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Pablo A Valdes Quevedo, M.D., Ph.D.

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Biography
Dartmouth Medical School, Hanover, NHMD06/2014Medicine
Thayer School of Engineering at Dartmouth, Hanover, NHPhD06/2011Engineering Sciences

Overview
We are currently working on developing novel imaging technologies for macroscopic and nanoscopic imaging of brain tumors. These include but are not limited to optical imaging technologies such as intraoperative fluorescence imaging for brain tumor surgery, diffuse reflectance spectroscopy, wide-field imaging for optical property measurements, hyperspectral imaging, and nanoscale imaging of cells and molecules.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Valdes PA, Angelo JP, Choi HS, Gioux S. qF-SSOP: real-time optical property corrected fluorescence imaging. Biomed Opt Express. 2017 Aug 01; 8(8):3597-3605. PMID: 28856038.
    Citations: 3     
  2. Dasenbrock HH, Yan SC, Smith TR, Valdes PA, Gormley WB, Claus EB, Dunn IF. Readmission After Craniotomy for Tumor: A National Surgical Quality Improvement Program Analysis. Neurosurgery. 2017 04 01; 80(4):551-562. PMID: 28362921.
    Citations: 1     Fields:    Translation:Humans
  3. Valdés PA, Roberts DW, Lu FK, Golby A. Optical technologies for intraoperative neurosurgical guidance. Neurosurg Focus. 2016 Mar; 40(3):E8. PMID: 26926066.
    Citations: 5     Fields:    Translation:Humans
  4. Jermyn M, Gosselin Y, Valdes PA, Sibai M, Kolste K, Mercier J, Angulo L, Roberts DW, Paulsen KD, Petrecca K, Daigle O, Wilson BC, Leblond F. Improved sensitivity to fluorescence for cancer detection in wide-field image-guided neurosurgery. Biomed Opt Express. 2015 Dec 01; 6(12):5063-74. PMID: 26713218.
    Citations: 1     
  5. Valdés PA, Jacobs V, Harris BT, Wilson BC, Leblond F, Paulsen KD, Roberts DW. Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. J Neurosurg. 2015 Sep; 123(3):771-80. PMID: 26140489.
    Citations: 9     Fields:    Translation:Humans
  6. Kolste KK, Kanick SC, Valdés PA, Jermyn M, Wilson BC, Roberts DW, Paulsen KD, Leblond F. Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance. J Biomed Opt. 2015 Feb; 20(2):26002. PMID: 25652704.
    Citations: 5     Fields:    
  7. Valdes PA, Bekelis K, Harris BT, Wilson BC, Leblond F, Kim A, Simmons NE, Erkmen K, Paulsen KD, Roberts DW. 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo. Neurosurgery. 2014 Mar; 10 Suppl 1:74-82; discussion 82-3. PMID: 23887194.
    Citations: 14     Fields:    Translation:Humans
  8. Sexton K, Davis SC, McClatchy D, Valdes PA, Kanick SC, Paulsen KD, Roberts DW, Pogue BW. Pulsed-light imaging for fluorescence guided surgery under normal room lighting. Opt Lett. 2013 Sep 01; 38(17):3249-52. PMID: 23988926.
    Citations: 10     Fields:    Translation:Animals
  9. Valdes PA, Jacobs VL, Wilson BC, Leblond F, Roberts DW, Paulsen KD. System and methods for wide-field quantitative fluorescence imaging during neurosurgery. Opt Lett. 2013 Aug 01; 38(15):2786-8. PMID: 23903142.
    Citations: 10     Fields:    Translation:Animals
  10. Li Y, Rey-Dios R, Roberts DW, Valdés PA, Cohen-Gadol AA. Intraoperative fluorescence-guided resection of high-grade gliomas: a comparison of the present techniques and evolution of future strategies. World Neurosurg. 2014 Jul-Aug; 82(1-2):175-85. PMID: 23851210.
    Citations: 28     Fields:    Translation:Humans
  11. Kadoury S, Abi-Jaoudeh N, Valdes PA. Higher-order CRF tumor segmentation with discriminant manifold potentials. Med Image Comput Comput Assist Interv. 2013; 16(Pt 1):719-26. PMID: 24505731.
    Citations:    Fields:    Translation:Humans
  12. Valdés PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW. Quantitative, spectrally-resolved intraoperative fluorescence imaging. Sci Rep. 2012; 2:798. PMID: 23152935.
    Citations: 27     Fields:    Translation:HumansAnimals
  13. Valdés PA, Moses ZB, Kim A, Belden CJ, Wilson BC, Paulsen KD, Roberts DW, Harris BT. Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. J Neuropathol Exp Neurol. 2012 Sep; 71(9):806-13. PMID: 22878664.
    Citations: 5     Fields:    Translation:Humans
  14. Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Ji S, Leblond F, Tosteson TD, Wilson BC, Paulsen KD. Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid). Neurosurg Clin N Am. 2012 Jul; 23(3):371-7. PMID: 22748650.
    Citations: 15     Fields:    Translation:Humans
  15. Valdés PA, Leblond F, Kim A, Wilson BC, Paulsen KD, Roberts DW. A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery. Opt Lett. 2012 Jun 01; 37(11):1817-9. PMID: 22660039.
