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profileSimon L. Dove, Ph.D.

TitleAssociate Professor of Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildrens Hospital
Infectious Diseases, Enders Bldg., Room 754
300 Longwood Ave
Boston MA 02115
Phone617/432-1922
Fax617/730-0254
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AI125876     (DOVE, SIMON L)Jan 16, 2017 - Dec 31, 2018
NIH/NIAID
An essential RNA chaperone in Pseudomonas aeruginosa
Role: Principal Investigator

R01AI118955     (DOVE, SIMON L)Feb 15, 2016 - Jan 31, 2021
NIH/NIAID
Programmed cell death in P. aeruginosa
Role: Principal Investigator

R01AI105013     (DOVE, SIMON L)Jan 1, 2014 - Dec 31, 2018
NIH/NIAID
Control of fimbrial gene expression in Pseudomonas aeruginosa
Role: Principal Investigator

R21AI105463     (DOVE, SIMON L)Feb 1, 2013 - Jan 31, 2015
NIH/NIAID
An essential transcription regulator in Pseudomonas aeruginosa
Role: Principal Investigator

R01GM096454     (NICKELS, BRYCE EDWARD)Sep 30, 2010 - Aug 31, 2015
NIH/NIGMS
NanoRNA-mediated control of gene expression
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Cuthbert BJ, Ross W, Rohlfing AE, Dove SL, Gourse RL, Brennan RG, Schumacher MA. Dissection of the molecular circuitry controlling virulence in Francisella tularensis. Genes Dev. 2017 Sep 01. PMID: 28864445.
    View in: PubMed
  2. Basset A, Herd M, Daly R, Dove SL, Malley R. The Pneumococcal Type 1 Pilus Genes Are Thermoregulated and Are Repressed by a Member of the Snf2 Protein Family. J Bacteriol. 2017 Aug 01; 199(15). PMID: 28507246.
    View in: PubMed
  3. Eshraghi A, Kim J, Walls AC, Ledvina HE, Miller CN, Ramsey KM, Whitney JC, Radey MC, Peterson SB, Ruhland BR, Tran BQ, Goo YA, Goodlett DR, Dove SL, Celli J, Veesler D, Mougous JD. Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Cell Host Microbe. 2016 Nov 09; 20(5):573-583. PMID: 27832588.
    View in: PubMed
  4. Ramsey KM, Dove SL. A response regulator promotes Francisella tularensis intramacrophage growth by repressing an anti-virulence factor. Mol Microbiol. 2016 Aug; 101(4):688-700. PMID: 27169554; PMCID: PMC5020902 [Available on 08/01/17].
  5. McGuffie BA, Vallet-Gely I, Dove SL. s Factor and Anti-s Factor That Control Swarming Motility and Biofilm Formation in Pseudomonas aeruginosa. J Bacteriol. 2015 Nov 30; 198(5):755-65. PMID: 26620262; PMCID: PMC4810613.
  6. Druzhinin SY, Tran NT, Skalenko KS, Goldman SR, Knoblauch JG, Dove SL, Nickels BE. A Conserved Pattern of Primer-Dependent Transcription Initiation in Escherichia coli and Vibrio cholerae Revealed by 5' RNA-seq. PLoS Genet. 2015 Jul; 11(7):e1005348. PMID: 26131907; PMCID: PMC4488433.
  7. McFarland KA, Dolben EL, LeRoux M, Kambara TK, Ramsey KM, Kirkpatrick RL, Mougous JD, Hogan DA, Dove SL. A self-lysis pathway that enhances the virulence of a pathogenic bacterium. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8433-8. PMID: 26100878; PMCID: PMC4500232.
  8. Ding P, McFarland KA, Jin S, Tong G, Duan B, Yang A, Hughes TR, Liu J, Dove SL, Navarre WW, Xia B. A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT. PLoS Pathog. 2015 Jun; 11(6):e1004967. PMID: 26068099; PMCID: PMC4466236.
  9. Ramsey KM, Osborne ML, Vvedenskaya IO, Su C, Nickels BE, Dove SL. Ubiquitous promoter-localization of essential virulence regulators in Francisella tularensis. PLoS Pathog. 2015 Apr; 11(4):e1004793. PMID: 25830507; PMCID: PMC4382096.
