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Saef Izzy, M.B.,Ch.B.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Migdady I, Roy A, Duskin JA, McKeown ME, Fischer D, Barra ME, Schontz M, Wongboonsin J, Bevers MB, Arnaout O, Izzy S, Snider SB. Volume replacement is associated with a diminished osmolar effect of mannitol in patients with acute brain injury. J Stroke Cerebrovasc Dis. 2022 Dec; 31(12):106867. PMID: 36334372.
    Citations:    Fields:    
  2. Das AS, Vicenty-Padilla JC, Chua MMJ, Jeelani Y, Snider SB, Regenhardt RW, Al-Mufti F, Du R, Izzy S. Cerebrovascular injuries in traumatic brain injury. Clin Neurol Neurosurg. 2022 Oct 21; 223:107479. PMID: 36308809.
    Citations:    Fields:    
  3. Reilly AS, Khawaja AM, Ali AB, Madsen T, Molino-Bacic J, Heffernan DS, Zonfrillo MR, Vaitkevicius H, Gormley WB, Izzy S, Rao SS. Disparities in Decompressive Cranial Surgery Utilization in Severe Traumatic Brain Injury Patients without a Primary Extra-Axial Hematoma: A U.S. Nationwide Study. World Neurosurg. 2022 Oct 04. PMID: 36202343.
    Citations:    Fields:    
  4. Snider SB, Kowalski RG, Hammond FM, Izzy S, Shih SL, Rovito C, Edlow BL, Zafonte RD, Giacino JT, Bodien YG. Comparison of Common Outcome Measures for Assessing Independence in Patients Diagnosed with Disorders of Consciousness: A Traumatic Brain Injury Model Systems Study. J Neurotrauma. 2022 09; 39(17-18):1222-1230. PMID: 35531895; PMCID: PMC9422782.
    Citations:    Fields:    
  5. Izzy S, Chen PM, Tahir Z, Grashow R, Radmanesh F, Cote DJ, Yahya T, Dhand A, Taylor H, Shih SL, Albastaki O, Rovito C, Snider SB, Whalen M, Nathan DM, Miller KK, Speizer FE, Baggish A, Weisskopf MG, Zafonte R. Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders. JAMA Netw Open. 2022 04 01; 5(4):e229478. PMID: 35482306; PMCID: PMC9051987.
    Citations:    Fields:    Translation:Humans
  6. Kals M, Kunzmann K, Parodi L, Radmanesh F, Wilson L, Izzy S, Anderson CD, Puccio AM, Okonkwo DO, Temkin N, Steyerberg EW, Stein MB, Manley GT, Maas AIR, Richardson S, Diaz-Arrastia R, Palotie A, Ripatti S, Rosand J, Menon DK. A genome-wide association study of outcome from traumatic brain injury. EBioMedicine. 2022 Mar; 77:103933. PMID: 35301180; PMCID: PMC8927841.
    Citations: 1     Fields:    Translation:HumansCells
  7. Ali AB, Khawaja AM, Reilly A, Tahir Z, Rao SS, Bernstock JD, Chen P, Molino J, Gormley W, Izzy S. Venous Thromboembolism Risk and Outcomes Following Decompressive Craniectomy in Severe Traumatic Brain Injury: An Analysis of the Nationwide Inpatient Sample Database. World Neurosurg. 2022 05; 161:e531-e545. PMID: 35196589.
    Citations:    Fields:    Translation:Humans
  8. Moreira TG, Matos KTF, De Paula GS, Santana TMM, Da Mata RG, Pansera FC, Cortina AS, Spinola MG, Baecher-Allan CM, Keppeke GD, Jacob J, Palejwala V, Chen K, Izzy S, Healey BC, Rezende RM, Dedivitis RA, Shailubhai K, Weiner HL. Corrigendum: Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study. Front Immunol. 2021; 12:815812. PMID: 35095916; PMCID: PMC8790742.
    Citations:    Fields:    
  9. Migdady I, Chen P, Loza AM, Cashman CR, Izzy S. Cerebral Hyperperfusion and Delayed Coma Recovery after Subdural Hematoma Evacuation. J Stroke Cerebrovasc Dis. 2021 Dec; 30(12):106165. PMID: 34666233.
    Citations:    Fields:    Translation:Humans
  10. Stopa BM, Tahir Z, Mezzalira E, Boaro A, Khawaja A, Grashow R, Zafonte RD, Smith TR, Gormley WB, Izzy S. The Impact of Age and Severity on Dementia After Traumatic Brain Injury: A Comparison Study. Neurosurgery. 2021 10 13; 89(5):810-818. PMID: 34392366.
