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Saef Izzy, M.B.,Ch.B.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Migdady I, Chen P, Loza AM, Cashman CR, Izzy S. Cerebral Hyperperfusion and Delayed Coma Recovery after Subdural Hematoma Evacuation. J Stroke Cerebrovasc Dis. 2021 Dec; 30(12):106165. PMID: 34666233.
    Citations:    Fields:    
  2. Stopa BM, Tahir Z, Mezzalira E, Boaro A, Khawaja A, Grashow R, Zafonte RD, Smith TR, Gormley WB, Izzy S. The Impact of Age and Severity on Dementia After Traumatic Brain Injury: A Comparison Study. Neurosurgery. 2021 Oct 13; 89(5):810-818. PMID: 34392366.
    Citations:    Fields:    
  3. Gupta S, Vicenty-Padilla J, Lai PMR, Zhou X, Bernstock JD, Chua M, Izzy S, Aziz-Sultan MA, Du R, Patel NJ. Posterior Cerebral Artery Aneurysm Re-Rupture Following Revascularization for Moyamoya Disease. J Stroke Cerebrovasc Dis. 2021 Nov; 30(11):106048. PMID: 34534774.
    Citations:    Fields:    
  4. Moreira TG, Matos KTF, De Paula GS, Santana TMM, Da Mata RG, Pansera FC, Cortina AS, Spinola MG, Keppeke GD, Jacob J, Palejwala V, Chen K, Izzy S, Healey BC, Rezende RM, Dedivitis RA, Shailubhai K, Weiner HL. Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study. Front Immunol. 2021; 12:709861. PMID: 34475873.
    Citations:    Fields:    Translation:Humans
  5. Bernier TD, Schontz MJ, Izzy S, Chung DY, Nelson SE, Leslie-Mazwi TM, Henderson GV, Dasenbrock H, Patel N, Aziz-Sultan MA, Feske S, Du R, Abulhasan YB, Angle MR. Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal. J Neurosurg Anesthesiol. 2021 Jul 01; 33(3):195-202. PMID: 33480639.
    Citations: 2     Fields:    
  6. Bianciardi M, Izzy S, Rosen BR, Wald LL, Edlow BL. Location of Subcortical Microbleeds and Recovery of Consciousness After Severe Traumatic Brain Injury. Neurology. 2021 07 13; 97(2):e113-e123. PMID: 34050005.
    Citations: 1     Fields:    Translation:Humans
  7. Aldhaeefi M, Tahir Z, Cote DJ, Izzy S, El Khoury J. Comorbidities and Age Are Associated With Persistent COVID-19 PCR Positivity. Front Cell Infect Microbiol. 2021; 11:650753. PMID: 33889551.
    Citations: 1     Fields:    Translation:Humans
  8. Izzy S, Tahir Z, Grashow R, Cote DJ, Jarrah AA, Dhand A, Taylor H, Whalen M, Nathan DM, Miller KK, Speizer F, Baggish A, Weisskopf MG, Zafonte R. Concussion and Risk of Chronic Medical and Behavioral Health Comorbidities. J Neurotrauma. 2021 Jun 01; 38(13):1834-1841. PMID: 33451255.
    Citations:    Fields:    
  9. DiRisio AC, Stopa BM, Pompeu YA, Vasudeva V, Khawaja AM, Izzy S, Gormley WB. Extra-Axial Fluid Collections After Decompressive Craniectomy: Management, Outcomes, and Treatment Algorithm. World Neurosurg. 2021 05; 149:e188-e196. PMID: 33639283.
    Citations:    Fields:    Translation:Humans
  10. Izzy S, Brown-Whalen A, Yahya T, Sarro-Schwartz A, Jin G, Chung JY, Lule S, Morsett LM, Alquraini A, Wu L, Hickman SE, Whalen MJ, El Khoury J. Repetitive Traumatic Brain Injury Causes Neuroinflammation before Tau Pathology in Adolescent P301S Mice. Int J Mol Sci. 2021 Jan 18; 22(2). PMID: 33477535.
    Citations: 1     Fields:    Translation:HumansAnimals
  11. Das AS, Regenhardt RW, Patel N, Feske SK, Bevers MB, Vaitkevicius H, Izzy S. Diffuse Cerebral Edema After Moyamoya Disease-Related Intracerebral Hemorrhage: A Case Report. Neurohospitalist. 2021 Jul; 11(3):251-254. PMID: 34163552.
