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profileMin Dong, Ph.D.

TitleAssistant Professor of Surgery
InstitutionBoston Children's Hospital
DepartmentSurgery
AddressChildren's Hospital
Dept. of Urology, En 1070
300 Longwood Ave
Boston MA 02115
Phone857/218-4232
Fax617/525-2510
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Available: 07/06/17, Expires: 06/12/19

Investigate how botulinum neurotoxins target and enter neurons and also improving the therapeutic efficacy of botulinum neurotoxins through protein engineering.


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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AI132387     (DONG, MIN)Jun 1, 2017 - May 31, 2022
NIH/NIAID
Molecular basis of action and pathogenesis of Clostridium difficile toxin B
Role: Principal Investigator

R21NS082830     (DONG, MIN)Sep 30, 2013 - Aug 31, 2015
NIH/NINDS
Next generation of botulinum neurotoxins with enhanced binding to human receptors
Role: Principal Investigator

R01NS080833     (DONG, MIN)Mar 1, 2013 - Feb 28, 2018
NIH/NINDS
Long-term effects of botulinum neurotoxins on neuronal viability
Role: Principal Investigator

R56AI097834     (DONG, MIN)Aug 20, 2012 - Aug 19, 2014
NIH/NIAID
Cytotoxicity of botulinum neurotoxins
Role: Principal Investigator

P51RR000168     (FLIER, JEFFREY S)Jun 1, 1978 - Apr 30, 2013
NIH/NCRR
New England Primate Research Center Base Grant
Role: Co-Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P. Identification and characterization of a novel botulinum neurotoxin. Nat Commun. 2017 Aug 03; 8:14130. PMID: 28770820.
    View in: PubMed
  2. Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M. Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nat Commun. 2017 Jul 03; 8(1):53. PMID: 28674381.
    View in: PubMed
  3. Ma Y, Yang AC, Duan Y, Dong M, Yeung AS. Quality and readability of online information resources on insomnia. Front Med. 2017 Sep; 11(3):423-431. PMID: 28500432.
    View in: PubMed
  4. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. PMID: 27680706.
    View in: PubMed
  5. Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014 Jul; 10(7):e1004177. PMID: 25010769; PMCID: PMC4092145.
  6. Lü J, Yang J, Dong M, Sahin O. Nanomechanical spectroscopy of synthetic and biological membranes. Nanoscale. 2014 Jul 07; 6(13):7604-8. PMID: 24895687.
    View in: PubMed
  7. Zhang Z, Song J, Besenbacher F, Dong M, Gothelf KV. Self-assembly of DNA origami and single-stranded tile structures at room temperature. Angew Chem Int Ed Engl. 2013 Aug 26; 52(35):9219-23. PMID: 23843201.
    View in: PubMed
  8. Song J, Zhang Z, Zhang S, Liu L, Li Q, Xie E, Gothelf KV, Besenbacher F, Dong M. Isothermal hybridization kinetics of DNA assembly of two-dimensional DNA origami. Small. 2013 Sep 09; 9(17):2954-9. PMID: 23436715.
    View in: PubMed
  9. Zhang S, Andreasen M, Nielsen JT, Liu L, Nielsen EH, Song J, Ji G, Sun F, Skrydstrup T, Besenbacher F, Nielsen NC, Otzen DE, Dong M. Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2798-803. PMID: 23388629; PMCID: PMC3581879.
  10. Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong M. Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun. 2013; 4:1472. PMID: 23403573; PMCID: PMC4052923.
  11. Pfeffer C, Larsen S, Song J, Dong M, Besenbacher F, Meyer RL, Kjeldsen KU, Schreiber L, Gorby YA, El-Naggar MY, Leung KM, Schramm A, Risgaard-Petersen N, Nielsen LP. Filamentous bacteria transport electrons over centimetre distances. Nature. 2012 Nov 08; 491(7423):218-21. PMID: 23103872.
    View in: PubMed
  12. Song J, Arbona JM, Zhang Z, Liu L, Xie E, Elezgaray J, Aime JP, Gothelf KV, Besenbacher F, Dong M. Direct visualization of transient thermal response of a DNA origami. J Am Chem Soc. 2012 Jun 20; 134(24):9844-7. PMID: 22646845.
    View in: PubMed
  13. Chen M, Gao S, Dong M, Song J, Yang C, Howard KA, Kjems J, Besenbacher F. Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano. 2012 Jun 26; 6(6):4835-44. PMID: 22621383.
    View in: PubMed
  14. Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M. Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci. 2012 Jul 01; 125(Pt 13):3233-42. PMID: 22454523; PMCID: PMC4067266.
  15. Song J, Kahveci D, Chen M, Guo Z, Xie E, Xu X, Besenbacher F, Dong M. Enhanced catalytic activity of lipase encapsulated in PCL nanofibers. Langmuir. 2012 Apr 10; 28(14):6157-62. PMID: 22397625.
    View in: PubMed
  16. Song J, Chen M, Olesen MB, Wang C, Havelund R, Li Q, Xie E, Yang R, Bøggild P, Wang C, Besenbacher F, Dong M. Direct electrospinning of Ag/polyvinylpyrrolidone nanocables. Nanoscale. 2011 Dec; 3(12):4966-71. PMID: 21989684.
    View in: PubMed
  17. Peng L, Tepp WH, Johnson EA, Dong M. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog. 2011 Mar; 7(3):e1002008. PMID: 21483489; PMCID: PMC3068998.
  18. Dong M, Sahin O. A nanomechanical interface to rapid single-molecule interactions. Nat Commun. 2011; 2:247. PMID: 21427718.
    View in: PubMed
  19. Liu H, Tørring T, Dong M, Rosen CB, Besenbacher F, Gothelf KV. DNA-templated covalent coupling of G4 PAMAM dendrimers. J Am Chem Soc. 2010 Dec 29; 132(51):18054-6. PMID: 21133363.
    View in: PubMed
  20. Michelow IC, Dong M, Mungall BA, Yantosca LM, Lear C, Ji X, Karpel M, Rootes CL, Brudner M, Houen G, Eisen DP, Kinane TB, Takahashi K, Stahl GL, Olinger GG, Spear GT, Ezekowitz RA, Schmidt EV. A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus. J Biol Chem. 2010 Aug 06; 285(32):24729-39. PMID: 20516066; PMCID: PMC2915709.
  21. Dong M, Husale S, Sahin O. Determination of protein structural flexibility by microsecond force spectroscopy. Nat Nanotechnol. 2009 Aug; 4(8):514-7. PMID: 19662014.
    View in: PubMed
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