    Citations: 2     Fields:    Translation:Humans
  11. Gupta S, Vicenty-Padilla J, Lai PMR, Zhou X, Bernstock JD, Chua M, Izzy S, Aziz-Sultan MA, Du R, Patel NJ. Posterior Cerebral Artery Aneurysm Re-Rupture Following Revascularization for Moyamoya Disease. J Stroke Cerebrovasc Dis. 2021 Nov; 30(11):106048. PMID: 34534774.
    Citations:    Fields:    Translation:Humans
  12. Moreira TG, Matos KTF, De Paula GS, Santana TMM, Da Mata RG, Pansera FC, Cortina AS, Spinola MG, Baecher-Allan CM, Keppeke GD, Jacob J, Palejwala V, Chen K, Izzy S, Healey BC, Rezende RM, Dedivitis RA, Shailubhai K, Weiner HL. Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study. Front Immunol. 2021; 12:709861. PMID: 34475873; PMCID: PMC8406802.
    Citations:    Fields:    Translation:Humans
  13. Bernier TD, Schontz MJ, Izzy S, Chung DY, Nelson SE, Leslie-Mazwi TM, Henderson GV, Dasenbrock H, Patel N, Aziz-Sultan MA, Feske S, Du R, Abulhasan YB, Angle MR. Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal. J Neurosurg Anesthesiol. 2021 Jul 01; 33(3):195-202. PMID: 33480639; PMCID: PMC8192346.
    Citations: 4     Fields:    Translation:Humans
  14. Bianciardi M, Izzy S, Rosen BR, Wald LL, Edlow BL. Location of Subcortical Microbleeds and Recovery of Consciousness After Severe Traumatic Brain Injury. Neurology. 2021 07 13; 97(2):e113-e123. PMID: 34050005; PMCID: PMC8279563.
    Citations: 3     Fields:    Translation:Humans
  15. Aldhaeefi M, Tahir Z, Cote DJ, Izzy S, El Khoury J. Comorbidities and Age Are Associated With Persistent COVID-19 PCR Positivity. Front Cell Infect Microbiol. 2021; 11:650753. PMID: 33889551; PMCID: PMC8056299.
    Citations: 5     Fields:    Translation:Humans
  16. Izzy S, Tahir Z, Grashow R, Cote DJ, Jarrah AA, Dhand A, Taylor H, Whalen M, Nathan DM, Miller KK, Speizer F, Baggish A, Weisskopf MG, Zafonte R. Concussion and Risk of Chronic Medical and Behavioral Health Comorbidities. J Neurotrauma. 2021 06 01; 38(13):1834-1841. PMID: 33451255; PMCID: PMC8219193.
    Citations: 2     Fields:    Translation:Humans
  17. DiRisio AC, Stopa BM, Pompeu YA, Vasudeva V, Khawaja AM, Izzy S, Gormley WB. Extra-Axial Fluid Collections After Decompressive Craniectomy: Management, Outcomes, and Treatment Algorithm. World Neurosurg. 2021 05; 149:e188-e196. PMID: 33639283.
    Citations:    Fields:    Translation:Humans
  18. Izzy S, Brown-Whalen A, Yahya T, Sarro-Schwartz A, Jin G, Chung JY, Lule S, Morsett LM, Alquraini A, Wu L, Hickman SE, Whalen MJ, El Khoury J. Repetitive Traumatic Brain Injury Causes Neuroinflammation before Tau Pathology in Adolescent P301S Mice. Int J Mol Sci. 2021 Jan 18; 22(2). PMID: 33477535.
    Citations: 2     Fields:    Translation:HumansAnimals
  19. Chua MMJ, Gupta S, Essayed W, Donnelly DJ, Ziayee H, Vicenty-Padilla J, Das AS, Lai RPM, Izzy S, Aziz-Sultan MA. Endovascular treatment of a ruptured posterior fossa pure arterial malformation: illustrative case. J Neurosurg Case Lessons. 2021 Jan 11; 1(2):CASE2073. PMID: 35854927; PMCID: PMC9241320.
    Citations:    
  20. Das AS, Regenhardt RW, Patel N, Feske SK, Bevers MB, Vaitkevicius H, Izzy S. Diffuse Cerebral Edema After Moyamoya Disease-Related Intracerebral Hemorrhage: A Case Report. Neurohospitalist. 2021 Jul; 11(3):251-254. PMID: 34163552; PMCID: PMC8182400.
