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Asimenia Angelidou, M.D.

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Mentoring
Available: 10/16/20, Expires: 10/16/21

Bacille Calmette-Guerin (BCG), the live attenuated Mycobacterium bovis vaccine is given at birth in most countries to protect against tuberculosis (TB). Multiple BCG strains/formulations exist and are used interchangeably despite significant differences in their viability and immune-activating potential. Our goal is to advance and implement an optimal BCG vaccine against TB and potentially heterologous infections, in collaboration with the Mueller Health Foundation. As part of this project we are conducting a landscape analysis to determine:

  1. which BCG vaccine provides optimal vaccine-specific protection against TB
    and non-specific heterologous protection against off-target respiratory infections (e.g., influenza and SARS-CoV-2).
  2. Define biomarkers of BCG immunogenicity and protection to guide selection of optimal BCG vaccines and inform development of novel TB vaccines.
  3. Inform and advance a clinical trial to compare BCG formulations in vivo.

We would welcome a medical student with an interest in infectious diseases and immunology to our team, to assist with literature review and compilation towards a manuscript. There will be opportunity for participation in developing an analysis plan and scientific writing with resulting authorship. We will be complementing our methods with AI technology. Skills in this area are desired but not required. The student will receive direct mentorship from faculty of the Precision Vaccines Program at Boston Children's Hospital. Most of the project can be conducted remotely.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Angelidou A, Sullivan K, Melvin PR, Shui JE, Goldfarb IT, Bartolome R, Chaudhary N, Vaidya R, Culic I, Singh R, Yanni D, Patrizi S, Hudak ML, Parker MG, Belfort MB. Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts. JAMA Netw Open. 2021 04 01; 4(4):e217523. PMID: 33890989.
    Citations:    Fields:    
  2. Angelidou A, Levy O. Vaccination of Term and Preterm Infants. Neoreviews. 2020 12; 21(12):e817-e827. PMID: 33262208.
    Citations:    Fields:    
  3. Diray-Arce J, Conti MG, Petrova B, Kanarek N, Angelidou A, Levy O. Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections. Metabolites. 2020 Nov 30; 10(12). PMID: 33266347.
    Citations: 1     
  4. Bennike TB, Fatou B, Angelidou A, Diray-Arce J, Falsafi R, Ford R, Gill EE, van Haren SD, Idoko OT, Lee AH, Ben-Othman R, Pomat WS, Shannon CP, Smolen KK, Tebbutt SJ, Ozonoff A, Richmond PC, van den Biggelaar AHJ, Hancock REW, Kampmann B, Kollmann TR, Levy O, Steen H. Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life. Front Immunol. 2020; 11:578505. PMID: 33329546.
    Citations:    Fields:    
  5. Angelidou A, Diray-Arce J, Conti MG, Smolen KK, van Haren SD, Dowling DJ, Husson RN, Levy O. BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny. Front Microbiol. 2020; 11:332. PMID: 32218774.
    Citations: 12     
  6. Angelidou A, Conti MG, Diray-Arce J, Benn CS, Shann F, Netea MG, Liu M, Potluri LP, Sanchez-Schmitz G, Husson R, Ozonoff A, Kampmann B, van Haren SD, Levy O. Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation. Vaccine. 2020 02 24; 38(9):2229-2240. PMID: 32005538.
    Citations: 11     Fields:    Translation:HumansCells
  7. Conti MG, Angelidou A, Diray-Arce J, Smolen KK, Lasky-Su J, De Curtis M, Levy O. Immunometabolic approaches to prevent, detect, and treat neonatal sepsis. Pediatr Res. 2020 01; 87(2):399-405. PMID: 31689710.
    Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
  8. Lee AH, Shannon CP, Amenyogbe N, Bennike TB, Diray-Arce J, Idoko OT, Gill EE, Ben-Othman R, Pomat WS, van Haren SD, Cao KL, Cox M, Darboe A, Falsafi R, Ferrari D, Harbeson DJ, He D, Bing C, Hinshaw SJ, Ndure J, Njie-Jobe J, Pettengill MA, Richmond PC, Ford R, Saleu G, Masiria G, Matlam JP, Kirarock W, Roberts E, Malek M, Sanchez-Schmitz G, Singh A, Angelidou A, Smolen KK, Brinkman RR, Ozonoff A, Hancock REW, van den Biggelaar AHJ, Steen H, Tebbutt SJ, Kampmann B, Levy O, Kollmann TR. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. Nat Commun. 2019 03 12; 10(1):1092. PMID: 30862783.
    Citations: 30     Fields:    Translation:Humans
  9. Angelidou A, Michael Z, Hotz A, Friedman K, Emani S, LaRovere K, Christou H. Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome. Neonatology. 2018; 113(2):177-182. PMID: 29248924.
    Citations: 7     Fields:    Translation:HumansCells
  10. Angelidou A, Bell K, Gupta M, Tropea Leeman K, Hansen A. Implementation of a Guideline to Decrease Use of Acid-Suppressing Medications in the NICU. Pediatrics. 2017 Dec; 140(6). PMID: 29162657.
    Citations: 3     Fields:    Translation:Humans