    Citations: 10     Fields:    Translation:HumansAnimals
  16. Konecky SD, Owen CM, Rice T, Valdés PA, Kolste K, Wilson BC, Leblond F, Roberts DW, Paulsen KD, Tromberg BJ. Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models. J Biomed Opt. 2012 May; 17(5):056008. PMID: 22612131.
    Citations: 9     Fields:    Translation:AnimalsCells
  17. Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Ji S, Pogue BW, Leblond F, Tosteson TD, Wilson BC, Paulsen KD. Adjuncts for maximizing resection: 5-aminolevuinic acid. Clin Neurosurg. 2012; 59:75-8. PMID: 22960516.
    Citations: 3     Fields:    Translation:Humans
  18. Valdés PA, Kim A, Leblond F, Conde OM, Harris BT, Paulsen KD, Wilson BC, Roberts DW. Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. J Biomed Opt. 2011 Nov; 16(11):116007. PMID: 22112112.
    Citations: 25     Fields:    Translation:Humans
  19. Leblond F, Ovanesyan Z, Davis SC, Valdés PA, Kim A, Hartov A, Wilson BC, Pogue BW, Paulsen KD, Roberts DW. Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub-surface imaging. Phys Med Biol. 2011 Nov 07; 56(21):6823-37. PMID: 21971201.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Belden CJ, Valdes PA, Ran C, Pastel DA, Harris BT, Fadul CE, Israel MA, Paulsen K, Roberts DW. Genetics of glioblastoma: a window into its imaging and histopathologic variability. Radiographics. 2011 Oct; 31(6):1717-40. PMID: 21997991.
    Citations: 9     Fields:    Translation:HumansAnimals
  21. Jacobs VL, Valdes PA, Hickey WF, De Leo JA. Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model. ASN Neuro. 2011 Aug 03; 3(3):e00063. PMID: 21740400.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  22. Valdés PA, Kim A, Brantsch M, Niu C, Moses ZB, Tosteson TD, Wilson BC, Paulsen KD, Roberts DW, Harris BT. d-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy. Neuro Oncol. 2011 Aug; 13(8):846-56. PMID: 21798847.
    Citations: 31     Fields:    Translation:Humans
  23. Whitson WJ, Valdes PA, Harris BT, Paulsen KD, Roberts DW. Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report. Neurosurgery. 2011 Jun; 68(6):E1768-72; discussion E1772-3. PMID: 21389893.
    Citations: 8     Fields:    Translation:Humans
  24. Bekelis K, Valdés PA, Erkmen K, Leblond F, Kim A, Wilson BC, Harris BT, Paulsen KD, Roberts DW. Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. Neurosurg Focus. 2011 May; 30(5):E8. PMID: 21529179.
    Citations: 14     Fields:    Translation:Humans
  25. Valdés PA, Leblond F, Kim A, Harris BT, Wilson BC, Fan X, Tosteson TD, Hartov A, Ji S, Erkmen K, Simmons NE, Paulsen KD, Roberts DW. Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. J Neurosurg. 2011 Jul; 115(1):11-7. PMID: 21438658.
    Citations: 53     Fields:    Translation:HumansCTClinical Trials
  26. Lollis SS, Valdes PA, Li Z, Ball PA, Roberts DW. Cause-specific mortality among neurosurgeons. J Neurosurg. 2010 Sep; 113(3):474-8. PMID: 20170305.
    Citations: 2     Fields:    Translation:Humans
  27. Pogue BW, Gibbs-Strauss S, Valdés PA, Samkoe K, Roberts DW, Paulsen KD. Review of Neurosurgical Fluorescence Imaging Methodologies. IEEE J Sel Top Quantum Electron. 2010 May; 16(3):493-505. PMID: 20671936.
    Citations: 28     
  28. Roberts DW, Valdés PA, Harris BT, Fontaine KM, Hartov A, Fan X, Ji S, Lollis SS, Pogue BW, Leblond F, Tosteson TD, Wilson BC, Paulsen KD. Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between d-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article. J Neurosurg. 2011 Mar; 114(3):595-603. PMID: 20380535.
    Citations: 59     Fields:    Translation:Humans
  29. Valdés PA, Samkoe K, O'Hara JA, Roberts DW, Paulsen KD, Pogue BW. Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model. Photochem Photobiol. 2010 Mar-Apr; 86(2):471-5. PMID: 20003159.
    Citations: 12     Fields:    Translation:HumansAnimals
  30. Leblond F, Davis SC, Valdés PA, Pogue BW. Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications. J Photochem Photobiol B. 2010 Jan 21; 98(1):77-94. PMID: 20031443.
    Citations: 117     Fields:    Translation:Animals
  31. Valdés PA, Fan X, Ji S, Harris BT, Paulsen KD, Roberts DW. Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection. Stereotact Funct Neurosurg. 2010; 88(1):1-10. PMID: 19907205.
    Citations: 20     Fields:    Translation:Humans
  32. Geoghegan JC, Valdes PA, Orem NR, Deleault NR, Williamson RA, Harris BT, Supattapone S. Selective incorporation of polyanionic molecules into hamster prions. J Biol Chem. 2007 Dec 14; 282(50):36341-53. PMID: 17940287.
    Citations: 43     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.