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Yoko Okunuki, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Okunuki Y, Mukai R, Nakao T, Tabor SJ, Butovsky O, Dana R, Ksander BR, Connor KM. Retinal microglia initiate neuroinflammation in ocular autoimmunity. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):9989-9998. PMID: 31023885.
    Citations: 4     Fields:    Translation:AnimalsCells
  2. Mukai R, Park DH, Okunuki Y, Hasegawa E, Klokman G, Kim CB, Krishnan A, Gregory-Ksander M, Husain D, Miller JW, Connor KM. Mouse model of ocular hypertension with retinal ganglion cell degeneration. PLoS One. 2019; 14(1):e0208713. PMID: 30640920.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Okunuki Y, Mukai R, Pearsall EA, Klokman G, Husain D, Park DH, Korobkina E, Weiner HL, Butovsky O, Ksander BR, Miller JW, Connor KM. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6264-E6273. PMID: 29915052.
    Citations: 13     Fields:    Translation:AnimalsCells
  4. Mukai R, Okunuki Y, Husain D, Kim CB, Lambris JD, Connor KM. The Complement System Is Critical in Maintaining Retinal Integrity during Aging. Front Aging Neurosci. 2018; 10:15. PMID: 29497373.
    Citations: 6     
  5. Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A. 2017 09 05; 114(36):E7545-E7553. PMID: 28827330.
    Citations: 9     Fields:    Translation:AnimalsCells
  6. Usui Y, Tsubota K, Agawa T, Ueda S, Umazume K, Okunuki Y, Kezuka T, Yamakawa N, Goto H. Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors. Graefes Arch Clin Exp Ophthalmol. 2017 Feb; 255(2):393-399. PMID: 27878431.
    Citations: 1     Fields:    Translation:Humans
  7. Matsuda R, Kezuka T, Umazume A, Okunuki Y, Goto H, Tanaka K. Clinical Profile of Anti-Myelin Oligodendrocyte Glycoprotein Antibody Seropositive Cases of Optic Neuritis. Neuroophthalmology. 2015 Oct; 39(5):213-219. PMID: 27928358.
    Citations: 6     
  8. Okunuki Y, Tsubota K, Kezuka T, Goto H. Differences in the clinical features of two types of Vogt-Koyanagi-Harada disease: serous retinal detachment and optic disc swelling. Jpn J Ophthalmol. 2015 Mar; 59(2):103-8. PMID: 25465197.
    Citations: 3     Fields:    Translation:Humans
  9. Agawa T, Usui Y, Wakabayashi Y, Okunuki Y, Juan M, Umazume K, Kezuka T, Takeuchi M, Yamauchi Y, Goto H. Profile of intraocular immune mediators in patients with age-related macular degeneration and the effect of intravitreal bevacizumab injection. Retina. 2014 Sep; 34(9):1811-8. PMID: 24801651.
    Citations: 17     Fields:    Translation:Humans
  10. Okunuki Y, Sakai J, Kezuka T, Goto H. A case of herpes zoster uveitis with severe hyphema. BMC Ophthalmol. 2014 May 29; 14:74. PMID: 24885484.
    Citations: 6     Fields:    Translation:HumansCells
  11. Umazume A, Kezuka T, Okunuki Y, Ooshita M, Usui Y, Hirano M, Yamashina A, Goto H. Prediction of severe cardiac involvement by fundus lesion in sarcoidosis. Jpn J Ophthalmol. 2014 Jan; 58(1):81-5. PMID: 24212542.
    Citations: 2     Fields:    Translation:Humans
  12. Okunuki Y, Usui Y, Nakagawa H, Tajima K, Matsuda R, Ueda S, Hattori T, Kezuka T, Goto H. Peroxisome proliferator-activated receptor-? agonist pioglitazone suppresses experimental autoimmune uveitis. Exp Eye Res. 2013 Nov; 116:291-7. PMID: 24107513.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  13. Umazume K, Usui Y, Wakabayashi Y, Okunuki Y, Kezuka T, Goto H. Effects of soluble CD14 and cytokine levels on diabetic macular edema and visual acuity. Retina. 2013 May; 33(5):1020-5. PMID: 23095769.
