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Gunsagar Gulati, M.D., Ph.D.

Title
Institution
Department
Address
Profile Picture

Biography
education and training
Harvard CollegeBA2014Human Developmental and Regenerative Biology
Stanford UniversityPhD2020Cancer Biology
Stanford UniversityMD2021Medicine
awards and honors
2020
Denise Chan Best Thesis Award
2019
NIH/NHLBI Ruth L. Kirschstein National Research Service Award (F30)
2018
Bio-X Bowes Graduate Student Fellowship
2016
Howard Hughes Medical Institute Medical Research Fellowship
2015
Albert Schweitzer Fellowship
2014
magna cum laude
2011
Howard Hughes Medical Institute Interdisciplinary Undergraduate Fellowship
2011
Harvard College Scholar

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. F30HL147460 (GULATI, GUNSAGAR SINGH) Jul 1, 2019 - Jun 30, 2021
    NIH
    Investigating the role of the Neogenin-1/Netrin-1 axis in aging and lineage bias of hematopoietic stem cells (HSCs)
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sikandar SS, Gulati GS, Antony J, Fetter I, Kuo AH, Ho WHD, Haro-Acosta V, Das S, Steen CB, Pereira TA, Qian D, Beachy PA, Dirbas F, Red-Horse K, Rabbitts TH, Thiery JP, Newman AM, Clarke MF. Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis. Sci Adv. 2022 11 11; 8(45):eabm3548. PMID: 36351009.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Andrew TW, Koepke LS, Wang Y, Lopez M, Steininger H, Struck D, Boyko T, Ambrosi TH, Tong X, Sun Y, Gulati GS, Murphy MP, Marecic O, Telvin R, Schallmoser K, Strunk D, Seita J, Goodman SB, Yang F, Longaker MT, Yang GP, Chan CKF. Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration. Nat Commun. 2022 10 30; 13(1):6491. PMID: 36310174; PMCID: PMC9618571.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Gulati GS. A Truckstop on Cancer's Road. J Gen Intern Med. 2022 08; 37(11):2868-2869. PMID: 35581457; PMCID: PMC9411294.
    Citations:    Fields:    
  4. Chowdhury RR, D'Addabbo J, Huang X, Veizades S, Sasagawa K, Louis DM, Cheng P, Sokol J, Jensen A, Tso A, Shankar V, Wendel BS, Bakerman I, Liang G, Koyano T, Fong R, Nau AN, Ahmad H, Gopakumar J, Wirka R, Lee AS, Boyd J, Woo YJ, Quertermous T, Gulati GS, Jaiswal S, Chien YH, Chan CKF, Davis MM, Nguyen PK. Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self. Circ Res. 2022 05 13; 130(10):1510-1530. PMID: 35430876; PMCID: PMC9286288.
    Citations:    Fields:    Translation:HumansCells
  5. Lozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM. T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma. Nat Med. 2022 02; 28(2):353-362. PMID: 35027754; PMCID: PMC8866214.
    Citations: 7     Fields:    Translation:HumansCells
  6. Foster DS, Januszyk M, Yost KE, Chinta MS, Gulati GS, Nguyen AT, Burcham AR, Salhotra A, Ransom RC, Henn D, Chen K, Mascharak S, Tolentino K, Titan AL, Jones RE, da Silva O, Leavitt WT, Marshall CD, des Jardins-Park HE, Hu MS, Wan DC, Wernig G, Wagh D, Coller J, Norton JA, Gurtner GC, Newman AM, Chang HY, Longaker MT. Integrated spatial multiomics reveals fibroblast fate during tissue repair. Proc Natl Acad Sci U S A. 2021 10 12; 118(41). PMID: 34620713; PMCID: PMC8521719.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Ambrosi TH, Marecic O, McArdle A, Sinha R, Gulati GS, Tong X, Wang Y, Steininger HM, Hoover MY, Koepke LS, Murphy MP, Sokol J, Seo EY, Tevlin R, Lopez M, Brewer RE, Mascharak S, Lu L, Ajanaku O, Conley SD, Seita J, Morri M, Neff NF, Sahoo D, Yang F, Weissman IL, Longaker MT, Chan CKF. Aged skeletal stem cells generate an inflammatory degenerative niche. Nature. 2021 09; 597(7875):256-262. PMID: 34381212; PMCID: PMC8721524.