    Citations:    
  12. Chua MMJ, Das AS, Losman JA, Patel NJ, Izzy S. Spontaneous hemorrhage after external ventricular drain placement in the setting of low factor VII secondary to liver cirrhosis. Surg Neurol Int. 2020; 11:403. PMID: 33365166.
    Citations:    
  13. Stopa BM, Harary M, Jhun R, Job A, Izzy S, Smith TR, Gormley WB. Divergence in the epidemiological estimates of traumatic brain injury in the United States: comparison of two national databases. J Neurosurg. 2020 Nov 20; 1-10. PMID: 33254146.
    Citations:    Fields:    
  14. Lule S, Wu L, Sarro-Schwartz A, Edmiston WJ, Izzy S, Songtachalert T, Ahn SH, Fernandes ND, Jin G, Chung JY, Balachandran S, Lo EH, Kaplan D, Degterev A, Whalen MJ. Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 2021 07; 41(7):1623-1633. PMID: 33210566.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Izzy S, Tahir Z, Cote DJ, Al Jarrah A, Roberts MB, Turbett S, Kadar A, Smirnakis SM, Feske SK, Zafonte R, Fishman JA, El Khoury J. Characteristics and Outcomes of Latinx Patients With COVID-19 in Comparison With Other Ethnic and Racial Groups. Open Forum Infect Dis. 2020 Oct; 7(10):ofaa401. PMID: 33088846.
    Citations: 9     
  16. Otite FO, Patel S, Sharma R, Khandwala P, Desai D, Latorre JG, Akano EO, Anikpezie N, Izzy S, Malik AM, Yavagal D, Khandelwal P, Chaturvedi S. Trends in incidence and epidemiologic characteristics of cerebral venous thrombosis in the United States. Neurology. 2020 10 20; 95(16):e2200-e2213. PMID: 32847952.
    Citations: 3     Fields:    Translation:Humans
  17. Roberts MB, Izzy S, Tahir Z, Al Jarrah A, Fishman JA, El Khoury J. COVID-19 in solid organ transplant recipients: Dynamics of disease progression and inflammatory markers in ICU and non-ICU admitted patients. Transpl Infect Dis. 2020 Oct; 22(5):e13407. PMID: 32654303.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  18. Stopa BM, Dolmans RGF, Broekman MLD, Gormley WB, Mannix R, Izzy S. Hyperosmolar Therapy in Pediatric Severe Traumatic Brain Injury-A Systematic Review. Crit Care Med. 2019 12; 47(12):e1022-e1031. PMID: 31567404.
    Citations: 2     Fields:    Translation:Humans
  19. Mazwi NL, Izzy S, Tan CO, Martinez S, Glenn MB, Giacino JT, Wu O, Zafonte R, Edlow BL. Traumatic Microbleeds in the Hippocampus and Corpus Callosum Predict Duration of Posttraumatic Amnesia. J Head Trauma Rehabil. 2019 Nov/Dec; 34(6):E10-E18. PMID: 31033742.
    Citations: 1     Fields:    Translation:Humans
  20. Izzy S, Liu Q, Fang Z, Lule S, Wu L, Chung JY, Sarro-Schwartz A, Brown-Whalen A, Perner C, Hickman SE, Kaplan DL, Patsopoulos NA, El Khoury J, Whalen MJ. Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury. Front Cell Neurosci. 2019; 13:307. PMID: 31440141.
    Citations: 18     
  21. Rubin DB, Danish HH, Ali AB, Li K, LaRose S, Monk AD, Cote DJ, Spendley L, Kim AH, Robertson MS, Torre M, Smith TR, Izzy S, Jacobson CA, Lee JW, Vaitkevicius H. Neurological toxicities associated with chimeric antigen receptor T-cell therapy. Brain. 2019 05 01; 142(5):1334-1348. PMID: 30891590.
    Citations: 29     Fields:    Translation:Humans
  22. Barra ME, Izzy S, Sarro-Schwartz A, Hirschberg RE, Mazwi N, Edlow BL. Stimulant Therapy in Acute Traumatic Brain Injury: Prescribing Patterns and Adverse Event Rates at 2 Level 1 Trauma Centers. J Intensive Care Med. 2020 Nov; 35(11):1196-1202. PMID: 30966863.