    Citations:    
  21. Chua MMJ, Das AS, Losman JA, Patel NJ, Izzy S. Spontaneous hemorrhage after external ventricular drain placement in the setting of low factor VII secondary to liver cirrhosis. Surg Neurol Int. 2020; 11:403. PMID: 33365166; PMCID: PMC7749959.
    Citations:    
  22. Stopa BM, Harary M, Jhun R, Job A, Izzy S, Smith TR, Gormley WB. Divergence in the epidemiological estimates of traumatic brain injury in the United States: comparison of two national databases. J Neurosurg. 2020 Nov 20; 1-10. PMID: 33254146.
    Citations:    Fields:    
  23. Lule S, Wu L, Sarro-Schwartz A, Edmiston WJ, Izzy S, Songtachalert T, Ahn SH, Fernandes ND, Jin G, Chung JY, Balachandran S, Lo EH, Kaplan D, Degterev A, Whalen MJ. Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 2021 07; 41(7):1623-1633. PMID: 33210566.
    Citations: 8     Fields:    Translation:AnimalsCells
  24. Izzy S, Tahir Z, Cote DJ, Al Jarrah A, Roberts MB, Turbett S, Kadar A, Smirnakis SM, Feske SK, Zafonte R, Fishman JA, El Khoury J. Characteristics and Outcomes of Latinx Patients With COVID-19 in Comparison With Other Ethnic and Racial Groups. Open Forum Infect Dis. 2020 Oct; 7(10):ofaa401. PMID: 33088846; PMCID: PMC7499713.
    Citations: 14     
  25. Otite FO, Patel S, Sharma R, Khandwala P, Desai D, Latorre JG, Akano EO, Anikpezie N, Izzy S, Malik AM, Yavagal D, Khandelwal P, Chaturvedi S. Trends in incidence and epidemiologic characteristics of cerebral venous thrombosis in the United States. Neurology. 2020 10 20; 95(16):e2200-e2213. PMID: 32847952.
    Citations: 11     Fields:    Translation:Humans
  26. Roberts MB, Izzy S, Tahir Z, Al Jarrah A, Fishman JA, El Khoury J. COVID-19 in solid organ transplant recipients: Dynamics of disease progression and inflammatory markers in ICU and non-ICU admitted patients. Transpl Infect Dis. 2020 Oct; 22(5):e13407. PMID: 32654303; PMCID: PMC7404585.
    Citations: 22     Fields:    Translation:HumansCellsPHPublic Health
  27. Stopa BM, Dolmans RGF, Broekman MLD, Gormley WB, Mannix R, Izzy S. Hyperosmolar Therapy in Pediatric Severe Traumatic Brain Injury-A Systematic Review. Crit Care Med. 2019 12; 47(12):e1022-e1031. PMID: 31567404.
    Citations: 3     Fields:    Translation:Humans
  28. Mazwi NL, Izzy S, Tan CO, Martinez S, Glenn MB, Giacino JT, Wu O, Zafonte R, Edlow BL. Traumatic Microbleeds in the Hippocampus and Corpus Callosum Predict Duration of Posttraumatic Amnesia. J Head Trauma Rehabil. 2019 Nov/Dec; 34(6):E10-E18. PMID: 31033742.
    Citations: 4     Fields:    Translation:Humans
  29. Izzy S, Liu Q, Fang Z, Lule S, Wu L, Chung JY, Sarro-Schwartz A, Brown-Whalen A, Perner C, Hickman SE, Kaplan DL, Patsopoulos NA, El Khoury J, Whalen MJ. Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury. Front Cell Neurosci. 2019; 13:307. PMID: 31440141; PMCID: PMC6694299.
    Citations: 34     
  30. Rubin DB, Danish HH, Ali AB, Li K, LaRose S, Monk AD, Cote DJ, Spendley L, Kim AH, Robertson MS, Torre M, Smith TR, Izzy S, Jacobson CA, Lee JW, Vaitkevicius H. Neurological toxicities associated with chimeric antigen receptor T-cell therapy. Brain. 2019 05 01; 142(5):1334-1348. PMID: 30891590.
