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William Renthal, M.D., Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP1DA054343 (RENTHAL, WILLIAM RUSSELL) Aug 15, 2021 - Jun 30, 2026
    NIH
    Epigenomic labeling of cells that drive drug abuse behavior
    Role: Principal Investigator
  2. K08NS101064 (RENTHAL, WILLIAM RUSSELL) Jul 1, 2017 - Jun 30, 2022
    NIH
    CONTROL OF LONG GENE EXPRESSION AS A NOVEL THERAPEUTIC APPROACH FOR RETT SYNDROME
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yang L, Xu M, Bhuiyan SA, Li J, Zhao J, Cohrs RJ, Susterich JT, Signorelli S, Green U, Stone JR, Levy D, Lennerz JK, Renthal W. Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine. Neuron. 2022 Mar 25. PMID: 35349784.
    Citations:    Fields:    
  2. Yang L, Tochitsky I, Woolf CJ, Renthal W. Isolation of Nuclei from Mouse Dorsal Root Ganglia for Single-nucleus Genomics. Bio Protoc. 2021 Aug 05; 11(15):e4102. PMID: 34458396.
    Citations:    
  3. Renthal W, Chamessian A, Curatolo M, Davidson S, Burton M, Dib-Hajj S, Dougherty PM, Ebert AD, Gereau RW, Ghetti A, Gold MS, Hoben G, Menichella DM, Mercier P, Ray WZ, Salvemini D, Seal RP, Waxman S, Woolf CJ, Stucky CL, Price TJ. Human cells and networks of pain: Transforming pain target identification and therapeutic development. Neuron. 2021 05 05; 109(9):1426-1429. PMID: 33957072.
    Citations: 5     Fields:    Translation:Humans
  4. Renthal W, Tochitsky I, Yang L, Cheng YC, Li E, Kawaguchi R, Geschwind DH, Woolf CJ. Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury. Neuron. 2020 10 14; 108(1):128-144.e9. PMID: 32810432.
    Citations: 40     Fields:    Translation:AnimalsCells
  5. Vgontzas A, Renthal W. Predicting erenumab adverse events with single-cell genomics. Lancet. 2020 07 11; 396(10244):95-96. PMID: 32653068.
    Citations: 1     Fields:    Translation:HumansAnimals
  6. Boxer LD, Renthal W, Greben AW, Whitwam T, Silberfeld A, Stroud H, Li E, Yang MG, Kinde B, Griffith EC, Bonev B, Greenberg ME. MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes. Mol Cell. 2020 01 16; 77(2):294-309.e9. PMID: 31784358.
    Citations: 21     Fields:    Translation:AnimalsCells
  7. Vgontzas A, Renthal W. Migraine-associated gene expression in cell types of the central and peripheral nervous system. Cephalalgia. 2020 04; 40(5):517-523. PMID: 31660761.
    Citations: 2     Fields:    Translation:HumansCells
  8. Tsankova N, Renthal W, Kumar A, Nestler EJ. Author Correction: Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci. 2019 Mar; 20(3):187-188. PMID: 30546104.
    Citations: 1     Fields:    
  9. Loder E, Renthal W. Calcitonin Gene-Related Peptide Monoclonal Antibody Treatments for Migraine. JAMA Intern Med. 2019 03 01; 179(3):421-422. PMID: 30640381.
    Citations:    Fields:    Translation:Humans
  10. Renthal W, Boxer LD, Hrvatin S, Li E, Silberfeld A, Nagy MA, Griffith EC, Vierbuchen T, Greenberg ME. Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing. Nat Neurosci. 2018 12; 21(12):1670-1679. PMID: 30455458.
    Citations: 40     Fields:    Translation:HumansCells
  11. Nourbakhsh B, Cordano C, Renthal W. Determining the Etiology of Internuclear Ophthalmoplegia in a Patient with a Cardiac Pacemaker and Complex Neurological Presentation. J Clin Neurol. 2018 Oct; 14(4):574-576. PMID: 30198234.
    Citations:    
  12. Vgontzas A, Renthal W. Introduction to Neurogenetics. Am J Med. 2019 02; 132(2):142-152. PMID: 30098310.
    Citations: 2     Fields:    Translation:Humans
  13. Renthal W. Localization of migraine susceptibility genes in human brain by single-cell RNA sequencing. Cephalalgia. 2018 11; 38(13):1976-1983. PMID: 29498289.