    Citations: 4     Fields:    Translation:Humans
  23. Das AS, Lee JW, Izzy S, Vaitkevicius H. Ultra-short burst suppression as a "reset switch" for refractory status epilepticus. Seizure. 2019 Jan; 64:41-44. PMID: 30553087.
    Citations: 2     Fields:    Translation:Humans
  24. Hickman S, Izzy S, Sen P, Morsett L, El Khoury J. Microglia in neurodegeneration. Nat Neurosci. 2018 10; 21(10):1359-1369. PMID: 30258234.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  25. Das AS, Lerner DP, Mason XL, Aziz-Sultan MA, Vaitkevicius H, Feske SK, Izzy S. Clinical Reasoning: Moyamoya disease masquerading as acute refractory cerebral vasospasm. Neurology. 2018 08 07; 91(6):e594-e598. PMID: 30082446.
    Citations:    Fields:    Translation:Humans
  26. Chung JY, Krapp N, Wu L, Lule S, McAllister LM, Edmiston WJ, Martin S, Levy E, Songtachalert T, Sherwood JS, Buckley EM, Sanders B, Izzy S, Hickman S, Guo S, Lok J, El Khoury J, Lo EH, Kaplan D, Whalen MJ. Interleukin-1 Receptor 1 Deletion in Focal and Diffuse Experimental Traumatic Brain Injury in Mice. J Neurotrauma. 2019 01 15; 36(2):370-379. PMID: 29768967.
    Citations: 10     Fields:    Translation:Animals
  27. Izzy S, Rubin DB, Ahmed FS, Feske SK. Response by Izzy et al to Letter Regarding Article, "Cerebrovascular Accidents During Mechanical Circulatory Support: New Predictors of Ischemic and Hemorrhagic Stroke and Outcome". Stroke. 2018 08; 49(8):e278. PMID: 29976583.
    Citations:    Fields:    Translation:Humans
  28. Wu L, Chung JY, Saith S, Tozzi L, Buckley EM, Sanders B, Franceschini MA, Lule S, Izzy S, Lok J, Edmiston WJ, McAllister LM, Mebane S, Jin G, Lu J, Sherwood JS, Willwerth S, Hickman S, Khoury JE, Lo EH, Kaplan D, Whalen MJ. Repetitive head injury in adolescent mice: A role for vascular inflammation. J Cereb Blood Flow Metab. 2019 11; 39(11):2196-2209. PMID: 30001646.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  29. Cohen AS, Izzy S, Kumar MA, Joyce CJ, Figueroa SA, Maas MB, Hall CE, McDonagh DL, Lerner DP, Vespa PM, Shutter LA, Rosenthal ES. Education Research: Variation in priorities for neurocritical care education expressed across role groups. Neurology. 2018 06 12; 90(24):1117-1122. PMID: 29891575.
    Citations: 1     Fields:    Translation:Humans
  30. Izzy S, Rubin DB, Ahmed FS, Akbik F, Renault S, Sylvester KW, Vaitkevicius H, Smallwood JA, Givertz MM, Feske SK. Cerebrovascular Accidents During Mechanical Circulatory Support: New Predictors of Ischemic and Hemorrhagic Strokes and Outcome. Stroke. 2018 05; 49(5):1197-1203. PMID: 29643259.
    Citations: 3     Fields:    Translation:Humans
  31. Izzy S, Mazwi NL, Martinez S, Spencer CA, Klein JP, Parikh G, Glenn MB, Greenberg SM, Greer DM, Wu O, Edlow BL. Revisiting Grade 3 Diffuse Axonal Injury: Not All Brainstem Microbleeds are Prognostically Equal. Neurocrit Care. 2017 Oct; 27(2):199-207. PMID: 28477152.
    Citations: 14     Fields:    Translation:Humans
  32. Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift. Neuron. 2017 Sep 13; 95(6):1246-1265. PMID: 28910616.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  33. Snider S, Stojanovic K, Donnelly D, Etherton M, Feske SK, Izzy S. Clinical Problem-Solving: Lethargy and Fever in an Immunocompromised Patient. Neurohospitalist. 2018 Jan; 8(1):38-41. PMID: 29276563.
