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Min Dong, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21CA235533 (DONG, MIN) Dec 7, 2018 - Nov 30, 2020
    Novel anti-cancer biologics targeting Wnt signaling pathway
    Role: Principal Investigator
  2. R01AI139087 (DONG, MIN) May 15, 2018 - Apr 30, 2023
    Structure and Function of C. Difficile Toxins
    Role: Principal Investigator
  3. R21NS106159 (DONG, MIN) Apr 1, 2018 - Mar 31, 2020
    Molecular mechanism for retrograde transport of tetanus neurotoxin
    Role: Principal Investigator
  4. R01AI132387 (DONG, MIN) Jun 1, 2017 - May 31, 2022
    Molecular basis of action and pathogenesis of Clostridium difficile toxin B
    Role: Principal Investigator
  5. R21NS082830 (DONG, MIN) May 1, 2015 - Aug 31, 2015
    Next generation of botulinum neurotoxins with enhanced binding to human receptors
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tian S, Liu Y, Appleton E, Wang H, Church GM, Dong M. Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms. Cell Rep. 2022 03 08; 38(10):110476. PMID: 35263584; PMCID: PMC8958846.
    Citations:    Fields:    Translation:HumansCells
  2. Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS, Abraham J, Dong M. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 2022 03 31; 185(7):1157-1171.e22. PMID: 35259335; PMCID: PMC8978092.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Thaker H, Zhang J, Miyashita SI, Cristofaro V, Park S, Hashemi Gheinani A, Sullivan MP, Adam RM, Dong M. Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins. PLoS Pathog. 2021 10; 17(10):e1009994. PMID: 34662366; PMCID: PMC8553082.
    Citations: 2     Fields:    Translation:Animals
  4. Thaker H, Zhang S, Diamond DA, Dong M. Beyond botulinum neurotoxin A for chemodenervation of the bladder. Curr Opin Urol. 2021 03 01; 31(2):140-146. PMID: 33394765; PMCID: PMC7983298.
    Citations: 1     Fields:    Translation:Humans
  5. Blum TR, Liu H, Packer MS, Xiong X, Lee PG, Zhang S, Richter M, Minasov G, Satchell KJF, Dong M, Liu DR. Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity. Science. 2021 02 19; 371(6531):803-810. PMID: 33602850.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  6. Shao DD, Straussberg R, Ahmed H, Khan A, Tian S, Hill RS, Smith RS, Majmundar AJ, Ameziane N, Neil JE, Yang E, Al Tenaiji A, Jamuar SS, Schlaeger TM, Al-Saffar M, Hovel I, Al-Shamsi A, Basel-Salmon L, Amir AZ, Rento LM, Lim JY, Ganesan I, Shril S, Evrony G, Barkovich AJ, Bauer P, Hildebrandt F, Dong M, Borck G, Beetz C, Al-Gazali L, Eyaid W, Walsh CA. A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features. Genet Med. 2021 06; 23(6):1158-1162. PMID: 33531666; PMCID: PMC8187145.
    Citations: 4     Fields:    Translation:Humans
  7. Miyashita SI, Zhang J, Zhang S, Shoemaker CB, Dong M. Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism. Sci Transl Med. 2021 01 06; 13(575). PMID: 33408184.
    Citations: 12     Fields:    Translation:AnimalsCells
  8. Dong M, Stenmark P. The Structure and Classification of Botulinum Toxins. Handb Exp Pharmacol. 2021; 263:11-33. PMID: 31792680.
    Citations: 10     Fields:    Translation:Humans
  9. Soul JS, Bergin AM, Stopp C, Hayes B, Singh A, Fortuno CR, O'Reilly D, Krishnamoorthy K, Jensen FE, Rofeberg V, Dong M, Vinks AA, Wypij D, Staley KJ. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Ann Neurol. 2021 02; 89(2):327-340. PMID: 33201535; PMCID: PMC8122513.