    Citations: 3     Fields:    Translation:Humans
  14. Stroud H, Su SC, Hrvatin S, Greben AW, Renthal W, Boxer LD, Nagy MA, Hochbaum DR, Kinde B, Gabel HW, Greenberg ME. Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States. Cell. 2017 Nov 16; 171(5):1151-1164.e16. PMID: 29056337.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  15. Renthal W. Seeking Balance Between Pain Relief and Safety: CDC Issues New Opioid-Prescribing Guidelines. JAMA Neurol. 2016 05 01; 73(5):513-4. PMID: 26978030.
    Citations: 11     Fields:    Translation:Humans
  16. Renthal W, Alberts M, Shang T. Clinical Reasoning: A 76-year-old man with acute-onset left-sided weakness and numbness. Neurology. 2016 04 12; 86(15):e156-e160. PMID: 27163666.
    Citations:    Fields:    Translation:Humans
  17. Renthal W, Marin-Valencia I, Evans PA. Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence. Pediatr Neurol. 2014 Jul; 51(1):100-3. PMID: 24938142.
    Citations: 19     Fields:    Translation:Humans
  18. Ferguson D, Koo JW, Feng J, Heller E, Rabkin J, Heshmati M, Renthal W, Neve R, Liu X, Shao N, Sartorelli V, Shen L, Nestler EJ. Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. J Neurosci. 2013 Oct 09; 33(41):16088-98. PMID: 24107942.
    Citations: 54     Fields:    Translation:AnimalsCells
  19. Vialou V, Maze I, Renthal W, LaPlant QC, Watts EL, Mouzon E, Ghose S, Tamminga CA, Nestler EJ. Serum response factor promotes resilience to chronic social stress through the induction of DeltaFosB. J Neurosci. 2010 Oct 27; 30(43):14585-92. PMID: 20980616.
    Citations: 45     Fields:    Translation:HumansAnimals
  20. Renthal NE, Guidry PA, Shanmuganad S, Renthal W, Stroynowski I. Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide. Immunogenetics. 2011 Jan; 63(1):57-64. PMID: 20967542.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. LaPlant Q, Vialou V, Covington HE, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci. 2010 Sep; 13(9):1137-43. PMID: 20729844.
    Citations: 303     Fields:    Translation:AnimalsCells
  22. Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science. 2010 Jan 08; 327(5962):213-6. PMID: 20056891.
    Citations: 328     Fields:    Translation:AnimalsCells
  23. Covington HE, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, Fass DM, Renthal W, Rush AJ, Wu EY, Ghose S, Krishnan V, Russo SJ, Tamminga C, Haggarty SJ, Nestler EJ. Antidepressant actions of histone deacetylase inhibitors. J Neurosci. 2009 Sep 16; 29(37):11451-60. PMID: 19759294.
    Citations: 262     Fields:    Translation:HumansAnimals
  24. Wilkinson MB, Xiao G, Kumar A, LaPlant Q, Renthal W, Sikder D, Kodadek TJ, Nestler EJ. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J Neurosci. 2009 Jun 17; 29(24):7820-32. PMID: 19535594.
    Citations: 107     Fields:    Translation:AnimalsCells
  25. Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron. 2009 May 14; 62(3):335-48. PMID: 19447090.
    Citations: 203     Fields:    Translation:AnimalsCells
  26. Russo SJ, Wilkinson MB, Mazei-Robison MS, Dietz DM, Maze I, Krishnan V, Renthal W, Graham A, Birnbaum SG, Green TA, Robison B, Lesselyong A, Perrotti LI, Bolaños CA, Kumar A, Clark MS, Neumaier JF, Neve RL, Bhakar AL, Barker PA, Nestler EJ. Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci. 2009 Mar 18; 29(11):3529-37. PMID: 19295158.
