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Sijumon Kunjachan, Ph.D.


DFCI/BWH/Harvard Medical School, USAFellow03/2017Cancer Nanotechnology
RWTH Aachen University, GermanyPh D12/2013Experimental Medicine
Indian Institute of Technology Kanpur, IndiaPh D (dis.)12/2009Drug Delivery
Mahatma Gandhi University, IndiaM Pharm10/2007Pharmaceutical Science
Dr. MGR Medical University, IndiaB Pharm09/2004Pharmacy
2018 - 2018
Young Investigator Award (runner), World Molecular Imaging Conference, Seattle
2018 - 2018
Scholar-in-Training (SIT) Award, Radiation Research Society, Chicago
2018 - 2018
Best in Physics (Therapy) Award, Annual Association of Physicists in Medicine (AAPM), Nashville
2017 - 2017
Invited talk - National Nanomedicine Seminar, CaNCURE and Nanomedicine Academy Program, Boston
2016 - 2016
Scholar-in-Training (SIT) Award, Radiation Research Society, Hawaii
2016 - 2016
Invited talk - Innovative Technologies in Radiation Oncology, ASTRO, Boston
2016 - 2016
Elsevier Reviewer Recognition Award, Elsevier, The Netherlands
2015 - 2016
Featured Vodcast, Radiation Research Society, Florida
2015 - 2015
Scholar-in-Training (SIT) Award, Radiation Research Society, Florida
2015 - 2015
Elsevier Reviewer Recognition Award, Elsevier, The Netherlands
2013 - 2013
COST-Action Travel Award, London
2012 - 2012
Best Poster Award (Preclinical Oncology), World Molecular Imaging Conference, Dublin
2007 - 2010
GATE Senior Research Fellow Funding, All India Council for Technical Education
2005 - 2007
GATE Junior Research Fellow Funding, All India Council for Technical Education

Sijumon Kunjachan is an Instructor/junior faculty in Radiation Oncology at Harvard Medical School and conducts research at Dana-Farber Cancer Institute and Brigham and Women’s Hospital. Following a 6 yr-Bachelor plus Master’s degree in Pharmaceutical Sciences (2000-2007), Sijumon carried out research at Central Drug Research Institute and Indian Institute of Technology Kanpur (2007-2010). In 2013, Sijumon was awarded a PhD in Experimental Medicine (2010-2013) from RWTH-Aachen University, Germany.
Dr. Kunjachan's research aims to identify and tackle various pathophysiological barriers that prevent effective delivery of drugs or biologics, and to devise novel nanotechnology platforms to improve therapy in cancer or infectious disease. Over the years, Dr. Kunjachan acquired substantial knowledge and experience in the field of nanomedicine, noninvasive imaging, radiation therapy and drug delivery. His research findings are published in high-impact journals, including Nano Letters, Chemical Reviews, ACS Nano, Theranostics, Advanced Drug Del Rev, JCR etc. His research is widely cited with ~1000+ citations since 2012. Dr. Kunjachan sits on the editorial board of four international journals and serve as an assigned editor for Clinical & Experimental Oncology. He reviews articles for 40+ scientific journals, including Clinical Cancer Research, Cancer Research, Nanoscale, Nano Research, Biomaterials, Theranostics, Medical Physics, Nature Scientific Reports, and Journal of Controlled Release. He reviews grant for several national and international funding agencies, including Cost-Action (EU) and National Research, Development and Innovation Office (Hungary) and evaluates abstracts for scientific conferences (incl. WMIC, ICONAN, etc.). Twice-featured as a vodcast speaker at the Radiation Research meeting, Dr. Kunjachan delivered invited talks at ASTRO, AAPM, National Nanomedicine Seminar and World Molecular Imaging conferences. Sijumon is a recipient of several awards, including, Scholar-in-Training Award, Elsevier Reviewer Recognition Award and the World Molecular Imaging-Young Investigator Award (finalist).

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Ross Berbeco) Jan 1, 2016 - Jan 31, 2017
    JCRT Foundation
    Gold nanoparticles as vascular disrupting agents with radiation therapy
    Role Description: The major goal is to assess gold nanoparticle (GNP) mediated tumor vascular disruption by external beam radiation therapy.