  10. Winardhi RS, Castang S, Dove SL, Yan J. Single-molecule study on histone-like nucleoid-structuring protein (H-NS) paralogue in Pseudomonas aeruginosa: MvaU bears DNA organization mode similarities to MvaT. PLoS One. 2014; 9(11):e112246. PMID: 25372370; PMCID: PMC4221281.
  11. Rohlfing AE, Dove SL. Coordinate control of virulence gene expression in Francisella tularensis involves direct interaction between key regulators. J Bacteriol. 2014 Oct; 196(19):3516-26. PMID: 25070738; PMCID: PMC4187675.
  12. Balasubramanian D, Kumari H, Jaric M, Fernandez M, Turner KH, Dove SL, Narasimhan G, Lory S, Mathee K. Deep sequencing analyses expands the Pseudomonas aeruginosa AmpR regulon to include small RNA-mediated regulation of iron acquisition, heat shock and oxidative stress response. Nucleic Acids Res. 2014 Jan; 42(2):979-98. PMID: 24157832; PMCID: PMC3902932.
  13. Jackson AA, Gross MJ, Daniels EF, Hampton TH, Hammond JH, Vallet-Gely I, Dove SL, Stanton BA, Hogan DA. Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence. J Bacteriol. 2013 Jul; 195(13):3093-104. PMID: 23667230; PMCID: PMC3697539.
  14. Castang S, Dove SL. Basis for the essentiality of H-NS family members in Pseudomonas aeruginosa. J Bacteriol. 2012 Sep; 194(18):5101-9. PMID: 22821971; PMCID: PMC3430348.
  15. Winardhi RS, Fu W, Castang S, Li Y, Dove SL, Yan J. Higher order oligomerization is required for H-NS family member MvaT to form gene-silencing nucleoprotein filament. Nucleic Acids Res. 2012 Oct; 40(18):8942-52. PMID: 22798496; PMCID: PMC3467065.
  16. Vvedenskaya IO, Sharp JS, Goldman SR, Kanabar PN, Livny J, Dove SL, Nickels BE. Growth phase-dependent control of transcription start site selection and gene expression by nanoRNAs. Genes Dev. 2012 Jul 01; 26(13):1498-507. PMID: 22751503; PMCID: PMC3403017.
  17. Li M, Le Trong I, Carl MA, Larson ET, Chou S, De Leon JA, Dove SL, Stenkamp RE, Mougous JD. Structural basis for type VI secretion effector recognition by a cognate immunity protein. PLoS Pathog. 2012; 8(4):e1002613. PMID: 22511866; PMCID: PMC3325213.
  18. Basset A, Turner KH, Boush E, Sayeed S, Dove SL, Malley R. An epigenetic switch mediates bistable expression of the type 1 pilus genes in Streptococcus pneumoniae. J Bacteriol. 2012 Mar; 194(5):1088-91. PMID: 22194460; PMCID: PMC3294793.
  19. McManus HR, Dove SL. The CgrA and CgrC proteins form a complex that positively regulates cupA fimbrial gene expression in Pseudomonas aeruginosa. J Bacteriol. 2011 Nov; 193(22):6152-61. PMID: 21926232; PMCID: PMC3209204.
  20. Goldman SR, Sharp JS, Vvedenskaya IO, Livny J, Dove SL, Nickels BE. NanoRNAs prime transcription initiation in vivo. Mol Cell. 2011 Jun 24; 42(6):817-25. PMID: 21700226; PMCID: PMC3130991.
  21. Nickels BE, Dove SL. NanoRNAs: a class of small RNAs that can prime transcription initiation in bacteria. J Mol Biol. 2011 Oct 07; 412(5):772-81. PMID: 21704045; PMCID: PMC3184357.
  22. Basset A, Turner KH, Boush E, Sayeed S, Dove SL, Malley R. Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA. Infect Immun. 2011 Aug; 79(8):2974-83. PMID: 21576325; PMCID: PMC3147576.
  23. Cho H, McManus HR, Dove SL, Bernhardt TG. Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonist. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3773-8. PMID: 21321206; PMCID: PMC3048121.
  24. Karna SL, Zogaj X, Barker JR, Seshu J, Dove SL, Klose KE. A bacterial two-hybrid system that utilizes Gateway cloning for rapid screening of protein-protein interactions. Biotechniques. 2010 Nov; 49(5):831-3. PMID: 21091448.
