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profileYoko Okunuki, Ph.D., M.D.

TitleResearch Fellow in Ophthalmology (EXT)
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
Angiogenesis Lab. 4th floor
325 Cambridge St
Boston MA 02114
Phone617/573-4008
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A. 2017 Sep 05; 114(36):E7545-E7553. PMID: 28827330.
    View in: PubMed
  2. Usui Y, Tsubota K, Agawa T, Ueda S, Umazume K, Okunuki Y, Kezuka T, Yamakawa N, Goto H. Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors. Graefes Arch Clin Exp Ophthalmol. 2017 Feb; 255(2):393-399. PMID: 27878431.
    View in: PubMed
  3. Matsuda R, Kezuka T, Umazume A, Okunuki Y, Goto H, Tanaka K. Clinical Profile of Anti-Myelin Oligodendrocyte Glycoprotein Antibody Seropositive Cases of Optic Neuritis. Neuroophthalmology. 2015 Oct; 39(5):213-219. PMID: 27928358.
    View in: PubMed
  4. Okunuki Y, Tsubota K, Kezuka T, Goto H. Differences in the clinical features of two types of Vogt-Koyanagi-Harada disease: serous retinal detachment and optic disc swelling. Jpn J Ophthalmol. 2015 Mar; 59(2):103-8. PMID: 25465197.
    View in: PubMed
  5. Agawa T, Usui Y, Wakabayashi Y, Okunuki Y, Juan M, Umazume K, Kezuka T, Takeuchi M, Yamauchi Y, Goto H. Profile of intraocular immune mediators in patients with age-related macular degeneration and the effect of intravitreal bevacizumab injection. Retina. 2014 Sep; 34(9):1811-8. PMID: 24801651.
    View in: PubMed
  6. Okunuki Y, Sakai J, Kezuka T, Goto H. A case of herpes zoster uveitis with severe hyphema. BMC Ophthalmol. 2014 May 29; 14:74. PMID: 24885484; PMCID: PMC4046036.
  7. Umazume A, Kezuka T, Okunuki Y, Ooshita M, Usui Y, Hirano M, Yamashina A, Goto H. Prediction of severe cardiac involvement by fundus lesion in sarcoidosis. Jpn J Ophthalmol. 2014 Jan; 58(1):81-5. PMID: 24212542.
    View in: PubMed
  8. Okunuki Y, Usui Y, Nakagawa H, Tajima K, Matsuda R, Ueda S, Hattori T, Kezuka T, Goto H. Peroxisome proliferator-activated receptor-? agonist pioglitazone suppresses experimental autoimmune uveitis. Exp Eye Res. 2013 Nov; 116:291-7. PMID: 24107513.
    View in: PubMed
  9. Umazume K, Usui Y, Wakabayashi Y, Okunuki Y, Kezuka T, Goto H. Effects of soluble CD14 and cytokine levels on diabetic macular edema and visual acuity. Retina. 2013 May; 33(5):1020-5. PMID: 23095769.
    View in: PubMed
  10. Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, Yamakawa N, Ogawa H, Okumura K, Goto H. Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis. Invest Ophthalmol Vis Sci. 2012 Oct 19; 53(11):7235-45. PMID: 23033382.
    View in: PubMed
  11. Wakabayashi Y, Usui Y, Okunuki Y, Ueda S, Kimura K, Muramatsu D, Kezuka T, Goto H. Intraocular VEGF level as a risk factor for postoperative complications after vitrectomy for proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012 Sep 21; 53(10):6403-10. PMID: 22899753.
    View in: PubMed
  12. Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, Yamakawa N, Ogawa H, Okumura K, Goto H. Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related Peptide gene. Invest Ophthalmol Vis Sci. 2012 Aug 13; 53(9):5475-85. PMID: 22807299.
    View in: PubMed
  13. Usui Y, Wakabayashi Y, Okunuki Y, Kimura K, Tajima K, Matsuda R, Ueda S, Ma J, Nagai T, Mori H, Kezuka T, Nagao T, Goto H. Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma. Invest Ophthalmol Vis Sci. 2012 Aug 09; 53(9):5395-402. PMID: 22789925.
    View in: PubMed
  14. Muramatsu D, Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Goto H. Correlation of complement fragment C5a with inflammatory cytokines in the vitreous of patients with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2013 Jan; 251(1):15-7. PMID: 22527328.
    View in: PubMed
  15. Ma J, Usui Y, Kezuka T, Okunuki Y, Zhang L, An X, Mizota A, Goto H. Costimulatory molecule expression on human uveal melanoma cells: functional analysis of CD40 and B7-H1. Exp Eye Res. 2012 Mar; 96(1):98-106. PMID: 22200489.
    View in: PubMed
  16. Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Iwasaki T, Ohno A, Goto H. Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy. Retina. 2011 Oct; 31(9):1951-7. PMID: 21610567.
    View in: PubMed
  17. Okunuki Y, Usui Y, Katai N, Kezuka T, Takeuchi M, Goto H, Wakabayashi Y. Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion. Am J Ophthalmol. 2011 Apr; 151(4):610-616.e1. PMID: 21257152.
    View in: PubMed
  18. Okunuki Y, Usui Y, Kezuka T, Takeuchi M, Goto H. Four cases of bilateral acute retinal necrosis with a long interval after the initial onset. Br J Ophthalmol. 2011 Sep; 95(9):1251-4. PMID: 21242577.