  11. Alysandratos KD, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, Critchfield A, Theoharides TC. Neurotensin and CRH interactions augment human mast cell activation. PLoS One. 2012; 7(11):e48934. PMID: 23155429.
    Citations: 20     Fields:    Translation:HumansCells
  12. Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012 Jul 02; 12:89. PMID: 22747567.
    Citations: 38     Fields:    Translation:Humans
  13. Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos KD, Angelidou A, Shirihai O, Theoharides TC. Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol. 2012; 159(1):23-32. PMID: 22555146.
    Citations: 13     Fields:    Translation:HumansCells
  14. Theoharides TC, Enakuaa S, Sismanopoulos N, Asadi S, Papadimas EC, Angelidou A, Alysandratos KD. Contribution of stress to asthma worsening through mast cell activation. Ann Allergy Asthma Immunol. 2012 Jul; 109(1):14-9. PMID: 22727152.
    Citations: 17     Fields:    Translation:HumansCells
  15. Sismanopoulos N, Delivanis DA, Alysandratos KD, Angelidou A, Vasiadi M, Therianou A, Theoharides TC. IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis. PLoS One. 2012; 7(3):e33271. PMID: 22413008.
    Citations: 18     Fields:    Translation:HumansCells
  16. Sismanopoulos N, Delivanis DA, Alysandratos KD, Angelidou A, Therianou A, Kalogeromitros D, Theoharides TC. Mast cells in allergic and inflammatory diseases. Curr Pharm Des. 2012; 18(16):2261-77. PMID: 22390690.
    Citations: 27     Fields:    Translation:HumansCells
  17. Asadi S, Alysandratos KD, Angelidou A, Miniati A, Sismanopoulos N, Vasiadi M, Zhang B, Kalogeromitros D, Theoharides TC. Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells. J Invest Dermatol. 2012 Feb; 132(2):324-9. PMID: 22089831.
    Citations: 27     Fields:    Translation:HumansCells
  18. Angelidou A, Alysandratos KD, Asadi S, Zhang B, Francis K, Vasiadi M, Kalogeromitros D, Theoharides TC. Brief report: "allergic symptoms" in children with Autism Spectrum Disorders. More than meets the eye? J Autism Dev Disord. 2011 Nov; 41(11):1579-85. PMID: 21210299.
    Citations: 18     Fields:    Translation:HumansCells
  19. Zhang B, Alysandratos KD, Angelidou A, Asadi S, Sismanopoulos N, Delivanis DA, Weng Z, Miniati A, Vasiadi M, Katsarou-Katsari A, Miao B, Leeman SE, Kalogeromitros D, Theoharides TC. Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: relevance to atopic dermatitis. J Allergy Clin Immunol. 2011 Jun; 127(6):1522-31.e8. PMID: 21453958.
    Citations: 36     Fields:    Translation:HumansCells
  20. Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D. Mast cell activation and autism. Biochim Biophys Acta. 2012 Jan; 1822(1):34-41. PMID: 21193035.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  21. Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. Mast cells and inflammation. Biochim Biophys Acta. 2012 Jan; 1822(1):21-33. PMID: 21185371.
    Citations: 193     Fields:    Translation:HumansAnimalsCells
  22. Zhang B, Angelidou A, Alysandratos KD, Vasiadi M, Francis K, Asadi S, Theoharides A, Sideri K, Lykouras L, Kalogeromitros D, Theoharides TC. Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children. J Neuroinflammation. 2010 Nov 17; 7:80. PMID: 21083929.
    Citations: 32     Fields:    Translation:HumansCells
  23. Alysandratos KD, Angelidou A, Vasiadi M, Zhang B, Kalogeromitros D, Katsarou-Katsari A, Theoharides TC. Increased affected skin gene expression and serum levels of thymic stromal lymphopoietin in atopic dermatitis. Ann Allergy Asthma Immunol. 2010 Nov; 105(5):403-4. PMID: 21055671.
    Citations: 7     Fields:    Translation:Humans
  24. Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos KD, Theoharides TC. Luteolin and thiosalicylate inhibit HgCl(2) and thimerosal-induced VEGF release from human mast cells. Int J Immunopathol Pharmacol. 2010 Oct-Dec; 23(4):1015-20. PMID: 21244751.
    Citations: 12     Fields:    Translation:HumansCells
  25. Angelidou A, Francis K, Vasiadi M, Alysandratos KD, Zhang B, Theoharides A, Lykouras L, Sideri K, Kalogeromitros D, Theoharides TC. Neurotensin is increased in serum of young children with autistic disorder. J Neuroinflammation. 2010 Aug 23; 7:48. PMID: 20731814.
    Citations: 26     Fields:    Translation:Humans
  26. Theoharides TC, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos KD, Kalogeromitros D, Asadi S, Stavrianeas N, Peterson E, Leeman S, Conti P. IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4448-53. PMID: 20160089.
    Citations: 87     Fields:    Translation:HumansCells
  27. Angelidou A, Strintzis MG, Panas S, Anogianakis G. On AR modelling for MEG spectral estimation, data compression and classification. Comput Biol Med. 1992 Nov; 22(6):379-87. PMID: 1458850.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.