    Citations: 48     Fields:    Translation:Humans
  31. Barra ME, Izzy S, Sarro-Schwartz A, Hirschberg RE, Mazwi N, Edlow BL. Stimulant Therapy in Acute Traumatic Brain Injury: Prescribing Patterns and Adverse Event Rates at 2 Level 1 Trauma Centers. J Intensive Care Med. 2020 Nov; 35(11):1196-1202. PMID: 30966863; PMCID: PMC6785356.
    Citations: 8     Fields:    Translation:Humans
  32. Das AS, Lee JW, Izzy S, Vaitkevicius H. Ultra-short burst suppression as a "reset switch" for refractory status epilepticus. Seizure. 2019 Jan; 64:41-44. PMID: 30553087.
    Citations: 2     Fields:    Translation:Humans
  33. Hickman S, Izzy S, Sen P, Morsett L, El Khoury J. Microglia in neurodegeneration. Nat Neurosci. 2018 10; 21(10):1359-1369. PMID: 30258234.
    Citations: 364     Fields:    Translation:HumansAnimalsCells
  34. Das AS, Lerner DP, Mason XL, Aziz-Sultan MA, Vaitkevicius H, Feske SK, Izzy S. Clinical Reasoning: Moyamoya disease masquerading as acute refractory cerebral vasospasm. Neurology. 2018 08 07; 91(6):e594-e598. PMID: 30082446.
    Citations:    Fields:    Translation:Humans
  35. Chung JY, Krapp N, Wu L, Lule S, McAllister LM, Edmiston WJ, Martin S, Levy E, Songtachalert T, Sherwood JS, Buckley EM, Sanders B, Izzy S, Hickman S, Guo S, Lok J, El Khoury J, Lo EH, Kaplan D, Whalen MJ. Interleukin-1 Receptor 1 Deletion in Focal and Diffuse Experimental Traumatic Brain Injury in Mice. J Neurotrauma. 2019 01 15; 36(2):370-379. PMID: 29768967; PMCID: PMC6338578.
    Citations: 16     Fields:    Translation:Animals
  36. Izzy S, Rubin DB, Ahmed FS, Feske SK. Response by Izzy et al to Letter Regarding Article, "Cerebrovascular Accidents During Mechanical Circulatory Support: New Predictors of Ischemic and Hemorrhagic Stroke and Outcome". Stroke. 2018 08; 49(8):e278. PMID: 29976583.
    Citations:    Fields:    Translation:Humans
  37. Wu L, Chung JY, Saith S, Tozzi L, Buckley EM, Sanders B, Franceschini MA, Lule S, Izzy S, Lok J, Edmiston WJ, McAllister LM, Mebane S, Jin G, Lu J, Sherwood JS, Willwerth S, Hickman S, Khoury JE, Lo EH, Kaplan D, Whalen MJ. Repetitive head injury in adolescent mice: A role for vascular inflammation. J Cereb Blood Flow Metab. 2019 11; 39(11):2196-2209. PMID: 30001646.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  38. Cohen AS, Izzy S, Kumar MA, Joyce CJ, Figueroa SA, Maas MB, Hall CE, McDonagh DL, Lerner DP, Vespa PM, Shutter LA, Rosenthal ES. Education Research: Variation in priorities for neurocritical care education expressed across role groups. Neurology. 2018 06 12; 90(24):1117-1122. PMID: 29891575.
    Citations: 2     Fields:    Translation:Humans
  39. Izzy S, Rubin DB, Ahmed FS, Akbik F, Renault S, Sylvester KW, Vaitkevicius H, Smallwood JA, Givertz MM, Feske SK. Cerebrovascular Accidents During Mechanical Circulatory Support: New Predictors of Ischemic and Hemorrhagic Strokes and Outcome. Stroke. 2018 05; 49(5):1197-1203. PMID: 29643259.
    Citations: 3     Fields:    Translation:Humans
  40. Izzy S, Mazwi NL, Martinez S, Spencer CA, Klein JP, Parikh G, Glenn MB, Greenberg SM, Greer DM, Wu O, Edlow BL. Revisiting Grade 3 Diffuse Axonal Injury: Not All Brainstem Microbleeds are Prognostically Equal. Neurocrit Care. 2017 Oct; 27(2):199-207. PMID: 28477152.
    Citations: 20     Fields:    Translation:Humans
  41. Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift. Neuron. 2017 Sep 13; 95(6):1246-1265. PMID: 28910616.
    Citations: 198     Fields:    Translation:HumansAnimalsCells
  42. Snider S, Stojanovic K, Donnelly D, Etherton M, Feske SK, Izzy S. Clinical Problem-Solving: Lethargy and Fever in an Immunocompromised Patient. Neurohospitalist. 2018 Jan; 8(1):38-41. PMID: 29276563; PMCID: PMC5734509.
