman S, Khoury JE, Whalen MJ, Harriott AM, Chung DY, Ayata C. Non-invasively triggered spreading depolarizations induce a rapid pro-inflammatory response in cerebral cortex. J Cereb Blood Flow Metab. 2020 05; 40(5):1117-1131. PMID: 31242047.
    Citations: 24     Fields:    Translation:Animals
  31. Xie H, Chung DY, Kura S, Sugimoto K, Aykan SA, Wu Y, Sakadžic S, Yaseen MA, Boas DA, Ayata C. Differential effects of anesthetics on resting state functional connectivity in the mouse. J Cereb Blood Flow Metab. 2020 04; 40(4):875-884. PMID: 31092086.
    Citations: 13     Fields:    Translation:Animals
  32. Böhm M, Chung DY, Gómez CA, Qin T, Takizawa T, Sadeghian H, Sugimoto K, Sakadžic S, Yaseen MA, Ayata C. Neurovascular coupling during optogenetic functional activation: Local and remote stimulus-response characteristics, and uncoupling by spreading depression. J Cereb Blood Flow Metab. 2020 04; 40(4):808-822. PMID: 31063009.
    Citations: 8     Fields:    Translation:Animals
  33. Harriott AM, Takizawa T, Chung DY, Chen SP. Spreading depression as a preclinical model of migraine. J Headache Pain. 2019 May 02; 20(1):45. PMID: 31046659.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  34. Rao SS, Chung DY, Wolcott Z, Sheriff F, Khawaja AM, Lee H, Guanci MM, Leslie-Mazwi TM, Kimberly WT, Patel AB, Rordorf GA. Intermittent CSF drainage and rapid EVD weaning approach after subarachnoid hemorrhage: association with fewer VP shunts and shorter length of stay. J Neurosurg. 2019 Apr 26; 132(5):1583-1588. PMID: 31026832; PMCID: PMC7402493.
    Citations: 9     Fields:    
  35. Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2019 03 01; 29(3):1150-1161. PMID: 29425263.
    Citations: 17     Fields:    Translation:AnimalsCells
  36. Chung DY, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakadžic S, Ayata C. Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 11 01; 309:143-146. PMID: 30194041; PMCID: PMC6214472.
    Citations: 17     Fields:    Translation:Animals
  37. Sadeghian H, Lacoste B, Qin T, Toussay X, Rosa R, Oka F, Chung DY, Takizawa T, Gu C, Ayata C. Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis. Ann Neurol. 2018 09; 84(3):409-423. PMID: 30014540.
    Citations: 39     Fields:    Translation:AnimalsCells
  38. Bouley J, Chung DY, Ayata C, Brown RH, Henninger N. Cortical Spreading Depression Denotes Concussion Injury. J Neurotrauma. 2019 04 01; 36(7):1008-1017. PMID: 29999455; PMCID: PMC6444888.
    Citations: 17     Fields:    Translation:Animals
  39. Chung DY, Mayer SA, Rordorf GA. External Ventricular Drains After Subarachnoid Hemorrhage: Is Less More? Neurocrit Care. 2018 04; 28(2):157-161. PMID: 28929378; PMCID: PMC5858985.
    Citations: 16     Fields:    Translation:Humans
  40. Chung DY, Leslie-Mazwi TM, Patel AB, Rordorf GA. Management of External Ventricular Drains After Subarachnoid Hemorrhage: A Multi-Institutional Survey. Neurocrit Care. 2017 Jun; 26(3):356-361. PMID: 28000129.
    Citations: 11     Fields:    Translation:Humans
  41. Chung DY, Edlow BL. Teaching NeuroImages: Traumatic blown pupil without herniation. Neurology. 2017 05 09; 88(19):e190-e191. PMID: 28483996; PMCID: PMC5419987.
    Citations:    Fields:    Translation:Humans
  42. Chung DY, Ayata C. Spreading Depolarizations. Primer on Cerebrovascular Diseases. ed. Caplan LR, Biller J, Leary MC, Lo EH, Thomas AJ, Yenari M, Zhang JH. 2017; 149-153. View Publication.
  43. Chung DY, Oka F, Ayata C. Spreading Depolarizations: A Therapeutic Target Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. J Clin Neurophysiol. 2016 Jun; 33(3):196-202. PMID: 27258442.
    Citations: 23     Fields:    Translation:Humans
  44. Chung DY, Claassen J, Agarwal S, Schmidt JM, Mayer SA. Assessment of Noninvasive Regional Brain Oximetry in Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome. J Intensive Care Med. 2016 Jul; 31(6):415-9. PMID: 26732768.
    Citations: 3     Fields:    Translation:Humans
  45. Oka F, Hoffmann U, Lee JH, Shin HK, Chung DY, Yuzawa I, Chen SP, Atalay YB, Nozari A, Hopson KP, Qin T, Ayata C. Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents. J Cereb Blood Flow Metab. 2017 May; 37(5):1829-1840. PMID: 27432225; PMCID: PMC5435293.
    Citations: 17     Fields:    Translation:Animals
  46. Nelson S, Chung DY, Rordorf G. Recanalization and Remarkable Outcome after Subocclusive Thrombus: A Case Report. J Stroke Cerebrovasc Dis. 2016 Mar; 25(3):e28-30. PMID: 26725124.
    Citations: 1     Fields:    Translation:Humans
  47. Gutierrez J, Elkind MS, Petito C, Chung DY, Dwork AJ, Marshall RS. The contribution of HIV infection to intracranial arterial remodeling: a pilot study. Neuropathology. 2013 Jun; 33(3):256-63. PMID: 23067346; PMCID: PMC4388028.
    Citations: 20     Fields:    Translation:Humans
  48. Chung DY, Sampson KJ, Kass RS. Adrenergic regulation and heritable arrhythmias: key roles of the slowly activating heart IKS potassium channel. Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation and Clinical Implications, ed. Tripathi ON, Ravens U, and Sanguinetti MC. 2011; p451-460. View Publication.
  49. Chung DY, Chan PJ, Bankston JR, Yang L, Liu G, Marx SO, Karlin A, Kass RS. Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):743-8. PMID: 19131515.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Chung's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (164)
Co-Authors (29)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.