    Citations: 142     Fields:    Translation:AnimalsCells
  27. Renthal W, Nestler EJ. Histone acetylation in drug addiction. Semin Cell Dev Biol. 2009 Jun; 20(4):387-94. PMID: 19560043.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  28. Renthal W, Nestler EJ. Chromatin regulation in drug addiction and depression. Dialogues Clin Neurosci. 2009; 11(3):257-68. PMID: 19877494.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  29. Winstanley CA, Green TA, Theobald DE, Renthal W, LaPlant Q, DiLeone RJ, Chakravarty S, Nestler EJ. DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine. Pharmacol Biochem Behav. 2009 Sep; 93(3):278-84. PMID: 19135469.
    Citations: 18     Fields:    Translation:Animals
  30. Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC. Epigenetics in the nervous system. J Neurosci. 2008 Nov 12; 28(46):11753-9. PMID: 19005036.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  31. Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW. Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron. 2008 Aug 28; 59(4):621-33. PMID: 18760698.
    Citations: 159     Fields:    Translation:AnimalsCells
  32. Renthal W, Nestler EJ. Epigenetic mechanisms in drug addiction. Trends Mol Med. 2008 Aug; 14(8):341-50. PMID: 18635399.
    Citations: 161     Fields:    Translation:HumansAnimalsCells
  33. Renthal W, Carle TL, Maze I, Covington HE, Truong HT, Alibhai I, Kumar A, Montgomery RL, Olson EN, Nestler EJ. Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci. 2008 Jul 16; 28(29):7344-9. PMID: 18632938.
    Citations: 125     Fields:    Translation:AnimalsCells
  34. Perrotti LI, Weaver RR, Robison B, Renthal W, Maze I, Yazdani S, Elmore RG, Knapp DJ, Selley DE, Martin BR, Sim-Selley L, Bachtell RK, Self DW, Nestler EJ. Distinct patterns of DeltaFosB induction in brain by drugs of abuse. Synapse. 2008 May; 62(5):358-69. PMID: 18293355.
    Citations: 97     Fields:    Translation:Animals
  35. Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, Nestler EJ. Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biol Psychiatry. 2008 Jun 01; 63(11):1013-21. PMID: 18222416.
    Citations: 33     Fields:    Translation:Animals
  36. Renthal W, Maze I, Krishnan V, Covington HE, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. 2007 Nov 08; 56(3):517-29. PMID: 17988634.
    Citations: 285     Fields:    Translation:AnimalsCells
  37. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007 Oct 19; 131(2):391-404. PMID: 17956738.
    Citations: 865     Fields:    Translation:HumansAnimalsCells
  38. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci. 2007 May; 8(5):355-67. PMID: 17453016.
    Citations: 468     Fields:    Translation:HumansAnimalsCells
  39. Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal W, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ. IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci. 2007 Jan; 10(1):93-9. PMID: 17143271.
    Citations: 106     Fields:    Translation:AnimalsCells
  40. Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006 Apr; 9(4):519-25. PMID: 16501568.
    Citations: 650     Fields:    Translation:AnimalsCells
  41. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006 Feb 10; 311(5762):864-8. PMID: 16469931.
    Citations: 784     Fields:    Translation:AnimalsCells
  42. Colvis CM, Pollock JD, Goodman RH, Impey S, Dunn J, Mandel G, Champagne FA, Mayford M, Korzus E, Kumar A, Renthal W, Theobald DE, Nestler EJ. Epigenetic mechanisms and gene networks in the nervous system. J Neurosci. 2005 Nov 09; 25(45):10379-89. PMID: 16280577.
    Citations: 46     Fields:    Translation:AnimalsCells
  43. Kumar A, Choi KH, Renthal W, Tsankova NM, Theobald DE, Truong HT, Russo SJ, Laplant Q, Sasaki TS, Whistler KN, Neve RL, Self DW, Nestler EJ. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron. 2005 Oct 20; 48(2):303-14. PMID: 16242410.
    Citations: 364     Fields:    Translation:AnimalsCells
  44. Willie JT, Renthal W, Chemelli RM, Miller MS, Scammell TE, Yanagisawa M, Sinton CM. Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Neuroscience. 2005; 130(4):983-95. PMID: 15652995.
    Citations: 37     Fields:    Translation:AnimalsCells
  45. Zhao S, Renthal W, Lee EY. Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses. Nucleic Acids Res. 2002 Nov 15; 30(22):4815-22. PMID: 12433983.
    Citations: 25     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.