Harvard Catalyst Profiles

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Jacob Eric Lazarus, M.D., Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08AI155830 (LAZARUS, JACOB ERIC) Dec 15, 2020 - Nov 30, 2025
    Intrinsic modifiers of beta-lactam resistance in nosocomial Enterobacterales
    Role: Principal Investigator
  2. CMeRIT (LAZARUS, JACOB ERIC) Oct 1, 2018 - Sep 30, 2020
    Harvard Catalyst
    Defining bacterial pathways mediating inducible resistance to antibiotics
    Role: Principal Investigator
  3. F30DK089714 (LAZARUS, JACOB ERIC) Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Albin JS, Lazarus JE, Hysell KM, Rubins DM, Germaine L, Dugdale CM, Heller HM, Hohmann EL, Baugh JJ, Shenoy ES. Development and implementation of a clinical decision support system tool for the evaluation of suspected monkeypox infection. J Am Med Inform Assoc. 2022 11 14; 29(12):2124-2127. PMID: 36036367; PMCID: PMC9667162.
    Citations:    Fields:    Translation:HumansPHPublic Health
  2. Matias WR, Koshy JM, Nagami EH, Kovac V, Moeng LR, Shenoy ES, Hooper DC, Madoff LC, Barshak MB, Johnson JA, Rowley CF, Julg B, Hohmann EL, Lazarus JE. Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States. Open Forum Infect Dis. 2022 Aug; 9(8):ofac377. PMID: 35949403; PMCID: PMC9356679.
    Citations: 12     
  3. Ko ER, Henao R, Frankey K, Petzold EA, Isner PD, Jaehne AK, Allen N, Gardner-Gray J, Hurst G, Pflaum-Carlson J, Jayaprakash N, Rivers EP, Wang H, Ugalde I, Amanullah S, Mercurio L, Chun TH, May L, Hickey RW, Lazarus JE, Gunaratne SH, Pallin DJ, Jambaulikar G, Huckins DS, Ampofo K, Jhaveri R, Jiang Y, Komarow L, Evans SR, Ginsburg GS, Tillekeratne LG, McClain MT, Burke TW, Woods CW, Tsalik EL. Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection. JAMA Netw Open. 2022 04 01; 5(4):e227299. PMID: 35420659; PMCID: PMC9011121.
    Citations: 1     Fields:    Translation:HumansCells
  4. Dugdale CM, Rubins DM, Lee H, McCluskey SM, Ryan ET, Kotton CN, Hurtado RM, Ciaranello AL, Barshak MB, McEvoy DS, Nelson SB, Basgoz N, Lazarus JE, Ivers LC, Reedy JL, Hysell KM, Lemieux JE, Heller HM, Dutta S, Albin JS, Brown TS, Miller AL, Calderwood SB, Walensky RP, Zachary KC, Hooper DC, Hyle EP, Shenoy ES. Coronavirus Disease 2019 (COVID-19) Diagnostic Clinical Decision Support: A Pre-Post Implementation Study of CORAL (COvid Risk cALculator). Clin Infect Dis. 2021 12 16; 73(12):2248-2256. PMID: 33564833.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Lazarus JE, Warr AR, Westervelt KA, Hooper DC, Waldor MK. A Genome-Scale Antibiotic Screen in Serratia marcescens Identifies YdgH as a Conserved Modifier of Cephalosporin and Detergent Susceptibility. Antimicrob Agents Chemother. 2021 11 17; 65(12):e0078621. PMID: 34491801; PMCID: PMC8597751.
    Citations:    Fields:    Translation:Cells
  6. Dugdale CM, Anahtar MN, Chiosi JJ, Lazarus JE, McCluskey SM, Ciaranello AL, Gogakos T, Little BP, Branda JA, Shenoy ES, Walensky RP, Zachary KC, Hooper DC, Turbett SE, Hyle EP. Clinical, Laboratory, and Radiologic Characteristics of Patients With Initial False-Negative Severe Acute Respiratory Syndrome Coronavirus 2 Nucleic Acid Amplification Test Results. Open Forum Infect Dis. 2021 Jan; 8(1):ofaa559. PMID: 34164560; PMCID: PMC7717411.
    Citations: 7     
  7. Lazarus JE, Branda JA, Gandhi RG, Barshak MB, Zachary KC, Barczak AK. Disseminated Intravascular Infection Caused by Paecilomyces variotii: Case Report and Review of the Literature. Open Forum Infect Dis. 2020 Jun; 7(6):ofaa166. PMID: 32617367; PMCID: PMC7314584.
  8. Lazarus JE, Warr AR, Kuehl CJ, Giorgio RT, Davis BM, Waldor MK. A New Suite of Allelic-Exchange Vectors for the Scarless Modification of Proteobacterial Genomes. Appl Environ Microbiol. 2019 08 15; 85(16). PMID: 31201277.
