Harvard Catalyst Profiles

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Leon M. Ptaszek, M.D., Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sharif Z, Ptaszek LM. Global disparities in arrhythmia care: Mind the gap. Heart Rhythm O2. 2022 Dec; 3(6Part B):783-792. PMID: 36589003; PMCID: PMC9795303.
  2. Ptaszek LM, Koruth J, Santangeli P, Piccini JP, Ranjan R, Mahapatra S, Pipenhagen C, Fish JM, Moon LB, Ambrosius NM, Boudlali H, Jensen JA. Safe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter. Heart Rhythm O2. 2023 Jan; 4(1):42-50. PMID: 36713045; PMCID: PMC9877396.
  3. Khaloo P, Uzomah UA, Shaqdan A, Ledesma PA, Galvin J, Ptaszek LM, Ruskin JN. Outcomes of Patients Hospitalized With Cardiovascular Implantable Electronic Device-Related Infective Endocarditis, Prosthetic Valve Endocarditis, and Native Valve Endocarditis: A Nationwide Study, 2003 to 2017. J Am Heart Assoc. 2022 09 06; 11(17):e025600. PMID: 36000421; PMCID: PMC9496407.
    Citations: 2     Fields:    Translation:Humans
  4. August A, Attarwala HZ, Himansu S, Kalidindi S, Lu S, Pajon R, Han S, Lecerf JM, Tomassini JE, Hard M, Ptaszek LM, Crowe JE, Zaks T. Author Correction: A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus. Nat Med. 2022 May; 28(5):1095-1096. PMID: 35449420; PMCID: PMC9117134.
    Citations:    Fields:    
  5. Qin D, Ptaszek LM. A Practical Guide to Ultrasound-guided Venous Access During Implantation of Pacemakers and Defibrillators. J Innov Card Rhythm Manag. 2022 Feb; 13(2):4873-4877. PMID: 35251755; PMCID: PMC8887928.
  6. Khaloo P, Shaqdan A, Ledesma PA, Uzomah UA, Galvin J, Ptaszek LM, Ruskin JN. Distinct etiologies of high-sensitivity troponin T elevation predict different mortality risks for patients hospitalized with COVID-19. Int J Cardiol. 2022 03 15; 351:118-125. PMID: 34952038; PMCID: PMC8690225.
    Citations: 2     Fields:    Translation:HumansCells
  7. August A, Attarwala HZ, Himansu S, Kalidindi S, Lu S, Pajon R, Han S, Lecerf JM, Tomassini JE, Hard M, Ptaszek LM, Crowe JE, Zaks T. A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus. Nat Med. 2021 12; 27(12):2224-2233. PMID: 34887572; PMCID: PMC8674127.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  8. Uzomah UA, Rozen G, Mohammadreza Hosseini S, Shaqdan A, Ledesma PA, Yu X, Khaloo P, Galvin J, Ptaszek LM, Ruskin JN. Incidence of carditis and predictors of pacemaker implantation in patients hospitalized with Lyme disease. PLoS One. 2021; 16(11):e0259123. PMID: 34731187.
    Citations:    Fields:    Translation:Humans
  9. Bode W, Ptaszek LM. Management of Atrial Fibrillation in the Emergency Department. Curr Cardiol Rep. 2021 10 16; 23(12):179. PMID: 34657210.
    Citations:    Fields:    Translation:Humans
  10. Ledesma PA, Uzomah UA, Yu X, Shaqdan A, Khaloo P, Galvin J, Mansour M, Ptaszek LM, Ruskin JN. MAUDE Database Analysis of Post-Approval Outcomes following Left Atrial Appendage Closure with the Watchman Device. Am J Cardiol. 2021 08 01; 152:78-87. PMID: 34116792.
    Citations:    Fields:    Translation:HumansPHPublic Health
  11. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 Jul 02; 27(1):178-180. PMID: 32619513.
    Citations: 2     Fields:    
  12. Ptaszek LM, Portillo Lara R, Shirzaei Sani E, Xiao C, Roh J, Yu X, Ledesma PA, Hsiang Yu C, Annabi N, Ruskin JN. Gelatin Methacryloyl Bioadhesive Improves Survival and Reduces Scar Burden in a Mouse Model of Myocardial Infarction. J Am Heart Assoc. 2020 06 02; 9(11):e014199. PMID: 32458746.
    Citations: 4     Fields:    Translation:Animals
  13. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 07 02; 27(1):147-157.e7. PMID: 32413331.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Ptaszek LM, Baugh CW, Lubitz SA, Ruskin JN, Ha G, Forsch M, DeOliveira SA, Baig S, Heist EK, Wasfy JH, Brown DF, Biddinger PD, Raja AS, Scirica B, White BA, Mansour M. Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi-Center Study. J Am Heart Assoc. 2019 09 17; 8(18):e012656. PMID: 31510841.