    View in: PubMed
  19. Ma J, Usui Y, Takeuchi M, Okunuki Y, Kezuka T, Zhang L, Mizota A, Goto H. Human uveal melanoma cells inhibit the immunostimulatory function of dendritic cells. Exp Eye Res. 2010 Oct; 91(4):491-9. PMID: 20624388.
    View in: PubMed
  20. Usui Y, Takeuchi M, Yamakawa N, Takeuchi A, Kezuka T, Ma J, Matsuda R, Okunuki Y, Akiba H, Goto H. Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behçet's patients with uveitis: a new activity marker? Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5099-104. PMID: 20445113.
    View in: PubMed
  21. Usui Y, Takeuchi M, Yamauchi Y, Kezuka T, Okunuki Y, Mori H, Sakai J, Goto H. [Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]. Nippon Ganka Gakkai Zasshi. 2010 Apr; 114(4):362-8. PMID: 20432961.
    View in: PubMed
  22. Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Goto H, Iwasaki T. Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy. Retina. 2010 Feb; 30(2):339-44. PMID: 20142713.
    View in: PubMed
  23. Takeuchi M, Usui Y, Okunuki Y, Zhang L, Ma J, Yamakawa N, Hattori T, Kezuka T, Sakai J, Goto H. Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3067-75. PMID: 20089879.
    View in: PubMed
  24. Zhang L, Ma J, Takeuchi M, Usui Y, Hattori T, Okunuki Y, Yamakawa N, Kezuka T, Kuroda M, Goto H. Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):2109-17. PMID: 20007828.
    View in: PubMed
  25. Takeuchi M, Iwasaki T, Kezuka T, Usui Y, Okunuki Y, Sakai J, Goto H. Functional and morphological changes in the eyes of Behçet's patients with uveitis. Acta Ophthalmol. 2010 Mar; 88(2):257-62. PMID: 19489762.
    View in: PubMed
  26. Hattori T, Kezuka T, Usui Y, Okunuki Y, Takeuchi M, Maruyama K, Haneda M, Shirato S, Goto H. Human iris pigment epithelial cells suppress T-cell activation via direct cell contact. Exp Eye Res. 2009 Sep; 89(3):358-64. PMID: 19379738.
    View in: PubMed
  27. Usui Y, Takeuchi M, Hattori T, Okunuki Y, Nagasawa K, Kezuka T, Okumura K, Yagita H, Akiba H, Goto H. Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice. Arch Ophthalmol. 2009 Apr; 127(4):514-9. PMID: 19365033.
    View in: PubMed
  28. Takeuchi A, Takeuchi M, Oikawa K, Sonoda KH, Usui Y, Okunuki Y, Takeda A, Oshima Y, Yoshida K, Usui M, Goto H, Kuroda M. Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3410-6. PMID: 19182260.
    View in: PubMed
  29. Okunuki Y, Usui Y, Nagai N, Kezuka T, Ishida S, Takeuchi M, Goto H. Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2255-61. PMID: 19136706.
    View in: PubMed
  30. Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Goto H, Usui M, Nishioka K, Kato T, Takeuchi M. Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain-type creatine kinase as novel autoantigens. Mol Vis. 2008 Jun 12; 14:1094-104. PMID: 18552983; PMCID: PMC2426731.
  31. Hattori T, Usui Y, Okunuki Y, Sonoda Y, Usui M, Takada E, Mizuguchi J, Yagita H, Okumura K, Akiba H, Takeuchi M. Blockade of the OX40 ligand prolongs corneal allograft survival. Eur J Immunol. 2007 Dec; 37(12):3597-604. PMID: 18022861.
    View in: PubMed
  32. Usui Y, Okunuki Y, Hattori T, Kezuka T, Keino H, Ebihara N, Sugita S, Usui M, Goto H, Takeuchi M. Functional expression of B7H1 on retinal pigment epithelial cells. Exp Eye Res. 2008 Jan; 86(1):52-9. PMID: 17981268.
    View in: PubMed
  33. Okunuki Y, Usui Y, Takeuchi M, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Usui M, Nishioka K, Kato T. Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. Exp Eye Res. 2007 May; 84(5):823-31. PMID: 17343851.
    View in: PubMed
  34. Usui Y, Akiba H, Takeuchi M, Kezuka T, Takeuchi A, Hattori T, Okunuki Y, Yamazaki T, Yagita H, Usui M, Okumura K. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis. Eur J Immunol. 2006 Nov; 36(11):3071-81. PMID: 17039566.
    View in: PubMed
  35. Takeuchi M, Keino H, Suzuki J, Usui Y, Hattori T, Takeuchi A, Oh-I K, Okunuki Y, Kezuka T, Usui M. Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients. Exp Eye Res. 2006 Oct; 83(4):981-8. PMID: 16822510.
    View in: PubMed
  36. Takeuchi M, Oh-I K, Suzuki J, Hattori T, Takeuchi A, Okunuki Y, Usui Y, Usui M. Elevated serum levels of CXCL9/monokine induced by interferon-gamma and CXCL10/interferon-gamma-inducible protein-10 in ocular sarcoidosis. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1063-8. PMID: 16505042.
    View in: PubMed
  37. Takeuchi A, Usui Y, Takeuchi M, Hattori T, Kezuka T, Suzuki J, Okunuki Y, Iwasaki T, Haino M, Matsushima K, Usui M. CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3753-60. PMID: 16186359.
    View in: PubMed
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