    Role: Co-Investigator
  2. GATE Senior Research Fellowship (Sijumon Kunjachan) Jan 1, 2008 - Jan 1, 2010
    MHRD & All India Council for Technical Education
    Drug delivery systems for cancer therapy
  3. GATE Junior Research Fellowship (Sijumon Kunjachan) Sep 1, 2005 - Sep 1, 2007
    MHRD & All India Council for Technical Education
    Chitosan-based macrophage-mediated drug targeting for the treatment of experimental visceral leishmaniasis

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schuemann J, Bagley A, Berbeco R, Bromma K, Butterworth KT, Byrne H, Chithrani DB, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon SJ, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani NA, Yantasee W, Krishnan S. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Phys Med Biol. 2020 May 07. PMID: 32380492.
  2. Kwon J, Rajamahendiran RM, Virani NA, Kunjachan S, Snay E, Harlacher M, Myronakis M, Shimizu S, Shirato H, Czernuszewicz TJ, Gessner R, Berbeco R. Use of 3-D Contrast-Enhanced Ultrasound to Evaluate Tumor Microvasculature After Nanoparticle-Mediated Modulation. Ultrasound Med Biol. 2020 Feb; 46(2):369-376. PMID: 31694771.
  3. Kunjachan S, Kotb S, Pola R, Pechar M, Kumar R, Singh B, Gremse F, Taleeli R, Trichard F, Motto-Ros V, Sancey L, Detappe A, Yasmin-Karim S, Protti A, Shanmugam I, Ireland T, Etrych T, Sridhar S, Tillement O, Makrigiorgos M, Berbeco RI. Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery. Sci Rep. 2019 11 01; 9(1):15844. PMID: 31676822.
  4. Yasmin-Karim S, Bruck PT, Moreau M, Kunjachan S, Chen GZ, Kumar R, Grabow S, Dougan SK, Ngwa W. Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer. Front Immunol. 2018; 9:2030. PMID: 30245691.
  5. Moreau M, Yasmin-Karim S, Kunjachan S, Sinha N, Gremse F, Kumar R, Chow KF, Ngwa W. Priming the Abscopal Effect Using Multifunctional Smart Radiotherapy Biomaterials Loaded with Immunoadjuvants. Front Oncol. 2018; 8:56. PMID: 29594038.
  6. Detappe A, Thomas E, Tibbitt MW, Kunjachan S, Zavidij O, Parnandi N, Reznichenko E, Lux F, Tillement O, Berbeco R. Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance-Computed Tomography Image Guided Radiation Therapy. Nano Lett. 2017 03 08; 17(3):1733-1740. PMID: 28145723.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  7. Detappe A, Kunjachan S, Drané P, Kotb S, Myronakis M, Biancur DE, Ireland T, Wagar M, Lux F, Tillement O, Berbeco R. Key clinical beam parameters for nanoparticle-mediated radiation dose amplification. Sci Rep. 2016 Sep 23; 6:34040. PMID: 27658637.
    Citations: 1     Fields:    
  8. Detappe A, Kunjachan S, Sancey L, Motto-Ros V, Biancur D, Drane P, Guieze R, Makrigiorgos GM, Tillement O, Langer R, Berbeco R. Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy. J Control Release. 2016 09 28; 238:103-113. PMID: 27423325.
    Citations: 6     Fields:    Translation:Animals
  9. Appelboom G, Detappe A, LoPresti M, Kunjachan S, Mitrasinovic S, Goldman S, Chang SD, Tillement O. Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery. Neuro Oncol. 2016 12; 18(12):1601-1609. PMID: 27407134.
    Citations: 5     Fields:    Translation:HumansAnimals
  10. Detappe A, Kunjachan S, Sancey L, Motto-Ros V, Tillement O, Berbeco R. WE-FG-BRA-07: Theranostic Nanoparticles Improve Clinical MR-Guided Radiation Therapy. Med Phys. 2016 Jun; 43(6):3824-3825. PMID: 28046347.
  11. Kunjachan S, Detappe A, Kumar R, Ireland T, Cameron L, Biancur DE, Motto-Ros V, Sancey L, Sridhar S, Makrigiorgos GM, Berbeco RI. Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy. Nano Lett. 2015 Nov 11; 15(11):7488-96. PMID: 26418302.