    View in: PubMed
  25. Castang S, Dove SL. High-order oligomerization is required for the function of the H-NS family member MvaT in Pseudomonas aeruginosa. Mol Microbiol. 2010 Nov; 78(4):916-31. PMID: 20815825; PMCID: PMC2978250.
  26. Turner KH, Vallet-Gely I, Dove SL. Epigenetic control of virulence gene expression in Pseudomonas aeruginosa by a LysR-type transcription regulator. PLoS Genet. 2009 Dec; 5(12):e1000779. PMID: 20041030; PMCID: PMC2796861.
  27. Charity JC, Blalock LT, Costante-Hamm MM, Kasper DL, Dove SL. Small molecule control of virulence gene expression in Francisella tularensis. PLoS Pathog. 2009 Oct; 5(10):e1000641. PMID: 19876386; PMCID: PMC2763202.
  28. Brencic A, McFarland KA, McManus HR, Castang S, Mogno I, Dove SL, Lory S. The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. Mol Microbiol. 2009 Aug; 73(3):434-45. PMID: 19602144; PMCID: PMC2761719.
  29. Castang S, McManus HR, Turner KH, Dove SL. H-NS family members function coordinately in an opportunistic pathogen. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18947-52. PMID: 19028873; PMCID: PMC2596223.
  30. Yuan AH, Gregory BD, Sharp JS, McCleary KD, Dove SL, Hochschild A. Rsd family proteins make simultaneous interactions with regions 2 and 4 of the primary sigma factor. Mol Microbiol. 2008 Dec; 70(5):1136-51. PMID: 18826409; PMCID: PMC2581641.
  31. Johnson SJ, Close D, Robinson H, Vallet-Gely I, Dove SL, Hill CP. Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa. J Mol Biol. 2008 Apr 11; 377(5):1460-73. PMID: 18321528; PMCID: PMC2680229.
  32. Vallet-Gely I, Sharp JS, Dove SL. Local and global regulators linking anaerobiosis to cupA fimbrial gene expression in Pseudomonas aeruginosa. J Bacteriol. 2007 Dec; 189(23):8667-76. PMID: 17890313; PMCID: PMC2168922.
  33. Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. PLoS Pathog. 2007 Jun; 3(6):e84. PMID: 17571921; PMCID: PMC1891329.
  34. Vallet-Gely I, Donovan KE, Fang R, Joung JK, Dove SL. Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11082-7. PMID: 16043713; PMCID: PMC1182424.
  35. Rietsch A, Vallet-Gely I, Dove SL, Mekalanos JJ. ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2005 May 31; 102(22):8006-11. PMID: 15911752; PMCID: PMC1142391.
  36. Sun L, Dove SL, Panaghie G, deHaseth PL, Hochschild A. An RNA polymerase mutant deficient in DNA melting facilitates study of activation mechanism: application to an artificial activator of transcription. J Mol Biol. 2004 Nov 05; 343(5):1171-82. PMID: 15491604.
    View in: PubMed
  37. Harnasch M, Grau S, Behrends C, Dove SL, Hochschild A, Iskandar MK, Xia W, Ehrmann M. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins. Mol Membr Biol. 2004 Nov-Dec; 21(6):373-83. PMID: 15764367.
    View in: PubMed
  38. Dove SL, Hochschild A. A bacterial two-hybrid system based on transcription activation. Methods Mol Biol. 2004; 261:231-46. PMID: 15064462.
    View in: PubMed
  39. Song T, Dove SL, Lee KH, Husson RN. RshA, an anti-sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH. Mol Microbiol. 2003 Nov; 50(3):949-59. PMID: 14617153.
    View in: PubMed
  40. Dove SL, Darst SA, Hochschild A. Region 4 of sigma as a target for transcription regulation. Mol Microbiol. 2003 May; 48(4):863-74. PMID: 12753182.
    View in: PubMed
  41. Dove SL. Studying protein-protein interactions using a bacterial two-hybrid system. Methods Mol Biol. 2003; 205:251-65. PMID: 12491892.
    View in: PubMed
  42. Nickels BE, Dove SL, Murakami KS, Darst SA, Hochschild A. Protein-protein and protein-DNA interactions of sigma70 region 4 involved in transcription activation by lambdacI. J Mol Biol. 2002 Nov 15; 324(1):17-34. PMID: 12421556.
