Harvard Catalyst Profiles

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Masato Maesako, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG079838 (MASATO MAESAKO) Mar 1, 2023 - Nov 30, 2027
    A unique subpopulation of wild-type neurons recapitulating FAD phenotypes
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Houser MCQ, Mitchell SPC, Sinha P, Lundin B, Berezovska O, Maesako M. Endosome and Lysosome Membrane Properties Functionally Link to ?-Secretase in Live/Intact Cells. Sensors (Basel). 2023 Feb 28; 23(5). PMID: 36904854; PMCID: PMC10007619.
    Citations:    Fields:    
  2. McKendell AK, Houser MCQ, Mitchell SPC, Wolfe MS, Berezovska O, Maesako M. In-Depth Characterization of Endo-Lysosomal Aß in Intact Neurons. Biosensors (Basel). 2022 Aug 20; 12(8). PMID: 36005059.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Maesako M, Houser MCQ, Turchyna Y, Wolfe MS, Berezovska O. Presenilin/?-Secretase Activity Is Located in Acidic Compartments of Live Neurons. J Neurosci. 2022 01 05; 42(1):145-154. PMID: 34810230; PMCID: PMC8741161.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Houser MCQ, Turchyna Y, Perrin F, Chibnik L, Berezovska O, Maesako M. Limited Substrate Specificity of PS/?-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells. Biosensors (Basel). 2021 May 26; 11(6). PMID: 34073182; PMCID: PMC8228125.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Houser MC, Hou SS, Perrin F, Turchyna Y, Bacskai BJ, Berezovska O, Maesako M. A Novel NIR-FRET Biosensor for Reporting PS/?-Secretase Activity in Live Cells. Sensors (Basel). 2020 Oct 22; 20(21). PMID: 33105735.
    Citations: 4     Fields:    Translation:HumansCells
  6. Maesako M, Sekula NM, Aristarkhova A, Feschenko P, Anderson LC, Berezovska O. Visualization of PS/?-Secretase Activity in Living Cells. iScience. 2020 Jun 26; 23(6):101139. PMID: 32438286.
    Citations: 5     
  7. Maesako M, Zoltowska KM, Berezovska O. Synapsin 1 promotes Aß generation via BACE1 modulation. PLoS One. 2019; 14(12):e0226368. PMID: 31830091; PMCID: PMC6907790.
    Citations: 4     Fields:    Translation:Animals
  8. Keller LJ, Sekula NM, Svirsky S, Maesako M, Zoltowska KM, Berezovska O. Presenilin 1 increases association with synaptotagmin 1 during normal aging. Neurobiol Aging. 2020 02; 86:156-161. PMID: 31864759; PMCID: PMC7325863.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Noda Y, Kuzuya A, Tanigawa K, Araki M, Kawai R, Ma B, Sasakura Y, Maesako M, Tashiro Y, Miyamoto M, Uemura K, Okuno Y, Kinoshita A. Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid ß production in Alzheimer's disease. Mol Brain. 2018 10 24; 11(1):61. PMID: 30355327.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  10. Zoltowska KM, Maesako M, Meier J, Berezovska O. Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1. Sci Rep. 2018 06 07; 8(1):8718. PMID: 29880815.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Kara E, Marks JD, Fan Z, Klickstein JA, Roe AD, Krogh KA, Wegmann S, Maesako M, Luo CC, Mylvaganam R, Berezovska O, Hudry E, Hyman BT. Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay. J Biol Chem. 2017 09 08; 292(36):14720-14729. PMID: 28684412.
    Citations: 13     Fields:    Translation:HumansCells
  12. Zoltowska KM, Maesako M, Lushnikova I, Takeda S, Keller LJ, Skibo G, Hyman BT, Berezovska O. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid ß production. Mol Neurodegener. 2017 02 13; 12(1):15. PMID: 28193235.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  13. Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 2017 01 30; 6. PMID: 28132667.