    Citations: 9     Fields:    Translation:Cells
  9. Park JS, Helble JD, Lazarus JE, Yang G, Blondel CJ, Doench JG, Starnbach MN, Waldor MK. A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion. iScience. 2019 Jan 25; 11:71-84. PMID: 30590252; PMCID: PMC6308251.
    Citations: 5     
  10. Pacheco AR, Lazarus JE, Sit B, Schmieder S, Lencer WI, Blondel CJ, Doench JG, Davis BM, Waldor MK. CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. mBio. 2018 06 19; 9(3). PMID: 29921669; PMCID: PMC6016243.
    Citations: 25     Fields:    Translation:HumansCells
  11. Hillis JM, Ruan AB, Lazarus JE, Montgomery MW, Berkowitz AL. Clinical Reasoning: A 48-year-old woman with confusion, personality change, and multiple enhancing brain lesions. Neurology. 2018 05 08; 90(19):e1724-e1729. PMID: 29735779.
    Citations:    Fields:    Translation:Humans
  12. Jain N, Doyon JB, Lazarus JE, Schaefer IM, Johncilla ME, Agoston AT, Dalal AK, Velásquez GE. A Case of Disseminated Histoplasmosis in a Patient with Rheumatoid Arthritis on Abatacept. J Gen Intern Med. 2018 05; 33(5):769-772. PMID: 29532302; PMCID: PMC5910370.
    Citations: 1     Fields:    Translation:HumansAnimals
  13. Nirschl JJ, Magiera MM, Lazarus JE, Janke C, Holzbaur EL. a-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep. 2016 Mar 22; 14(11):2637-52. PMID: 26972003.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  14. Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ. Trim58 degrades Dynein and regulates terminal erythropoiesis. Dev Cell. 2014 Sep 29; 30(6):688-700. PMID: 25241935.
    Citations: 36     Fields:    Translation:AnimalsCells
  15. Ayloo S, Lazarus JE, Dodda A, Tokito M, Ostap EM, Holzbaur EL. Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nat Commun. 2014 Sep 04; 5:4807. PMID: 25185702.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  16. Perlson E, Hendricks AG, Lazarus JE, Ben-Yaakov K, Gradus T, Tokito M, Holzbaur EL. Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons. J Biol Chem. 2013 Sep 27; 288(39):27812-24. PMID: 23960070.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  17. Moughamian AJ, Osborn GE, Lazarus JE, Maday S, Holzbaur EL. Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport. J Neurosci. 2013 Aug 07; 33(32):13190-203. PMID: 23926272.
    Citations: 87     Fields:    Translation:AnimalsCells
  18. Lazarus JE, Moughamian AJ, Tokito MK, Holzbaur EL. Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. PLoS Biol. 2013 Jul; 11(7):e1001611. PMID: 23874158.
    Citations: 42     Fields:    Translation:HumansCells
  19. Zhang J, Twelvetrees AE, Lazarus JE, Blasier KR, Yao X, Inamdar NA, Holzbaur EL, Pfister KK, Xiang X. Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions. Cytoskeleton (Hoboken). 2013 Apr; 70(4):215-27. PMID: 23475693.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  20. Hendricks AG, Lazarus JE, Perlson E, Gardner MK, Odde DJ, Goldman YE, Holzbaur EL. Dynein tethers and stabilizes dynamic microtubule plus ends. Curr Biol. 2012 Apr 10; 22(7):632-7. PMID: 22445300.
    Citations: 63     Fields:    Translation:AnimalsCells
  21. Hendricks AG, Lazarus JE, Holzbaur EL. Dynein at odd angles? Nat Cell Biol. 2010 Dec; 12(12):1126-8. PMID: 21102436.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Dixit R, Barnett B, Lazarus JE, Tokito M, Goldman YE, Holzbaur EL. Microtubule plus-end tracking by CLIP-170 requires EB1. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):492-7. PMID: 19126680.
    Citations: 97     Fields:    Translation:HumansCells
  23. Finkielstain GP, Forcinito P, Lui JC, Barnes KM, Marino R, Makaroun S, Nguyen V, Lazarus JE, Nilsson O, Baron J. An extensive genetic program occurring during postnatal growth in multiple tissues. Endocrinology. 2009 Apr; 150(4):1791-800. PMID: 19036884; PMCID: PMC2659288.
    Citations: 42     Fields:    Translation:HumansAnimals
  24. Lazarus JE, Hegde A, Andrade AC, Nilsson O, Baron J. Fibroblast growth factor expression in the postnatal growth plate. Bone. 2007 Mar; 40(3):577-86. PMID: 17169623.
    Citations: 41     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.