    Citations: 3     Fields:    Translation:Humans
  15. Chen JA, Ptaszek LM, Celano CM, Beach SR. Case 9-2019: A 62-Year-Old Man with Atrial Fibrillation, Depression, and Worsening Anxiety. N Engl J Med. 2019 Mar 21; 380(12):1167-1174. PMID: 30893540.
    Citations:    Fields:    Translation:Humans
  16. Rozen G, Ptaszek LM, Zilberman I, Douglas V, Heist EK, Beeckler C, Altmann A, Ruskin JN, Govari A, Mansour M. Safety and efficacy of delivering high-power short-duration radiofrequency ablation lesions utilizing a novel temperature sensing technology. Europace. 2018 11 01; 20(FI_3):f444-f450. PMID: 29579196.
    Citations: 4     Fields:    Translation:Animals
  17. Faramarzi N, Yazdi IK, Nabavinia M, Gemma A, Fanelli A, Caizzone A, Ptaszek LM, Sinha I, Khademhosseini A, Ruskin JN, Tamayol A. Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds. Adv Healthc Mater. 2018 06; 7(11):e1701347. PMID: 29663706; PMCID: PMC6422175.
    Citations: 40     Fields:    Translation:HumansCells
  18. Alpert NM, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour MC, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup TM, Normandin MD, El Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS One. 2018; 13(1):e0190968. PMID: 29338024.
    Citations: 13     Fields:    Translation:Animals
  19. Ptaszek LM, Moon B, Rozen G, Mahapatra S, Mansour M. Novel automated point collection software facilitates rapid, high-density electroanatomical mapping with multiple catheter types. J Cardiovasc Electrophysiol. 2018 01; 29(1):186-195. PMID: 29024200.
    Citations: 7     Fields:    Translation:Animals
  20. Guehl NJ, Normandin MD, Wooten DW, Rozen G, Ruskin JN, Shoup TM, Woo J, Ptaszek LM, Fakhri GE, Alpert NM. Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up. Med Phys. 2017 Sep; 44(9):4643-4651. PMID: 28594441; PMCID: PMC5603217.
    Citations: 1     Fields:    Translation:HumansAnimals
  21. Guehl NJ, Normandin MD, Wooten DW, Rozen G, Sitek A, Ruskin J, Shoup TM, Ptaszek LM, El Fakhri G, Alpert NM. Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. Eur J Nucl Med Mol Imaging. 2017 Aug; 44(9):1538-1546. PMID: 28365789.
    Citations: 8     Fields:    Translation:Animals
  22. Asnani A, Manning A, Mansour M, Ruskin J, Hochberg EP, Ptaszek LM. Management of atrial fibrillation in patients taking targeted cancer therapies. Cardiooncology. 2017; 3:2. PMID: 32153998; PMCID: PMC7048041.
    Citations: 4     
  23. Rozen G, Ptaszek L, Zilberman I, Cordaro K, Heist EK, Beeckler C, Altmann A, Ying Z, Liu Z, Ruskin JN, Govari A, Mansour M. Prediction of radiofrequency ablation lesion formation using a novel temperature sensing technology incorporated in a force sensing catheter. Heart Rhythm. 2017 02; 14(2):248-254. PMID: 28104089.
    Citations: 7     Fields:    Translation:Animals
  24. Ptaszek LM, White B, Lubitz SA, Carnicelli AP, Heist EK, Ellinor PT, Machado M, Wasfy JH, Ruskin JN, Armstrong K, Brown DF, Biddinger PD, Mansour M. Effect of a Multidisciplinary Approach for the Management of Patients With Atrial Fibrillation in the Emergency Department on Hospital Admission Rate and Length of Stay. Am J Cardiol. 2016 Jul 01; 118(1):64-71. PMID: 27206910.
    Citations: 7     Fields:    Translation:Humans
  25. Dudzinski DM, Prabhakar AM, Ptaszek LM, Vlahakes GJ. Case Records of the Massachusetts General Hospital. Case 19-2015. A 71-Year-Old Man with Chest Pain and Shortness of Breath. N Engl J Med. 2015 Jun 18; 372(25):2438-46. PMID: 26083209.
    Citations: 1     Fields:    Translation:Humans
  26. Maan A, Refaat MM, Heist EK, Passeri J, Inglessis I, Ptaszek L, Vlahakes G, Ruskin JN, Palacios I, Sundt T, Mansour M. Incidence and Predictors of Pacemaker Implantation in Patients Undergoing Transcatheter Aortic Valve Replacement. Pacing Clin Electrophysiol. 2015 Jul; 38(7):878-86. PMID: 25940067.