    Citations: 10     Fields:    Translation:AnimalsCells
  14. Zoltowska KM, Maesako M, Berezovska O. Interrelationship between Changes in the Amyloid ß 42/40 Ratio and Presenilin 1 Conformation. Mol Med. 2016 Sep; 22:329-337. PMID: 27391800; PMCID: PMC5023509.
    Citations: 6     Fields:    
  15. Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016 Mar 31; 14:25. PMID: 27036734; PMCID: PMC4818459.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  16. Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Mol Brain. 2015 Dec 04; 8(1):82. PMID: 26637371.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  17. Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, Ueda K, Asada-Utsugi M, Kubota M, Okawa K, Ihara M, Shimohama S, Uemura K, Kinoshita A. High Fat Diet Enhances ß-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting ß-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation. PLoS One. 2015; 10(9):e0131199. PMID: 26414661.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  18. Yuki D, Sugiura Y, Zaima N, Akatsu H, Takei S, Yao I, Maesako M, Kinoshita A, Yamamoto T, Kon R, Sugiyama K, Setou M. DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease. Sci Rep. 2014 Nov 20; 4:7130. PMID: 25410733.
    Citations: 52     Fields:    Translation:HumansCells
  19. Maesako M and Kinoshita A. Strides in Medicine. Alzheimer's disease and type II diabetes. 2014; 523-527.
  20. Maesako M, Uemura K, Iwata A, Kubota M, Watanabe K, Uemura M, Noda Y, Asada-Utsugi M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Continuation of exercise is necessary to inhibit high fat diet-induced ß-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. PLoS One. 2013; 8(9):e72796. PMID: 24023774.
    Citations: 21     Fields:    Translation:Animals
  21. Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K. Copper enhances APP dimerization and promotes Aß production. Neurosci Lett. 2013 Jun 28; 547:10-5. PMID: 23669644.
    Citations: 19     Fields:    Translation:HumansCells
  22. Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Hayashida N, Asada-Utsugi M, Watanabe K, Uemura M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Exercise is more effective than diet control in preventing high fat diet-induced ß-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. J Biol Chem. 2012 Jun 29; 287(27):23024-33. PMID: 22563077.
    Citations: 61     Fields:    Translation:HumansAnimals
  23. Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A. Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling. J Neurochem. 2012 Jun; 121(6):964-73. PMID: 22443192.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A. Environmental enrichment ameliorated high-fat diet-induced Aß deposition and memory deficit in APP transgenic mice. Neurobiol Aging. 2012 May; 33(5):1011.e11-23. PMID: 22197104.
    Citations: 41     Fields:    Translation:HumansAnimalsPHPublic Health
  25. Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A. N-cadherin enhances APP dimerization at the extracellular domain and modulates Aß production. J Neurochem. 2011 Oct; 119(2):354-63. PMID: 21699541.
    Citations: 20     Fields:    Translation:HumansCells
  26. Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Kihara T, Kinoshita A. Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism. J Biol Chem. 2011 Jul 15; 286(28):25309-16. PMID: 21622565.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Maesako M, Uemura K, Kubota M, Hiyoshi K, Ando K, Kuzuya A, Kihara T, Asada M, Akiyama H, Kinoshita A. Effect of glycogen synthase kinase 3 ß-mediated presenilin 1 phosphorylation on amyloid ß production is negatively regulated by insulin receptor cleavage. Neuroscience. 2011 Mar 17; 177:298-307. PMID: 21238544.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  28. Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. J Biol Chem. 2011 Mar 04; 286(9):7619-28. PMID: 21177868.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  29. Maesako M, Uemura K, Kubota M, Ando K, Kuzuya A, Asada M, Kihara T, Kinoshita A. Insulin regulates Presenilin 1 localization via PI3K/Akt signaling. Neurosci Lett. 2010 Oct 15; 483(3):157-61. PMID: 20696212.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.