    Citations:    
  43. Lerner DP, Kim J, Izzy S. Neurocritical Care Education During Residency: Opinions (NEURON) Study. Neurocrit Care. 2017 02; 26(1):115-118. PMID: 27619228.
    Citations: 2     Fields:    Translation:Humans
  44. Bick SK, Izzy S, Rubin DB, Zafar SF, Rosenthal ES, Eskandar EN. Anterior Temporal Lobectomy for Refractory Status Epilepticus in Herpes Simplex Encephalitis. Neurocrit Care. 2016 12; 25(3):458-463. PMID: 27473208.
    Citations: 4     Fields:    Translation:Humans
  45. Muehlschlegel S, Ayturk D, Ahlawat A, Izzy S, Scalea TM, Stein DM, Emhoff T, Sheth KN. Predicting survival after acute civilian penetrating brain injuries: The SPIN score. Neurology. 2016 Nov 22; 87(21):2244-2253. PMID: 27784772; PMCID: PMC5123553.
    Citations: 13     Fields:    Translation:Humans
  46. Edlow BL, Copen WA, Izzy S, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Longitudinal Diffusion Tensor Imaging Detects Recovery of Fractional Anisotropy Within Traumatic Axonal Injury Lesions. Neurocrit Care. 2016 06; 24(3):342-52. PMID: 26690938.
    Citations: 9     Fields:    Translation:Humans
  47. Edlow BL, Copen WA, Izzy S, Bakhadirov K, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis. BMC Neurol. 2016 Jan 11; 16:2. PMID: 26754948.
    Citations: 23     Fields:    Translation:Humans
  48. Gupta A, Etherton MR, McKee K, Baker JM, Izzy S, Feske SK. Clinical Reasoning: A 68-year-old man with a history of lung cancer presenting with right-sided weakness and aphasia. Neurology. 2015 Oct 06; 85(14):e104-7. PMID: 26438622; PMCID: PMC4607602.
    Citations:    Fields:    Translation:Humans
  49. Henninger N, Izzy S, Carandang R, Hall W, Muehlschlegel S. Severe leukoaraiosis portends a poor outcome after traumatic brain injury. Neurocrit Care. 2014 Dec; 21(3):483-95. PMID: 24752459.
    Citations:    Fields:    Translation:Humans
  50. Muehlschlegel S, Carandang R, Hall W, Kini N, Izzy S, Garland B, Ouillette C, van der Bom IM, Flood TF, Gounis MJ, Weaver JP, Barton B, Wakhloo AK. Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial. J Neurol Neurosurg Psychiatry. 2015 Sep; 86(9):1029-35. PMID: 25344064.
    Citations: 6     Fields:    Translation:Humans
  51. Izzy S, Deeb W, Peters GB, Mitchell A. Isolated optic nerve oedema as unusual presentation of electric injury. BMJ Case Rep. 2014 Oct 15; 2014. PMID: 25320254.
    Citations:    Fields:    Translation:Humans
  52. Cachia D, Izzy S, Berriosmorales I, Ionete C. Drug-induced thrombocytopenia secondary to natalizumab treatment. BMJ Case Rep. 2014 May 30; 2014. PMID: 24879724.
    Citations: 2     Fields:    Translation:Humans
  53. Izzy S, Muehlschlegel S. Cerebral vasospasm after aneurysmal subarachnoid hemorrhage and traumatic brain injury. Curr Treat Options Neurol. 2014 Jan; 16(1):278. PMID: 24347030.
    Citations: 13     
  54. Izzy S, Compton R, Carandang R, Hall W, Muehlschlegel S. Self-fulfilling prophecies through withdrawal of care: do they exist in traumatic brain injury, too? Neurocrit Care. 2013 Dec; 19(3):347-63. PMID: 24132565.
    Citations: 41     Fields:    Translation:Humans
  55. Cachia D, Izzy S, Smith T, Ionete C. A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma. JAMA Neurol. 2013 Sep 01; 70(9):1192-3. PMID: 23857254.
    Citations: 2     Fields:    Translation:Humans
  56. Cachia D, Izzy S, Ionete C, Salameh J. Brachial amyotrophic diplegia in the setting of complete HIV viral load suppression. BMJ Case Rep. 2012 Dec 06; 2012. PMID: 23220836.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.