    Citations: 3     Fields:    Translation:Humans
  14. Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, Yamakawa N, Ogawa H, Okumura K, Goto H. Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis. Invest Ophthalmol Vis Sci. 2012 Oct 19; 53(11):7235-45. PMID: 23033382.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Wakabayashi Y, Usui Y, Okunuki Y, Ueda S, Kimura K, Muramatsu D, Kezuka T, Goto H. Intraocular VEGF level as a risk factor for postoperative complications after vitrectomy for proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012 Sep 21; 53(10):6403-10. PMID: 22899753.
    Citations: 15     Fields:    Translation:Humans
  16. Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, Yamakawa N, Ogawa H, Okumura K, Goto H. Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related Peptide gene. Invest Ophthalmol Vis Sci. 2012 Aug 13; 53(9):5475-85. PMID: 22807299.
    Citations: 6     Fields:    Translation:AnimalsCells
  17. Usui Y, Wakabayashi Y, Okunuki Y, Kimura K, Tajima K, Matsuda R, Ueda S, Ma J, Nagai T, Mori H, Kezuka T, Nagao T, Goto H. Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma. Invest Ophthalmol Vis Sci. 2012 Aug 09; 53(9):5395-402. PMID: 22789925.
    Citations: 8     Fields:    Translation:Humans
  18. Muramatsu D, Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Goto H. Correlation of complement fragment C5a with inflammatory cytokines in the vitreous of patients with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2013 Jan; 251(1):15-7. PMID: 22527328.
    Citations: 13     Fields:    Translation:Humans
  19. Ma J, Usui Y, Kezuka T, Okunuki Y, Zhang L, An X, Mizota A, Goto H. Costimulatory molecule expression on human uveal melanoma cells: functional analysis of CD40 and B7-H1. Exp Eye Res. 2012 Mar; 96(1):98-106. PMID: 22200489.
    Citations: 4     Fields:    Translation:HumansCells
  20. Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Iwasaki T, Ohno A, Goto H. Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy. Retina. 2011 Oct; 31(9):1951-7. PMID: 21610567.
    Citations: 12     Fields:    Translation:Humans
  21. Okunuki Y, Usui Y, Katai N, Kezuka T, Takeuchi M, Goto H, Wakabayashi Y. Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion. Am J Ophthalmol. 2011 Apr; 151(4):610-616.e1. PMID: 21257152.
    Citations: 7     Fields:    Translation:Humans
  22. Okunuki Y, Usui Y, Kezuka T, Takeuchi M, Goto H. Four cases of bilateral acute retinal necrosis with a long interval after the initial onset. Br J Ophthalmol. 2011 Sep; 95(9):1251-4. PMID: 21242577.
    Citations: 3     Fields:    Translation:HumansCells
  23. Ma J, Usui Y, Takeuchi M, Okunuki Y, Kezuka T, Zhang L, Mizota A, Goto H. Human uveal melanoma cells inhibit the immunostimulatory function of dendritic cells. Exp Eye Res. 2010 Oct; 91(4):491-9. PMID: 20624388.
    Citations: 5     Fields:    Translation:HumansCells
  24. Usui Y, Takeuchi M, Yamakawa N, Takeuchi A, Kezuka T, Ma J, Matsuda R, Okunuki Y, Akiba H, Goto H. Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behçet's patients with uveitis: a new activity marker? Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5099-104. PMID: 20445113.
    Citations: 5     Fields:    Translation:HumansCells
  25. Usui Y, Takeuchi M, Yamauchi Y, Kezuka T, Okunuki Y, Mori H, Sakai J, Goto H. [Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]. Nippon Ganka Gakkai Zasshi. 2010 Apr; 114(4):362-8. PMID: 20432961.
    Citations:    Fields:    Translation:Humans
  26. Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Goto H, Iwasaki T. Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy. Retina. 2010 Feb; 30(2):339-44. PMID: 20142713.
    Citations: 19     Fields:    Translation:Humans
  27. Takeuchi M, Usui Y, Okunuki Y, Zhang L, Ma J, Yamakawa N, Hattori T, Kezuka T, Sakai J, Goto H. Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3067-75. PMID: 20089879.
    Citations: 9     Fields:    Translation:HumansCells
  28. Zhang L, Ma J, Takeuchi M, Usui Y, Hattori T, Okunuki Y, Yamakawa N, Kezuka T, Kuroda M, Goto H. Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):2109-17. PMID: 20007828.