    Citations: 12     Fields:    Translation:Humans
  10. Tian S, Liu Y, Wu H, Liu H, Zeng J, Choi MY, Chen H, Gerhard R, Dong M. Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL. Cell Host Microbe. 2020 05 13; 27(5):782-792.e7. PMID: 32302524; PMCID: PMC7228847.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. Yin L, Masuyer G, Zhang S, Zhang J, Miyashita SI, Burgin D, Lovelock L, Coker SF, Fu TM, Stenmark P, Dong M. Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. PLoS Biol. 2020 03; 18(3):e3000618. PMID: 32182233.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Tian S, Wu Q, Zhou B, Choi MY, Ding B, Yang W, Dong M. Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Cell Rep. 2019 09 03; 28(10):2517-2526.e5. PMID: 31484065.
    Citations: 18     Fields:    Translation:HumansCells
  13. Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769. PMID: 31160825; PMCID: PMC6754795.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  14. Mansfield MJ, Wentz TG, Zhang S, Lee EJ, Dong M, Sharma SK, Doxey AC. Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins. Sci Rep. 2019 02 07; 9(1):1634. PMID: 30733520.
    Citations: 18     Fields:    Translation:HumansCells
  15. Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp J. Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Sci Adv. 2019 01; 5(1):eaau7196. PMID: 30746458; PMCID: PMC6357751.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  16. Shen Y, Wu SY, Rancic V, Aggarwal A, Qian Y, Miyashita SI, Ballanyi K, Campbell RE, Dong M. Genetically encoded fluorescent indicators for imaging intracellular potassium ion concentration. Commun Biol. 2019 Jan 14; 2(1):18. PMID: 31924910.
  17. Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M. Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS Biol. 2018 11; 16(11):e2006951. PMID: 30481169; PMCID: PMC6258472.
    Citations: 32     Fields:    Translation:HumansCells
  18. Dong M, Masuyer G, Stenmark P. Botulinum and Tetanus Neurotoxins. Annu Rev Biochem. 2019 06 20; 88:811-837. PMID: 30388027.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  19. Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R. Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science. 2018 05 11; 360(6389):664-669. PMID: 29748286; PMCID: PMC6231499.
    Citations: 48     Fields:    Translation:HumansCells
  20. Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding. Toxins (Basel). 2018 04 12; 10(4). PMID: 29649119.
    Citations: 8     Fields:    Translation:Cells
  21. Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host Microbe. 2018 Feb 14; 23(2):169-176.e6. PMID: 29396040.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  22. Zhang S, Berntsson RP, Tepp WH, Tao L, Johnson EA, Stenmark P, Dong M. Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC. Nat Commun. 2017 11 21; 8(1):1637. PMID: 29158482.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  23. Huang NJ, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, Dong M, Shoemaker CB, Lodish HF. Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Nat Commun. 2017 09 04; 8(1):423. PMID: 28871080.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  24. Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P. Identification and characterization of a novel botulinum neurotoxin. Nat Commun. 2017 08 03; 8:14130. PMID: 28770820.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  25. Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M. Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nat Commun. 2017 07 03; 8(1):53. PMID: 28674381.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  26. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. PMID: 27680706; PMCID: PMC5519134.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  27. Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 2016 07; 23(7):656-62. PMID: 27294781; PMCID: PMC5033645.
    Citations: 50     Fields:    Translation:HumansCells
  28. Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014 Jul; 10(7):e1004177. PMID: 25010769.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  29. Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science. 2014 Jun 20; 344(6190):1405-10. PMID: 24948737.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  30. Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong M. Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun. 2013; 4:1472. PMID: 23403573.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  31. Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M. Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci. 2012 Jul 01; 125(Pt 13):3233-42. PMID: 22454523.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  32. Peng L, Tepp WH, Johnson EA, Dong M. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog. 2011 Mar; 7(3):e1002008. PMID: 21483489.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.