    Citations: 21     Fields:    Translation:AnimalsCells
  8. Moreno-Nieves UY, Tay JK, Saumyaa S, Horowitz NB, Shin JH, Mohammad IA, Luca B, Mundy DC, Gulati GS, Bedi N, Chang S, Chen C, Kaplan MJ, Rosenthal EL, Holsinger FC, Divi V, Baik FM, Sirjani DB, Gentles AJ, Newman AM, Freud AG, Sunwoo JB. Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment. Proc Natl Acad Sci U S A. 2021 07 13; 118(28). PMID: 34244432; PMCID: PMC8285950.
    Citations: 11     Fields:    Translation:HumansCells
  9. Zalc A, Sinha R, Gulati GS, Wesche DJ, Daszczuk P, Swigut T, Weissman IL, Wysocka J. Reactivation of the pluripotency program precedes formation of the cranial neural crest. Science. 2021 02 05; 371(6529). PMID: 33542111; PMCID: PMC8557957.
    Citations: 16     Fields:    Translation:AnimalsCells
  10. Zaro BW, Noh JJ, Mascetti VL, Demeter J, George B, Zukowska M, Gulati GS, Sinha R, Flynn RA, Banuelos A, Zhang A, Wilkinson AC, Jackson P, Weissman IL. Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells. Elife. 2020 11 25; 9. PMID: 33236985; PMCID: PMC7688314.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Murphy MP, Koepke LS, Lopez MT, Tong X, Ambrosi TH, Gulati GS, Marecic O, Wang Y, Ransom RC, Hoover MY, Steininger H, Zhao L, Walkiewicz MP, Quarto N, Levi B, Wan DC, Weissman IL, Goodman SB, Yang F, Longaker MT, Chan CKF. Articular cartilage regeneration by activated skeletal stem cells. Nat Med. 2020 10; 26(10):1583-1592. PMID: 32807933; PMCID: PMC7704061.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  12. Foster DS, Marshall CD, Gulati GS, Chinta MS, Nguyen A, Salhotra A, Jones RE, Burcham A, Lerbs T, Cui L, King ME, Titan AL, Ransom RC, Manjunath A, Hu MS, Blackshear CP, Mascharak S, Moore AL, Norton JA, Kin CJ, Shelton AA, Januszyk M, Gurtner GC, Wernig G, Longaker MT. Elucidating the fundamental fibrotic processes driving abdominal adhesion formation. Nat Commun. 2020 08 13; 11(1):4061. PMID: 32792541.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  13. Zabala M, Lobo NA, Antony J, Heitink LS, Gulati GS, Lam J, Parashurama N, Sanchez K, Adorno M, Sikandar SS, Kuo AH, Qian D, Kalisky T, Sim S, Li L, Dirbas FM, Somlo G, Newman A, Quake SR, Clarke MF. LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis. Cell Stem Cell. 2020 08 06; 27(2):284-299.e8. PMID: 32693087.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020 07; 583(7817):596-602. PMID: 32669715; PMCID: PMC7757734.
    Citations: 69     Fields:    Translation:AnimalsCells
  15. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020 07; 583(7817):590-595. PMID: 32669714.
    Citations: 122     Fields:    Translation:AnimalsCells
  16. Gulati GS, Sikandar SS, Wesche DJ, Manjunath A, Bharadwaj A, Berger MJ, Ilagan F, Kuo AH, Hsieh RW, Cai S, Zabala M, Scheeren FA, Lobo NA, Qian D, Yu FB, Dirbas FM, Clarke MF, Newman AM. Single-cell transcriptional diversity is a hallmark of developmental potential. Science. 2020 01 24; 367(6476):405-411. PMID: 31974247.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  17. Szade K, Zukowska M, Szade A, Nowak W, Skulimowska I, Ciesla M, Bukowska-Strakova K, Gulati GS, Kachamakova-Trojanowska N, Kusienicka A, Einwallner E, Kijowski J, Czauderna S, Esterbauer H, Benes V, L Weissman I, Dulak J, Jozkowicz A. Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. EMBO Rep. 2020 02 05; 21(2):e47895. PMID: 31885181.
    Citations: 12     Fields:    Translation:AnimalsCells
  18. Gulati GS, Zukowska M, Noh JJ, Zhang A, Wesche DJ, Sinha R, George BM, Weissman IL, Szade K. Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5+ mouse long-term hematopoietic stem cells. Proc Natl Acad Sci U S A. 2019 12 10; 116(50):25115-25125. PMID: 31754028; PMCID: PMC6911217.