    Citations:    
  34. Lerner DP, Kim J, Izzy S. Neurocritical Care Education During Residency: Opinions (NEURON) Study. Neurocrit Care. 2017 02; 26(1):115-118. PMID: 27619228.
    Citations:    Fields:    Translation:Humans
  35. Bick SK, Izzy S, Rubin DB, Zafar SF, Rosenthal ES, Eskandar EN. Anterior Temporal Lobectomy for Refractory Status Epilepticus in Herpes Simplex Encephalitis. Neurocrit Care. 2016 12; 25(3):458-463. PMID: 27473208.
    Citations: 4     Fields:    Translation:Humans
  36. Muehlschlegel S, Ayturk D, Ahlawat A, Izzy S, Scalea TM, Stein DM, Emhoff T, Sheth KN. Predicting survival after acute civilian penetrating brain injuries: The SPIN score. Neurology. 2016 Nov 22; 87(21):2244-2253. PMID: 27784772.
    Citations: 9     Fields:    Translation:Humans
  37. Edlow BL, Copen WA, Izzy S, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Longitudinal Diffusion Tensor Imaging Detects Recovery of Fractional Anisotropy Within Traumatic Axonal Injury Lesions. Neurocrit Care. 2016 06; 24(3):342-52. PMID: 26690938.
    Citations: 9     Fields:    Translation:Humans
  38. Edlow BL, Copen WA, Izzy S, Bakhadirov K, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis. BMC Neurol. 2016 Jan 11; 16:2. PMID: 26754948.
    Citations: 22     Fields:    Translation:Humans
  39. Gupta A, Etherton MR, McKee K, Baker JM, Izzy S, Feske SK. Clinical Reasoning: A 68-year-old man with a history of lung cancer presenting with right-sided weakness and aphasia. Neurology. 2015 Oct 06; 85(14):e104-7. PMID: 26438622.
    Citations:    Fields:    Translation:Humans
  40. Henninger N, Izzy S, Carandang R, Hall W, Muehlschlegel S. Severe leukoaraiosis portends a poor outcome after traumatic brain injury. Neurocrit Care. 2014 Dec; 21(3):483-95. PMID: 24752459.
    Citations:    Fields:    Translation:Humans
  41. Muehlschlegel S, Carandang R, Hall W, Kini N, Izzy S, Garland B, Ouillette C, van der Bom IM, Flood TF, Gounis MJ, Weaver JP, Barton B, Wakhloo AK. Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial. J Neurol Neurosurg Psychiatry. 2015 Sep; 86(9):1029-35. PMID: 25344064.
    Citations: 5     Fields:    Translation:Humans
  42. Izzy S, Deeb W, Peters GB, Mitchell A. Isolated optic nerve oedema as unusual presentation of electric injury. BMJ Case Rep. 2014 Oct 15; 2014. PMID: 25320254.
    Citations:    Fields:    Translation:Humans
  43. Cachia D, Izzy S, Berriosmorales I, Ionete C. Drug-induced thrombocytopenia secondary to natalizumab treatment. BMJ Case Rep. 2014 May 30; 2014. PMID: 24879724.
    Citations: 2     Fields:    Translation:Humans
  44. Izzy S, Muehlschlegel S. Cerebral vasospasm after aneurysmal subarachnoid hemorrhage and traumatic brain injury. Curr Treat Options Neurol. 2014 Jan; 16(1):278. PMID: 24347030.
    Citations: 9     
  45. Izzy S, Compton R, Carandang R, Hall W, Muehlschlegel S. Self-fulfilling prophecies through withdrawal of care: do they exist in traumatic brain injury, too? Neurocrit Care. 2013 Dec; 19(3):347-63. PMID: 24132565.
    Citations: 31     Fields:    Translation:Humans
  46. Cachia D, Izzy S, Smith T, Ionete C. A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma. JAMA Neurol. 2013 Sep 01; 70(9):1192-3. PMID: 23857254.
    Citations: 1     Fields:    Translation:Humans
  47. Cachia D, Izzy S, Ionete C, Salameh J. Brachial amyotrophic diplegia in the setting of complete HIV viral load suppression. BMJ Case Rep. 2012 Dec 06; 2012. PMID: 23220836.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.