    Citations: 13     Fields:    Translation:Humans
  27. Ptaszek LM, Kim K, Spooner AE, MacGillivray TE, Cambria RP, Lindsay ME, Isselbacher EM. Marfan syndrome is associated with recurrent dissection of the dissected aorta. Ann Thorac Surg. 2015 May; 99(5):1616-23. PMID: 25818572.
    Citations: 2     Fields:    Translation:Humans
  28. Acha MR, Keaney JJ, Lubitz SA, Milan DJ, Mansour M, Heist KE, Ptaszek LM, Singh JP, Blendea D, Mela T. Increased perforation risk with an MRI-conditional pacing lead: a single-center study. Pacing Clin Electrophysiol. 2015 Mar; 38(3):334-42. PMID: 25469809.
    Citations: 9     Fields:    Translation:Humans
  29. Maan A, Heist EK, Passeri J, Inglessis I, Baker J, Ptaszek L, Vlahakes G, Ruskin JN, Palacios I, Sundt T, Mansour M. Impact of atrial fibrillation on outcomes in patients who underwent transcatheter aortic valve replacement. Am J Cardiol. 2015 Jan 15; 115(2):220-6. PMID: 25465936.
    Citations: 12     Fields:    Translation:Humans
  30. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. PMID: 24013197.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  31. Ptaszek LM, Chalhoub F, Perna F, Beinart R, Barrett CD, Danik SB, Heist EK, Ruskin JN, Mansour M. Rapid acquisition of high-resolution electroanatomical maps using a novel multielectrode mapping system. J Interv Card Electrophysiol. 2013 Apr; 36(3):233-42. PMID: 23179916.
    Citations: 6     Fields:    Translation:Animals
  32. Ptaszek LM, Mansour M, Ruskin JN, Chien KR. Towards regenerative therapy for cardiac disease. Lancet. 2012 Mar 10; 379(9819):933-942. PMID: 22405796.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  33. Lau FH, Deo RC, Mowrer G, Caplin J, Ahfeldt T, Kaplan A, Ptaszek L, Walker JD, Rosengard BR, Cowan CA. Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue. PLoS One. 2011; 6(10):e26092. PMID: 22022522.
    Citations: 3     Fields:    Translation:HumansCells
  34. Contreras-Valdes FM, Heist EK, Danik SB, Barrett CD, Blendea D, Brugge WR, Ptaszek L, Ruskin JN, Mansour M. Severity of esophageal injury predicts time to healing after radiofrequency catheter ablation for atrial fibrillation. Heart Rhythm. 2011 Dec; 8(12):1862-8. PMID: 21782773.
    Citations: 14     Fields:    Translation:Humans
  35. Truong QA, Banerji D, Ptaszek LM, Taylor C, Fontes JD, Kriegel M, Irlbeck T, Nagurney JT, Hoffmann U. Utility of nonspecific resting electrocardiographic features for detection of coronary artery stenosis by computed tomography in acute chest pain patients: from the ROMICAT trial. Int J Cardiovasc Imaging. 2012 Feb; 28(2):365-74. PMID: 21287278.
    Citations: 1     Fields:    Translation:Humans
  36. Singh JP, Ptaszek LM, Verma A. Elusive atrial substrate: complex fractionated atrial electrograms and beyond. Heart Rhythm. 2010 Dec; 7(12):1886-90. PMID: 20817015.
    Citations: 2     Fields:    Translation:HumansAnimals
  37. Truong QA, Ptaszek LM, Charipar EM, Taylor C, Fontes JD, Kriegel M, Irlbeck T, Toepker M, Schlett CL, Bamberg F, Blankstein R, Brady TJ, Nagurney JT, Hoffmann U. Performance of electrocardiographic criteria for left ventricular hypertrophy as compared with cardiac computed tomography: from the Rule Out Myocardial Infarction Using Computer Assisted Tomography trial. J Hypertens. 2010 Sep; 28(9):1959-67. PMID: 20498615.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  38. Truong QA, Charipar EM, Ptaszek LM, Taylor C, Fontes JD, Kriegel M, Irlbeck T, Mahabadi AA, Blankstein R, Hoffmann U. Usefulness of electrocardiographic parameters as compared with computed tomography measures of left atrial volume enlargement: from the ROMICAT trial. J Electrocardiol. 2011 Mar-Apr; 44(2):257-64. PMID: 20537347.
    Citations: 9     Fields:    Translation:Humans
  39. Xie D, Chen CC, Ptaszek LM, Xiao S, Cao X, Fang F, Ng HH, Lewin HA, Cowan C, Zhong S. Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species. Genome Res. 2010 Jun; 20(6):804-15. PMID: 20219939; PMCID: PMC2877577.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  40. Tsai VW, Cooper J, Garan H, Natale A, Ptaszek LM, Ellinor PT, Hickey K, Downey R, Zei P, Hsia H, Wang P, Hunt S, Haddad F, Al-Ahmad A. The efficacy of implantable cardioverter-defibrillators in heart transplant recipients: results from a multicenter registry. Circ Heart Fail. 2009 May; 2(3):197-201. PMID: 19808340.
