Instructor in Pediatrics
Boston Children's Hospital
Newborn Enders 961
300 Longwood Ave
Boston MA 02115
Available: 10/16/20, Expires: 10/16/21
Bacille Calmette-Guerin (BCG), the live attenuated Mycobacterium bovis vaccine is given at birth in most countries to protect against tuberculosis (TB). Multiple BCG strains/formulations exist and are used interchangeably despite significant differences in their viability and immune-activating potential. Our goal is to advance and implement an optimal BCG vaccine against TB and potentially heterologous infections, in collaboration with the Mueller Health Foundation. As part of this project we are conducting a landscape analysis to determine:
- which BCG vaccine provides optimal vaccine-specific protection against TB
and non-specific heterologous protection against off-target respiratory infections (e.g., influenza and SARS-CoV-2).
- Define biomarkers of BCG immunogenicity and protection to guide selection of optimal BCG vaccines and inform development of novel TB vaccines.
- Inform and advance a clinical trial to compare BCG formulations in vivo.
We would welcome a medical student with an interest in infectious diseases and immunology to our team, to assist with literature review and compilation towards a manuscript. There will be opportunity for participation in developing an analysis plan and scientific writing with resulting authorship. We will be complementing our methods with AI technology. Skills in this area are desired but not required. The student will receive direct mentorship from faculty of the Precision Vaccines Program at Boston Children's Hospital. Most of the project can be conducted remotely.
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