    Citations: 11     Fields:    Translation:AnimalsCells
  19. Aalipour A, Chuang HY, Murty S, D'Souza AL, Park SM, Gulati GS, Patel CB, Beinat C, Simonetta F, Martinic I, Gowrishankar G, Robinson ER, Aalipour E, Zhian Z, Gambhir SS. Engineered immune cells as highly sensitive cancer diagnostics. Nat Biotechnol. 2019 05; 37(5):531-539. PMID: 30886438.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  20. Myers LM, Tal MC, Torrez Dulgeroff LB, Carmody AB, Messer RJ, Gulati G, Yiu YY, Staron MM, Angel CL, Sinha R, Markovic M, Pham EA, Fram B, Ahmed A, Newman AM, Glenn JS, Davis MM, Kaech SM, Weissman IL, Hasenkrug KJ. A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPa expression. Nat Commun. 2019 02 15; 10(1):794. PMID: 30770827.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  21. Li Q, Cheng Z, Zhou L, Darmanis S, Neff NF, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, Marschallinger J, Yu G, Quake SR, Wyss-Coray T, Barres BA. Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing. Neuron. 2019 01 16; 101(2):207-223.e10. PMID: 30606613; PMCID: PMC6336504.
    Citations: 249     Fields:    Translation:AnimalsCells
  22. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018 10; 562(7727):367-372. PMID: 30283141.
    Citations: 598     Fields:    Translation:AnimalsCells
  23. Chan CKF, Gulati GS, Sinha R, Tompkins JV, Lopez M, Carter AC, Ransom RC, Reinisch A, Wearda T, Murphy M, Brewer RE, Koepke LS, Marecic O, Manjunath A, Seo EY, Leavitt T, Lu WJ, Nguyen A, Conley SD, Salhotra A, Ambrosi TH, Borrelli MR, Siebel T, Chan K, Schallmoser K, Seita J, Sahoo D, Goodnough H, Bishop J, Gardner M, Majeti R, Wan DC, Goodman S, Weissman IL, Chang HY, Longaker MT. Identification of the Human Skeletal Stem Cell. Cell. 2018 09 20; 175(1):43-56.e21. PMID: 30241615; PMCID: PMC6400492.
    Citations: 184     Fields:    Translation:HumansAnimalsCells
  24. Gulati GS, Murphy MP, Marecic O, Lopez M, Brewer RE, Koepke LS, Manjunath A, Ransom RC, Salhotra A, Weissman IL, Longaker MT, Chan CKF. Isolation and functional assessment of mouse skeletal stem cell lineage. Nat Protoc. 2018 06; 13(6):1294-1309. PMID: 29748647.
    Citations: 29     Fields:    Translation:AnimalsCells
  25. Ouyang D, Gulati G, Ha R, Banerjee D. Incidence of temporary mechanical circulatory support before heart transplantation and impact on post-transplant outcomes. J Heart Lung Transplant. 2018 09; 37(9):1060-1066. PMID: 29907499.
    Citations: 4     Fields:    Translation:Humans
  26. Szade K, Gulati GS, Chan CKF, Kao KS, Miyanishi M, Marjon KD, Sinha R, George BM, Chen JY, Weissman IL. Where Hematopoietic Stem Cells Live: The Bone Marrow Niche. Antioxid Redox Signal. 2018 07 10; 29(2):191-204. PMID: 29113449; PMCID: PMC6016729.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  27. Gulati G, Ouyang D, Ha R, Banerjee D. Optimal timing of same-admission orthotopic heart transplantation after left ventricular assist device implantation. World J Cardiol. 2017 Feb 26; 9(2):154-161. PMID: 28289529; PMCID: PMC5329742.
    Citations:    
  28. Tevlin R, Seo EY, Marecic O, McArdle A, Tong X, Zimdahl B, Malkovskiy A, Sinha R, Gulati G, Li X, Wearda T, Morganti R, Lopez M, Ransom RC, Duldulao CR, Rodrigues M, Nguyen A, Januszyk M, Maan Z, Paik K, Yapa KS, Rajadas J, Wan DC, Gurtner GC, Snyder M, Beachy PA, Yang F, Goodman SB, Weissman IL, Chan CK, Longaker MT. Pharmacological rescue of diabetic skeletal stem cell niches. Sci Transl Med. 2017 01 11; 9(372). PMID: 28077677.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.