    Citations: 5     Fields:    Translation:Humans
  41. Ptaszek LM, Saldana F, Palacios IF, M Wu S. Platypnea-Orthodeoxia Syndrome in Two Previously Healthy Adults: A Case-based Review. Clin Med Cardiol. 2009 Apr 09; 3:37-43. PMID: 20508765.
    Citations: 4     
  42. Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H, Bernstein BE. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 2008 Oct; 4(10):e1000242. PMID: 18974828; PMCID: PMC2567431.
    Citations: 557     Fields:    Translation:HumansAnimalsCells
  43. Fenno LE, Ptaszek LM, Cowan CA. Human embryonic stem cells: emerging technologies and practical applications. Curr Opin Genet Dev. 2008 Aug; 18(4):324-9. PMID: 18625311.
    Citations: 8     Fields:    Translation:HumansCells
  44. Ptaszek LM, Cowan CA. New tools for genome modification in human embryonic stem cells. Cell Stem Cell. 2007 Dec 13; 1(6):600-2. PMID: 18371400.
    Citations: 1     Fields:    Translation:HumansCells
  45. D'Avila A, Ptaszek LM, Yu PB, Walker JD, Wright C, Noseworthy PA, Myers A, Refaat M, Ruskin JN. Images in cardiovascular medicine. Left atrial-esophageal fistula after pulmonary vein isolation: a cautionary tale. Circulation. 2007 May 01; 115(17):e432-3. PMID: 17470703.
    Citations: 7     Fields:    Translation:Humans
  46. Vagefi PA, Bates NR, Ptaszek LM, Adams MS, Walker JD. Valve-sparing excision of aortic valve papillary fibroelastoma. J Thorac Cardiovasc Surg. 2006 May; 131(5):1177-8. PMID: 16678612.
    Citations: 1     Fields:    Translation:HumansCells
  47. Ptaszek LM, Wang PJ, Hunt SA, Valantine H, Perlroth M, Al-Ahmad A. Use of the implantable cardioverter-defibrillator in long-term survivors of orthotopic heart transplantation. Heart Rhythm. 2005 Sep; 2(9):931-3. PMID: 16171746.
    Citations: 6     Fields:    Translation:Humans
  48. Ptaszek LM, Price ET, Hu MY, Yang PC. Early diagnosis of hemochromatosis-related cardiomyopathy with magnetic resonance imaging. J Cardiovasc Magn Reson. 2005; 7(4):689-92. PMID: 16136860.
    Citations: 7     Fields:    Translation:Humans
  49. Lee AI, Fugmann SD, Cowell LG, Ptaszek LM, Kelsoe G, Schatz DG. A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol. 2003 Oct; 1(1):E1. PMID: 14551903; PMCID: PMC212687.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  50. Ciubotaru M, Ptaszek LM, Baker GA, Baker SN, Bright FV, Schatz DG. RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy. J Biol Chem. 2003 Feb 21; 278(8):5584-96. PMID: 12488446.
    Citations: 16     Fields:    Translation:AnimalsCells
  51. Arbuckle JL, Fauss LA, Simpson R, Ptaszek LM, Rodgers KK. Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination. J Biol Chem. 2001 Oct 05; 276(40):37093-101. PMID: 11479318.
    Citations: 22     Fields:    Translation:AnimalsCells
  52. Gomez CA, Ptaszek LM, Villa A, Bozzi F, Sobacchi C, Brooks EG, Notarangelo LD, Spanopoulou E, Pan ZQ, Vezzoni P, Cortes P, Santagata S. Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies. Mol Cell Biol. 2000 Aug; 20(15):5653-64. PMID: 10891502; PMCID: PMC86034.
    Citations: 28     Fields:    Translation:HumansCells
  53. Fugmann SD, Villey IJ, Ptaszek LM, Schatz DG. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. Mol Cell. 2000 Jan; 5(1):97-107. PMID: 10678172.
    Citations: 69     Fields:    Translation:AnimalsCells
  54. Rodgers KK, Villey IJ, Ptaszek L, Corbett E, Schatz DG, Coleman JE. A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2. Nucleic Acids Res. 1999 Jul 15; 27(14):2938-46. PMID: 10390537; PMCID: PMC148510.
    Citations: 35     Fields:    Translation:AnimalsCells
  55. Ptaszek LM, Vijayakumar S, Ravishanker G, Beveridge DL. Molecular dynamics studies of the human CD4 protein. Biopolymers. 1994 Sep; 34(9):1145-53. PMID: 7948728.
    Citations: 1     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.