    Citations: 32     Fields:    Translation:AnimalsCells
  29. Takeuchi M, Iwasaki T, Kezuka T, Usui Y, Okunuki Y, Sakai J, Goto H. Functional and morphological changes in the eyes of Behçet's patients with uveitis. Acta Ophthalmol. 2010 Mar; 88(2):257-62. PMID: 19489762.
    Citations: 6     Fields:    Translation:Humans
  30. Hattori T, Kezuka T, Usui Y, Okunuki Y, Takeuchi M, Maruyama K, Haneda M, Shirato S, Goto H. Human iris pigment epithelial cells suppress T-cell activation via direct cell contact. Exp Eye Res. 2009 Sep; 89(3):358-64. PMID: 19379738.
    Citations: 2     Fields:    Translation:HumansCells
  31. Usui Y, Takeuchi M, Hattori T, Okunuki Y, Nagasawa K, Kezuka T, Okumura K, Yagita H, Akiba H, Goto H. Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice. Arch Ophthalmol. 2009 Apr; 127(4):514-9. PMID: 19365033.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Takeuchi A, Takeuchi M, Oikawa K, Sonoda KH, Usui Y, Okunuki Y, Takeda A, Oshima Y, Yoshida K, Usui M, Goto H, Kuroda M. Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3410-6. PMID: 19182260.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  33. Okunuki Y, Usui Y, Nagai N, Kezuka T, Ishida S, Takeuchi M, Goto H. Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2255-61. PMID: 19136706.
    Citations: 14     Fields:    Translation:AnimalsCells
  34. Wakabayashi Y, Usui Y, Okunuki Y, Takeuchi M, Kezuka T, Iwasaki T, Goto H. Increased levels of monokine induced by interferon-gamma (Mig) in the vitreous of patients with diabetic retinopathy. Diabet Med. 2008 Jul; 25(7):875-7. PMID: 18644076.
    Citations: 5     Fields:    Translation:Humans
  35. Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Goto H, Usui M, Nishioka K, Kato T, Takeuchi M. Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain-type creatine kinase as novel autoantigens. Mol Vis. 2008 Jun 12; 14:1094-104. PMID: 18552983.
    Citations: 6     Fields:    Translation:HumansAnimals
  36. Hattori T, Usui Y, Okunuki Y, Sonoda Y, Usui M, Takada E, Mizuguchi J, Yagita H, Okumura K, Akiba H, Takeuchi M. Blockade of the OX40 ligand prolongs corneal allograft survival. Eur J Immunol. 2007 Dec; 37(12):3597-604. PMID: 18022861.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  37. Usui Y, Okunuki Y, Hattori T, Kezuka T, Keino H, Ebihara N, Sugita S, Usui M, Goto H, Takeuchi M. Functional expression of B7H1 on retinal pigment epithelial cells. Exp Eye Res. 2008 Jan; 86(1):52-9. PMID: 17981268.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  38. Okunuki Y, Usui Y, Takeuchi M, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Usui M, Nishioka K, Kato T. Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. Exp Eye Res. 2007 May; 84(5):823-31. PMID: 17343851.
    Citations: 14     Fields:    Translation:Humans
  39. Usui Y, Akiba H, Takeuchi M, Kezuka T, Takeuchi A, Hattori T, Okunuki Y, Yamazaki T, Yagita H, Usui M, Okumura K. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis. Eur J Immunol. 2006 Nov; 36(11):3071-81. PMID: 17039566.
    Citations: 7     Fields:    Translation:AnimalsCells
  40. Takeuchi M, Keino H, Suzuki J, Usui Y, Hattori T, Takeuchi A, Oh-I K, Okunuki Y, Kezuka T, Usui M. Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients. Exp Eye Res. 2006 Oct; 83(4):981-8. PMID: 16822510.
    Citations: 1     Fields:    Translation:HumansCells
  41. Takeuchi M, Oh-I K, Suzuki J, Hattori T, Takeuchi A, Okunuki Y, Usui Y, Usui M. Elevated serum levels of CXCL9/monokine induced by interferon-gamma and CXCL10/interferon-gamma-inducible protein-10 in ocular sarcoidosis. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1063-8. PMID: 16505042.
    Citations: 12     Fields:    Translation:Humans
  42. Takeuchi A, Usui Y, Takeuchi M, Hattori T, Kezuka T, Suzuki J, Okunuki Y, Iwasaki T, Haino M, Matsushima K, Usui M. CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3753-60. PMID: 16186359.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.