    Citations: 16     Fields:    Translation:HumansCells
  12. Detappe A, Kunjachan S, Rottmann J, Robar J, Tsiamas P, Korideck H, Tillement O, Berbeco R. AGuIX nanoparticles as a promising platform for image-guided radiation therapy. Cancer Nanotechnol. 2015; 6(1):4. PMID: 26345984.
    Citations: 6     
  13. Kunjachan S, Ehling J, Storm G, Kiessling F, Lammers T. Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects. Chem Rev. 2015 Oct 14; 115(19):10907-37. PMID: 26166537.
    Citations: 18     Fields:    Translation:HumansAnimals
  14. Shi Y, Kunjachan S, Wu Z, Gremse F, Moeckel D, van Zandvoort M, Kiessling F, Storm G, van Nostrum CF, Hennink WE, Lammers T. Fluorophore labeling of core-crosslinked polymeric micelles for multimodal in vivo and ex vivo optical imaging. Nanomedicine (Lond). 2015; 10(7):1111-25. PMID: 25929568.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Gremse F, Theek B, Kunjachan S, Lederle W, Pardo A, Barth S, Lammers T, Naumann U, Kiessling F. Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid fluorescence-mediated tomography. Theranostics. 2014; 4(10):960-71. PMID: 25157277.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  16. Theek B, Gremse F, Kunjachan S, Fokong S, Pola R, Pechar M, Deckers R, Storm G, Ehling J, Kiessling F, Lammers T. Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging. J Control Release. 2014 May 28; 182:83-9. PMID: 24631862.
    Citations: 16     Fields:    Translation:AnimalsCells
  17. Kunjachan S, Pola R, Gremse F, Theek B, Ehling J, Moeckel D, Hermanns-Sachweh B, Pechar M, Ulbrich K, Hennink WE, Storm G, Lederle W, Kiessling F, Lammers T. Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines. Nano Lett. 2014 Feb 12; 14(2):972-81. PMID: 24422585.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  18. Kunjachan S, Rychlik B, Storm G, Kiessling F, Lammers T. Multidrug resistance: Physiological principles and nanomedical solutions. Adv Drug Deliv Rev. 2013 Nov; 65(13-14):1852-1865. PMID: 24120954.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  19. Kunjachan S, Gremse F, Theek B, Koczera P, Pola R, Pechar M, Etrych T, Ulbrich K, Storm G, Kiessling F, Lammers T. Noninvasive optical imaging of nanomedicine biodistribution. ACS Nano. 2013 Jan 22; 7(1):252-62. PMID: 23067565.
    Citations: 27     Fields:    Translation:AnimalsCells
  20. Kunjachan S, Jayapaul J, Mertens ME, Storm G, Kiessling F, Lammers T. Theranostic systems and strategies for monitoring nanomedicine-mediated drug targeting. Curr Pharm Biotechnol. 2012 Mar; 13(4):609-22. PMID: 22214503.
    Citations: 8     Fields:    Translation:HumansAnimals
  21. Kunjachan S, Blauz A, Möckel D, Theek B, Kiessling F, Etrych T, Ulbrich K, van Bloois L, Storm G, Bartosz G, Rychlik B, Lammers T. Overcoming cellular multidrug resistance using classical nanomedicine formulations. Eur J Pharm Sci. 2012 Mar 12; 45(4):421-8. PMID: 21907796.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. Kunjachan S, Jose S, Thomas CA, Joseph E, Kiessling F, Lammers T. Physicochemical and biological aspects of macrophage-mediated drug targeting in anti-microbial therapy. Fundam Clin Pharmacol. 2012 Feb; 26(1):63-71. PMID: 21631585.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  23. Kunjachan S, Gupta S, Dwivedi AK, Dube A, Chourasia MK. Chitosan-based macrophage-mediated drug targeting for the treatment of experimental visceral leishmaniasis. J Microencapsul. 2011; 28(4):301-10. PMID: 21545321.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Kunjachan S, Jose S, Lammers T. Understanding the mechanism of ionic gelation for synthesis of chitosan nanoparticles using qualitative techniques. Asian Journal of Pharmaceutics. 2010; 4(2):148-153. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.