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Abby Olsen, M.D.,Ph.D.

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Carleton College, Northfield, MNBA06/2003Women's and Gender Studies
University of Pennsylvania, Philadelphia, PAMD, PhD06/2013Cell and Molecular Biology
Pennsylvania Hospital, Philadelphia, PAInternship06/2014Medicine
Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MAResidency06/2017Neurology
Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MAFellowship06/2019Movement Disorders

Dr. Abby Olsen is an Associate Neurologist at Brigham and Women's Hospital and Brigham and Women's Faulkner Hospital and an Instructor at Harvard Medical School. She obtained her MD and PhD degrees at the University of Pennsylvania and completed her neurology residency and fellowship at Brigham and Women's Hospital and Massachusetts General Hospital, where she also served as a Chief Resident. She currently divides her time between conducting research in the laboratory of Dr. Mel Feany and caring for patients with Parkinson's disease and other movement disorders. The overarching purpose of her research program is to define the contribution of glia to Parkinson's disease and other alpha-synucleinopathies in an effort to identify novel glial therapeutic targets in these disorders. To do this she uses innovative Drosophila model systems that were created by Dr. Feany, along with human iPSC models and human genetic data. Dr. Olsen also has a fruitful collaboration with Dr. Clemens Scherzer and is utilizing the Harvard Biomarkers Study to investigate gene-environment interactions in Parkinson's disease. She is a recent NINDS K08 recipient and a recipient of the Parkinson's Disease Early Investigator Award from the Department of Defense.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. L30NS108208-01 (Abby Olsen) Oct 1, 2018 - Sep 30, 2020
    Environmental modulation of alpha-synuclein toxicity in Parkinson’s disease
    Role: Principal Investigator
  2. K08NS109344 (OLSEN, ABBY LAUREN) Sep 30, 2018 - Jun 30, 2023
    Defining the genetic contribution of glia in Parkinson's disease pathogenesis
    Role: Principal Investigator
  3. W81XWH1810395 (Abby Olsen) Aug 1, 2018 - Jul 31, 2020
    Department of Defense
    Environmental modulation of alpha-synuclein toxicity in Parkinson's disease
    Role: Principal Investigator
  4. R25NS065743 (Abby Olsen) Jul 1, 2016 - Sep 29, 2018
    Defining the contribution of glia to Parkinson's disease
    Role: Principal Investigator
  5. F30DK081265 (OLSEN, ABBY LAUREN) Mar 1, 2008 - Feb 29, 2012
    Cellular fibronectin and hepatic stellate cell function in liver fibrosis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sarkar S, Olsen AL, Sygnecka K, Lohr KM, Feany MB. a-synuclein impairs autophagosome maturation through abnormal actin stabilization. PLoS Genet. 2021 Feb; 17(2):e1009359. PMID: 33556113.
    Citations:    Fields:    
  2. Parkhitko AA, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen AL, Asara JM, Cracan V, Rabinowitz JD, Brockmann A, Perrimon N. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Elife. 2020 12 15; 9. PMID: 33319750.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Sarkar S, Murphy MA, Dammer EB, Olsen AL, Rangaraju S, Fraenkel E, Feany MB. Comparative proteomic analysis highlights metabolic dysfunction in a-synucleinopathy. NPJ Parkinsons Dis. 2020 Dec 11; 6(1):40. PMID: 33311497.
    Citations: 1     
  4. Vaswani PA, Olsen AL. Immunotherapy in progressive supranuclear palsy. Curr Opin Neurol. 2020 08; 33(4):527-533. PMID: 32657895.
    Citations:    Fields:    
  5. Argent L, Winter F, Prickett I, Carrasquero-Ordaz M, Olsen AL, Kramer H, Lancaster E, Becker EBE. Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology. J Biol Chem. 2020 09 04; 295(36):12716-12726. PMID: 32675284.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Vaswani PA, Olsen AL. Immunotherapy in progressive supranuclear palsy. Curr Opin Neurol. 2020 Jun 08. PMID: 32520801.
