Harvard Catalyst Profiles

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Charles Lee Evavold, Ph.D.

Title
Institution
Department
Address

Biography
Emory University, Atlanta, GABS05/2013Physics and Astronomy
Emory University, Atlanta, GABS05/2013Chemistry
Harvard University, Cambridge, MAPhD11/2021Immunology

Overview
Research Overview


The Evavold lab studies fundamental cellular decision making towards different cell fates using cell death programs as a model system. We have a particular interest in the intersection of microbiology and metabolism with impact on host cell survival or death.

Regulated cell death can serve different functions within the innate immune system. For example, immunologically silent cell death can remove unnecessary, damaged, or pre-malignant cells during development and homeostasis. Alternatively, during the early containment of a pathogen, inflammatory cell death can alert the immune system to a foreign invader. However, inflammatory cell death can become pathogenic during systemic infection or contribute to sterile autoimmunity and chronic inflammation. Conversely, acquired resistance to cell death programs can promote cancer progression or resistance to chemotherapies. Dysfunction of cell death regulation may underlie much of the pathology related to human diseases. Thus, we aim to uncover novel regulation in these processes using precision screening that combines genomic or chemical perturbations with synthetic biology models of discrete signaling nodes.

Dr. Charlie Evavold received his PhD in Immunology from Harvard University. He received his BS in Physics and Astronomy with a double major in Chemistry from Emory University. Charlie is one of the inaugural Ragon Early Independence Fellows on the basic science track.

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Evavold CL, Hafner-Bratkovic I, Devant P, D'Andrea JM, Ngwa EM, Boršic E, Doench JG, LaFleur MW, Sharpe AH, Thiagarajah JR, Kagan JC. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021 08 19; 184(17):4495-4511.e19. PMID: 34289345.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  2. Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020 09 18; 369(6510). PMID: 32943500.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  3. Smith CB, Evavold C, Kersh GJ. The Effect of pH on Antibiotic Efficacy against Coxiella burnetii in Axenic Media. Sci Rep. 2019 12 02; 9(1):18132. PMID: 31792307.
    Citations:    
  4. Evavold CL, Kagan JC. Inflammasomes: Threat-Assessment Organelles of the Innate Immune System. Immunity. 2019 10 15; 51(4):609-624. PMID: 31473100.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  5. Evavold CL, Kagan JC. Defying Death: The (W)hole Truth about the Fate of GSDMD Pores. Immunity. 2019 01 15; 50(1):15-17. PMID: 30650374.
    Citations: 9     Fields:    Translation:Cells
  6. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. 2018 01 16; 48(1):35-44.e6. PMID: 29195811.
    Citations: 288     Fields:    Translation:HumansAnimalsCells
  7. Evavold CL, Kagan JC. How Inflammasomes Inform Adaptive Immunity. J Mol Biol. 2018 01 19; 430(2):217-237. PMID: 28987733.
    Citations: 53     Fields:    Translation:HumansAnimals
  8. Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ. PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016 11 08; 17(7):1764-1772. PMID: 27829148.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  9. Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ. SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 2016 Apr 08; 352(6282):242-6. PMID: 26989197.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  10. Biggs HM, Turabelidze G, Pratt D, Todd SR, Jacobs-Slifka K, Drexler NA, McCurdy G, Lloyd J, Evavold CL, Fitzpatrick KA, Priestley RA, Singleton J, Sun D, Tang M, Kato C, Kersh GJ, Anderson A. Coxiella burnetii Infection in a Community Operating a Large-Scale Cow and Goat Dairy, Missouri, 2013. Am J Trop Med Hyg. 2016 Mar; 94(3):525-31. PMID: 26811433.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.