Harvard Catalyst Profiles

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Patrick Shea Ward, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08HL157620 (WARD, PATRICK S.) Apr 1, 2021 - Mar 31, 2026
    Mitochondrial redox regulation of adrenal steroidogenesis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rath S, Sharma R, Gupta R, Ast T, Chan C, Durham TJ, Goodman RP, Grabarek Z, Haas ME, Hung WHW, Joshi PR, Jourdain AA, Kim SH, Kotrys AV, Lam SS, McCoy JG, Meisel JD, Miranda M, Panda A, Patgiri A, Rogers R, Sadre S, Shah H, Skinner OS, To TL, Walker MA, Wang H, Ward PS, Wengrod J, Yuan CC, Calvo SE, Mootha VK. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 2021 01 08; 49(D1):D1541-D1547. PMID: 33174596.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  2. Ghosh RK, Gupta S, Singh V, Ward PS. Demand for Crop Insurance in Developing Countries: New Evidence from India. J Agric Econ. 2021 Feb; 72(1):293-320. PMID: 33518794.
  3. Ward PS, Makhija S, Spielman DJ. Drought-tolerant rice, weather index insurance, and comprehensive risk management for smallholders: evidence from a multi-year field experiment in India. Aust J Agric Resour Econ. 2020 Apr; 64(2):421-454. PMID: 32362768.
    Citations: 1     
  4. Ortega DL, Ward PS, Caputo V. Evaluating producer preferences and information processing strategies for drought risk management tools in Bangladesh. World Dev Perspect. 2019 Sep; 15:100132. PMID: 32201750.
  5. Tamal MEH, Bell AR, Killilea ME, Ward PS. Social dynamics of short term variability in key measures of household and community wellbeing in Bangladesh. Sci Data. 2019 07 17; 6(1):125. PMID: 31316067.
    Citations: 1     Fields:    Translation:Humans
  6. Gars J, Ward PS. Corrigendum to 'Can differences in individual learning explain patterns of technology adoption? Evidence on heterogeneous learning patterns and hybrid rice adoption in Bihar, India' [World Dev. 115 (2018) 178-189]. World Dev. 2019 06; 118:15. PMID: 31186598.
  7. Gars J, Ward PS. Can differences in individual learning explain patterns of technology adoption? Evidence on heterogeneous learning patterns and hybrid rice adoption in Bihar, India. World Dev. 2019 Mar; 115:178-189. PMID: 30828125.
  8. Hill RV, Kumar N, Magnan N, Makhija S, de Nicola F, Spielman DJ, Ward PS. Ex ante and ex post effects of hybrid index insurance in Bangladesh. J Dev Econ. 2019 Jan; 136:1-17. PMID: 31007349.
    Citations: 1     
  9. Arora A, Bansal S, Ward PS. Do farmers value rice varieties tolerant to droughts and floods? Evidence from a discrete choice experiment in Odisha, India. Water Resour Econ. 2019 Jan; 25:27-41. PMID: 31608207.
    Citations: 3     
  10. Dexter JP, Ward PS, Dasgupta T, Hosios AM, Gunawardena J, Vander Heiden MG. Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate. J Biol Chem. 2018 12 28; 293(52):20051-20061. PMID: 30381394.
    Citations: 7     Fields:    Translation:HumansCells
  11. Shih AH, Meydan C, Shank K, Garrett-Bakelman FE, Ward PS, Intlekofer AM, Nazir A, Stein EM, Knapp K, Glass J, Travins J, Straley K, Gliser C, Mason CE, Yen K, Thompson CB, Melnick A, Levine RL. Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia. Cancer Discov. 2017 05; 7(5):494-505. PMID: 28193779.
    Citations: 33     Fields:    Translation:AnimalsCells
  12. Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Fuks F, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RL. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 2014 Dec 11; 9(5):1841-1855. PMID: 25482556.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  13. Chen C, Liu Y, Lu C, Cross JR, Morris JP, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev. 2013 Sep 15; 27(18):1974-85. PMID: 24065765.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  14. Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB. Induction of sarcomas by mutant IDH2. Genes Dev. 2013 Sep 15; 27(18):1986-98. PMID: 24065766.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  15. Finley LW, Zhang J, Ye J, Ward PS, Thompson CB. SnapShot: cancer metabolism pathways. Cell Metab. 2013 Mar 05; 17(3):466-466.e2. PMID: 23473039.
    Citations: 19     Fields:    Translation:Humans
  16. Ward PS, Lu C, Cross JR, Abdel-Wahab O, Levine RL, Schwartz GK, Thompson CB. The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. J Biol Chem. 2013 Feb 08; 288(6):3804-15. PMID: 23264629.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  17. Ward PS, Thompson CB. Signaling in control of cell growth and metabolism. Cold Spring Harb Perspect Biol. 2012 Jul 01; 4(7):a006783. PMID: 22687276.
    Citations: 86     Fields:    Translation:AnimalsCells
  18. Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):6904-9. PMID: 22509023.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  19. Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell. 2012 Mar 20; 21(3):297-308. PMID: 22439925.
    Citations: 1185     Fields:    Translation:HumansCells
  20. Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LG, Huse JT, Mellinghoff IK, Chan TA. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012 Feb 15; 483(7390):479-83. PMID: 22343889.
    Citations: 778     Fields:    Translation:HumansCells
  21. Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012 Feb 15; 483(7390):474-8. PMID: 22343901.
    Citations: 770     Fields:    Translation:HumansAnimalsCells
  22. Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of a-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19611-6. PMID: 22106302.
    Citations: 420     Fields:    Translation:HumansCells
  23. Ward PS, Cross JR, Lu C, Weigert O, Abel-Wahab O, Levine RL, Weinstock DM, Sharp KA, Thompson CB. Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. Oncogene. 2012 May 10; 31(19):2491-8. PMID: 21996744.
    Citations: 76     Fields:    Translation:HumansCells
  24. Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010 Dec 14; 18(6):553-67. PMID: 21130701.
    Citations: 1075     Fields:    Translation:HumansCells
  25. Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2010 Jun 17; 465(7300):966. PMID: 20559394.
    Citations: 158     Fields:    Translation:Humans
  26. Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010 Mar 16; 17(3):225-34. PMID: 20171147.
    Citations: 755     Fields:    Translation:HumansCells
  27. Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009 Dec 10; 462(7274):739-44. PMID: 19935646.
    Citations: 1321     Fields:    Translation:HumansCells
  28. Simpson AK, Ward PS, Wong KY, Collord GJ, Habib AM, Reimann F, Gribble FM. Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line. Diabetologia. 2007 Oct; 50(10):2181-9. PMID: 17643200.
    Citations: 22     Fields:    Translation:HumansCells
  29. Reimann F, Ward PS, Gribble FM. Signaling mechanisms underlying the release of glucagon-like peptide 1. Diabetes. 2006; 55(2):S78-85.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.