    View in: PubMed
  43. Shaywitz AJ, Dove SL, Greenberg ME, Hochschild A. Analysis of phosphorylation-dependent protein-protein interactions using a bacterial two-hybrid system. Sci STKE. 2002 Jul 23; 2002(142):pl11. PMID: 12138210.
    View in: PubMed
  44. Pande S, Makela A, Dove SL, Nickels BE, Hochschild A, Hinton DM. The bacteriophage T4 transcription activator MotA interacts with the far-C-terminal region of the sigma70 subunit of Escherichia coli RNA polymerase. J Bacteriol. 2002 Jul; 184(14):3957-64. PMID: 12081968; PMCID: PMC135182.
  45. Kuznedelov K, Minakhin L, Niedziela-Majka A, Dove SL, Rogulja D, Nickels BE, Hochschild A, Heyduk T, Severinov K. A role for interaction of the RNA polymerase flap domain with the sigma subunit in promoter recognition. Science. 2002 Feb 01; 295(5556):855-7. PMID: 11823642.
    View in: PubMed
  46. Kelley MT, Bürckstümmer T, Wenzel-Seifert K, Dove S, Buschauer A, Seifert R. Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists. Mol Pharmacol. 2001 Dec; 60(6):1210-25. PMID: 11723228.
    View in: PubMed
  47. Dove SL, Hochschild A. Bacterial two-hybrid analysis of interactions between region 4 of the sigma(70) subunit of RNA polymerase and the transcriptional regulators Rsd from Escherichia coli and AlgQ from Pseudomonas aeruginosa. J Bacteriol. 2001 Nov; 183(21):6413-21. PMID: 11591686; PMCID: PMC100137.
  48. Shaywitz AJ, Dove SL, Kornhauser JM, Hochschild A, Greenberg ME. Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB-binding protein. Mol Cell Biol. 2000 Dec; 20(24):9409-22. PMID: 11094091; PMCID: PMC102197.
  49. Dove SL, Huang FW, Hochschild A. Mechanism for a transcriptional activator that works at the isomerization step. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13215-20. PMID: 11087868; PMCID: PMC27205.
  50. Danese PN, Pratt LA, Dove SL, Kolter R. The outer membrane protein, antigen 43, mediates cell-to-cell interactions within Escherichia coli biofilms. Mol Microbiol. 2000 Jul; 37(2):424-32. PMID: 10931336.
    View in: PubMed
  51. Blum JH, Dove SL, Hochschild A, Mekalanos JJ. Isolation of peptide aptamers that inhibit intracellular processes. Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5):2241-6. PMID: 10688899; PMCID: PMC15785.
  52. Hochschild A, Dove SL. Protein-protein contacts that activate and repress prokaryotic transcription. Cell. 1998 Mar 06; 92(5):597-600. PMID: 9506513.
    View in: PubMed
  53. Dove SL, Hochschild A. Conversion of the omega subunit of Escherichia coli RNA polymerase into a transcriptional activator or an activation target. Genes Dev. 1998 Mar 01; 12(5):745-54. PMID: 9499408; PMCID: PMC316573.
  54. Dove SL, Hochschild A. Use of artificial activators to define a role for protein-protein and protein-DNA contacts in transcriptional activation. Cold Spring Harb Symp Quant Biol. 1998; 63:173-80. PMID: 10384281.
    View in: PubMed
  55. Dove SL, Joung JK, Hochschild A. Activation of prokaryotic transcription through arbitrary protein-protein contacts. Nature. 1997 Apr 10; 386(6625):627-30. PMID: 9121589.
    View in: PubMed
  56. Dove SL, Smith SG, Dorman CJ. Control of Escherichia coli type 1 fimbrial gene expression in stationary phase: a negative role for RpoS. Mol Gen Genet. 1997 Mar 18; 254(1):13-20. PMID: 9108285.
    View in: PubMed
  57. Dove SL, Dorman CJ. Multicopy fimB gene expression in Escherichia coli: binding to inverted repeats in vivo, effect on fimA gene transcription and DNA inversion. Mol Microbiol. 1996 Sep; 21(6):1161-73. PMID: 8898385.
    View in: PubMed
  58. Dove SL, Dorman CJ. The site-specific recombination system regulating expression of the type 1 fimbrial subunit gene of Escherichia coli is sensitive to changes in DNA supercoiling. Mol Microbiol. 1994 Dec; 14(5):975-88. PMID: 7715458.
    View in: PubMed
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