    Citations:    Fields:    
  7. Sarkar S, Dammer EB, Malovic E, Olsen AL, Raza SA, Gao T, Xiao H, Oliver DL, Duong D, Joers V, Seyfried N, Huang M, Kukar T, Tansey MG, Kanthasamy AG, Rangaraju S. Molecular Signatures of Neuroinflammation Induced by aSynuclein Aggregates in Microglial Cells. Front Immunol. 2020; 11:33. PMID: 32082315.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Olsen AL, Feany MB. Glial a-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo. Glia. 2019 10; 67(10):1933-1957. PMID: 31267577.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Olsen AL, Feany MB. PARP Inhibitors and Parkinson's Disease. N Engl J Med. 2019 01 31; 380(5):492-494. PMID: 30699325.
    Citations: 7     Fields:    Translation:HumansAnimals
  10. Olsen AL, Riise T, Scherzer CR. Discovering New Benefits From Old Drugs With Big Data-Promise for Parkinson Disease. JAMA Neurol. 2018 08 01; 75(8):917-920. PMID: 29710184.
    Citations:    Fields:    Translation:Humans
  11. Klingberg F, Chau G, Walraven M, Boo S, Koehler A, Chow ML, Olsen AL, Im M, Lodyga M, Wells RG, White ES, Hinz B. The fibronectin ED-A domain enhances recruitment of latent TGF-ß-binding protein-1 to the fibroblast matrix. J Cell Sci. 2018 03 01; 131(5). PMID: 29361522.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  12. Herrington T, Olsen AL. . Neurology Evidence: The Practice-Changing Studies. Movement Disorders. 2017; 156-158.
  13. Sackey-Aboagye B, Olsen AL, Mukherjee SM, Ventriglia A, Yokosaki Y, Greenbaum LE, Lee GY, Naga H, Wells RG. Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy. PLoS One. 2016; 11(10):e0163737. PMID: 27741254.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Olsen AL, Miller JJ, Bhattacharyya S, Voinescu PE, Klein JP. Cerebral perfusion in stroke-like migraine attacks after radiation therapy syndrome. Neurology. 2016 Feb 23; 86(8):787-9. PMID: 26819456.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  15. Olsen AL, Lai Y, Dalmau J, Scherer SS, Lancaster E. Caspr2 autoantibodies target multiple epitopes. Neurol Neuroimmunol Neuroinflamm. 2015 Aug; 2(4):e127. PMID: 26185774.
    Citations: 12     Fields:    
  16. Wen JW, Olsen AL, Perepelyuk M, Wells RG. Isolation of rat portal fibroblasts by in situ liver perfusion. J Vis Exp. 2012 Jun 29; (64). PMID: 22781701.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Olsen AL, Sackey BK, Marcinkiewicz C, Boettiger D, Wells RG. Fibronectin extra domain-A promotes hepatic stellate cell motility but not differentiation into myofibroblasts. Gastroenterology. 2012 Apr; 142(4):928-937.e3. PMID: 22202457.
    Citations: 22     Fields:    Translation:AnimalsCells
  18. Lang Kuhs KA, Toporovski R, Ginsberg AA, Olsen AL, Shedlock DJ, Morrow MP, Yan J, Wells RG, Weiner DB. Peripheral immunization induces functional intrahepatic hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver. Hum Vaccin. 2011 Dec; 7(12):1326-35. PMID: 22108033.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  19. Olsen AL, Bloomer SA, Chan EP, Gaça MD, Georges PC, Sackey B, Uemura M, Janmey PA, Wells RG. Hepatic stellate cells require a stiff environment for myofibroblastic differentiation. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G110-8. PMID: 21527725.
    Citations: 115     Fields:    Translation:AnimalsCells
  20. Olsen AL, Stachura DL, Weiss MJ. Designer blood: creating hematopoietic lineages from embryonic stem cells. Blood. 2006 Feb 15; 107(4):1265-75. PMID: 16254136.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  21. Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons D, Lange CA. Regulated association of protein kinase B/Akt with breast tumor kinase. J Biol Chem. 2005 Jan 21; 280(3):1982-91. PMID: 15539407.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  22. Qiu M, Olsen A, Faivre E, Horwitz KB, Lange CA. Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors. Mol Endocrinol. 2003 Apr; 17(4):628-42. PMID: 12554776.
    Citations: 49     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.